Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Substrate:

Bcl-2 (Apoptosis regulator Bcl-2)

Seq-ID:

P10415 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13660   B2L11_MOUSE
MINT-51440   MK01_HUMAN
MINT-51443   PP2AA_HUMAN
MINT-56637   FKBP8_HUMAN
MINT-56639   MK08_HUMAN
MINT-58237   CANB1_HUMAN
MINT-6629252   B2L11_HUMAN
MINT-7235965   ASPP2_HUMAN
MINT-7712827   BECN1_HUMAN
MINT-7717145   NAF1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, protein homodimerization activity, transcription activator activity, protease binding, BH3 domain binding, sequence-specific DNA binding	nuclear membrane, integral to membrane, mitochondrial outer membrane, endoplasmic reticulum membrane	negative regulation of cellular pH reduction, positive regulation of cell growth, regulation of protein homodimerization activity, response to toxin, anti-apoptosis, humoral immune response, defense response to virus, release of cytochrome c from mitochondria, response to drug, regulation of mitochondrial membrane potential, regulation of mitochondrial membrane permeability, regulation of protein heterodimerization activity, response to cytokine stimulus, apoptosis in response to endoplasmic reticulum stress, neuron apoptosis, female pregnancy, negative regulation of neuron apoptosis, response to iron ion, activation of pro-apoptotic gene products, negative regulation of mitochondrial depolarization, response to nicotine, protein polyubiquitination, B cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	69	PAASRDPVARTSPLQTPAAPG	MAPK_group	10567572	LTP	0.09	MOD_ProDKin_1	-	-	0.75	-	-
S	70	AASRDPVARTSPLQTPAAPGA	MAPK_group	10567572	LTP	1.00	MOD_ProDKin_1	PIN1 WW	-	0.75	-	-
S	87	APGAAAGPALSPVPPVVHLTL	MAPK_group	10567572	LTP	0.32	MOD_ProDKin_1	PIN1 WW	-	0.43	-	-

Substrate:

Beta-ARK-1 (Beta-adrenergic receptor kinase)

Seq-ID:

P25098 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-51490   EGFR_HUMAN
MINT-3376147   MDM2_HUMAN
MINT-6608788   GIT1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
G-protein coupled receptor kinase activity, ATP binding, Edg-2 lysophosphatidic acid receptor binding, alpha-2A adrenergic receptor binding, beta-adrenergic receptor kinase activity, signal transducer activity	cytosol, soluble fraction	negative regulation of striated muscle contraction, desensitization of G-protein coupled receptor protein signaling pathway, positive regulation of catecholamine secretion, muscarinic acetylcholine receptor signaling pathway, tachykinin receptor signaling pathway, peptidyl-serine phosphorylation, cardiac muscle contraction, negative regulation of the force of heart contraction by chemical signal

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	670	RVPKMKNKPRSPVVELSKVPL	MAPK_group	10727525	LTP	0.19	MOD_ProDKin_1	-	-	0.44	-	-

Substrate:

C-ets-1 protein (C-ets-1 protein)

Seq-ID:

P14921 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16586 DAXX_HUMAN
MINT-5207365 ANDR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, RNA polymerase II transcription factor activity, transcription factor binding, sequence-specific DNA binding transcription factor activity, protein binding	nucleus	transcription from RNA polymerase II promoter, positive regulation of gene-specific transcription from RNA polymerase II promoter, positive regulation of transcription, transcription, cell motility, negative regulation of cell proliferation, positive regulation of cellular component movement, immune response, PML body organization, positive regulation of erythrocyte differentiation, response to antibiotic, induction of apoptosis, negative regulation of cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	38	DMECADVPLLTPSSKEMMSQA	MAPK_group	8761310	LTP	0.70	MOD_ProDKin_1	-	-	0.37	-	-

Substrate:

c-Myb (Transcription factor)

Seq-ID:

P10242 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-6802128 CLH1_HUMAN
MINT-6802201 LIN9_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, transcription activator activity, protein binding	nuclear matrix	transcription, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	532	LLKKIKQEVESPTDKSGNFFC	MAPK_group	8960373	LTP	1.00	MOD_ProDKin_1	-	Cmyb_C	0.48	-	low

Substrate:

C/EBP beta (Transcription factor)

Seq-ID:

P17676 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14023   SMAD3_HUMAN
MINT-14687   SMAD4_HUMAN
MINT-49733   HMGA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
RNA polymerase II transcription factor activity, enhancer binding		transcription from RNA polymerase II promoter, immune response, acute-phase response

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	235	STSSSSSPPGTPSPADAKAPP	MAPK_group	8384717	LTP	0.97	MOD_ProDKin_1	-	-	0.89	-	-

Substrate:

C/EBP epsilon (Transcription factor)

Seq-ID:

Q15744 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7231963 DOCK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity	nucleus	transcription, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	74	PEARGLKGPGTPAFPHYLPPD	MAPK_group	9032264	LTP	0.00	MOD_ProDKin_1	-	-	0.73	-	low

Substrate:

Calcipressin 1 (Unclassified)

Seq-ID:

P53805 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding transcription factor activity, protein binding	nucleus	central nervous system development, calcium-mediated signaling, blood circulation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	112	DKQFLISPPASPPVGWKQVED	MAPK_group	12063245	LTP	0.74	MOD_ProDKin_1	-	Calcipressin	0.42	-	low

Substrate:

Cyclin B1 (Cell cycle control protein)

Seq-ID:

P14635 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-50660 CDN1A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	cytosol, spindle pole, microtubule organizing center, outer kinetochore of condensed nuclear chromosome, nucleoplasm	cell division, positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, positive regulation of mitotic cell cycle, mitotic prometaphase, positive regulation of attachment of spindle microtubules to kinetochore, mitotic cell cycle spindle checkpoint, mitotic metaphase plate congression, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, G2/M transition of mitotic cell cycle, mitotic spindle stabilization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	126	SPEPILVDTASPSPMETSGCA	MAPK_group	12447691	LTP	0.94	MOD_ProDKin_1	-	-	0.69	-	medium
S	128	EPILVDTASPSPMETSGCAPA	MAPK_group	12447691	LTP	0.16	MOD_ProDKin_1	-	-	0.69	-	medium

Substrate:

Cytosolic phospholipase A2 (Enzyme: Phospholipase)

Seq-ID:

P47712 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
lysophospholipase activity	cytosol, integral to membrane, endoplasmic reticulum membrane	platelet activating factor biosynthetic process, phospholipid catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	505	GLNLNTSYPLSPLSDFATQDS	MAPK_group	9468497	LTP	0.14	MOD_ProDKin_1	-	PLAc	0.36	-	-

Substrate:

Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )

Seq-ID:

P03372 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13786   BRCA1_HUMAN
MINT-50646   STA5A_HUMAN
MINT-50709   M3K1_HUMAN
MINT-5222241   NCOA1_HUMAN
MINT-6169667   EGFR_HUMAN
MINT-6614126   SMCA4_HUMAN
MINT-6614301   CHD3_HUMAN
MINT-6614361   MTA1_HUMAN
MINT-6614421   MTA2_HUMAN
MINT-6761899   PTN1_HUMAN
MINT-6761906   PTN6_HUMAN
MINT-7013584   PA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
beta-catenin binding, nitric-oxide synthase regulator activity, estrogen response element binding, steroid binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, estrogen receptor activity	chromatin remodeling complex	response to estradiol stimulus, transcription, DNA-dependent, regulation of transcription, DNA-dependent, positive regulation of retinoic acid receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	118	LMLLHPPPQLSPFLQPHGQQV	MAPK_group	12093745	LTP	1.00	MOD_ProDKin_1	-	Oest_recep	0.50	-	-
S	118	LMLLHPPPQLSPFLQPHGQQV	MAPK_group	12118371	LTP	1.00	MOD_ProDKin_1	-	Oest_recep	0.50	-	-
T	311	SKKNSLALSLTADQMVSALLD	MAPK_group	12138194	LTP	0.27		-	-	0.28	2IOG	52.05%

Substrate:

Fos (Transcription factor)

Seq-ID:

P01100 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-68804   JUN_HUMAN
MINT-68820   VE7_HPV16
MINT-1788374   JUNB_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
R-SMAD binding, specific RNA polymerase II transcription factor activity, promoter binding, sequence-specific DNA binding transcription factor activity		DNA methylation, inflammatory response, SMAD protein signal transduction, transforming growth factor beta receptor signaling pathway, cellular response to reactive oxygen species

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	374	SNEPSSDSLSSPTLLAL	MAPK_group	8248197	LTP	0.98	MOD_ProDKin_1	PIN1 WW	-	0.53	-	low

Substrate:

Glucocorticoid receptor (Transcription factor)

Seq-ID:

P04150 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14116   1433S_HUMAN
MINT-3373920   LCK_HUMAN
MINT-3373954   CD4_HUMAN
MINT-3374054   CD3D_HUMAN
MINT-6771456   KS6A5_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, glucocorticoid receptor activity, steroid binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, protein binding	mitochondrial matrix, nucleus	transcription from RNA polymerase II promoter, chromatin modification, response to protein stimulus, superior temporal gyrus development, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	226	DLLIDENCLLSPLAGEDDSFL	MAPK_group	9199329	LTP	0.98	MOD_ProDKin_1	-	GCR	0.34	-	low

Substrate:

Histone H3.1 (Histone H3)

Seq-ID:

P68431 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50057   UHRF1_MOUSE
MINT-61561   GRB2_HUMAN
MINT-2829033   CBX1_HUMAN
MINT-2829698   KDM4A_HUMAN
MINT-2830038   CDYL1_HUMAN
MINT-2830062   PHF20_HUMAN
MINT-2830088   TP53B_HUMAN
MINT-2830965   CBX5_HUMAN
MINT-2831013   CBX3_HUMAN
MINT-6665460   BRD7_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, protein binding	nucleus, nucleosome	nucleosome assembly

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	29	KQLATKAARKSAPATGGVKKP	MAPK_group	11278789	LTP	0.62		-	-	0.65	-	medium

Substrate:

HSF 1 (Transcription factor)

Seq-ID:

Q00613 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-1785958 STUB1_HUMAN
MINT-6743391 STRAP_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding transcription factor activity, protein binding	cytoplasm	transcription, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	307	VKEEPPSPPQSPRVEEASPGR	MAPK_group	8940068	LTP	1.00	MOD_ProDKin_1	-	Vert_HS_TF	0.96	-	high

Substrate:

LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))

Seq-ID:

ENSP00000328213 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide 3-kinase binding, protein C-terminus binding, protein kinase binding, protein serine/threonine phosphatase activity, glycoprotein binding, non-membrane spanning protein tyrosine kinase activity, ATP binding, CD8 receptor binding, ATPase binding, CD4 receptor binding, SH2 domain binding	plasma membrane, cytosol, Golgi apparatus, membrane raft, pericentriolar material	protein amino acid phosphorylation, T cell differentiation, response to drug, activation of caspase activity, positive regulation of T cell activation, positive regulation of T cell receptor signaling pathway, release of sequestered calcium ion into cytosol, interspecies interaction between organisms, cellular zinc ion homeostasis, induction of apoptosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	59	VTYEGSNPPASPLQDNLVIAL	MAPK_group	11847223	LTP	0.66	MOD_ProDKin_1	-	-	0.43	2IIM	55.74%

Substrate:

LIF-R (Cytokine receptor)

Seq-ID:

P42702 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
growth factor binding, leukemia inhibitory factor receptor activity, ciliary neurotrophic factor receptor binding	extracellular region, integral to plasma membrane	positive regulation of cell proliferation, leukemia inhibitory factor signaling pathway, response to cytokine stimulus, ciliary neurotrophic factor-mediated signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1044	VNTWNLVSPDSPRSIDSNSEI	MAPK_group	7777512	LTP	1.00	MOD_ProDKin_1	-	-	0.61	-	medium

Substrate:

Lipase hormone sensitive (Enzyme: Lipase)

Seq-ID:

P15304 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7211789 KAPCA_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
rRNA primary transcript binding, acylglycerol lipase activity, RNA polymerase I transcription termination factor activity, hormone-sensitive lipase activity, protein binding	lipid particle, mitochondrion, caveola, cytosol, extracellular space, nucleus	triglyceride catabolic process, response to drug, female pregnancy, cholesterol metabolic process, transcription initiation from RNA polymerase I promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	900	SFKGNSEPSDSPEMSQSMETL	MAPK_group	15294048	LTP	0.00	MOD_ProDKin_1	-	Abhydrolase_3	0.84	-	medium

Substrate:

MAP kinase-activated protein kinase 2 (MAP kinase-activated protein kinase 2 (EC 2.7.1.-) (from PhosphoBase))

Seq-ID:

P49137 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-2833388 LIMK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, signal transducer activity, protein binding	cytosol, nucleus	protein amino acid phosphorylation, MAPKKK cascade, Ras protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	25	PAPAPPPQPPTPALPHPPAQP	MAPK_group	8846784	LTP	0.03	MOD_ProDKin_1	-	-	0.95	-	-
T	222	KETTSHNSLTTPCYTPYYVAP	MAPK_group	8846784	LTP	0.95	MOD_ProDKin_1	-	S_TKc	0.26	2OZA	39.04%
S	272	PFYSNHGLAISPGMKTRIRMG	MAPK_group	8846784	LTP	1.00	MOD_ProDKin_1	-	S_TKc	0.29	1KWP	51.64%
T	334	WIMQSTKVPQTPLHTSRVLKE	MAPK_group	8846784	LTP	0.93	MOD_ProDKin_1	-	-	0.49	2OZA	19.86%

Substrate:

MAP kinase-activated protein kinase 2 (MAP kinase-activated protein kinase 2 (EC 2.7.1.-) (from PhosphoBase))

Seq-ID:

P49139 [Oryctolagus cuniculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding		protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	300	WIMQSTKVPQTPLHTSRXXXX	MAPK_group	1327754	LTP	0.92	MOD_ProDKin_1	-	-	0.56	-	low

Substrate:

MBP (myelin basic protein (MBP) (from PhosphoBase))

Seq-ID:

P02687 [Bos taurus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-6613181 MK01_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural constituent of myelin sheath, protein binding	plasma membrane, myelin sheath

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	94	PVVHFFKNIVTPRTPPPSQGK	MAPK_group	1699809	LTP	0.15	MOD_ProDKin_1	-	Myelin_MBP	0.78	-	low
T	97	HFFKNIVTPRTPPPSQGKGRG	MAPK_group	1651322	LTP	0.47	MOD_ProDKin_1	-	Myelin_MBP	0.79	-	low
T	97	HFFKNIVTPRTPPPSQGKGRG	MAPK_group	1907971	LTP	0.47	MOD_ProDKin_1	-	Myelin_MBP	0.79	-	low

Substrate:

Mitogen-activated protein kinase 6 (Mitogen-activated protein kinase 6)

Seq-ID:

Q16659 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP binding, MAP kinase activity		protein amino acid phosphorylation, cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	189	DPHYSHKGHLSEGLVTKWYRS	MAPK_group	8621539	LTP	1.00		-	S_TKc	0.21	2I6L	62.30%

Substrate:

MLCK (Serine/threonine Kinase)

Seq-ID:

Q15746 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-7250086 NCK1_HUMAN
MINT-7252174 P85A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
myosin light chain kinase activity, metal ion binding, ATP binding, actin binding, calmodulin binding	cytosol	protein amino acid phosphorylation, muscle contraction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	16	LVASSHISKTSLSVDPSRVDS	MAPK_group	11964068	LTP	1.00	MOD_GSK3_1	-	-	0.44	-	medium

Substrate:

Myocyte-specific enhancer factor 2C (Myocyte-specific enhancer factor 2C)

Seq-ID:

Q06413 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-49706 HDAC4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, protein binding	nuclear speck	negative regulation of gene-specific transcription from RNA polymerase II promoter, nervous system development, positive regulation of gene-specific transcription from RNA polymerase II promoter, transcription, apoptosis, positive regulation of survival gene product expression, muscle organ development, cell differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	387	SSNLSLPSTQSLNIKSEPVSP	MAPK_group	9069290	LTP	0.14		-	-	0.74	-	-

Substrate:

p21 (Cyclin-dependent kinase inhibitor 1 (p21))

Seq-ID:

P38936 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50392   CC45L_HUMAN
MINT-50407   CDC6_HUMAN
MINT-50418   CDK4_HUMAN
MINT-50421   CDK6_HUMAN
MINT-50432   CCNB2_HUMAN
MINT-50437   CCND1_HUMAN
MINT-50441   CCND3_HUMAN
MINT-50445   GEMI_HUMAN
MINT-50660   CCNB1_HUMAN
MINT-73322   VE7_HPV16
MINT-73323   CDK2_HUMAN
MINT-1774121   SKP2_HUMAN
MINT-1780042   MCM7_HUMAN
MINT-1891378   P53_HUMAN
MINT-2635177   CCNE1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cyclin-dependent protein kinase inhibitor activity, metal ion binding	cytosol, cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, PCNA-p21 complex	cellular response to extracellular stimulus, positive regulation of fibroblast proliferation, senescence, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, negative regulation of cell proliferation, negative regulation of cell growth, cell cycle arrest, G1/S transition of mitotic cell cycle, induction of apoptosis by intracellular signals, Ras protein signal transduction, G2/M transition of mitotic cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	57	ERWNFDFVTETPLEGDFAWER	MAPK_group	12058028	LTP	1.00	MOD_ProDKin_1	-	CDI	0.36	-	medium
S	130	VPRSGEQAEGSPGGPGDSQGR	MAPK_group	12058028	LTP	0.03	MOD_ProDKin_1	-	-	0.91	-	medium

Substrate:

p53 (Cellular tumor antigen p53)

Seq-ID:

P04637 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13742   CHK2_HUMAN
MINT-15878   UBP7_HUMAN
MINT-16161   BRCA1_HUMAN
MINT-16977   PARP1_HUMAN
MINT-19990   PIN1_HUMAN
MINT-24859   ASPP2_HUMAN
MINT-45889   CEBPZ_HUMAN
MINT-49767   ATM_HUMAN
MINT-50577   SAE1_HUMAN
MINT-56524   SP1_HUMAN
MINT-58470   MED1_HUMAN
MINT-58672   HNRL1_HUMAN
MINT-60094   HIPK2_HUMAN
MINT-61312   MK08_HUMAN
MINT-61317   WWOX_HUMAN
MINT-62206   PP1A_HUMAN
MINT-63290   ARI2_HUMAN
MINT-63365   KITH_HUMAN
MINT-63497   ZNF24_HUMAN
MINT-63537   IF2B_HUMAN
MINT-63547   RAB4A_HUMAN
MINT-63559   SAT1_HUMAN
MINT-64119   STX5_HUMAN
MINT-64188   MD2BP_HUMAN
MINT-64748   K0087_HUMAN
MINT-65132   HSPB1_HUMAN
MINT-65272   MPH6_HUMAN
MINT-68565   BMX_HUMAN
MINT-74886   NPM_HUMAN
MINT-74925   1433Z_HUMAN
MINT-1795431   NMT1_HUMAN
MINT-1891378   CDN1A_HUMAN
MINT-1958329   CHK1_HUMAN
MINT-2634790   RGRF1_HUMAN
MINT-2858243   DVL2_HUMAN
MINT-2866927   SCAM1_HUMAN
MINT-3390028   KC1D_RAT
MINT-3979604   P53_MOUSE
MINT-4049689   NR4A1_HUMAN
MINT-4052116   SYVN1_HUMAN
MINT-4052873   GRP78_HUMAN
MINT-4302642   HS71L_HUMAN
MINT-4303978   XPO1_HUMAN
MINT-4329805   TOPRS_HUMAN
MINT-4793180   EGR1_HUMAN
MINT-4793253   GSK3B_HUMAN
MINT-4793489   PML_HUMAN
MINT-5114724   ZN363_HUMAN
MINT-5207405   HDAC8_HUMAN
MINT-6540866   PSME3_HUMAN
MINT-6540889   MDM2_HUMAN
MINT-6628692   LT_SV40
MINT-6665320   CBP_HUMAN
MINT-6701342   MAP1B_HUMAN
MINT-7013631   PA1_HUMAN
MINT-7013916   RYBP_HUMAN
MINT-7103733   ANDR_HUMAN
MINT-7144912   TOE1_HUMAN
MINT-7222784   FRAP_HUMAN
MINT-7263630   EP300_HUMAN
MINT-7266250   PLK1_HUMAN
MINT-7294020   FAK1_HUMAN
MINT-7295816   IKKB_HUMAN
MINT-7557644   GRP75_HUMAN
MINT-7711943   1433S_HUMAN
MINT-7717378   PHB_HUMAN
MINT-7718917   SNAI1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity, protease binding, DNA strand annealing activity, chromatin binding, copper ion binding, ATP binding, transcription factor binding, chaperone binding, zinc ion binding, histone acetyltransferase binding, promoter binding, sequence-specific DNA binding transcription factor activity, protein N-terminus binding, protein heterodimerization activity, protein phosphatase 2A binding, protein kinase binding, ubiquitin protein ligase binding	nucleolus, nuclear matrix, insoluble fraction, protein complex, endoplasmic reticulum, PML body, mitochondrion	positive regulation of gene-specific transcription from RNA polymerase II promoter, senescence, mitotic cell cycle G1/S DNA damage checkpoint, cell cycle arrest, regulation of mitochondrial membrane permeability, response to gamma radiation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, response to tumor cell, ER overload response, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, interspecies interaction between organisms, Ras protein signal transduction, nucleotide-excision repair, protein tetramerization, cellular response to glucose starvation, negative regulation of helicase activity, negative regulation of cell growth, base-excision repair, activation of caspase activity by cytochrome c, cell aging

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	55	LSPDDIEQWFTEDPGPDEAPR	MAPK_group	11409876	LTP	0.00		-	-	0.82	-	-

Substrate:

PPAR (Nuclear receptor)

Seq-ID:

Q07869 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-15842 NCOR2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, transcription activator activity, lipid binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, drug binding, steroid hormone receptor activity	nucleus	negative regulation of gene-specific transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, negative regulation of receptor biosynthetic process, negative regulation of sequestering of triglyceride, positive regulation of fatty acid beta-oxidation, fatty acid metabolic process, negative regulation of macrophage derived foam cell differentiation, negative regulation of appetite, fatty acid transport, negative regulation of cholesterol storage

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	12	VDTESPLCPLSPLEAGDLESP	MAPK_group	10187842	LTP	0.40	MOD_ProDKin_1	-	-	0.58	-	low
S	21	LSPLEAGDLESPLSEEFLQEM	MAPK_group	10187842	LTP	0.65	MOD_ProDKin_1	-	-	0.53	-	low

Substrate:

Retinoic acid receptor RXR-alpha (Retinoic acid receptor RXR-alpha)

Seq-ID:

P19793 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-24895   RARA_HUMAN
MINT-61590   SMAD2_HUMAN
MINT-61758   KPCD2_HUMAN
MINT-5224970   NCOA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, retinoid-X receptor activity, transcription coactivator activity, zinc ion binding, sequence-specific DNA binding transcription factor activity, ligand-regulated transcription factor activity, vitamin D receptor binding, steroid hormone receptor activity	nucleus	negative regulation of gene-specific transcription from RNA polymerase II promoter, transcription, vitamin metabolic process, interspecies interaction between organisms, response to retinoic acid, cholesterol metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	82	MGPHSMSVPTTPTLGFSTGSP	MAPK_group	12048211	LTP	0.39	MOD_ProDKin_1	-	-	0.67	-	-
S	260	VEANMGLNPSSPNDPVTNICQ	MAPK_group	10377179	LTP	0.67	MOD_ProDKin_1	-	-	0.53	1FM6	60.66%

Substrate:

S6K-alpha 1 (Ribosomal protein S6 kinase alpha 1)

Seq-ID:

Q15418 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17060   EF2K_HUMAN
MINT-19367   1433B_HUMAN
MINT-2793474   IF4B_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding, protein binding	cytosol, nucleoplasm	protein amino acid phosphorylation, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	359	FYFDTEFTSRTPKDSPGIPPS	MAPK_group	9430688	LTP	1.00	MOD_ProDKin_1	-	S_TK_X	0.54	-	-
S	363	TEFTSRTPKDSPGIPPSAGAH	MAPK_group	9430688	LTP	0.98	MOD_ProDKin_1	-	S_TK_X	0.66	-	-

Substrate:

Stathmin (stathmin (phosphoprotein p19) (oncoprotein 18) (Op18) (from PhosphoBase))

Seq-ID:

P16949 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-2860477 UBQL4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
signal transducer activity, tubulin binding	cytoplasm, microtubule	intracellular signaling pathway, nervous system development, mitotic spindle organization, cell differentiation, microtubule depolymerization, response to virus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	25	ASGQAFELILSPRSKESVPEF	MAPK_group	8245003	LTP	0.32	MOD_ProDKin_1	-	Stathmin	0.53	-	medium
S	25	ASGQAFELILSPRSKESVPEF	MAPK_group	8245003	LTP	0.32	MOD_ProDKin_1	-	Stathmin	0.53	-	medium
S	25	ASGQAFELILSPRSKESVPEF	MAPK_group	8325880	LTP	0.32	MOD_ProDKin_1	-	Stathmin	0.53	-	medium
S	38	SKESVPEFPLSPPKKKDLSLE	MAPK_group	8245003	LTP	0.59	MOD_CDK_SPxK_1	-	Stathmin	0.69	-	medium
S	38	SKESVPEFPLSPPKKKDLSLE	MAPK_group	8325880	LTP	0.59	MOD_CDK_SPxK_1	-	Stathmin	0.69	-	medium

Substrate:

Stathmin 2 (Stathmin 2 (SCG10 protein) (Superior cervical ganglion-10 protein).)

Seq-ID:

Q93045 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	membrane fraction, soluble fraction, axon, perinuclear region of cytoplasm, growth cone, membrane	positive regulation of neuron projection development, negative regulation of microtubule polymerization, negative regulation of neuron projection development, positive regulation of microtubule depolymerization, negative regulation of microtubule depolymerization, neuron differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	62	QAFELILKPPSPISEAPRTLA	MAPK_group	11718727	LTP	0.92	MOD_ProDKin_1	-	Stathmin	0.48	-	medium
S	73	PISEAPRTLASPKKKDLSLEE	MAPK_group	11718727	LTP	0.61	MOD_ProDKin_1	-	Stathmin	0.59	-	medium

Substrate:

Synapsin-1 (Synapsin I (Brain protein 4.1))

Seq-ID:

P17599 [Bos taurus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
catalytic activity, ATP binding, actin binding	synaptonemal complex, cell junction, synaptic vesicle membrane, Golgi apparatus	neurotransmitter secretion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	62	ERASSAAPVASPAAPSPGSSG	MAPK_group	8702879	LTP	0.24	MOD_ProDKin_1	-	-	0.79	-	low
S	67	AAPVASPAAPSPGSSGGGGFF	MAPK_group	8702879	LTP	0.17	MOD_ProDKin_1	-	-	0.64	-	low

Substrate:

Syntrophin (Alpha-1-syntrophin)

Seq-ID:

Q13424 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-59511 MK12_HUMAN
MINT-64134 KU70_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
actin binding, calmodulin binding	sarcolemma, cell junction, cytoplasm, cytoskeleton	muscle contraction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	193	TSVGWDSPPASPLQRQPSSPG	MAPK_group	10212242	LTP	0.04	MOD_ProDKin_1	-	PH	0.83	-	low
S	201	PASPLQRQPSSPGPTPRNFSE	MAPK_group	10212242	LTP	0.06	MOD_ProDKin_1	-	PH	0.88	-	low

Substrate:

TCF-3 (Transcription factor)

Seq-ID:

P15923 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, protein homodimerization activity, transcription activator activity, E-box binding, bHLH transcription factor binding, vitamin D response element binding, transcription factor binding, sequence-specific DNA binding transcription factor activity	cytoplasm, transcription factor complex, nucleoplasm, nucleus, protein complex	positive regulation of B cell proliferation, positive regulation of gene-specific transcription from RNA polymerase II promoter, transcription, G1 phase of mitotic cell cycle, positive regulation of cell cycle, immunoglobulin V(D)J recombination, B cell lineage commitment

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	355	SSNNFSSSPSTPVGSPQGLAG	MAPK_group	14592976	LTP	1.00	MOD_ProDKin_1	-	-	0.81	-	low

Substrate:

Tristetraproline (tristetraproline (TTP) (TIS11A) (TIS11) (ZFP-36) (from PhosphoBase))

Seq-ID:

P22893 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, AU-rich element binding, mRNA binding, zinc ion binding	cytosol, nucleus	negative regulation of myeloid cell differentiation, negative regulation of inflammatory response, nuclear-transcribed mRNA poly(A) tail shortening, regulation of mRNA stability, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, RNA destabilization, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	220	SPPPPGDLPLSPSAFSAAPGT	MAPK_group	7768935	LTP	0.66	MOD_ProDKin_1	-	-	0.77	-	low