a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Actin filament-associated protein  RGS16  Ras GTPase-activating protein 1  Dystroglycan  CSFR-1  EPHB2  PDGF-R alpha  CD31  Estrogen receptor alpha  R-PTP-alpha  CDH5  FAK  P130Cas  Paxillin  EGFR  CDCP1  RET  FYN  LCK  PYK2  PDGF-R beta  Tyrosine-protein phosphatase, non-receptor type 6  c-met  Grb10  VEGFR-2  Src  ErbB2 

Substrate:	Actin filament-associated protein (Actin filament-associated protein)
Seq-ID:	ENSGALP00000036444 [Gallus gallus]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3 domain binding, actin binding cytoplasm, cytoskeleton
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	93	PLPTSSLPEGYYEEAVPLSPG	SRC	9655255	LTP	1.00		Src SH2	-	0.54	-	medium
Y	94	LPTSSLPEGYYEEAVPLSPGK	SRC	9655255	LTP	1.00		Src SH2	-	0.52	-	medium
Y	451	GSSTDPGALHYDYIDVEMTAS	SRC	9655255	LTP	1.00		Src SH2	-	0.33	-	medium
Y	453	STDPGALHYDYIDVEMTASVI	SRC	9655255	LTP	1.00		Src SH2	-	0.27	-	medium

Substrate:	RGS16 (Regulator of G-protein signaling 16)
Seq-ID:	O15492 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process GTPase activator activity, calmodulin binding, signal transducer activity negative regulation of signal transduction, visual perception, regulation of G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	177	SYPRFLKSPAYRDLAAQASAA	EGFR	11602604	LTP	1.00		Src SH2	RGS	0.29	2BT2	0.87%
Y	177	SYPRFLKSPAYRDLAAQASAA	Lyn	12588871	LTP	1.00		Src SH2	RGS	0.29	2BT2	0.87%
Y	177	SYPRFLKSPAYRDLAAQASAA	SRC	12588871	LTP	1.00		Src SH2	RGS	0.29	2BT2	0.87%

Substrate:	Ras GTPase-activating protein 1 (Ras p21 activator protein (GAP))
Seq-ID:	P20936 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-74708   ERBB3_HUMAN MINT-74709   ERBB4_HUMAN MINT-74711   EGFR_HUMAN MINT-74712   ERBB2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process potassium channel inhibitor activity, Ras GTPase activator activity, glycoprotein binding, GTPase binding, receptor binding cytoplasm intracellular signaling pathway, cytokinesis, regulation of actin filament polymerization, positive regulation of anti-apoptosis, regulation of cell shape, signal transduction, negative regulation of cell-matrix adhesion, vasculogenesis, negative regulation of neuron apoptosis, regulation of small GTPase mediated signal transduction, regulation of RNA metabolic process, embryo development
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	460	LNDTVDGKEIYNTIRRKTKDA	PDGFR_group	1850098	LTP	1.00		Lck SH2; Src SH2	-	0.31	-	low
Y	460	LNDTVDGKEIYNTIRRKTKDA	EGFR	1850098	LTP	1.00		Lck SH2; Src SH2	-	0.31	-	low

Substrate:	Dystroglycan (Adhesion molecule)
Seq-ID:	Q14118 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	[show] MINT-18977   UTRO_HUMAN MINT-7245682   SRC_HUMAN MINT-7247422   FYN_HUMAN MINT-7249366   NCK1_HUMAN MINT-7251982   P85A_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process calcium ion binding, structural constituent of muscle, laminin-1 binding, vinculin binding, actin binding, alpha-actinin binding, tubulin binding filopodium, basement membrane, integral to membrane of membrane fraction, lamellipodium, cytoskeleton, integral to membrane, extracellular space, nucleoplasm, contractile ring negative regulation of MAPKKK cascade, microtubule anchoring, negative regulation of cell migration, cytoskeletal anchoring at plasma membrane, negative regulation of protein kinase B signaling cascade
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	892	NMTPYRSPPPYVPP	SRC	12795607	LTP	1.00		Csk SH2; Fyn SH2; NCK SH2; Src SH2	DAG1	0.77	-	medium

Substrate:	CSFR-1 (Macrophage colony stimulating factor I receptor)
Seq-ID:	P07333 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process macrophage colony-stimulating factor receptor activity, protein homodimerization activity, ATP binding, cytokine binding receptor complex, integral to plasma membrane protein amino acid phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, multicellular organismal development, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	561	KIIESYEGNSYTFIDPTQLPY	CSF1R	15297464	LTP	1.00		Fyn SH2; Src SH2; YES1 SH2	-	0.14	-	low
Y	809	LARDIMNDSNYIVKGNARLPV	CSF1R	N.N.	LTP	1.00		Fyn SH2; Src SH2; YES1 SH2	TyrKc	0.15	-	low
Y	809	LARDIMNDSNYIVKGNARLPV	CSF1R	15297464	LTP	1.00		Fyn SH2; Src SH2; YES1 SH2	TyrKc	0.15	-	low
Y	809	LARDIMNDSNYIVKGNARLPV	-	7579387	LTP	1.00		Fyn SH2; Src SH2; YES1 SH2	TyrKc	0.15	-	low

Substrate:	EPHB2 (Receptor for member of the ephrinB family)
Seq-ID:	P54763 [Mus musculus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	MINT-3388251   EPHA4_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane-ephrin receptor activity, axon guidance receptor activity, ATP binding, receptor binding neuronal cell body, integral to plasma membrane, synapse negative regulation of axonogenesis, retinal ganglion cell axon guidance, positive regulation of long-term neuronal synaptic plasticity, ephrin receptor signaling pathway, learning, camera-type eye morphogenesis, central nervous system projection neuron axonogenesis, peptidyl-tyrosine phosphorylation, optic nerve morphogenesis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	610	GMKIYIDPFTYEDPNEAVREF	EphB2	8622893	LTP	1.00		Fyn SH2; RASA_group SH2; Src SH2	-	0.22	1JPA	19.72%
Y	610	GMKIYIDPFTYEDPNEAVREF	EphB2	10572014	LTP	1.00		Fyn SH2; RASA_group SH2; Src SH2	-	0.22	1JPA	19.72%
Y	610	GMKIYIDPFTYEDPNEAVREF	-	9233798	LTP	1.00		Fyn SH2; RASA_group SH2; Src SH2	-	0.22	1JPA	19.72%
Y	610	GMKIYIDPFTYEDPNEAVREF	EphB2	9632142	LTP	1.00		Fyn SH2; RASA_group SH2; Src SH2	-	0.22	1JPA	19.72%

Substrate:	PDGF-R alpha (Receptor tyrosine kinase)
Seq-ID:	P16234 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process platelet-derived growth factor alpha-receptor activity, vascular endothelial growth factor receptor activity, platelet-derived growth factor binding, protein homodimerization activity, platelet-derived growth factor receptor binding, ATP binding integral to plasma membrane positive regulation of DNA replication, positive regulation of fibroblast proliferation, cell activation, positive regulation of cell migration, protein amino acid autophosphorylation, peptidyl-tyrosine phosphorylation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	572	IESISPDGHEYIYVDPMQLPY	-	11818394	LTP	1.00		Src SH2	-	0.13	-	medium
Y	574	SISPDGHEYIYVDPMQLPYDS	-	11818394	LTP	1.00		Src SH2	-	0.15	-	medium

Substrate:	CD31 (Adhesion molecule)
Seq-ID:	P16284 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	[show] MINT-61866   PR40A_HUMAN MINT-63486   KU70_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein binding cell junction, integral to membrane, extracellular space, platelet alpha granule membrane signal transduction, diapedesis, cell recognition, cell adhesion, phagocytosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	690	NKEPLNSDVQYTEVQVSSAES	-	15201144	LTP	1.00		INPP5D SH2; PLCG1 SH2; PTPN11 SH2; PTPN6 SH2; Src SH2	-	0.58	-	medium
Y	713	DLGKKDTETVYSEVRKAVPDA	-	15592455	HTP	1.00		PLCG1 SH2; PTPN11 SH2; PTPN6 SH2; Src SH2	-	0.63	-	medium
Y	713	DLGKKDTETVYSEVRKAVPDA	-	18088087	HTP	1.00		PLCG1 SH2; PTPN11 SH2; PTPN6 SH2; Src SH2	-	0.63	-	medium
Y	713	DLGKKDTETVYSEVRKAVPDA	-	18083107	HTP	1.00		PLCG1 SH2; PTPN11 SH2; PTPN6 SH2; Src SH2	-	0.63	-	medium

Substrate:	Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )
Seq-ID:	P03372 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-13786   BRCA1_HUMAN MINT-50646   STA5A_HUMAN MINT-50709   M3K1_HUMAN MINT-5222241   NCOA1_HUMAN MINT-6169667   EGFR_HUMAN MINT-6614126   SMCA4_HUMAN MINT-6614301   CHD3_HUMAN MINT-6614361   MTA1_HUMAN MINT-6614421   MTA2_HUMAN MINT-6761899   PTN1_HUMAN MINT-6761906   PTN6_HUMAN MINT-7013584   PA1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process beta-catenin binding, nitric-oxide synthase regulator activity, estrogen response element binding, steroid binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, estrogen receptor activity chromatin remodeling complex response to estradiol stimulus, transcription, DNA-dependent, regulation of transcription, DNA-dependent, positive regulation of retinoic acid receptor signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	537	SMKCKNVVPLYDLLLEMLDAH	Lck	7539106	LTP	0.96		Src SH2	Hormone_recep	0.06	2IOG	27.07%
Y	537	SMKCKNVVPLYDLLLEMLDAH	SRC	7539106	LTP	0.96		Src SH2	Hormone_recep	0.06	2IOG	27.07%
Y	537	SMKCKNVVPLYDLLLEMLDAH	-	16741565	LTP	0.96		Src SH2	Hormone_recep	0.06	2IOG	27.07%

Substrate:	R-PTP-alpha (Receptor tyrosine phosphatase)
Seq-ID:	P18433 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-6762830   IRS1_RAT
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane receptor protein tyrosine phosphatase activity integral to plasma membrane protein amino acid dephosphorylation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	798	VQEYIDAFSDYANFK	-	11923305	LTP	1.00		GRB2 SH2; Src SH2	-	0.07	-	-
Y	798	VQEYIDAFSDYANFK	-	17507376	LTP	1.00		GRB2 SH2; Src SH2	-	0.07	-	-
Y	798	VQEYIDAFSDYANFK	-	18083107	HTP	1.00		GRB2 SH2; Src SH2	-	0.07	-	-

Substrate:	CDH5
Seq-ID:	P33151 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-49634   VGFR2_HUMAN MINT-49636   SHC1_HUMAN MINT-4085197   PARD3_HUMAN MINT-4085223   CTNB1_HUMAN MINT-4085515   PAR6A_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process calcium ion binding, beta-catenin binding, receptor binding membrane fraction, integral to membrane homophilic cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	685	RPALDARPSLYAQVQKPPRHA	-	18083107	HTP	0.24		Csk SH2; Src SH2	Cadherin_C	0.61	-	medium

Substrate:	FAK (Focal adhesion kinase)
Seq-ID:	Q05397 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-17602   LYN_HUMAN MINT-74938   BCAR1_HUMAN MINT-3381308   SRC_HUMAN MINT-6794892   PTN1_HUMAN MINT-7294020   P53_HUMAN MINT-7385708   SRC_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine kinase activity, ATP binding, SH2 domain binding, signal transducer activity focal adhesion, cytosol, cytoskeleton signal complex assembly, integrin-mediated signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	397	HAVSVSETDDYAEIIDEEDTY	FAK	7509446	LTP	1.00		Fyn SH2; GRB2 SH2; GRB7 SH2; NCK SH2; PIK3R1 SH2; Src SH2; STAT3 SH2	-	0.49	-	-
Y	397	HAVSVSETDDYAEIIDEEDTY	-	17192257	HTP	1.00		Fyn SH2; GRB2 SH2; GRB7 SH2; NCK SH2; PIK3R1 SH2; Src SH2; STAT3 SH2	-	0.49	-	-
Y	397	HAVSVSETDDYAEIIDEEDTY	-	18083107	HTP	1.00		Fyn SH2; GRB2 SH2; GRB7 SH2; NCK SH2; PIK3R1 SH2; Src SH2; STAT3 SH2	-	0.49	-	-

Substrate:	P130Cas (Adaptor molecule. Contain 15 YxxP motifs. )
Seq-ID:	P56945 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-74936   PTN12_HUMAN MINT-74938   FAK1_HUMAN MINT-3974941   1433S_HUMAN MINT-6174734   ACTB_HUMAN MINT-6763936   CRK_HUMAN MINT-6793484   PTN1_HUMAN MINT-7104353   CDC42_HUMAN MINT-7104422   SRC_HUMAN MINT-7104436   ACK1_HUMAN MINT-7247002   FYN_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3 domain binding, protein kinase binding, protein phosphatase binding, signal transducer activity focal adhesion, membrane fraction, cytosol, ruffle regulation of cell growth, B cell receptor signaling pathway, cell division, positive regulation of cell migration, nerve growth factor receptor signaling pathway, cell migration, integrin-mediated signaling pathway, epidermal growth factor receptor signaling pathway, actin filament organization, regulation of apoptosis, platelet-derived growth factor receptor signaling pathway, T cell receptor signaling pathway, cell adhesion, insulin receptor signaling pathway, cell proliferation, G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	653	FTSQDSPDGQYENSEGGWMED	SRC	11604500	LTP	1.00		GRB2 SH2; Src SH2	-	0.75	-	medium
Y	653	FTSQDSPDGQYENSEGGWMED	-	8670206	LTP	1.00		GRB2 SH2; Src SH2	-	0.75	-	medium
Y	653	FTSQDSPDGQYENSEGGWMED	-	12480533	LTP	1.00		GRB2 SH2; Src SH2	-	0.75	-	medium
Y	664	ENSEGGWMEDYDYVHLQGKEE	-	8621540	LTP	1.00		FES SH2; Fyn SH2; Lck SH2; Src SH2	-	0.49	-	medium
Y	664	ENSEGGWMEDYDYVHLQGKEE	-	11604500	LTP	1.00		FES SH2; Fyn SH2; Lck SH2; Src SH2	-	0.49	-	medium

Substrate:	Paxillin (Cytoskeletal protein; component of focal adhesion.)
Seq-ID:	P49023 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-1953339   GIT1_HUMAN MINT-1953360   GIT2_HUMAN MINT-6169431   CSK_HUMAN MINT-6169440   PTN11_HUMAN MINT-6169502   GAB1_HUMAN MINT-6763928   CRK_HUMAN MINT-7145479   ASAP1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process beta-catenin binding, vinculin binding, zinc ion binding focal adhesion, cytoplasm, microtubule associated complex, lamellipodium muscle contraction, signal complex assembly, signal transduction, cell-matrix adhesion, cellular response to reactive oxygen species
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	40	PYSYPTGNHTYQEIAVPPPVP	SRC	11695992	LTP	0.93		CRK SH2; Src SH2	-	0.77	-	low
Y	40	PYSYPTGNHTYQEIAVPPPVP	-	16254239	HTP	0.93		CRK SH2; Src SH2	-	0.77	-	low

Substrate:	EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID:	P00533 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16802   GRB10_HUMAN MINT-50935   1433Z_HUMAN MINT-51101   ANXA1_HUMAN MINT-51490   ARBK1_HUMAN MINT-60973   CBL_HUMAN MINT-61486   CRKL_HUMAN MINT-61487   CSK_HUMAN MINT-61490   STA5B_HUMAN MINT-61540   GRB2_HUMAN MINT-68514   PDC6I_HUMAN MINT-74427   ABL1_HUMAN MINT-74438   ABL2_HUMAN MINT-74460   ANS1A_HUMAN MINT-74469   APBB1_HUMAN MINT-74479   DP13A_HUMAN MINT-74487   BMX_HUMAN MINT-74497   CRK_HUMAN MINT-74535   FES_HUMAN MINT-74551   IRS1_HUMAN MINT-74555   IRS4_HUMAN MINT-74562   JAK2_HUMAN MINT-74566   SH2B3_HUMAN MINT-74572   JIP1_HUMAN MINT-74587   NCK1_HUMAN MINT-74593   NUMB_HUMAN MINT-74594   NUMBL_HUMAN MINT-74606   P85A_HUMAN MINT-74630   P85B_HUMAN MINT-74659   P55G_HUMAN MINT-74678   PLCG1_HUMAN MINT-74685   PLCG2_HUMAN MINT-74687   PTK6_HUMAN MINT-74689   PTN11_HUMAN MINT-74711   RASA1_HUMAN MINT-74717   SH2B1_HUMAN MINT-74720   SH22A_HUMAN MINT-74732   SHC1_HUMAN MINT-74746   SLAP1_HUMAN MINT-74763   KSYK_HUMAN MINT-74790   TLN1_HUMAN MINT-74807   ZAP70_HUMAN MINT-1788719   ERBB2_HUMAN MINT-6169667   ESR1_HUMAN MINT-6170031   SOS1_MOUSE MINT-6170198   SH3G2_HUMAN MINT-6170268   SH3K1_HUMAN MINT-6793358   PTN1_HUMAN MINT-7980526   TM1L1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process epidermal growth factor receptor activity, protein heterodimerization activity, identical protein binding, receptor signaling protein tyrosine kinase activity, double-stranded DNA binding, ATP binding, protein phosphatase binding, actin filament binding, MAP/ERK kinase kinase activity Shc-EGFR complex, endosome, basolateral plasma membrane, integral to membrane, extracellular space, nucleus activation of phospholipase C activity, protein insertion into membrane, response to UV-A, positive regulation of nitric oxide biosynthetic process, positive regulation of cell migration, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, positive regulation of catenin protein nuclear translocation, regulation of nitric-oxide synthase activity, positive regulation of protein kinase B signaling cascade, ossification, positive regulation of epithelial cell proliferation, activation of phospholipase A2 activity by calcium-mediated signaling, cell-cell adhesion, regulation of peptidyl-tyrosine phosphorylation, positive regulation of phosphorylation, positive regulation of MAP kinase activity, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	915	WELMTFGSKPYDGIPASEISS	SRC	11983694	LTP	1.00		PLCG1 SH2; Src SH2	TyrKc	0.18	3BEL	8.30%
Y	944	PQPPICTIDVYMIMVKCWMID	SRC	11983694	LTP	1.00		PIK3R1 SH2; Src SH2	TyrKc	0.05	3BEL	16.16%
Y	1016	DMDDVVDADEYLIPQQGFFSS	SRC	8845374	LTP	1.00		CRK SH2; PLCG1 SH2; RASA_group SH2; Src SH2	-	0.41	1XKK	41.92%
Y	1016	DMDDVVDADEYLIPQQGFFSS	-	7680558	LTP	1.00		CRK SH2; PLCG1 SH2; RASA_group SH2; Src SH2	-	0.41	1XKK	41.92%
Y	1016	DMDDVVDADEYLIPQQGFFSS	-	15302935	HTP	1.00		CRK SH2; PLCG1 SH2; RASA_group SH2; Src SH2	-	0.41	1XKK	41.92%
Y	1110	RPAGSVQNPVYHNQPLNPAPS	EGFR	8845374	LTP	1.00		GRB2 SH2; PLCG1 SH2; RASA_group SH2; SHC1 PTB; Src SH2; STAT3 SH2	-	0.80	-	-
Y	1110	RPAGSVQNPVYHNQPLNPAPS	-	15302935	HTP	1.00		GRB2 SH2; PLCG1 SH2; RASA_group SH2; SHC1 PTB; Src SH2; STAT3 SH2	-	0.80	-	-
Y	1125	LNPAPSRDPHYQDPHSTAVGN	SRC	8845374	LTP	1.00		PLCG1 SH2; RASA_group SH2; Src SH2	-	0.86	-	-
Y	1125	LNPAPSRDPHYQDPHSTAVGN	SRC	11983694	LTP	1.00		PLCG1 SH2; RASA_group SH2; Src SH2	-	0.86	-	-
Y	1125	LNPAPSRDPHYQDPHSTAVGN	SRC	10075741	LTP	1.00		PLCG1 SH2; RASA_group SH2; Src SH2	-	0.86	-	-
Y	1172	SHQISLDNPDYQQDFFPKEAK	EGFR	8845374	LTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 PTB; SHC3 PTB; Src SH2; VAV2 SH2	-	0.67	-	-
Y	1172	SHQISLDNPDYQQDFFPKEAK	-	15302935	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 PTB; SHC3 PTB; Src SH2; VAV2 SH2	-	0.67	-	-
Y	1172	SHQISLDNPDYQQDFFPKEAK	-	17081983	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 PTB; SHC3 PTB; Src SH2; VAV2 SH2	-	0.67	-	-
Y	1172	SHQISLDNPDYQQDFFPKEAK	-	18083107	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 PTB; SHC3 PTB; Src SH2; VAV2 SH2	-	0.67	-	-
Y	1197	FKGSTAENAEYLRVAPQSSEF	EGFR	8845374	LTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 SH2; SHC3 SH2; Src SH2	-	0.54	-	-
Y	1197	FKGSTAENAEYLRVAPQSSEF	-	15302935	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 SH2; SHC3 SH2; Src SH2	-	0.54	-	-
Y	1197	FKGSTAENAEYLRVAPQSSEF	-	17081983	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 SH2; SHC3 SH2; Src SH2	-	0.54	-	-
Y	1197	FKGSTAENAEYLRVAPQSSEF	-	18083107	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 SH2; SHC3 SH2; Src SH2	-	0.54	-	-

Substrate:	CDCP1 (cell adhesion molecule)
Seq-ID:	Q9H5V8 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-62336   KPCD_HUMAN MINT-62342   SRC_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process plasma membrane, extracellular region, integral to membrane
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	734	KGRKDNDSHVYAVIEDTMVYG	-	15851033	LTP	1.00		Src SH2	-	0.39	-	medium

Substrate:	RET (Probable receptor with tyrosine-protein kinase activity; important for development.)
Seq-ID:	P07949 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-60970   CBL_HUMAN MINT-60975   GRB2_HUMAN MINT-60981   SHC1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process calcium ion binding, transmembrane receptor protein tyrosine kinase activity, ATP binding integral to membrane protein amino acid phosphorylation, posterior midgut development, homophilic cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1015	LEKMMVKRRDYLDLAASTPSD	-	11470823	LTP	1.00		PLCG1 SH2; SHC1 SH2; Src SH2	-	0.33	-	-
Y	1015	LEKMMVKRRDYLDLAASTPSD	RET	14981541	LTP	1.00		PLCG1 SH2; SHC1 SH2; Src SH2	-	0.33	-	-
Y	1029	AASTPSDSLIYDDGLSEEETP	-	11470823	LTP	1.00		Src SH2	-	0.51	-	-
Y	1029	AASTPSDSLIYDDGLSEEETP	RET	8621380	LTP	1.00		Src SH2	-	0.51	-	-
Y	1029	AASTPSDSLIYDDGLSEEETP	RET	14766744	LTP	1.00		Src SH2	-	0.51	-	-

Substrate:	FYN (Cytoplasmic tyrosine kinase)
Seq-ID:	P06241 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-14847   WASP_HUMAN MINT-15132   HNRPK_RAT MINT-15408   KHDR1_HUMAN MINT-15425   SHC1_HUMAN MINT-16566   FYB_HUMAN MINT-46000   CTNB1_MOUSE MINT-50377   RASH_HUMAN MINT-50652   MAP2_HUMAN MINT-50666   CBL_HUMAN MINT-61277   G3BP1_HUMAN MINT-61574   CTNB1_RAT MINT-2792095   PAK2_HUMAN MINT-2792412   ADA15_HUMAN MINT-2859062   ATX1_HUMAN MINT-3381335   VGFR2_HUMAN MINT-3381360   SRC_HUMAN MINT-3381384   NCK1_HUMAN MINT-4085360   TNR6_HUMAN MINT-7214580   5HT6R_HUMAN MINT-7245838   TRI39_HUMAN MINT-7245886   ORC1_HUMAN MINT-7245898   AKAP6_HUMAN MINT-7245910   CENPA_HUMAN MINT-7245922   LRBA_HUMAN MINT-7245934   TRAIP_HUMAN MINT-7245958   RPP38_HUMAN MINT-7245970   HCN2_HUMAN MINT-7246030   ASAP2_HUMAN MINT-7246102   SYNJ2_HUMAN MINT-7246150   RIMS1_HUMAN MINT-7246210   DLGP4_HUMAN MINT-7246222   LAP2B_HUMAN MINT-7246246   TGON2_HUMAN MINT-7246270   EPS15_HUMAN MINT-7246306   CD2AP_HUMAN MINT-7246318   MLL4_HUMAN MINT-7246402   ARHGB_HUMAN MINT-7246426   FLNC_HUMAN MINT-7246450   SP1_HUMAN MINT-7246474   RIMS2_HUMAN MINT-7246522   ABL1_HUMAN MINT-7246534   SNX12_HUMAN MINT-7246558   M4K1_HUMAN MINT-7246570   PRIC3_HUMAN MINT-7246594   WNK2_HUMAN MINT-7246630   RTN4_HUMAN MINT-7246666   SF3B4_HUMAN MINT-7246678   NFASC_HUMAN MINT-7246714   GCF_HUMAN MINT-7246726   PPR3D_HUMAN MINT-7246750   BAZ2A_HUMAN MINT-7246774   KI67_HUMAN MINT-7246798   DDX41_HUMAN MINT-7246810   DPOD1_HUMAN MINT-7246834   FLNA_HUMAN MINT-7246846   CDC27_HUMAN MINT-7246870   SNX8_HUMAN MINT-7246882   ABL2_HUMAN MINT-7246918   ASAP1_HUMAN MINT-7246930   MED14_HUMAN MINT-7246954   WIPF1_HUMAN MINT-7246978   E41L3_HUMAN MINT-7247002   BCAR1_HUMAN MINT-7247014   MYPT1_HUMAN MINT-7247038   CAF1A_HUMAN MINT-7247050   SHRM2_HUMAN MINT-7247074   VP13A_HUMAN MINT-7247086   CDKL5_HUMAN MINT-7247098   ICAL_HUMAN MINT-7247122   RRAS_HUMAN MINT-7247134   NELFB_HUMAN MINT-7247146   SPN90_HUMAN MINT-7247158   CKAP5_HUMAN MINT-7247170   FANCA_HUMAN MINT-7247182   HDAC6_HUMAN MINT-7247194   SNX3_HUMAN MINT-7247206   BRPF3_HUMAN MINT-7247230   XRCC1_HUMAN MINT-7247242   DAB2_HUMAN MINT-7247254   M4K5_HUMAN MINT-7247290   STF1_HUMAN MINT-7247302   DOCK1_HUMAN MINT-7247350   BRCA2_HUMAN MINT-7247374   RPGF1_HUMAN MINT-7247422   DAG1_HUMAN MINT-7247434   SUV92_HUMAN MINT-7247446   FCG2B_HUMAN MINT-7247458   FCG2C_HUMAN MINT-7247482   CELR3_HUMAN MINT-7247530   SOS1_HUMAN MINT-7247554   MOS_HUMAN MINT-7247566   SNX17_HUMAN MINT-7306611   LCP2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process identical protein binding, metal ion binding, glycoprotein binding, non-membrane spanning protein tyrosine kinase activity, ATP binding plasma membrane, endosome, cytosol learning, feeding behavior, calcium ion transport, interspecies interaction between organisms, T cell receptor signaling pathway, intracellular protein kinase cascade
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	531	EDYFTATEPQYQPGENL	Csk	1985196	LTP	0.94	MOD_TYR_CSK	Fyn SH2; Src SH2	-	0.42	-	-

Substrate:	LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))
Seq-ID:	P06239 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-15516   CBL_HUMAN MINT-56730   KSYK_HUMAN MINT-59474   LCP2_HUMAN MINT-59476   ZAP70_HUMAN MINT-60779   MK01_HUMAN MINT-60782   CD3Z_HUMAN MINT-61276   G3BP1_HUMAN MINT-66002   CD4_HUMAN MINT-66003   P85A_HUMAN MINT-68489   DLG1_HUMAN MINT-3373863   HS90A_HUMAN MINT-3373920   GCR_HUMAN MINT-7135817   SH22A_HUMAN MINT-7212471   KHDR1_HUMAN MINT-7212499   WASP_HUMAN MINT-7218109   ADA15_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphoinositide 3-kinase binding, protein C-terminus binding, protein kinase binding, protein serine/threonine phosphatase activity, glycoprotein binding, non-membrane spanning protein tyrosine kinase activity, ATP binding, CD8 receptor binding, ATPase binding, CD4 receptor binding, SH2 domain binding plasma membrane, cytosol, Golgi apparatus, membrane raft, pericentriolar material protein amino acid phosphorylation, T cell differentiation, response to drug, activation of caspase activity, positive regulation of T cell activation, positive regulation of T cell receptor signaling pathway, release of sequestered calcium ion into cytosol, interspecies interaction between organisms, cellular zinc ion homeostasis, induction of apoptosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	505	EDFFTATEGQYQPQP	-	3265417	LTP	0.96		Lck SH2; Src SH2; SYK SH2	-	0.49	-	-
Y	505	EDFFTATEGQYQPQP	-	15592455	HTP	0.96		Lck SH2; Src SH2; SYK SH2	-	0.49	-	-
Y	505	EDFFTATEGQYQPQP	Lck	8945479	LTP	0.96		Lck SH2; Src SH2; SYK SH2	-	0.49	-	-
Y	505	EDFFTATEGQYQPQP	-	17192257	HTP	0.96		Lck SH2; Src SH2; SYK SH2	-	0.49	-	-
Y	505	EDFFTATEGQYQPQP	-	18083107	HTP	0.96		Lck SH2; Src SH2; SYK SH2	-	0.49	-	-

Substrate:	PYK2 (Focal adhesion kinase 2)
Seq-ID:	Q14289 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-68515   PDC6I_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine kinase activity, ATP binding, signal transducer activity positive regulation of cell proliferation, signal complex assembly, apoptosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	402	SESCSIESDIYAEIPDETLRR	SYK	8816475	LTP	1.00		Fyn SH2; MATK SH2; Src SH2	-	0.37	-	-
Y	402	SESCSIESDIYAEIPDETLRR	-	9560226	LTP	1.00		Fyn SH2; MATK SH2; Src SH2	-	0.37	-	-
Y	402	SESCSIESDIYAEIPDETLRR	PYK2	15105428	LTP	1.00		Fyn SH2; MATK SH2; Src SH2	-	0.37	-	-

Substrate:	PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID:	P09619 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-2832596   NHRF2_HUMAN MINT-2832984   PTEN_HUMAN MINT-2833042   NHRF1_HUMAN MINT-6762380   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process vascular endothelial growth factor receptor activity, platelet-derived growth factor binding, platelet activating factor receptor activity, platelet-derived growth factor receptor binding, ATP binding, platelet-derived growth factor beta-receptor activity integral to plasma membrane positive regulation of cell proliferation, positive regulation of cell migration, protein amino acid autophosphorylation, peptidyl-tyrosine phosphorylation, cell chemotaxis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	579	IESVSSDGHEYIYVDPMQLPY	PDGFR_beta	8195171	LTP	1.00		Fyn SH2; PIK3R1 SH2; PLCG1 SH2; PTPN11 SH2; RASA_group SH2; SHC1 SH2; SHC_group SH2; SLA SH2; Src SH2; STAT5 SH2; YES1 SH2	-	0.15	-	medium
Y	581	SVSSDGHEYIYVDPMQLPYDS	PDGFR_beta	8617789	LTP	1.00		Fyn SH2; PIK3R1 SH2; PLCG1 SH2; PTPN11 SH2; RASA_group SH2; SLA SH2; Src SH2; STAT5 SH2; YES1 SH2	-	0.16	-	medium
Y	751	MDMSKDESVDYVPMLDMKGDV	PDGFR_beta	8195171	LTP	1.00		Fyn SH2; NCK SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2; RASA_group SH2; SHC1 SH2; SHC_group SH2; Src SH2	TyrKc	0.29	-	medium
Y	751	MDMSKDESVDYVPMLDMKGDV	PDGFR_group	8195171	LTP	1.00		Fyn SH2; NCK SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2; RASA_group SH2; SHC1 SH2; SHC_group SH2; Src SH2	TyrKc	0.29	-	medium
Y	857	LARDIMRDSNYISKGSTFLPL	PDGFR_beta	10821867	LTP	1.00		Fyn SH2; RASA_group SH2; Src SH2; YES1 SH2	TyrKc	0.08	-	medium
Y	857	LARDIMRDSNYISKGSTFLPL	PDGFR_group	10821867	LTP	1.00		Fyn SH2; RASA_group SH2; Src SH2; YES1 SH2	TyrKc	0.08	-	medium
Y	857	LARDIMRDSNYISKGSTFLPL	PDGFR_beta	2550144	LTP	1.00		Fyn SH2; RASA_group SH2; Src SH2; YES1 SH2	TyrKc	0.08	-	medium
Y	857	LARDIMRDSNYISKGSTFLPL	PDGFR_group	2550144	LTP	1.00		Fyn SH2; RASA_group SH2; Src SH2; YES1 SH2	TyrKc	0.08	-	medium

Substrate:	Tyrosine-protein phosphatase, non-receptor type 6 (Protein tyrosine phosphatase containing SH2 domains)
Seq-ID:	P29350 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-56658   TFG_HUMAN MINT-73504   EPOR_HUMAN MINT-74919   FCG2B_HUMAN MINT-6761906   ESR1_HUMAN MINT-6793815   CAV1_HUMAN MINT-6799844   ROS_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein tyrosine phosphatase activity, protein binding cytosol, nucleus, membrane apoptosis, protein amino acid dephosphorylation, signal transduction, G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	536	LQSQKGQESEYGNITYPPAMK	-	12468540	LTP	1.00		Lck SH2; Src SH2	-	0.56	-	low
Y	536	LQSQKGQESEYGNITYPPAMK	Lck	8114715	LTP	1.00		Lck SH2; Src SH2	-	0.56	-	low
Y	536	LQSQKGQESEYGNITYPPAMK	Abl	8692915	LTP	1.00		Lck SH2; Src SH2	-	0.56	-	low
Y	536	LQSQKGQESEYGNITYPPAMK	-	7512963	LTP	1.00		Lck SH2; Src SH2	-	0.56	-	low
Y	536	LQSQKGQESEYGNITYPPAMK	-	14757045	LTP	1.00		Lck SH2; Src SH2	-	0.56	-	low
Y	536	LQSQKGQESEYGNITYPPAMK	SRC	14699166	LTP	1.00		Lck SH2; Src SH2	-	0.56	-	low
Y	536	LQSQKGQESEYGNITYPPAMK	-	18083107	HTP	1.00		Lck SH2; Src SH2	-	0.56	-	low

Substrate:	c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID:	P08581 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-18299   RANB9_HUMAN MINT-58374   GAB1_MOUSE MINT-58404   GAB1_HUMAN MINT-6539587   CBL_HUMAN MINT-6787689   PTN1_HUMAN MINT-6798640   PTN11_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process hepatocyte growth factor receptor activity, ATP binding, protein binding integral to plasma membrane, basal plasma membrane protein amino acid phosphorylation, multicellular organismal development, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1349	AIFSTFIGEHYVHVNATYVNV	Met	12475979	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	-	9444958	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	-	9252406	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	-	7513258	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	Met	7731718	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	Met	7687741	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	-	9826708	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	12475979	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	9444958	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	9252406	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	7513258	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7731718	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	8662889	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7961992	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7687741	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	9826708	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%

Substrate:	Grb10 (Adapter molecule)
Seq-ID:	Q13322 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-15644   IGF1R_HUMAN MINT-16516   INSR_HUMAN MINT-16802   EGFR_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process insulin receptor binding, SH3/SH2 adaptor activity plasma membrane, cytoplasm negative regulation of glycogen biosynthetic process, negative regulation of insulin receptor signaling pathway, negative regulation of glucose import, positive regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of Wnt receptor signaling pathway, insulin receptor signaling pathway, positive regulation of phosphorylation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	67	NDMNASLESLYSACSMQSDTV	Fyn	10871840	LTP	0.81		Fyn SH2; Src SH2	-	0.50	-	low
Y	67	NDMNASLESLYSACSMQSDTV	SRC	10871840	LTP	0.81		Fyn SH2; Src SH2	-	0.50	-	low

Substrate:	VEGFR-2 (Receptor tyrosine kinase)
Seq-ID:	P35918 [Mus musculus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process vascular endothelial growth factor receptor activity, ATP binding, growth factor binding integral to plasma membrane branching morphogenesis of a tube, positive regulation of mesenchymal cell proliferation, protein amino acid phosphorylation, angiogenesis, cell migration, hemopoiesis, cell fate commitment, cell maturation, endothelial cell differentiation, surfactant homeostasis, positive regulation of epithelial cell proliferation, vasculogenesis, lung alveolus development, calcium ion homeostasis, ovarian follicle development
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1212	EEEVCDPKFHYDNTAGISHYL	KDR	12023952	LTP	0.23		Src SH2	-	0.45	-	medium
Y	1212	EEEVCDPKFHYDNTAGISHYL	KDR	15107818	LTP	0.23		Src SH2	-	0.45	-	medium

Substrate:	VEGFR-2 (Receptor tyrosine kinase)
Seq-ID:	P35968 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-49634   CADH5_HUMAN MINT-49637   SHC1_HUMAN MINT-2834292   NRP1_HUMAN MINT-3381238   GRB2_HUMAN MINT-3381278   NCK1_HUMAN MINT-3381335   FYN_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process Hsp90 protein binding, vascular endothelial growth factor receptor activity, receptor signaling protein tyrosine kinase activity, ATP binding, growth factor binding, integrin binding integral to plasma membrane positive regulation of positive chemotaxis, protein amino acid phosphorylation, positive regulation of endothelial cell proliferation, angiogenesis, regulation of cell shape, interspecies interaction between organisms, positive regulation of endothelial cell migration, positive regulation of focal adhesion assembly
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1214	EEEVCDPKFHYDNTAGISQYL	KDR	12023952	LTP	0.24		Src SH2	-	0.46	-	-
Y	1214	EEEVCDPKFHYDNTAGISQYL	KDR	11387210	LTP	0.24		Src SH2	-	0.46	-	-

Substrate:	Src (Proto-oncogene tyrosine-protein kinase Src)
Seq-ID:	P12931 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-14765   DDR2_HUMAN MINT-15459   CAV1_HUMAN MINT-46002   CTNB1_MOUSE MINT-50376   RASH_HUMAN MINT-62340   KPCD_HUMAN MINT-62342   CDCP1_HUMAN MINT-65953   DYN1_HUMAN MINT-65954   DYN2_HUMAN MINT-68512   PDC6I_HUMAN MINT-74753   ERBB3_HUMAN MINT-2792760   PAK2_HUMAN MINT-2793013   ADA15_HUMAN MINT-2840132   TLR3_HUMAN MINT-3381308   FAK1_HUMAN MINT-3381360   FYN_HUMAN MINT-4051815   ADRB2_HUMAN MINT-4961196   AFAD_HUMAN MINT-4980122   SNIP_MOUSE MINT-5210599   SNIP_HUMAN MINT-6539730   CBL_HUMAN MINT-6771405   FAK1_MOUSE MINT-6794909   ACTS_HUMAN MINT-6795322   ACTN1_HUMAN MINT-6795447   PTN1_HUMAN MINT-7035260   HNRPK_HUMAN MINT-7040283   CBLB_HUMAN MINT-7104422   BCAR1_HUMAN MINT-7145938   RL10_HUMAN MINT-7244986   ASAP1_HUMAN MINT-7244998   FANCA_HUMAN MINT-7245022   PHAR2_HUMAN MINT-7245034   ABL1_HUMAN MINT-7245058   DLGP4_HUMAN MINT-7245070   SNX17_HUMAN MINT-7245106   RTN4_HUMAN MINT-7245118   ASAP2_HUMAN MINT-7245142   E41L3_HUMAN MINT-7245154   ICAL_HUMAN MINT-7245214   FCG2B_HUMAN MINT-7245226   FCG2C_HUMAN MINT-7245334   SHAN2_HUMAN MINT-7245346   SHRM2_HUMAN MINT-7245358   DNLI3_HUMAN MINT-7245370   EIF3D_HUMAN MINT-7245406   HCN2_HUMAN MINT-7245490   CKAP5_HUMAN MINT-7245502   M4K1_HUMAN MINT-7245538   RPP38_HUMAN MINT-7245562   SP1_HUMAN MINT-7245574   DOCK1_HUMAN MINT-7245586   RLGPB_HUMAN MINT-7245598   ABL2_HUMAN MINT-7245610   CELR2_HUMAN MINT-7245622   SOS1_HUMAN MINT-7245634   AKAP6_HUMAN MINT-7245670   DPOD1_HUMAN MINT-7245682   DAG1_HUMAN MINT-7245694   SNX3_HUMAN MINT-7245730   KI67_HUMAN MINT-7245742   CD97_HUMAN MINT-7245754   RPGF1_HUMAN MINT-7245778   ACAP1_HUMAN MINT-7245790   PRIC3_HUMAN MINT-7245814   AKAP2_HUMAN MINT-7245826   RRAS_HUMAN MINT-7296136   P85A_HUMAN MINT-7296149   ACTB_HUMAN MINT-7306598   LCP2_HUMAN MINT-7552515   PTPRA_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3/SH2 adaptor activity, non-membrane spanning protein tyrosine kinase activity, ATP binding, integrin binding, SH2 domain binding caveola, cytosol protein amino acid phosphorylation, regulation of bone resorption, signal complex assembly, regulation of vascular permeability, response to interleukin-1, interspecies interaction between organisms, Ras protein signal transduction, positive regulation of integrin activation, intracellular protein kinase cascade
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	419	GLARLIEDNEYTARQGAKFPI	-	6273838	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	-	11278940	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	SRC	7578094	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	SRC	11804588	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	SRC	15489898	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	-	17081983	HTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	-	17192257	HTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	530	EDYFTSTEPQYQPGENL	-	3103926	LTP	0.94	MOD_TYR_CSK	Csk SH2; Fyn SH2; Lck SH2; PIK3R1 SH2; Src SH2	-	0.46	1FMK	18.34%
Y	530	EDYFTSTEPQYQPGENL	Csk	12468645	LTP	0.94	MOD_TYR_CSK	Csk SH2; Fyn SH2; Lck SH2; PIK3R1 SH2; Src SH2	-	0.46	1FMK	18.34%
Y	530	EDYFTSTEPQYQPGENL	-	12387813	LTP	0.94	MOD_TYR_CSK	Csk SH2; Fyn SH2; Lck SH2; PIK3R1 SH2; Src SH2	-	0.46	1FMK	18.34%

Substrate:	ErbB2 (Receptor tyrosine kinase)
Seq-ID:	P04626 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-61505   P85B_HUMAN MINT-74429   ABL1_HUMAN MINT-74444   ABL2_HUMAN MINT-74462   ANS1A_HUMAN MINT-74470   APBB1_HUMAN MINT-74486   BLNK_HUMAN MINT-74488   BMX_HUMAN MINT-74498   CRK_HUMAN MINT-74502   CRKL_HUMAN MINT-74508   DAB1_HUMAN MINT-74512   DOK1_HUMAN MINT-74521   SPT6H_HUMAN MINT-74533   FER_HUMAN MINT-74538   FGR_HUMAN MINT-74540   GRAP2_HUMAN MINT-74542   GRB2_HUMAN MINT-74544   GRB7_HUMAN MINT-74553   IRS1_HUMAN MINT-74556   IRS4_HUMAN MINT-74558   ITK_HUMAN MINT-74561   JAK1_HUMAN MINT-74567   SH2B3_HUMAN MINT-74575   JIP1_HUMAN MINT-74582   MATK_HUMAN MINT-74590   NCK2_HUMAN MINT-74610   P85A_HUMAN MINT-74664   P55G_HUMAN MINT-74680   PLCG1_HUMAN MINT-74686   PLCG2_HUMAN MINT-74691   PTN11_HUMAN MINT-74712   RASA1_HUMAN MINT-74713   RIN1_HUMAN MINT-74722   SH22A_HUMAN MINT-74723   SH23A_HUMAN MINT-74724   3BP2_HUMAN MINT-74737   SHC1_HUMAN MINT-74747   SLAP1_HUMAN MINT-74755   STAT1_HUMAN MINT-74756   STAT3_HUMAN MINT-74769   KSYK_HUMAN MINT-74777   TEC_HUMAN MINT-74781   TENC1_HUMAN MINT-74786   TENS3_HUMAN MINT-74793   TLN1_HUMAN MINT-74794   TXK_HUMAN MINT-74802   VAV2_HUMAN MINT-1788719   EGFR_HUMAN MINT-1901925   LAP2_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process epidermal growth factor receptor activity, ErbB-3 class receptor binding, protein heterodimerization activity, DNA binding, protein C-terminus binding, identical protein binding, receptor signaling protein tyrosine kinase activity, ATP binding, protein phosphatase binding receptor complex, integral to membrane, nucleus, perinuclear region of cytoplasm regulation of angiogenesis, transcription, regulation of transcription, phosphoinositide 3-kinase cascade, phosphoinositide-mediated signaling, heart development, positive regulation of cell adhesion, protein amino acid autophosphorylation, positive regulation of epithelial cell proliferation, wound healing, positive regulation of MAP kinase activity, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1139	APLTCSPQPEYVNQPDVRPQP	ErbB2	11500516	LTP	1.00		GRB2 SH2; GRB7 SH2; Src SH2; STAT3 SH2	-	0.85	-	low