Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

40S ribosomal protein S3
ADAM 17
Bcl-2-like protein 11
C-ets-2 protein
c-Myb
C/EBP alpha
C/EBP beta
CAD
Caldesmon
CAPN2
Caspase 9
Connexin 43
Cytokeratin 8
Cytosolic phospholipase A2
DNA topoisomerase II, alpha
DUSP6
EGFR
Estrogen receptor alpha
ETS domain protein Elk-1
ETV6
Fos
Gab2
Grb10
GSK-3 beta
hnRNPK
HSP22
Insulin receptor substrate 1
LCK
LIF-R
MAP kinase-activated protein kinase 2
MAP kinase-interacting serine/threonine-protein kinase 1
MBP
MCL1
MKP-1
Myc-associated zinc finger protein
NCoA-1
Neural interleukin 16 protein
Neutrophil cytosol factor 1
NFATC4
PLC beta1
Progesterone receptor
Retinoic acid receptor RXR-alpha
RPB1
RPS6KA5
RRN3
S6K-alpha 3
SH2-B beta signaling protein
SMAD2
SMAD4
Sp1
Src substrate cortactin
SREBF2
SREBP1
STAT 5
Synapsin-3
TAL-1 protein
THRB
Transcription factor Spi-B
TRAP220
TTK
UBF-1

Substrate:

40S ribosomal protein S3 (ribosomal protein)

Seq-ID:

P23396 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48153   NEMO_HUMAN
MINT-48709   NFKB2_HUMAN
MINT-48801   M3K14_HUMAN
MINT-49388   TNR1B_HUMAN
MINT-3297088   1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural constituent of ribosome, endonuclease activity, iron-sulfur cluster binding, protein kinase binding, mRNA binding, damaged DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity, NF-kappaB binding	ruffle membrane, nucleus, cytosolic small ribosomal subunit	negative regulation of NF-kappaB transcription factor activity, activation of caspase activity, negative regulation of DNA repair, translational initiation, response to DNA damage stimulus, translational elongation, induction of apoptosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	42	DGYSGVEVRVTPTRTEIIILA	MAPK3	15950189	LTP	-	MOD_ProDKin_1	-	KH	0.19	-	-

Substrate:

ADAM 17 (Metallo protease)

Seq-ID:

P78536 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13999   MD2L1_HUMAN
MINT-58311   PTN3_HUMAN
MINT-1901801   DLG1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
interleukin-6 receptor binding, metalloendopeptidase activity, zinc ion binding, integrin binding, PDZ domain binding, SH3 domain binding	integral to plasma membrane, cell surface, actin cytoskeleton, apical plasma membrane, membrane raft	positive regulation of cell growth, response to hypoxia, response to high density lipoprotein stimulus, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, PMA-inducible membrane protein ectodomain proteolysis, response to drug, regulation of mast cell apoptosis, membrane protein intracellular domain proteolysis, positive regulation of epidermal growth factor receptor activity, epidermal growth factor receptor signaling pathway, positive regulation of T cell chemotaxis, germinal center formation, Notch signaling pathway, positive regulation of transforming growth factor beta receptor signaling pathway, cell adhesion mediated by integrin, response to lipopolysaccharide, T cell differentiation in the thymus, spleen development, positive regulation of chemokine production, neutrophil mediated immunity, B cell differentiation, positive regulation of protein amino acid phosphorylation, positive regulation of cell proliferation, wound healing, spreading of epidermal cells, negative regulation of interleukin-8 production

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	735	RIIKPFPAPQTPGRLQPAPVI	MAPK3	12058067	LTP	0.12	MOD_ProDKin_1	-	-	0.53	-	-

Substrate:

Bcl-2-like protein 11 (Unclassified)

Seq-ID:

O43521 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-68751   MCL1_HUMAN
MINT-6629252   BCL2_HUMAN
MINT-7034069   BAX_HUMAN
MINT-7034091   BAD_HUMAN
MINT-7965699   MCL1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	plasma membrane, mitochondrion, cytosol, endomembrane system	induction of apoptosis by extracellular signals, activation of pro-apoptotic gene products

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	69	SPQGPLAPPASPGPFATRSPL	MAPK3	15486195	LTP	0.93	MOD_ProDKin_1	-	-	0.76	-	low
S	69	SPQGPLAPPASPGPFATRSPL	MAPK3	14555991	LTP	0.93	MOD_ProDKin_1	-	-	0.76	-	low

Substrate:

C-ets-2 protein (Transcription factor)

Seq-ID:

P15037 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding	nucleus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	72	DSASCELPLLTPCSKAVMSQA	MAPK3	9710599	LTP	1.00	MOD_ProDKin_1	-	-	0.22	-	medium

Substrate:

c-Myb (Transcription factor)

Seq-ID:

P10242 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-6802128 CLH1_HUMAN
MINT-6802201 LIN9_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, transcription activator activity, protein binding	nuclear matrix	transcription, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	532	LLKKIKQEVESPTDKSGNFFC	MAPK3	8960373	LTP	1.00	MOD_ProDKin_1	-	Cmyb_C	0.48	-	low

Substrate:

C/EBP alpha (Transcription factor)

Seq-ID:

P49715 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-4791133 RUNX1_HUMAN
MINT-7720853 UBF1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
RNA polymerase II transcription factor activity, enhancer binding, transcription factor binding, promoter binding		transcription from RNA polymerase II promoter, generation of precursor metabolites and energy, cytokine-mediated signaling pathway, interspecies interaction between organisms, positive regulation of transcription from RNA polymerase III promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	21	PRPPMSSHLQSPPHAPSSAAF	MAPK3	14701740	LTP	0.41	MOD_ProDKin_1	-	-	0.85	-	low

Substrate:

C/EBP beta (Transcription factor)

Seq-ID:

P17676 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14023   SMAD3_HUMAN
MINT-14687   SMAD4_HUMAN
MINT-49733   HMGA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
RNA polymerase II transcription factor activity, enhancer binding		transcription from RNA polymerase II promoter, immune response, acute-phase response

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	235	STSSSSSPPGTPSPADAKAPP	MAPK3	12213825	LTP	0.97	MOD_ProDKin_1	-	-	0.89	-	-

Substrate:

C/EBP beta (Transcription factor)

Seq-ID:

P28033 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, protein homodimerization activity, transcription activator activity, RNA polymerase II transcription factor activity, enhancer binding	cytoplasm	mammary gland epithelial cell differentiation, regulation of interleukin-6 biosynthetic process, transcription, mammary gland epithelial cell proliferation, anti-apoptosis, embryonic placenta development, brown fat cell differentiation, response to lipopolysaccharide, induction of apoptosis, positive regulation of transcription from RNA polymerase II promoter, neuron differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	188	STSSSSSPPGTPSPADAKAAP	MAPK3	15367685	LTP	0.86	MOD_ProDKin_1	-	-	0.82	-	medium

Substrate:

CAD (carbamoyl-phosphate synthase (glutamine-hyd...)

Seq-ID:

P08955 [Mesocricetus auratus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
aspartate carbamoyltransferase activity, dihydroorotase activity, carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, metal ion binding, ATP binding, protein kinase activity, aspartate binding, UTP binding	mitochondrion, cytosol, nuclear matrix	`de novo` pyrimidine base biosynthetic process, protein amino acid autophosphorylation, pyrimidine nucleotide biosynthetic process, peptidyl-threonine phosphorylation, glutamine metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	456	LADKVYFLPITPHYVTQVIRN	MAPK3	11872754	LTP	1.00	MOD_ProDKin_1	-	CPSase_L_chain	0.17	-	medium
T	456	LADKVYFLPITPHYVTQVIRN	MAPK3	10659854	LTP	1.00	MOD_ProDKin_1	-	CPSase_L_chain	0.17	-	medium

Substrate:

CAD (carbamoyl-phosphate synthase (glutamine-hyd...)

Seq-ID:

P27708 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48168   NEMO_HUMAN
MINT-48300   M3K1_HUMAN
MINT-48426   M3K3_HUMAN
MINT-48660   NFKB1_HUMAN
MINT-48723   NFKB2_HUMAN
MINT-48821   M3K14_HUMAN
MINT-48995   RELB_HUMAN
MINT-49046   RIPK1_HUMAN
MINT-49196   TAB2_HUMAN
MINT-49403   TNR1B_HUMAN
MINT-3318321   1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
aspartate carbamoyltransferase activity, dihydroorotase activity, carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, metal ion binding, ATP binding, enzyme binding, protein kinase activity, aspartate binding	cytosol, nuclear matrix	`de novo` pyrimidine base biosynthetic process, protein amino acid autophosphorylation, pyrimidine nucleotide biosynthetic process, peptidyl-threonine phosphorylation, glutamine metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	456	LADKVYFLPITPHYVTQVIRN	MAPK3	15890648	LTP	1.00	MOD_ProDKin_1	-	CPSase_L_chain	0.20	-	medium

Substrate:

Caldesmon (Actin and myosin binding protein)

Seq-ID:

Q05682 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
tropomyosin binding, myosin binding, actin binding, calmodulin binding	myofibril, plasma membrane	muscle contraction, cellular component movement

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	789	WEKQSVDKVTSPTKV	MAPK3	10514499	LTP	1.00	MOD_ProDKin_1	-	Caldesmon	0.69	-	medium

Substrate:

CAPN2 (cysteine-type peptidase activity)

Seq-ID:

P17655 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-1795337 NMT1_HUMAN
MINT-6793394 PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	plasma membrane, cytoplasm

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	50	LEAGTLFQDPSFPAIPSALGF	MAPK3	14993287	LTP	0.46		-	CysPc	0.16	1KFX	38.52%

Substrate:

Caspase 9 (Cysteine protease)

Seq-ID:

P55211 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15372   APAF_HUMAN
MINT-18815   CASP3_HUMAN
MINT-25026   XIAP_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
enzyme activator activity, cysteine-type endopeptidase activity, protein binding	cytosol	proteolysis, activation of caspase activity by cytochrome c

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	125	IRKPEVLRPETPRPVDIGSGG	MAPK3	12792650	LTP	0.08	MOD_ProDKin_1	-	-	0.56	-	-

Substrate:

Connexin 43 (Intercellular channel)

Seq-ID:

P08050 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-1791070 ZO1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, gap junction channel activity, PDZ domain binding	connexon complex, Golgi-associated vesicle membrane, early endosome, integral to plasma membrane, lysosome, fascia adherens, mitochondrial outer membrane, endoplasmic reticulum membrane, multivesicular body, membrane raft	positive regulation of protein catabolic process, ATP transport, response to pH, negative regulation of cell proliferation, apoptosis, vascular transport, gap junction assembly, protein oligomerization, cell-cell signaling, neuron projection morphogenesis, regulation of calcium ion transport, response to peptide hormone stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	255	DPYHATTGPLSPSKDCGSPKY	MAPK3	8631994	LTP	0.22	MOD_ProDKin_1	-	-	0.40	-	-
S	279	NGCSSPTAPLSPMSPPGYKLV	MAPK3	8631994	LTP	0.15	MOD_ProDKin_1	-	-	0.45	-	-
S	279	NGCSSPTAPLSPMSPPGYKLV	MAPK3	15843167	LTP	0.15	MOD_ProDKin_1	-	-	0.45	-	-
S	282	SSPTAPLSPMSPPGYKLVTGD	MAPK3	8631994	LTP	0.98	MOD_ProDKin_1	-	-	0.57	-	-
S	282	SSPTAPLSPMSPPGYKLVTGD	MAPK3	15843167	LTP	0.98	MOD_ProDKin_1	-	-	0.57	-	-

Substrate:

Cytokeratin 8 (keratin, type II cytoskeletal 8 (cytokeratin 8) (K8) (CK8) (from PhosphoBase))

Seq-ID:

P05787 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-51056   RAF1_HUMAN
MINT-61555   GRB2_HUMAN
MINT-2984733   ZO1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural molecule activity, protein binding	cytoplasm, keratin filament	cytoskeleton organization, interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	432	GLSSAYGGLTSPGLSYSLGSS	MAPK3	9524113	LTP	0.40	MOD_ProDKin_1	-	-	0.31	-	low

Substrate:

Cytosolic phospholipase A2 (Enzyme: Phospholipase)

Seq-ID:

P47713 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
lysophospholipase activity		phospholipid catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	505	GLNLNTSYPLSPLRDFSSQDS	MAPK3	8381049	LTP	0.17	MOD_ProDKin_1	-	PLAc	0.38	-	medium

Substrate:

DNA topoisomerase II, alpha (DNA topoisomerase II alpha)

Seq-ID:

P11388 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-15316 PIN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C binding, DNA topoisomerase (ATP-hydrolyzing) activity, protein heterodimerization activity, protein C-terminus binding, protein homodimerization activity, DNA-dependent ATPase activity, chromatin binding, histone deacetylase binding, ATP binding, ubiquitin binding, drug binding	DNA topoisomerase complex (ATP-hydrolyzing), cytoplasm, chromosome, nucleoplasm	DNA repair, chromosome segregation, phosphoinositide-mediated signaling, positive regulation of apoptosis, DNA ligation, apoptotic chromosome condensation, DNA topological change, DNA replication, positive regulation of retroviral genome replication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1213	KKTQMAEVLPSPRGQRVIPRI	MAPK3	7635160	LTP	0.91	MOD_ProDKin_1	-	-	0.70	-	-
S	1247	KKIKNENTEGSPQEDGVELEG	MAPK3	7635160	LTP	0.20	MOD_ProDKin_1	-	-	0.82	-	-
S	1354	DDEDFVPSDASPPKTKTSPKL	MAPK3	7635160	LTP	0.04	MOD_CDK_SPxK_1	-	-	0.87	-	-
S	1361	SDASPPKTKTSPKLSNKELKP	MAPK3	7635160	LTP	0.24	MOD_ProDKin_1	-	-	0.89	-	-
S	1393	DVKGSVPLSSSPPATHFPDET	MAPK3	7635160	LTP	0.19	MOD_ProDKin_1	-	-	0.86	-	-

Substrate:

DUSP6 (protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity)

Seq-ID:

Q16828 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, MAP kinase tyrosine/serine/threonine phosphatase activity	cytoplasm, nucleoplasm	inactivation of MAPK activity, peptidyl-tyrosine dephosphorylation, positive regulation of apoptosis, response to nitrosative stress, negative regulation of ERK1 and ERK2 cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	159	TNLDGSCSSSSPPLPVLGLGG	MAPK3	15632084	LTP	1.00	MOD_ProDKin_1	-	-	0.37	-	-

Substrate:

EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)

Seq-ID:

P00533 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
epidermal growth factor receptor activity, protein heterodimerization activity, identical protein binding, receptor signaling protein tyrosine kinase activity, double-stranded DNA binding, ATP binding, protein phosphatase binding, actin filament binding, MAP/ERK kinase kinase activity	Shc-EGFR complex, endosome, basolateral plasma membrane, integral to membrane, extracellular space, nucleus	activation of phospholipase C activity, protein insertion into membrane, response to UV-A, positive regulation of nitric oxide biosynthetic process, positive regulation of cell migration, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, positive regulation of catenin protein nuclear translocation, regulation of nitric-oxide synthase activity, positive regulation of protein kinase B signaling cascade, ossification, positive regulation of epithelial cell proliferation, activation of phospholipase A2 activity by calcium-mediated signaling, cell-cell adhesion, regulation of peptidyl-tyrosine phosphorylation, positive regulation of phosphorylation, positive regulation of MAP kinase activity, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	693	LQERELVEPLTPSGEAPNQAL	MAPK3	1939237	LTP	1.00	MOD_ProDKin_1	-	-	0.41	-	-

Substrate:

Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )

Seq-ID:

P03372 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13786   BRCA1_HUMAN
MINT-50646   STA5A_HUMAN
MINT-50709   M3K1_HUMAN
MINT-5222241   NCOA1_HUMAN
MINT-6169667   EGFR_HUMAN
MINT-6614126   SMCA4_HUMAN
MINT-6614301   CHD3_HUMAN
MINT-6614361   MTA1_HUMAN
MINT-6614421   MTA2_HUMAN
MINT-6761899   PTN1_HUMAN
MINT-6761906   PTN6_HUMAN
MINT-7013584   PA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
beta-catenin binding, nitric-oxide synthase regulator activity, estrogen response element binding, steroid binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, estrogen receptor activity	chromatin remodeling complex	response to estradiol stimulus, transcription, DNA-dependent, regulation of transcription, DNA-dependent, positive regulation of retinoic acid receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	118	LMLLHPPPQLSPFLQPHGQQV	MAPK3	7491495	LTP	1.00	MOD_ProDKin_1	-	Oest_recep	0.50	-	-

Substrate:

ETS domain protein Elk-1 (Transcription factor)

Seq-ID:

P19419 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-3380443 SUMO1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity, protein binding	nucleus	transcription, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	383	PPSIHFWSTLSPIAPRSPAKL	MAPK3	8548291	LTP	1.00	MOD_ProDKin_1	-	-	0.43	-	medium
S	383	PPSIHFWSTLSPIAPRSPAKL	MAPK3	8262053	LTP	1.00	MOD_ProDKin_1	-	-	0.43	-	medium
S	389	WSTLSPIAPRSPAKLSFQFPS	MAPK3	8548291	LTP	0.89	MOD_ProDKin_1	-	-	0.46	-	medium
S	389	WSTLSPIAPRSPAKLSFQFPS	MAPK3	8262053	LTP	0.89	MOD_ProDKin_1	-	-	0.46	-	medium

Substrate:

ETS domain protein Elk-1 (Transcription factor)

Seq-ID:

P41969 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity	nucleoplasm	transcription, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	384	PPSIHFWSTLSPIAPRSPAKL	MAPK3	7889942	LTP	1.00	MOD_ProDKin_1	-	-	0.40	-	medium
S	390	WSTLSPIAPRSPAKLSFQFPS	MAPK3	7889942	LTP	0.74	MOD_ProDKin_1	-	-	0.44	-	medium

Substrate:

ETV6 (transcription factor activity)

Seq-ID:

P41212 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, protein domain specific binding, sequence-specific DNA binding transcription factor activity	cytoplasm, nucleolus	transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	213	SPLDNMIRRLSPAERAQGPRP	MAPK3	15060146	LTP	0.07	MOD_ProDKin_1	-	-	0.87	-	low
S	257	ASSESHPKPSSPRQESTRVIQ	MAPK3	15060146	LTP	1.00	MOD_ProDKin_1	-	-	0.88	-	low

Substrate:

Fos (Transcription factor)

Seq-ID:

P01100 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-68804   JUN_HUMAN
MINT-68820   VE7_HPV16
MINT-1788374   JUNB_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
R-SMAD binding, specific RNA polymerase II transcription factor activity, promoter binding, sequence-specific DNA binding transcription factor activity		DNA methylation, inflammatory response, SMAD protein signal transduction, transforming growth factor beta receptor signaling pathway, cellular response to reactive oxygen species

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	232	DLTGGLPEVATPESEEAFTLP	MAPK3	7816602	LTP	1.00	MOD_ProDKin_1	PIN1 WW	-	0.60	-	low
T	325	PMATELEPLCTPVVTCTPSCT	MAPK3	12972619	LTP	1.00	MOD_ProDKin_1	PIN1 WW	-	0.39	-	low
T	331	EPLCTPVVTCTPSCTAYTSSF	MAPK3	12972619	LTP	1.00	MOD_ProDKin_1	PIN1 WW	-	0.21	-	low

Substrate:

Gab2 (Adaptor molecule)

Seq-ID:

Q9UQC2 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14688   SHC1_HUMAN
MINT-56633   MK03_HUMAN
MINT-68496   P85A_HUMAN
MINT-7220613   GRB2_HUMAN
MINT-7300434   1433B_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3,4,5-trisphosphate binding, transmembrane receptor protein tyrosine kinase adaptor protein activity	plasma membrane, cytoplasm	positive regulation of cell proliferation, phosphoinositide-mediated signaling, positive regulation of mast cell degranulation, osteoclast differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	623	DYLALDFQPSSPSPHRKPSTS	MAPK3	15356145	LTP	0.90	MOD_ProDKin_1	-	-	0.74	-	low

Substrate:

Grb10 (Adapter molecule)

Seq-ID:

Q13322 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15644   IGF1R_HUMAN
MINT-16516   INSR_HUMAN
MINT-16802   EGFR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
insulin receptor binding, SH3/SH2 adaptor activity	plasma membrane, cytoplasm	negative regulation of glycogen biosynthetic process, negative regulation of insulin receptor signaling pathway, negative regulation of glucose import, positive regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of Wnt receptor signaling pathway, insulin receptor signaling pathway, positive regulation of phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	150	NPFPELCGPGSPPVLTPGSLP	MAPK3	15952796	LTP	0.71	MOD_ProDKin_1	-	-	0.65	-	low
S	476	STRMNILGSQSPLHPSTLSTV	MAPK3	15952796	LTP	0.89	MOD_ProDKin_1	-	-	0.42	-	low

Substrate:

GSK-3 beta (Glycogen synthase kinase-3 beta)

Seq-ID:

P49841 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-65985   DBPA_HUMAN
MINT-65986   YBOX1_HUMAN
MINT-2837737   PSN1_HUMAN
MINT-3974216   TAU_HUMAN
MINT-4049759   PCM1_HUMAN
MINT-4049773   NIN_HUMAN
MINT-4508051   CTNB1_HUMAN
MINT-4508259   AXN1_HUMAN
MINT-4793253   P53_HUMAN
MINT-6761890   PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, tau-protein kinase activity, p53 binding, beta-catenin binding, ATP binding, protein kinase A catalytic subunit binding, NF-kappaB binding	Axin-APC-beta-catenin-GSK3B complex, beta-catenin destruction complex, cytosol, nucleus	positive regulation of protein catabolic process, hippocampus development, negative regulation of apoptosis, positive regulation of protein export from nucleus, positive regulation of Rac GTPase activity, positive regulation of protein complex assembly, peptidyl-serine phosphorylation, glycogen metabolic process, superior temporal gyrus development, canonical Wnt receptor signaling pathway, ER overload response, negative regulation of protein binding, positive regulation of cell-matrix adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	43	DGSKVTTVVATPGQGPDRPQE	MAPK3	16039586	LTP	0.83	MOD_ProDKin_1	-	-	0.66	1Q5K	12.33%

Substrate:

hnRNPK (Ribonucleoprotein)

Seq-ID:

P61978 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-2859758   PCBP1_HUMAN
MINT-3296872   1433Z_HUMAN
MINT-6803834   ANM1_HUMAN
MINT-6803896   ANM3_HUMAN
MINT-7035260   SRC_HUMAN
MINT-7974306   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, RNA binding, protein binding	spliceosomal complex, cytoplasm, nucleoplasm, heterogeneous nuclear ribonucleoprotein complex	mRNA processing, signal transduction, interspecies interaction between organisms, RNA splicing

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	284	PPSRRDYDDMSPRRGPPPPPP	MAPK3	11259409	LTP	0.74	MOD_ProDKin_1	-	-	0.95	-	-
S	353	ETWDSAIDTWSPSEWQMAYEP	MAPK3	11259409	LTP	0.37	MOD_ProDKin_1	-	-	0.57	-	-

Substrate:

HSP22 (Heat shock protein)

Seq-ID:

Q9UJY1 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, identical protein binding	intracellular	response to heat, cell death

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	27	RRDPFRDSPLSSRLLDDGFGM	MAPK3	11342557	LTP	0.10	MOD_ProDKin_1	-	-	0.48	-	medium
T	87	ARFGVPAEGRTPPPFPGEPWK	MAPK3	11342557	LTP	0.03	MOD_ProDKin_1	-	-	0.61	-	medium

Substrate:

Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)

Seq-ID:

P35568 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19010   INSR_HUMAN
MINT-68735   P85A_HUMAN
MINT-74551   EGFR_HUMAN
MINT-74553   ERBB2_HUMAN
MINT-3975430   1433S_HUMAN
MINT-6628637   LT_SV40
MINT-6793745   PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide 3-kinase binding, protein kinase C binding, insulin-like growth factor receptor binding, insulin receptor binding, transmembrane receptor protein tyrosine kinase docking protein activity, SH2 domain binding	microsome, caveola, cytosol, insulin receptor complex, nucleus	negative regulation of insulin receptor signaling pathway, glucose homeostasis, positive regulation of insulin receptor signaling pathway, positive regulation of fatty acid beta-oxidation, phosphoinositide 3-kinase cascade, negative regulation of insulin secretion, positive regulation of glycogen biosynthetic process, insulin receptor signaling pathway, positive regulation of glucose import, positive regulation of phosphoinositide 3-kinase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	616	LHTDDGYMPMSPGVAPVPSGR	MAPK3	15001544	LTP	0.18	MOD_ProDKin_1	-	-	0.82	-	-

Substrate:

LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))

Seq-ID:

P06239 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15516   CBL_HUMAN
MINT-56730   KSYK_HUMAN
MINT-59474   LCP2_HUMAN
MINT-59476   ZAP70_HUMAN
MINT-60779   MK01_HUMAN
MINT-60782   CD3Z_HUMAN
MINT-61276   G3BP1_HUMAN
MINT-66002   CD4_HUMAN
MINT-66003   P85A_HUMAN
MINT-68489   DLG1_HUMAN
MINT-3373863   HS90A_HUMAN
MINT-3373920   GCR_HUMAN
MINT-7135817   SH22A_HUMAN
MINT-7212471   KHDR1_HUMAN
MINT-7212499   WASP_HUMAN
MINT-7218109   ADA15_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide 3-kinase binding, protein C-terminus binding, protein kinase binding, protein serine/threonine phosphatase activity, glycoprotein binding, non-membrane spanning protein tyrosine kinase activity, ATP binding, CD8 receptor binding, ATPase binding, CD4 receptor binding, SH2 domain binding	plasma membrane, cytosol, Golgi apparatus, membrane raft, pericentriolar material	protein amino acid phosphorylation, T cell differentiation, response to drug, activation of caspase activity, positive regulation of T cell activation, positive regulation of T cell receptor signaling pathway, release of sequestered calcium ion into cytosol, interspecies interaction between organisms, cellular zinc ion homeostasis, induction of apoptosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	42	GKGTLLIRNGSEVRDPLVTYE	MAPK3	8226850	LTP	0.25		-	-	0.40	-	-
S	42	GKGTLLIRNGSEVRDPLVTYE	MAPK3	8506364	LTP	0.25		-	-	0.40	-	-

Substrate:

LIF-R (Cytokine receptor)

Seq-ID:

P42702 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
growth factor binding, leukemia inhibitory factor receptor activity, ciliary neurotrophic factor receptor binding	extracellular region, integral to plasma membrane	positive regulation of cell proliferation, leukemia inhibitory factor signaling pathway, response to cytokine stimulus, ciliary neurotrophic factor-mediated signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1044	VNTWNLVSPDSPRSIDSNSEI	MAPK3	7777512	LTP	1.00	MOD_ProDKin_1	-	-	0.61	-	medium

Substrate:

MAP kinase-activated protein kinase 2 (MAP kinase-activated protein kinase 2 (EC 2.7.1.-) (from PhosphoBase))

Seq-ID:

P49138 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-7265076 MK14_MOUSE
MINT-7265089 PHC2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding	cytoplasm, nucleus	protein amino acid phosphorylation, mRNA stabilization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	208	KETTSHNSLTTPCYTPYYVAP	MAPK3	7592979	LTP	0.95	MOD_ProDKin_1	-	S_TKc	0.26	-	-
T	320	WIMQSTKVPQTPLHTSRVLKE	MAPK3	7592979	LTP	0.93	MOD_ProDKin_1	-	-	0.49	2PZY	30.82%

Substrate:

MAP kinase-interacting serine/threonine-protein kinase 1 (Protein serine/threonine kinase activity)

Seq-ID:

Q9BUB5 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13665   IF4E_HUMAN
MINT-13802   IF4G1_HUMAN
MINT-14777   IF4G2_HUMAN
MINT-17051   IF4G3_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, protein binding	cytoplasm, nucleus	protein amino acid phosphorylation, response to stress, regulation of translation, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	385	QGQAPEKGLPTPQVLQRNSST	MAPK3	9155018	LTP	0.97	MOD_ProDKin_1	-	-	0.67	-	low

Substrate:

MBP (myelin basic protein (MBP) (from PhosphoBase))

Seq-ID:

P02686 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-1792581   TOPK_HUMAN
MINT-2860743   ATN1_HUMAN
MINT-2860762   ATX1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	plasma membrane	central nervous system development, immune response, synaptic transmission

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	232	HFFKNIVTPRTPPPSQGKGRG	MAPK3	1939237	LTP	1.00	MOD_ProDKin_1	-	Myelin_MBP	0.77	-	medium

Substrate:

MCL1 (protein binding, protein channel activity)

Seq-ID:

Q07820 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17381   B2L11_MOUSE
MINT-68750   HUWE1_HUMAN
MINT-68751   B2L11_HUMAN
MINT-4821036   BECN1_HUMAN
MINT-4980380   B2L11_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, protein channel activity	integral to membrane, mitochondrial outer membrane, nucleoplasm	apoptosis, anti-apoptosis, cellular homeostasis, response to cytokine stimulus, cell fate determination, multicellular organismal development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	163	NTSTDGSLPSTPPPAEEEEDE	MAPK3	15241487	LTP	1.00	MOD_ProDKin_1	-	-	0.94	-	low

Substrate:

MKP-1 (Dual specificity phosphatase)

Seq-ID:

P28562 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
MAP kinase tyrosine/serine/threonine phosphatase activity, non-membrane spanning protein tyrosine phosphatase activity, protein binding		cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	364	LSYLQSPITTSPSC	MAPK3	10617468	LTP	0.96	MOD_ProDKin_1	-	-	0.26	-	medium

Substrate:

Myc-associated zinc finger protein (Myc-associated zinc finger protein (MAZ))

Seq-ID:

P56270 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, RNA binding, zinc ion binding, protein binding	nucleus	termination of RNA polymerase II transcription, regulation of transcription, transcription initiation from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	72	PFQAAPAPPPTPQAPAAEPLQ	MAPK3	11809795	LTP	0.40	MOD_ProDKin_1	-	-	0.82	-	medium

Substrate:

NCoA-1 (Nuclear receptor coactivator 1)

Seq-ID:

Q15788 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19932   CBP_HUMAN
MINT-4958560   NCOA3_HUMAN
MINT-4958729   KANK2_HUMAN
MINT-5209864   RARA_HUMAN
MINT-5222241   ESR1_HUMAN
MINT-5224970   RXRA_HUMAN
MINT-7013379   PA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	1179	YPPNYGTNPGTPPASTSPFSQ	MAPK3	12163482	LTP	0.03	MOD_ProDKin_1	-	DUF1518	0.86	-	-
S	1185	TNPGTPPASTSPFSQLAANPE	MAPK3	12163482	LTP	1.00	MOD_ProDKin_1	-	DUF1518	0.88	-	-

Substrate:

Neural interleukin 16 protein (Cytokine)

Seq-ID:

Q14005 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cytokine activity	cytoplasm, extracellular space, nucleus	transcription, regulation of transcription, immune response, interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	144	SSSSIRQRISSFETFGSSQLP	MAPK3	14768064	LTP	0.00		-	-	0.68	-	medium

Substrate:

Neutrophil cytosol factor 1 (Neutrophil cytosol factor 1)

Seq-ID:

P14598 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-58638   TF65_HUMAN
MINT-66383   TRIM9_HUMAN
MINT-74863   ACTB_HUMAN
MINT-3973484   KPCA_HUMAN
MINT-3973536   KPCD_HUMAN
MINT-7135171   GNAI2_HUMAN
MINT-7300360   NCF4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, phosphoinositide binding, GTPase activity, GTP binding, electron carrier activity	cytosol, NADPH oxidase complex, soluble fraction	protein targeting to membrane, superoxide anion generation, cellular defense response, innate immune response, cell communication, respiratory burst

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	345	RRRQARPGPQSPGSPLEEERQ	MAPK3	15629715	LTP	0.37	MOD_ProDKin_1	-	p47_phox_C	0.92	-	-
S	348	QARPGPQSPGSPLEEERQTQR	MAPK3	15629715	LTP	0.81	MOD_CK2_1	-	p47_phox_C	0.94	-	-

Substrate:

NFATC4 (transcription coactivator activity)

Seq-ID:

Q14934 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7972976 DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription coactivator activity, sequence-specific DNA binding transcription factor activity	cytoplasm, nucleus	transcription from RNA polymerase II promoter, inflammatory response, regulation of transcription, DNA-dependent, cell differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	676	FYVSNGRRKRSPTQSFRFLPV	MAPK3	15657420	LTP	1.00	MOD_ProDKin_1	-	IPT	0.32	-	-

Substrate:

PLC beta1 (Enzyme: Phospholipase)

Seq-ID:

Q9NQ66 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, phosphoinositide phospholipase C activity, enzyme binding, signal transducer activity	cytosol, nucleus	lipid catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	982	KDSKKKSEPSSPDHGSSTIEQ	MAPK3	11287604	LTP	0.04	MOD_ProDKin_1	-	-	0.84	-	medium

Substrate:

Progesterone receptor (Progesterone receptor (PR))

Seq-ID:

P06401 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-4788079 JDP2_HUMAN
MINT-4788120 NCOR2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
steroid binding, zinc ion binding, receptor binding, sequence-specific DNA binding transcription factor activity, protein binding, steroid hormone receptor activity	cytoplasm, nucleus	transcription, cell-cell signaling

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	294	EQDAPMAPGRSPLATTVMDFI	MAPK3	10655479	LTP	0.90	MOD_ProDKin_1	-	Prog_receptor	0.58	-	medium
S	294	EQDAPMAPGRSPLATTVMDFI	MAPK3	12529413	LTP	0.90	MOD_ProDKin_1	-	Prog_receptor	0.58	-	medium

Substrate:

Progesterone receptor (Progesterone receptor (PR))

Seq-ID:

Q00175 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, steroid binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, protein binding, steroid hormone receptor activity	cytoplasm, nucleus	regulation of epithelial cell proliferation, transcription, epithelial cell maturation, ovulation from ovarian follicle, progesterone receptor signaling pathway, regulation of transcription, DNA-dependent, tertiary branching involved in mammary gland duct morphogenesis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	294	EQDSPIAPGRSPLATTVVDFI	MAPK3	12529413	LTP	0.77	MOD_ProDKin_1	-	Prog_receptor	0.57	-	medium

Substrate:

Retinoic acid receptor RXR-alpha (Retinoic acid receptor RXR-alpha)

Seq-ID:

P19793 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-24895   RARA_HUMAN
MINT-61590   SMAD2_HUMAN
MINT-61758   KPCD2_HUMAN
MINT-5224970   NCOA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, retinoid-X receptor activity, transcription coactivator activity, zinc ion binding, sequence-specific DNA binding transcription factor activity, ligand-regulated transcription factor activity, vitamin D receptor binding, steroid hormone receptor activity	nucleus	negative regulation of gene-specific transcription from RNA polymerase II promoter, transcription, vitamin metabolic process, interspecies interaction between organisms, response to retinoic acid, cholesterol metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	260	VEANMGLNPSSPNDPVTNICQ	MAPK3	12048211	LTP	0.67	MOD_ProDKin_1	-	-	0.53	1FM6	60.66%

Substrate:

RPB1 (RNA polymerase)

Seq-ID:

P24928 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19371 CTDP1_HUMAN
MINT-72765 WWOX_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA-directed RNA polymerase activity, DNA binding, RNA-directed RNA polymerase activity, ubiquitin protein ligase binding, metal ion binding	DNA-directed RNA polymerase II, core complex	transcription initiation from RNA polymerase II promoter, regulation of transcription, DNA-dependent, RNA elongation from RNA polymerase II promoter, RNA splicing

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1619	TPQSPSYSPTSPSYSPTSPSY	MAPK3	12721286	LTP	0.98	MOD_ProDKin_1	PIN1 WW	RNA_pol_Rpb1_R	0.68	-	medium

Substrate:

RPS6KA5 (serine/threonine kinase)

Seq-ID:

O75582 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50073 TF65_HUMAN
MINT-6771456 GCR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding, protein binding	cytoplasm, nucleoplasm	response to chemical stimulus, response to stress, epidermal growth factor receptor signaling pathway, regulation of transcription, DNA-dependent, histone phosphorylation, response to external stimulus, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	360	EEFTEMDPTYSPAALPQSSEK	MAPK3	15568999	LTP	1.00	MOD_ProDKin_1	-	S_TK_X	0.47	-	-
T	581	LKPPDNQPLKTPCFTLHYAAP	MAPK3	15568999	LTP	1.00	MOD_ProDKin_1	-	S_TKc	0.33	-	-

Substrate:

RRN3 (Transcription initiation factor)

Seq-ID:

Q9NYV6 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-4544044 SET_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	nucleolus, nucleoplasm	transcription, regulation of transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	633	TPSSFDTHFRSPSSSVGSPPV	MAPK3	12620228	LTP	1.00	MOD_ProDKin_1	-	-	0.49	-	medium

Substrate:

S6K-alpha 3 (Serine/threonine kinase)

Seq-ID:

P51812 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding	cytosol, nucleoplasm	protein amino acid phosphorylation, central nervous system development, skeletal system development, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	577	QLRAENGLLMTPCYTANFVAP	MAPK3	10980595	LTP	1.00	MOD_ProDKin_1	-	S_TKc	0.12	2QR8	31.51%

Substrate:

SH2-B beta signaling protein (Unclassified)

Seq-ID:

ENSP00000352232 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-74717 EGFR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
signal transducer activity	cytoplasm, nucleus, membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	96	SLSPPILAPLSPGAEISPHDL	MAPK3	10473609	LTP	0.14	MOD_ProDKin_1	-	-	0.56	-	medium

Substrate:

SMAD2 (Transcription regulatory protein)

Seq-ID:

Q15796 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15900   SMAD4_HUMAN
MINT-17220   MED24_HUMAN
MINT-17344   MED15_HUMAN
MINT-60922   KAP0_HUMAN
MINT-60926   ZEB2_HUMAN
MINT-60929   NAGK_HUMAN
MINT-61580   RANB9_HUMAN
MINT-61581   BAZ1A_HUMAN
MINT-61583   AFAD_HUMAN
MINT-61584   DNJC7_HUMAN
MINT-61585   ROCK1_HUMAN
MINT-61587   CBP_HUMAN
MINT-61589   EF1A1_HUMAN
MINT-61590   RXRA_HUMAN
MINT-61591   NCOA6_HUMAN
MINT-61593   UBR5_HUMAN
MINT-61594   P66B_HUMAN
MINT-61597   IMB1_HUMAN
MINT-61598   F10A1_HUMAN
MINT-61599   PLIN3_HUMAN
MINT-61600   SNAPN_HUMAN
MINT-61601   RS14_HUMAN
MINT-61605   ANC2_HUMAN
MINT-61606   BCD1_HUMAN
MINT-61607   ZMY11_HUMAN
MINT-61610   PAPOA_HUMAN
MINT-61611   KHDR1_HUMAN
MINT-61615   NED4L_HUMAN
MINT-61618   ST5_HUMAN
MINT-61620   PEX19_HUMAN
MINT-61623   CUL5_HUMAN
MINT-61625   RU17_HUMAN
MINT-61627   TGM2_HUMAN
MINT-62063   SMAD9_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
I-SMAD binding, R-SMAD binding, co-SMAD binding, ubiquitin protein ligase binding, transcription activator activity, transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity, double-stranded DNA binding, type I transforming growth factor beta receptor binding, transcription factor binding, promoter binding, sequence-specific DNA binding transcription factor activity	cytosol, activin responsive factor complex	intracellular signaling pathway, paraxial mesoderm morphogenesis, regulation of binding, mesoderm formation, transcription, SMAD protein complex assembly, response to cholesterol, zygotic specification of dorsal/ventral axis, cell fate commitment, positive regulation of gene-specific transcription, negative regulation of transcription, DNA-dependent, regulation of transforming growth factor beta receptor signaling pathway, anterior/posterior pattern formation, transforming growth factor beta receptor signaling pathway, palate development, positive regulation of transcription from RNA polymerase II promoter, positive regulation of epithelial to mesenchymal transition, common-partner SMAD protein phosphorylation, primary microRNA processing

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	8	MSSILPFTPPVVKRLLGW	MAPK3	12193595	LTP	1.00	MOD_ProDKin_1	-	-	0.29	-	-
T	220	IEPQSNYIPETPPPGYISEDG	MAPK3	12193595	LTP	0.84	MOD_ProDKin_1	-	-	0.72	-	-
S	245	QQLNQSMDTGSPAELSPTTLS	MAPK3	12193595	LTP	0.88	MOD_ProDKin_1	-	-	0.76	-	-
S	250	SMDTGSPAELSPTTLSPVNHS	MAPK3	12193595	LTP	0.66	MOD_ProDKin_1	-	-	0.68	-	-
S	255	SPAELSPTTLSPVNHSLDLQP	MAPK3	12193595	LTP	0.85	MOD_ProDKin_1	-	-	0.57	-	-

Substrate:

SMAD4 (Transcription factor)

Seq-ID:

Q13485 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13793   MED15_HUMAN
MINT-14687   CEBPB_HUMAN
MINT-15900   SMAD2_HUMAN
MINT-58494   RAB3B_MOUSE
MINT-58519   CHK1_MOUSE
MINT-58525   TOPK_MOUSE
MINT-61942   ZMYM2_HUMAN
MINT-61943   PIAS1_HUMAN
MINT-61949   SMAD3_HUMAN
MINT-61951   SMAD5_HUMAN
MINT-61952   MYOD1_HUMAN
MINT-61955   PR40A_HUMAN
MINT-61957   MCAF1_HUMAN
MINT-61958   RFX1_HUMAN
MINT-61961   DCP1A_HUMAN
MINT-61962   DCP1B_HUMAN
MINT-61963   HM20A_HUMAN
MINT-61967   VIGLN_HUMAN
MINT-61974   MK13_HUMAN
MINT-61976   EF1A1_HUMAN
MINT-61978   CNKR1_HUMAN
MINT-61980   UHRF2_HUMAN
MINT-61982   JUNB_HUMAN
MINT-61984   RU17_HUMAN
MINT-62001   SMAD1_HUMAN
MINT-67350   SMAD9_HUMAN
MINT-7289576   KGP1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
I-SMAD binding, protein homodimerization activity, R-SMAD binding, promoter binding, sequence-specific DNA binding transcription factor activity, transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	cytosol, activin responsive factor complex	positive regulation of pathway-restricted SMAD protein phosphorylation, transcription, BMP signaling pathway, negative regulation of protein catabolic process, response to hypoxia, negative regulation of cell growth, SMAD protein complex assembly, SMAD protein signal transduction, negative regulation of transcription, DNA-dependent, positive regulation of transforming growth factor beta receptor signaling pathway, regulation of transforming growth factor-beta2 production, transforming growth factor beta receptor signaling pathway, palate development, positive regulation of SMAD protein nuclear translocation, positive regulation of epithelial to mesenchymal transition

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	277	TWTGSRTAPYTPNLPHHQNGH	MAPK3	12801888	LTP	0.81	MOD_ProDKin_1	-	-	0.77	-	low

Substrate:

Sp1 (Transcription factor Sp1)

Seq-ID:

P08047 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14843   HD_HUMAN
MINT-49665   AATF_HUMAN
MINT-49667   HDAC1_HUMAN
MINT-49728   HMGA1_HUMAN
MINT-56524   P53_HUMAN
MINT-69591   LT_SV40
MINT-3378435   HIF1A_HUMAN
MINT-6803426   PO2F1_HUMAN
MINT-7244314   ABL1_HUMAN
MINT-7245562   SRC_HUMAN
MINT-7246450   FYN_HUMAN
MINT-7249690   NCK1_HUMAN
MINT-7254478   CRK_HUMAN
MINT-7384908   EGR1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein C-terminus binding, protein homodimerization activity, RNA polymerase II transcription factor activity, transcription activator activity, histone deacetylase binding, zinc ion binding, promoter binding, sequence-specific DNA binding transcription factor activity	cytoplasm, nucleus	transcription, positive regulation by host of viral transcription, positive regulation of transcription from RNA polymerase II promoter, global

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	453	VPNSGPIIIRTPTVGPNGQVS	MAPK3	14593115	LTP	0.58	MOD_ProDKin_1	-	-	0.58	-	-
T	453	VPNSGPIIIRTPTVGPNGQVS	MAPK3	11904305	LTP	0.58	MOD_ProDKin_1	-	-	0.58	-	-
T	739	GAGSEGSGTATPSALITTNMV	MAPK3	14593115	LTP	0.45	MOD_ProDKin_1	-	-	0.56	-	-
T	739	GAGSEGSGTATPSALITTNMV	MAPK3	11904305	LTP	0.45	MOD_ProDKin_1	-	-	0.56	-	-

Substrate:

Src substrate cortactin (Involved in the organization of cell structure)

Seq-ID:

Q14247 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-6541916   WASL_HUMAN
MINT-6541935   PAK1_HUMAN
MINT-6541954   PAK2_HUMAN
MINT-6795199   PTN1_HUMAN
MINT-7103135   KCMA1_MOUSE
MINT-7145534   ASAP1_HUMAN
MINT-7145612   DYN2_HUMAN
MINT-7306884   MTSS1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	lamellipodium, cytoskeleton, soluble fraction, cell cortex, ruffle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	405	ARAKTQTPPVSPAPQPTEERL	MAPK3	10537323	LTP	0.10	MOD_ProDKin_1	-	-	0.94	-	-
S	418	PQPTEERLPSSPVYEDAASFK	MAPK3	10537323	LTP	0.08	MOD_ProDKin_1	-	-	0.75	-	-

Substrate:

SREBF2 (protein binding, RNA polymerase II transcription factor acti...)

Seq-ID:

Q12772 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16696 HNF4A_HUMAN
MINT-51235 SMAD3_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein C-terminus binding	Golgi membrane, ER to Golgi transport vesicle membrane, SREBP-SCAP-Insig complex, nucleus	transcription, cholesterol metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	432	EDFNQNVLLMSPPASDSGSQA	MAPK3	14988395	LTP	0.05	MOD_ProDKin_1	-	-	0.46	-	medium
S	455	SPYSIDSEPGSPLLDDAKVKD	MAPK3	14988395	LTP	1.00	MOD_ProDKin_1	-	-	0.45	-	medium

Substrate:

SREBP1 (Transcription factor)

Seq-ID:

P36956 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-2863379 ATX1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sterol response element binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, protein binding	Golgi membrane, ER to Golgi transport vesicle membrane, integral to membrane, nuclear envelope, endoplasmic reticulum membrane, nucleus, endoplasmic reticulum	cellular response to starvation, transcription, regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, cholesterol metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	117	LKMYPSMPAFSPGPGIKEESV	MAPK3	10915800	LTP	0.13	MOD_ProDKin_1	-	-	0.66	-	medium

Substrate:

STAT 5 (Transcription factor)

Seq-ID:

P42229 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50646   ESR1_HUMAN
MINT-58264   STAP2_HUMAN
MINT-6793989   PTN1_HUMAN
MINT-7891339   EPOR_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, sequence-specific DNA binding transcription factor activity, protein binding	cytoplasm, nucleus	valine metabolic process, oxaloacetate metabolic process, transcription, creatinine metabolic process, isoleucine metabolic process, JAK-STAT cascade, taurine metabolic process, allantoin metabolic process, fatty acid metabolic process, citrate metabolic process, 2-oxoglutarate metabolic process, succinate metabolic process, creatine metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	780	RPMDSLDSRLSPPAGLFTSAR	MAPK3	10194762	LTP	0.43	MOD_ProDKin_1	-	-	0.55	-	medium

Substrate:

Synapsin-3 (Unclassified)

Seq-ID:

O14994 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
catalytic activity, ATP binding	cell junction, synaptic vesicle membrane	neurotransmitter secretion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	470	RLSPQGQQPLSPQSGSPQQQR	MAPK3	14732590	LTP	0.23	MOD_ProDKin_1	-	-	0.99	-	medium

Substrate:

TAL-1 protein (Transcription factor)

Seq-ID:

P17542 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7254852 CRK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
histone deacetylase binding, promoter binding, sequence-specific DNA binding transcription factor activity	nucleus	regulation of gene-specific transcription from RNA polymerase II promoter, transcription, cell fate commitment, erythrocyte differentiation, positive regulation of erythrocyte differentiation, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	122	LPGDGRMVQLSPPALAAPAAP	MAPK3	8423803	LTP	0.35	MOD_ProDKin_1	-	-	0.70	-	high

Substrate:

THRB (protein binding, thyroid hormone receptor activity)

Seq-ID:

P10828 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, thyroid hormone receptor activity, transcription corepressor activity, zinc ion binding, sequence-specific DNA binding transcription factor activity, steroid hormone receptor activity	nucleus	transcription, DNA-dependent, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	142	RRTIQKNLHPSYSCKYEGKCV	MAPK3	12809513	LTP	0.46		-	ZnF_C4	0.17	2NLL	75.41%

Substrate:

Transcription factor Spi-B (Transcription factor)

Seq-ID:

Q01892 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, RNA polymerase II transcription factor activity	cytoplasm, microtubule cytoskeleton, nucleus	transcription, regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	56	DWTVAPPVPATPYEAFDPAAA	MAPK3	8632909	LTP	0.56	MOD_ProDKin_1	-	-	0.39	-	medium

Substrate:

TRAP220 (Transcription regulatory protein)

Seq-ID:

Q15648 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-58469   MDM2_HUMAN
MINT-58470   P53_HUMAN
MINT-5209905   RARA_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
peroxisome proliferator activated receptor binding, RNA polymerase II transcription mediator activity, receptor activity, DNA binding, estrogen receptor binding, ligand-dependent nuclear receptor transcription coactivator activity, retinoic acid receptor binding, ligand-dependent nuclear receptor binding, vitamin D receptor binding, thyroid hormone receptor binding	mediator complex	fat cell differentiation, androgen receptor signaling pathway, transcription initiation from RNA polymerase II promoter, androgen biosynthetic process, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	1457	SPSHSKSPAYTPQNLDSESES	MAPK3	12356758	LTP	0.13	MOD_ProDKin_1	-	Med1-Trap220	0.89	-	medium
T	1457	SPSHSKSPAYTPQNLDSESES	MAPK3	16314496	LTP	0.13	MOD_ProDKin_1	-	Med1-Trap220	0.89	-	medium

Substrate:

TTK (Dual specificity protein kinase)

Seq-ID:

Q98T92 [Xenopus laevis]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding		protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	844	RILGQLIGLNSPNSISRAAKN	MAPK3	16950116	LTP	0.97	MOD_ProDKin_1	-	-	0.35	-	low

Substrate:

UBF-1 (Transcription factor)

Seq-ID:

P17480 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-62331   ZMYM2_HUMAN
MINT-63514   SCG1_HUMAN
MINT-1894291   FBRL_HUMAN
MINT-4543985   SET_HUMAN
MINT-7720853   CEBPA_HUMAN
MINT-7971422   DLG4_RAT

GO-Terms:

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Molecular Function	Cellular Component	Biological Process
DNA binding, RNA polymerase I transcription factor activity, protein binding	nucleolus, nucleoplasm	transcription, positive regulation of transcription from RNA polymerase I promoter

Conservation:

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Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	117	KHPDFPKKPLTPYFRFFMEKR	MAPK3	11741541	LTP	1.00	MOD_ProDKin_1	-	HMG	0.27	-	-
T	201	KKSDIPEKPKTPQQLWYTHEK	MAPK3	11741541	LTP	1.00	MOD_ProDKin_1	-	HMG	0.56	-	-