List of substrates found:


Substrate: CD150 (T cell antigen receptor)
Seq-ID: Q13291 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 307 FPAQDPCTTIYVAATEPVPES Lck 11806999
LTP
1.00
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.40
- low

Substrate: CD28 (Involved in T cell activation)
Seq-ID: P10747 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 191 SKRSRLLHSDYMNMTPRRPGP Lck 8992971
LTP
0.95
GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2
-
0.44
- medium

Substrate: CD31 (Adhesion molecule)
Seq-ID: Q08481 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 679 NKDPQNMDVEYTEVEVSSLEP Lck 9624175
LTP
1.00
- -
0.60
- medium

Substrate: CD33 (CD antigen)
Seq-ID: P20138 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 340 PTVEMDEELHYASLNFHGMNP Lck 10887109
LTP
1.00
PTPN11 SH2;
PTPN6 SH2
-
0.54
- low

Substrate: CD5 (T-cell surface glycoprotein CD5 precursor (Lymphocyte glycoprotein T1/Leu-1) (Lymphocyte antigen CD5))
Seq-ID: P06127 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
scavenger receptor activity integral to plasma membrane cell recognition,
cell proliferation
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 453 NPTASHVDNEYSQPPRNSRLS Lck 11298344
LTP
1.00
Lck SH2;
RASA_group SH2
-
0.71
- medium
Y 487 MQPDNSSDSDYDLHGAQRL   Lck 11298344
LTP
1.00
Lck SH2 -
0.70
- medium

Substrate: CTLA-4 (CD152 antigen)
Seq-ID: P09793 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
external side of plasma membrane,
integral to membrane
immune response
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 201 KKRSPLTTGVYVKMPPTEPEC Lck 9973379
LTP
1.00
- -
0.36
- low
Y 218 EPECEKQFQPYFIPIN      Lck 9973379
LTP
1.00
- -
0.13
- low

Substrate: DAPP1 (Adapter molecule)
Seq-ID: Q9UN19 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 139 YPRKVEEPSIYESVRVHTAMQ Lck 10880360
LTP
1.00
- -
0.40
- low

Substrate: Erzin (Connection of cytoscheletro structure to plasma membrane)
Seq-ID: P15311 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 146 DYNKEVHKSGYLSSERLIPQR Lck 12560083
LTP
0.76
- B41
0.26
1NI2 9.61%

Substrate: Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )
Seq-ID: P03372 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 537 SMKCKNVVPLYDLLLEMLDAH Lck 7539106
LTP
0.96
Src SH2 Hormone_recep
0.06
2IOG 27.07%

Substrate: IKB-alpha (Major histocompatibility complex enhancer-binding protein MAD3)
Seq-ID: P25963 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 42 SGLDSMKDEEYEQMVKELQEI Lck 8797825
LTP
1.00
PIK3R1 SH2 -
0.55
--

Substrate: IL-2R beta (Cytokin receptor)
Seq-ID: P14784 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 381 DALEIEACQVYFTYDPYSEED Lck 10214954
LTP
1.00
- -
0.40
- medium
Y 381 DALEIEACQVYFTYDPYSEED Lck 2047859
LTP
1.00
- -
0.40
- medium
Y 384 EIEACQVYFTYDPYSEEDPDE Lck 10214954
LTP
1.00
- -
0.46
- medium
Y 384 EIEACQVYFTYDPYSEEDPDE Lck 2047859
LTP
1.00
- -
0.46
- medium
Y 387 ACQVYFTYDPYSEEDPDEGVA Lck 10214954
LTP
0.00
- -
0.53
- medium
Y 387 ACQVYFTYDPYSEEDPDEGVA Lck 2047859
LTP
0.00
- -
0.53
- medium
Y 418 LQPLSGEDDAYCTFPSRDDLL Lck 10214954
LTP
1.00
SHB SH2;
STAT5 SH2
-
0.55
- medium
Y 536 NARLPLNTDAYLSLQELQGQD Lck 10214954
LTP
1.00
SHB SH2;
STAT5 SH2
-
0.71
- medium

Substrate: ITK (Tyrosine kinase)
Seq-ID: Q08881 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 512 GMTRFVLDDQYTSSTGTKFPV Lck 9312162
LTP
1.00
- TyrKc
0.15
--
Y 512 GMTRFVLDDQYTSSTGTKFPV Lck 12842872
LTP
1.00
- TyrKc
0.15
--

Substrate: LAMP (Unclassified)
Seq-ID: Q91GT2 [Human herpesvirus 8]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 480 QAATQPTDDLYEEVLFPRN   Lck 12915550
LTP
- - Herpes_LAMP2
0.68
- low

Substrate: LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))
Seq-ID: P06239 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 394 GLARLIEDNEYTAREGAKFPI Lck 3265417
LTP
0.84
Csk SH2 TyrKc
0.18
3LCK 54.59%
Y 505 EDFFTATEGQYQPQP       Lck 8945479
LTP
0.96
Lck SH2;
Src SH2;
SYK SH2
-
0.49
--

Substrate: LNK (Adapter molecule)
Seq-ID: Q9UQQ2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
Molecular FunctionCellular ComponentBiological Process
signal transducer activity
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 273 CTRLEMPDNLYTFVLKVKDRT Lck 9169414
LTP
0.03
- PH
0.22
- medium

Substrate: PKC delta (Protein kinase C, delta)
Seq-ID: P28867 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 311 KLDTTESVGIYQGFEKKPEVS Lck 11381116
LTP
0.16
- -
0.33
- low

Substrate: PKC theta (Serine/threonine kinase)
Seq-ID: Q04759 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 90 DLISETTVELYSLAERCRKNN Lck 10652356
LTP
0.00
- -
0.23
--

Substrate: PLC gamma 2 (Involved in transmembrane signaling)
Seq-ID: P16885 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 743 YPVTPELLERYNMERDINSLY Lck 12181444
LTP
0.05
- -
0.27
- medium
Y 753 YNMERDINSLYDVSRMYVDPS Lck 11606584
LTP
0.37
PLCG2 SH2 -
0.26
- medium
Y 753 YNMERDINSLYDVSRMYVDPS Lck 12181444
LTP
0.37
PLCG2 SH2 -
0.26
- medium
Y 759 INSLYDVSRMYVDPSEINPSM Lck 11606584
LTP
0.98
PLCG2 SH2 -
0.33
- medium
Y 759 INSLYDVSRMYVDPSEINPSM Lck 12181444
LTP
0.98
PLCG2 SH2 -
0.33
- medium
Y 1197 RPVLESEEELYSSCRQLRRRQ Lck 15184383
LTP
1.00
- -
0.33
- medium
Y 1217 QEELNNQLFLYDTHQNLRNAN Lck 15184383
LTP
1.00
- -
0.35
- medium

Substrate: PTEN (Lipid phosphatase)
Seq-ID: P60484 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 240 GPTRREDKFMYFEFPQPLPVC Lck 11948419
LTP
0.46
- PTEN_C2
0.22
1D5R 10.48%
Y 315 SIERADNDKEYLVLTLTKNDL Lck 11948419
LTP
0.11
- PTEN_C2
0.38
1D5R 27.95%

Substrate: SIGLEC10 (cell adhesion molecule)
Seq-ID: Q96LC7 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sugar binding plasma membrane,
extracellular region,
integral to membrane
cell adhesion
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 597 RFSRHSTILDYINVVPTAGPL Lck 11733002
LTP
0.17
- -
0.39
- low
Y 667 ESQESQEELHYATLNFPGVRP Lck 11733002
LTP
1.00
PTPN6 SH2 -
0.78
- low
Y 691 ARMPKGTQADYAEVKFQ     Lck 11733002
LTP
1.00
- -
0.74
- low

Substrate: SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)
Seq-ID: Q13094 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 113 GGWSSFEEDDYESPNDDQDGE Lck 8702662
LTP
0.99
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.92
- medium
Y 128 DDQDGEDDGDYESPNEEEEAP Lck 8702662
LTP
0.30
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.98
- medium

Substrate: SOCS3 (protein kinase inhibitor activity)
Seq-ID: O14543 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 204 RKTVNGHLDSYEKVTQLPGPI Lck 12783885
LTP
0.19
- SOCS_box
0.51
--
Y 221 PGPIREFLDQYDAPL       Lck 15173187
LTP
0.99
CRKL SH2;
NCK SH2;
RASA_group SH2
SOCS_box
0.43
--

Substrate: Spectrin (Cytoskeletal protein)
Seq-ID: Q13813 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1176 EVQAVQQQEVYGMMPRDETDS Lck 11971983
LTP
0.00
- SPEC
0.63
- medium

Substrate: Tyrosine-protein phosphatase, non-receptor type 6 (Protein tyrosine phosphatase containing SH2 domains)
Seq-ID: P29350 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 536 LQSQKGQESEYGNITYPPAMK Lck 8114715
LTP
1.00
Lck SH2;
Src SH2
-
0.56
- low
Y 564 RTSSKHKEDVYENLHTKNKRE Lck 8114715
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low
Y 564 RTSSKHKEDVYENLHTKNKRE Lck 10488096
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low

Substrate: Vav (Adaptor molecule. GDP/GTP exchange factor in Rho/Rac molecule)
Seq-ID: P15498 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 142 EEESVGDEDIYSGLSDQIDDT Lck 16285729
LTP
1.00
Lck SH2 -
0.49
- medium
Y 160 DDTVEEDEDLYDCVENEEAEG Lck 16285729
LTP
1.00
- -
0.51
- medium

Substrate: Vav (Adaptor molecule. GDP/GTP exchange factor in Rho/Rac molecule)
Seq-ID: P27870 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 142 EDSALNDEDIYSGLSDQIDDT Lck 10669745
LTP
1.00
- -
0.46
--
Y 160 DDTAEEDEDLYDCVENEEAEG Lck 10669745
LTP
1.00
- -
0.56
--
Y 174 ENEEAEGDEIYEDLMRLESVP Lck 10669745
LTP
1.00
- -
0.49
--

Substrate: Vav 2 (Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases)
Seq-ID: P52735 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 142 EETTENDDDVYRSLEELADEH Lck 12454019
LTP
1.00
- -
0.54
- low
Y 159 ADEHDLGEDIYDCVPCEDGGD Lck 12454019
LTP
0.04
- -
0.31
- low
Y 172 VPCEDGGDDIYEDIIKVEVQQ Lck 12454019
LTP
1.00
- -
0.25
- low

Substrate: ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID: P43403 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 292 RRIDTLNSDGYTPEPARITSP Lck 8756661
LTP
1.00
CBL PTB;
CBL SH2;
CRKL SH2
-
0.65
--
Y 292 RRIDTLNSDGYTPEPARITSP Lck 7961936
LTP
1.00
CBL PTB;
CBL SH2;
CRKL SH2
-
0.65
--
Y 474 ARNVLLVNRHYAKISDFGLSK Lck 9685404
LTP
1.00
SHC_group SH2 TyrKc
0.07
1U59 13.97%
Y 492 LSKALGADDSYYTARSAGKWP Lck 8756661
LTP
1.00
Fyn SH2 TyrKc
0.14
1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP Lck 7961936
LTP
1.00
Fyn SH2 TyrKc
0.14
1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP Lck 7642520
LTP
1.00
Fyn SH2 TyrKc
0.14
1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP Lck 11270871
LTP
1.00
Fyn SH2 TyrKc
0.14
1U59 13.10%
Y 493 SKALGADDSYYTARSAGKWPL Lck 8756661
LTP
1.00
Fyn SH2 TyrKc
0.13
1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL Lck 7961936
LTP
1.00
Fyn SH2 TyrKc
0.13
1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL Lck 7642520
LTP
1.00
Fyn SH2 TyrKc
0.13
1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL Lck 11270871
LTP
1.00
Fyn SH2 TyrKc
0.13
1U59 68.12%

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