List of substrates found:

Vav  SYK  SH2 domain protein 2A  ZAP70  CD3 epsilon  CD3 delta  Ras GTPase-activating protein 1  P130Cas  EGFR  SH3 domain-binding protein 2  CD5  CD3 gamma  LCK  Tyrosine-protein phosphatase, non-receptor type 6  CD45  c-met  CD3 zeta  Src 


Substrate: Vav (Adaptor molecule. GDP/GTP exchange factor in Rho/Rac molecule)
Seq-ID: P15498 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-17467   CRK_HUMAN
MINT-2837376   PLCG1_BOVIN
MINT-4549720   3BP2_HUMAN
MINT-6743318   RAC1_HUMAN
MINT-6743347   RHOA_HUMAN
MINT-6743356   CDC42_HUMAN
MINT-7226634   ITB2_HUMAN
MINT-7226674   ABL1_HUMAN
MINT-7300569   KHDR1_MOUSE
MINT-7300587   KHDR1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Rho guanyl-nucleotide exchange factor activity,
metal ion binding,
sequence-specific DNA binding transcription factor activity,
protein binding		 plasma membrane,
cytosol		 induction of apoptosis by extracellular signals,
apoptosis,
regulation of Rho protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 142 EEESVGDEDIYSGLSDQIDDT Lck 16285729
LTP
1.00
 Lck SH2 -
0.49
 - medium

Substrate: SYK (Spleen tyrosine kinase )
Seq-ID: P43405 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-56730   LCK_HUMAN
MINT-56732   P85A_HUMAN
MINT-56739   FGR_HUMAN
MINT-56749   P85B_HUMAN
MINT-74763   EGFR_HUMAN
MINT-74769   ERBB2_HUMAN
MINT-74775   ERBB3_HUMAN
MINT-74776   ERBB4_HUMAN
MINT-6538977   CBL_HUMAN
MINT-6621148   BLNK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
integrin binding		 cytoplasm,
T cell receptor complex		 protein complex assembly,
organ morphogenesis,
integrin-mediated signaling pathway,
neutrophil chemotaxis,
interspecies interaction between organisms,
cell proliferation,
leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 348 REALPMDTEVYESPYADPEEI SYK 8657103
LTP
0.93
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.59
 --
Y 348 REALPMDTEVYESPYADPEEI - 12522270
HTP
0.93
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.59
 --
Y 348 REALPMDTEVYESPYADPEEI - 18083107
HTP
0.93
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.59
 --
Y 352 PMDTEVYESPYADPEEIRPKE SYK 8657103
LTP
1.00
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.53
 --
Y 352 PMDTEVYESPYADPEEIRPKE - 12522270
HTP
1.00
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.53
 --
Y 352 PMDTEVYESPYADPEEIRPKE - 18083107
HTP
1.00
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.53
 --
Y 525 LSKALRADENYYKAQTHGKWP SYK 8657103
LTP
1.00
 CBL PTB;
Lck SH2		 TyrKc
0.19
 1XBA 41.92%
Y 526 SKALRADENYYKAQTHGKWPV SYK 8657103
LTP
1.00
 CBL PTB;
Lck SH2		 TyrKc
0.17
 1XBA 30.57%
Y 526 SKALRADENYYKAQTHGKWPV - 18083107
HTP
1.00
 CBL PTB;
Lck SH2		 TyrKc
0.17
 1XBA 30.57%

Substrate: SH2 domain protein 2A (Adapter molecule)
Seq-ID: Q9NP31 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-74720   EGFR_HUMAN
MINT-74722   ERBB2_HUMAN
MINT-7135817   LCK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
SH3/SH2 adaptor activity		 cytoplasm,
soluble fraction		 angiogenesis,
cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 280 APRPKPSNPIYNEPDEPIAFY - 16497976
HTP
0.09
 Lck SH2 -
0.77
 - low
Y 290 YNEPDEPIAFYAMGRGSPGEA - 16497976
HTP
0.16
 Lck SH2 -
0.76
 - low
Y 305 GSPGEAPSNIYVEVEDEGLPA - 15592455
HTP
0.16
 Lck SH2 -
0.76
 - low

Substrate: ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID: P43403 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-59476   LCK_HUMAN
MINT-60980   SHC1_HUMAN
MINT-74806   ERBB3_HUMAN
MINT-74807   EGFR_HUMAN
MINT-3374106   HS90A_HUMAN
MINT-3382488   LAT_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 cytosol,
T cell receptor complex		 positive thymic T cell selection,
immune response,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 319 PMDTSVYESPYSDPEELKDKK - 10202147
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 10318843
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 12522270
HTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15592455
HTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 16094384
HTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 10037717
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15268851
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15292262
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%

Substrate: CD3 epsilon (T cell surface glycoprotein)
Seq-ID: P07766 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-7213943   NCK2_HUMAN
MINT-7214058   EPS8_HUMAN
MINT-7214076   ES8L2_HUMAN
MINT-7214253   ES8L1_HUMAN
MINT-7234008   NCK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
T cell receptor binding,
protein heterodimerization activity,
protein kinase binding,
receptor signaling complex scaffold activity,
transmembrane receptor activity,
receptor signaling protein activity		 external side of plasma membrane,
integral to plasma membrane		 signal complex assembly,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 188 ERPPPVPNPDYEPIRKGQRDL - 15592455
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.67
 - medium
Y 188 ERPPPVPNPDYEPIRKGQRDL - 16094384
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.67
 - medium
Y 188 ERPPPVPNPDYEPIRKGQRDL - 15659558
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.67
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 12522270
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15144186
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15592455
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 16094384
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15659558
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 18083107
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium

Substrate: CD3 delta (T cell surface glycoprotein)
Seq-ID: P04234 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-3374054   GCR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
transmembrane receptor activity		 cytoplasm,
integral to membrane		 positive thymic T cell selection,
cell surface receptor linked signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 149 TQALLRNDQVYQPLRDRDDAQ - 12522270
HTP
1.00
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.36
 - low
Y 149 TQALLRNDQVYQPLRDRDDAQ - 15144186
HTP
1.00
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.36
 - low
Y 149 TQALLRNDQVYQPLRDRDDAQ - 15592455
HTP
1.00
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.36
 - low
Y 149 TQALLRNDQVYQPLRDRDDAQ - 16094384
HTP
1.00
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.36
 - low
Y 149 TQALLRNDQVYQPLRDRDDAQ - 15659558
HTP
1.00
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.36
 - low

Substrate: Ras GTPase-activating protein 1 (Ras p21 activator protein (GAP))
Seq-ID: P20936 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-74708   ERBB3_HUMAN
MINT-74709   ERBB4_HUMAN
MINT-74711   EGFR_HUMAN
MINT-74712   ERBB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
potassium channel inhibitor activity,
Ras GTPase activator activity,
glycoprotein binding,
GTPase binding,
receptor binding		 cytoplasm intracellular signaling pathway,
cytokinesis,
regulation of actin filament polymerization,
positive regulation of anti-apoptosis,
regulation of cell shape,
signal transduction,
negative regulation of cell-matrix adhesion,
vasculogenesis,
negative regulation of neuron apoptosis,
regulation of small GTPase mediated signal transduction,
regulation of RNA metabolic process,
embryo development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 460 LNDTVDGKEIYNTIRRKTKDA PDGFR_group 1850098
LTP
1.00
 Lck SH2;
Src SH2		 -
0.31
 - low
Y 460 LNDTVDGKEIYNTIRRKTKDA EGFR 1850098
LTP
1.00
 Lck SH2;
Src SH2		 -
0.31
 - low

Substrate: P130Cas (Adaptor molecule. Contain 15 YxxP motifs. )
Seq-ID: P56945 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74936   PTN12_HUMAN
MINT-74938   FAK1_HUMAN
MINT-3974941   1433S_HUMAN
MINT-6174734   ACTB_HUMAN
MINT-6763936   CRK_HUMAN
MINT-6793484   PTN1_HUMAN
MINT-7104353   CDC42_HUMAN
MINT-7104422   SRC_HUMAN
MINT-7104436   ACK1_HUMAN
MINT-7247002   FYN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
protein kinase binding,
protein phosphatase binding,
signal transducer activity		 focal adhesion,
membrane fraction,
cytosol,
ruffle		 regulation of cell growth,
B cell receptor signaling pathway,
cell division,
positive regulation of cell migration,
nerve growth factor receptor signaling pathway,
cell migration,
integrin-mediated signaling pathway,
epidermal growth factor receptor signaling pathway,
actin filament organization,
regulation of apoptosis,
platelet-derived growth factor receptor signaling pathway,
T cell receptor signaling pathway,
cell adhesion,
insulin receptor signaling pathway,
cell proliferation,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 664 ENSEGGWMEDYDYVHLQGKEE - 8621540
LTP
1.00
 FES SH2;
Fyn SH2;
Lck SH2;
Src SH2		 -
0.49
 - medium
Y 664 ENSEGGWMEDYDYVHLQGKEE - 11604500
LTP
1.00
 FES SH2;
Fyn SH2;
Lck SH2;
Src SH2		 -
0.49
 - medium

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor activity,
protein heterodimerization activity,
identical protein binding,
receptor signaling protein tyrosine kinase activity,
double-stranded DNA binding,
ATP binding,
protein phosphatase binding,
actin filament binding,
MAP/ERK kinase kinase activity		 Shc-EGFR complex,
endosome,
basolateral plasma membrane,
integral to membrane,
extracellular space,
nucleus		 activation of phospholipase C activity,
protein insertion into membrane,
response to UV-A,
positive regulation of nitric oxide biosynthetic process,
positive regulation of cell migration,
positive regulation of cyclin-dependent protein kinase activity involved in G1/S,
positive regulation of catenin protein nuclear translocation,
regulation of nitric-oxide synthase activity,
positive regulation of protein kinase B signaling cascade,
ossification,
positive regulation of epithelial cell proliferation,
activation of phospholipase A2 activity by calcium-mediated signaling,
cell-cell adhesion,
regulation of peptidyl-tyrosine phosphorylation,
positive regulation of phosphorylation,
positive regulation of MAP kinase activity,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1092 IDDTFLPVPEYINQSVPKRPA EGFR 8845374
LTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1092 IDDTFLPVPEYINQSVPKRPA - 15302935
HTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1092 IDDTFLPVPEYINQSVPKRPA - 17081983
HTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1092 IDDTFLPVPEYINQSVPKRPA - 18083107
HTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --

Substrate: SH3 domain-binding protein 2 (Adaptor molecule)
Seq-ID: Q06649 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 446 DTGEEDSDEDYEKVPLPNSVF - 12709437
LTP
1.00
 Lck SH2;
Lyn SH2;
VAV1 SH2		 -
0.70
 - low

Substrate: CD5 (T-cell surface glycoprotein CD5 precursor (Lymphocyte glycoprotein T1/Leu-1) (Lymphocyte antigen CD5))
Seq-ID: P06127 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
scavenger receptor activity integral to plasma membrane cell recognition,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 453 NPTASHVDNEYSQPPRNSRLS - 12522270
HTP
1.00
 Lck SH2;
RASA_group SH2		 -
0.71
 - medium
Y 453 NPTASHVDNEYSQPPRNSRLS - 15144186
HTP
1.00
 Lck SH2;
RASA_group SH2		 -
0.71
 - medium
Y 453 NPTASHVDNEYSQPPRNSRLS Lck 11298344
LTP
1.00
 Lck SH2;
RASA_group SH2		 -
0.71
 - medium
Y 453 NPTASHVDNEYSQPPRNSRLS - 15659558
HTP
1.00
 Lck SH2;
RASA_group SH2		 -
0.71
 - medium
Y 465 QPPRNSRLSAYPALEGVLHRS - 11751967
LTP
1.00
 Lck SH2 -
0.49
 - medium
Y 487 MQPDNSSDSDYDLHGAQRL   Lck 11298344
LTP
1.00
 Lck SH2 -
0.70
 - medium

Substrate: CD3 gamma (T-cell surface glycoprotein CD3 gamma chain (T3 gamma chain) (from PhosphoBase))
Seq-ID: P09693 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
T cell receptor binding,
protein heterodimerization activity,
receptor signaling complex scaffold activity,
transmembrane receptor activity		 integral to plasma membrane protein complex assembly,
T cell activation,
protein transport,
establishment or maintenance of cell polarity,
regulation of apoptosis,
cell surface receptor linked signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 160 KQTLLPNDQLYQPLKDREDDQ - 16094384
HTP
0.95
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.48
 - low

Substrate: LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))
Seq-ID: P06239 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15516   CBL_HUMAN
MINT-56730   KSYK_HUMAN
MINT-59474   LCP2_HUMAN
MINT-59476   ZAP70_HUMAN
MINT-60779   MK01_HUMAN
MINT-60782   CD3Z_HUMAN
MINT-61276   G3BP1_HUMAN
MINT-66002   CD4_HUMAN
MINT-66003   P85A_HUMAN
MINT-68489   DLG1_HUMAN
MINT-3373863   HS90A_HUMAN
MINT-3373920   GCR_HUMAN
MINT-7135817   SH22A_HUMAN
MINT-7212471   KHDR1_HUMAN
MINT-7212499   WASP_HUMAN
MINT-7218109   ADA15_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein C-terminus binding,
protein kinase binding,
protein serine/threonine phosphatase activity,
glycoprotein binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
CD8 receptor binding,
ATPase binding,
CD4 receptor binding,
SH2 domain binding		 plasma membrane,
cytosol,
Golgi apparatus,
membrane raft,
pericentriolar material		 protein amino acid phosphorylation,
T cell differentiation,
response to drug,
activation of caspase activity,
positive regulation of T cell activation,
positive regulation of T cell receptor signaling pathway,
release of sequestered calcium ion into cytosol,
interspecies interaction between organisms,
cellular zinc ion homeostasis,
induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 505 EDFFTATEGQYQPQP       - 3265417
LTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --
Y 505 EDFFTATEGQYQPQP       - 15592455
HTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --
Y 505 EDFFTATEGQYQPQP       Lck 8945479
LTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --
Y 505 EDFFTATEGQYQPQP       - 17192257
HTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --
Y 505 EDFFTATEGQYQPQP       - 18083107
HTP
0.96
 Lck SH2;
Src SH2;
SYK SH2		 -
0.49
 --

Substrate: Tyrosine-protein phosphatase, non-receptor type 6 (Protein tyrosine phosphatase containing SH2 domains)
Seq-ID: P29350 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-56658   TFG_HUMAN
MINT-73504   EPOR_HUMAN
MINT-74919   FCG2B_HUMAN
MINT-6761906   ESR1_HUMAN
MINT-6793815   CAV1_HUMAN
MINT-6799844   ROS_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
protein binding		 cytosol,
nucleus,
membrane		 apoptosis,
protein amino acid dephosphorylation,
signal transduction,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 536 LQSQKGQESEYGNITYPPAMK - 12468540
LTP
1.00
 Lck SH2;
Src SH2		 -
0.56
 - low
Y 536 LQSQKGQESEYGNITYPPAMK Lck 8114715
LTP
1.00
 Lck SH2;
Src SH2		 -
0.56
 - low
Y 536 LQSQKGQESEYGNITYPPAMK Abl 8692915
LTP
1.00
 Lck SH2;
Src SH2		 -
0.56
 - low
Y 536 LQSQKGQESEYGNITYPPAMK - 7512963
LTP
1.00
 Lck SH2;
Src SH2		 -
0.56
 - low
Y 536 LQSQKGQESEYGNITYPPAMK - 14757045
LTP
1.00
 Lck SH2;
Src SH2		 -
0.56
 - low
Y 536 LQSQKGQESEYGNITYPPAMK SRC 14699166
LTP
1.00
 Lck SH2;
Src SH2		 -
0.56
 - low
Y 536 LQSQKGQESEYGNITYPPAMK - 18083107
HTP
1.00
 Lck SH2;
Src SH2		 -
0.56
 - low

Substrate: CD45 (Receptor tyrosine phosphatase)
Seq-ID: P08575 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase binding,
transmembrane receptor protein tyrosine phosphatase activity		 focal adhesion,
integral to plasma membrane,
membrane raft		 positive regulation of B cell proliferation,
B cell receptor signaling pathway,
regulation of S phase,
immunoglobulin biosynthetic process,
defense response to virus,
protein amino acid dephosphorylation,
positive regulation of antigen receptor-mediated signaling pathway,
release of sequestered calcium ion into cytosol,
negative regulation of T cell mediated cytotoxicity,
T cell receptor signaling pathway,
negative regulation of protein kinase activity,
B cell proliferation,
negative regulation of cytokine-mediated signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1216 RPGMVSTFEQYQFLYDVIAST Csk 7507203
LTP
1.00
 Lck SH2 PTPc
0.26
 - medium

Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID: P08581 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-18299   RANB9_HUMAN
MINT-58374   GAB1_MOUSE
MINT-58404   GAB1_HUMAN
MINT-6539587   CBL_HUMAN
MINT-6787689   PTN1_HUMAN
MINT-6798640   PTN11_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
hepatocyte growth factor receptor activity,
ATP binding,
protein binding		 integral to plasma membrane,
basal plasma membrane		 protein amino acid phosphorylation,
multicellular organismal development,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 12475979
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9444958
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9252406
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 7513258
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7731718
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7687741
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9826708
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%

Substrate: CD3 zeta (T-cell surface glycoprotein CD3 zeta chain precursor (from PhosphoBase))
Seq-ID: P20963 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-60782   LCK_HUMAN
MINT-7301967   NCK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
transmembrane receptor activity		 cytoplasm,
integral to membrane		 interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 72 PAYQQGQNQLYNELNLGRREE - 15144186
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.44
 - medium
Y 72 PAYQQGQNQLYNELNLGRREE - 15592455
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.44
 - medium
Y 72 PAYQQGQNQLYNELNLGRREE - 16094384
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.44
 - medium
Y 72 PAYQQGQNQLYNELNLGRREE - 15659558
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.44
 - medium
Y 83 NELNLGRREEYDVLDKRRGRD - 12522270
HTP
1.00
 Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.47
 - medium
Y 83 NELNLGRREEYDVLDKRRGRD - 15592455
HTP
1.00
 Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.47
 - medium
Y 83 NELNLGRREEYDVLDKRRGRD - 16094384
HTP
1.00
 Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.47
 - medium
Y 83 NELNLGRREEYDVLDKRRGRD - 15659558
HTP
1.00
 Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.47
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE Fyn 8578591
LTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 12522270
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15144186
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15592455
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 16094384
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15659558
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 18083107
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 123 ELQKDKMAEAYSEIGMKGERR Fyn 8578591
LTP
1.00
 LIG_TYR_ITAM
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.49
 - medium
Y 123 ELQKDKMAEAYSEIGMKGERR - 12522270
HTP
1.00
 LIG_TYR_ITAM
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.49
 - medium
Y 123 ELQKDKMAEAYSEIGMKGERR - 16094384
HTP
1.00
 LIG_TYR_ITAM
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.49
 - medium
Y 123 ELQKDKMAEAYSEIGMKGERR - 15659558
HTP
1.00
 LIG_TYR_ITAM
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.49
 - medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 12522270
HTP
1.00
 Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 15592455
HTP
1.00
 Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 16094384
HTP
1.00
 Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 15659558
HTP
1.00
 Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium
Y 153 QGLSTATKDTYDALHMQALPP - 16094384
HTP
0.90
 Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium
Y 153 QGLSTATKDTYDALHMQALPP - 15659558
HTP
0.90
 Fyn SH2;
Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium

Substrate: Src (Proto-oncogene tyrosine-protein kinase Src)
Seq-ID: P12931 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14765   DDR2_HUMAN
MINT-15459   CAV1_HUMAN
MINT-46002   CTNB1_MOUSE
MINT-50376   RASH_HUMAN
MINT-62340   KPCD_HUMAN
MINT-62342   CDCP1_HUMAN
MINT-65953   DYN1_HUMAN
MINT-65954   DYN2_HUMAN
MINT-68512   PDC6I_HUMAN
MINT-74753   ERBB3_HUMAN
MINT-2792760   PAK2_HUMAN
MINT-2793013   ADA15_HUMAN
MINT-2840132   TLR3_HUMAN
MINT-3381308   FAK1_HUMAN
MINT-3381360   FYN_HUMAN
MINT-4051815   ADRB2_HUMAN
MINT-4961196   AFAD_HUMAN
MINT-4980122   SNIP_MOUSE
MINT-5210599   SNIP_HUMAN
MINT-6539730   CBL_HUMAN
MINT-6771405   FAK1_MOUSE
MINT-6794909   ACTS_HUMAN
MINT-6795322   ACTN1_HUMAN
MINT-6795447   PTN1_HUMAN
MINT-7035260   HNRPK_HUMAN
MINT-7040283   CBLB_HUMAN
MINT-7104422   BCAR1_HUMAN
MINT-7145938   RL10_HUMAN
MINT-7244986   ASAP1_HUMAN
MINT-7244998   FANCA_HUMAN
MINT-7245022   PHAR2_HUMAN
MINT-7245034   ABL1_HUMAN
MINT-7245058   DLGP4_HUMAN
MINT-7245070   SNX17_HUMAN
MINT-7245106   RTN4_HUMAN
MINT-7245118   ASAP2_HUMAN
MINT-7245142   E41L3_HUMAN
MINT-7245154   ICAL_HUMAN
MINT-7245214   FCG2B_HUMAN
MINT-7245226   FCG2C_HUMAN
MINT-7245334   SHAN2_HUMAN
MINT-7245346   SHRM2_HUMAN
MINT-7245358   DNLI3_HUMAN
MINT-7245370   EIF3D_HUMAN
MINT-7245406   HCN2_HUMAN
MINT-7245490   CKAP5_HUMAN
MINT-7245502   M4K1_HUMAN
MINT-7245538   RPP38_HUMAN
MINT-7245562   SP1_HUMAN
MINT-7245574   DOCK1_HUMAN
MINT-7245586   RLGPB_HUMAN
MINT-7245598   ABL2_HUMAN
MINT-7245610   CELR2_HUMAN
MINT-7245622   SOS1_HUMAN
MINT-7245634   AKAP6_HUMAN
MINT-7245670   DPOD1_HUMAN
MINT-7245682   DAG1_HUMAN
MINT-7245694   SNX3_HUMAN
MINT-7245730   KI67_HUMAN
MINT-7245742   CD97_HUMAN
MINT-7245754   RPGF1_HUMAN
MINT-7245778   ACAP1_HUMAN
MINT-7245790   PRIC3_HUMAN
MINT-7245814   AKAP2_HUMAN
MINT-7245826   RRAS_HUMAN
MINT-7296136   P85A_HUMAN
MINT-7296149   ACTB_HUMAN
MINT-7306598   LCP2_HUMAN
MINT-7552515   PTPRA_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
integrin binding,
SH2 domain binding		 caveola,
cytosol		 protein amino acid phosphorylation,
regulation of bone resorption,
signal complex assembly,
regulation of vascular permeability,
response to interleukin-1,
interspecies interaction between organisms,
Ras protein signal transduction,
positive regulation of integrin activation,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 530 EDYFTSTEPQYQPGENL     - 3103926
LTP
0.94
 MOD_TYR_CSK
 Csk SH2;
Fyn SH2;
Lck SH2;
PIK3R1 SH2;
Src SH2		 -
0.46
 1FMK 18.34%
Y 530 EDYFTSTEPQYQPGENL     Csk 12468645
LTP
0.94
 MOD_TYR_CSK
 Csk SH2;
Fyn SH2;
Lck SH2;
PIK3R1 SH2;
Src SH2		 -
0.46
 1FMK 18.34%
Y 530 EDYFTSTEPQYQPGENL     - 12387813
LTP
0.94
 MOD_TYR_CSK
 Csk SH2;
Fyn SH2;
Lck SH2;
PIK3R1 SH2;
Src SH2		 -
0.46
 1FMK 18.34%

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