List of substrates found:


Substrate: CD150 (T cell antigen receptor)
Seq-ID: Q13291 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 307 FPAQDPCTTIYVAATEPVPES Lck 11806999
LTP
1.00
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.40
- low

Substrate: CD28 (Involved in T cell activation)
Seq-ID: P10747 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 191 SKRSRLLHSDYMNMTPRRPGP Lck 8992971
LTP
0.95
GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2
-
0.44
- medium

Substrate: CD31 (Adhesion molecule)
Seq-ID: Q08481 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 679 NKDPQNMDVEYTEVEVSSLEP Lck 9624175
LTP
1.00
- -
0.60
- medium

Substrate: CD33 (CD antigen)
Seq-ID: P20138 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 340 PTVEMDEELHYASLNFHGMNP Lck 10887109
LTP
1.00
PTPN11 SH2;
PTPN6 SH2
-
0.54
- low

Substrate: CD5 (T-cell surface glycoprotein CD5 precursor (Lymphocyte glycoprotein T1/Leu-1) (Lymphocyte antigen CD5))
Seq-ID: P06127 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
scavenger receptor activity integral to plasma membrane cell recognition,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 453 NPTASHVDNEYSQPPRNSRLS Lck 11298344
LTP
1.00
Lck SH2;
RASA_group SH2
-
0.71
- medium
Y 487 MQPDNSSDSDYDLHGAQRL   Lck 11298344
LTP
1.00
Lck SH2 -
0.70
- medium

Substrate: CTLA-4 (CD152 antigen)
Seq-ID: P09793 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
external side of plasma membrane,
integral to membrane
immune response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 201 KKRSPLTTGVYVKMPPTEPEC Lck 9973379
LTP
1.00
- -
0.36
- low
Y 218 EPECEKQFQPYFIPIN      Lck 9973379
LTP
1.00
- -
0.13
- low

Substrate: DAPP1 (Adapter molecule)
Seq-ID: Q9UN19 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 139 YPRKVEEPSIYESVRVHTAMQ Lck 10880360
LTP
1.00
- -
0.40
- low

Substrate: Erzin (Connection of cytoscheletro structure to plasma membrane)
Seq-ID: P15311 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 146 DYNKEVHKSGYLSSERLIPQR Lck 12560083
LTP
0.76
- B41
0.26
1NI2 9.61%

Substrate: Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )
Seq-ID: P03372 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 537 SMKCKNVVPLYDLLLEMLDAH Lck 7539106
LTP
0.96
Src SH2 Hormone_recep
0.06
2IOG 27.07%

Substrate: IKB-alpha (Major histocompatibility complex enhancer-binding protein MAD3)
Seq-ID: P25963 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 42 SGLDSMKDEEYEQMVKELQEI Lck 8797825
LTP
1.00
PIK3R1 SH2 -
0.55
--

Substrate: IL-2R beta (Cytokin receptor)
Seq-ID: P14784 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 381 DALEIEACQVYFTYDPYSEED Lck 10214954
LTP
1.00
- -
0.40
- medium
Y 381 DALEIEACQVYFTYDPYSEED Lck 2047859
LTP
1.00
- -
0.40
- medium
Y 384 EIEACQVYFTYDPYSEEDPDE Lck 10214954
LTP
1.00
- -
0.46
- medium
Y 384 EIEACQVYFTYDPYSEEDPDE Lck 2047859
LTP
1.00
- -
0.46
- medium
Y 387 ACQVYFTYDPYSEEDPDEGVA Lck 10214954
LTP
0.00
- -
0.53
- medium
Y 387 ACQVYFTYDPYSEEDPDEGVA Lck 2047859
LTP
0.00
- -
0.53
- medium
Y 418 LQPLSGEDDAYCTFPSRDDLL Lck 10214954
LTP
1.00
SHB SH2;
STAT5 SH2
-
0.55
- medium
Y 536 NARLPLNTDAYLSLQELQGQD Lck 10214954
LTP
1.00
SHB SH2;
STAT5 SH2
-
0.71
- medium

Substrate: ITK (Tyrosine kinase)
Seq-ID: Q08881 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 512 GMTRFVLDDQYTSSTGTKFPV Lck 9312162
LTP
1.00
- TyrKc
0.15
--
Y 512 GMTRFVLDDQYTSSTGTKFPV Lck 12842872
LTP
1.00
- TyrKc
0.15
--

Substrate: LAMP (Unclassified)
Seq-ID: Q91GT2 [Human herpesvirus 8]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 480 QAATQPTDDLYEEVLFPRN   Lck 12915550
LTP
- - Herpes_LAMP2
0.68
- low

Substrate: LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))
Seq-ID: P06239 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 394 GLARLIEDNEYTAREGAKFPI Lck 3265417
LTP
0.84
Csk SH2 TyrKc
0.18
3LCK 54.59%
Y 505 EDFFTATEGQYQPQP       Lck 8945479
LTP
0.96
Lck SH2;
Src SH2;
SYK SH2
-
0.49
--

Substrate: LNK (Adapter molecule)
Seq-ID: Q9UQQ2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
Molecular FunctionCellular ComponentBiological Process
signal transducer activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 273 CTRLEMPDNLYTFVLKVKDRT Lck 9169414
LTP
0.03
- PH
0.22
- medium

Substrate: PKC delta (Protein kinase C, delta)
Seq-ID: P28867 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 311 KLDTTESVGIYQGFEKKPEVS Lck 11381116
LTP
0.16
- -
0.33
- low

Substrate: PKC theta (Serine/threonine kinase)
Seq-ID: Q04759 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 90 DLISETTVELYSLAERCRKNN Lck 10652356
LTP
0.00
- -
0.23
--

Substrate: PLC gamma 2 (Involved in transmembrane signaling)
Seq-ID: P16885 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 743 YPVTPELLERYNMERDINSLY Lck 12181444
LTP
0.05
- -
0.27
- medium
Y 753 YNMERDINSLYDVSRMYVDPS Lck 11606584
LTP
0.37
PLCG2 SH2 -
0.26
- medium
Y 753 YNMERDINSLYDVSRMYVDPS Lck 12181444
LTP
0.37
PLCG2 SH2 -
0.26
- medium
Y 759 INSLYDVSRMYVDPSEINPSM Lck 11606584
LTP
0.98
PLCG2 SH2 -
0.33
- medium
Y 759 INSLYDVSRMYVDPSEINPSM Lck 12181444
LTP
0.98
PLCG2 SH2 -
0.33
- medium
Y 1197 RPVLESEEELYSSCRQLRRRQ Lck 15184383
LTP
1.00
- -
0.33
- medium
Y 1217 QEELNNQLFLYDTHQNLRNAN Lck 15184383
LTP
1.00
- -
0.35
- medium

Substrate: PTEN (Lipid phosphatase)
Seq-ID: P60484 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 240 GPTRREDKFMYFEFPQPLPVC Lck 11948419
LTP
0.46
- PTEN_C2
0.22
1D5R 10.48%
Y 315 SIERADNDKEYLVLTLTKNDL Lck 11948419
LTP
0.11
- PTEN_C2
0.38
1D5R 27.95%

Substrate: SIGLEC10 (cell adhesion molecule)
Seq-ID: Q96LC7 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sugar binding plasma membrane,
extracellular region,
integral to membrane
cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 597 RFSRHSTILDYINVVPTAGPL Lck 11733002
LTP
0.17
- -
0.39
- low
Y 667 ESQESQEELHYATLNFPGVRP Lck 11733002
LTP
1.00
PTPN6 SH2 -
0.78
- low
Y 691 ARMPKGTQADYAEVKFQ     Lck 11733002
LTP
1.00
- -
0.74
- low

Substrate: SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)
Seq-ID: Q13094 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 113 GGWSSFEEDDYESPNDDQDGE Lck 8702662
LTP
0.99
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.92
- medium
Y 128 DDQDGEDDGDYESPNEEEEAP Lck 8702662
LTP
0.30
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.98
- medium

Substrate: SOCS3 (protein kinase inhibitor activity)
Seq-ID: O14543 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 204 RKTVNGHLDSYEKVTQLPGPI Lck 12783885
LTP
0.19
- SOCS_box
0.51
--
Y 221 PGPIREFLDQYDAPL       Lck 15173187
LTP
0.99
CRKL SH2;
NCK SH2;
RASA_group SH2
SOCS_box
0.43
--

Substrate: Spectrin (Cytoskeletal protein)
Seq-ID: Q13813 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1176 EVQAVQQQEVYGMMPRDETDS Lck 11971983
LTP
0.00
- SPEC
0.63
- medium

Substrate: Tyrosine-protein phosphatase, non-receptor type 6 (Protein tyrosine phosphatase containing SH2 domains)
Seq-ID: P29350 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 536 LQSQKGQESEYGNITYPPAMK Lck 8114715
LTP
1.00
Lck SH2;
Src SH2
-
0.56
- low
Y 564 RTSSKHKEDVYENLHTKNKRE Lck 8114715
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low
Y 564 RTSSKHKEDVYENLHTKNKRE Lck 10488096
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low

Substrate: Vav (Adaptor molecule. GDP/GTP exchange factor in Rho/Rac molecule)
Seq-ID: P15498 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 142 EEESVGDEDIYSGLSDQIDDT Lck 16285729
LTP
1.00
Lck SH2 -
0.49
- medium
Y 160 DDTVEEDEDLYDCVENEEAEG Lck 16285729
LTP
1.00
- -
0.51
- medium

Substrate: Vav (Adaptor molecule. GDP/GTP exchange factor in Rho/Rac molecule)
Seq-ID: P27870 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 142 EDSALNDEDIYSGLSDQIDDT Lck 10669745
LTP
1.00
- -
0.46
--
Y 160 DDTAEEDEDLYDCVENEEAEG Lck 10669745
LTP
1.00
- -
0.56
--
Y 174 ENEEAEGDEIYEDLMRLESVP Lck 10669745
LTP
1.00
- -
0.49
--

Substrate: Vav 2 (Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases)
Seq-ID: P52735 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 142 EETTENDDDVYRSLEELADEH Lck 12454019
LTP
1.00
- -
0.54
- low
Y 159 ADEHDLGEDIYDCVPCEDGGD Lck 12454019
LTP
0.04
- -
0.31
- low
Y 172 VPCEDGGDDIYEDIIKVEVQQ Lck 12454019
LTP
1.00
- -
0.25
- low

Substrate: ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID: P43403 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 292 RRIDTLNSDGYTPEPARITSP Lck 8756661
LTP
1.00
CBL PTB;
CBL SH2;
CRKL SH2
-
0.65
--
Y 292 RRIDTLNSDGYTPEPARITSP Lck 7961936
LTP
1.00
CBL PTB;
CBL SH2;
CRKL SH2
-
0.65
--
Y 474 ARNVLLVNRHYAKISDFGLSK Lck 9685404
LTP
1.00
SHC_group SH2 TyrKc
0.07
1U59 13.97%
Y 492 LSKALGADDSYYTARSAGKWP Lck 8756661
LTP
1.00
Fyn SH2 TyrKc
0.14
1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP Lck 7961936
LTP
1.00
Fyn SH2 TyrKc
0.14
1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP Lck 7642520
LTP
1.00
Fyn SH2 TyrKc
0.14
1U59 13.10%
Y 492 LSKALGADDSYYTARSAGKWP Lck 11270871
LTP
1.00
Fyn SH2 TyrKc
0.14
1U59 13.10%
Y 493 SKALGADDSYYTARSAGKWPL Lck 8756661
LTP
1.00
Fyn SH2 TyrKc
0.13
1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL Lck 7961936
LTP
1.00
Fyn SH2 TyrKc
0.13
1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL Lck 7642520
LTP
1.00
Fyn SH2 TyrKc
0.13
1U59 68.12%
Y 493 SKALGADDSYYTARSAGKWPL Lck 11270871
LTP
1.00
Fyn SH2 TyrKc
0.13
1U59 68.12%

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