Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

AhR
Alpha adducin
ATP-sensitive inward rectifier potassium channel 11
Beta adducin
Beta-ARK-1
BK-2 receptor
BNC1
c-kit
C22orf19
Calcium sensing receptor
CD226
CD44
CD5
CD71
CD88
CFTR
CGK 1 alpha
CPI-17
CREB-binding protein
Cytohesin 2
DGKD
E1A-associated protein p300
EGFR
eIF-4E
EMK1
FGF2
GluR-1
Glutamate [NMDA] receptor subunit epsilon 2
GMF-beta
GNG12
Gz-alpha
HRH1
Insulin R
Integrin beta 2
IPP1
Iron-responsive element binding protein 1
ITGB4
ITGB4BP
KCNC4
Lamin A/C
Lipocortin I (annexinI)
Lipocortin II (annexinII)
MARCKS
Myosin-9
Neuronal membrane glycoprotein M6-a
Neutrophil cytosol factor 1
Neutrophil cytosol factor 4
NFE2L2
NHERF-1
Nitric-oxide synthase, endothelial
p21
PEBP1
PITPNA
PKC alpha
PKC mu
PLAU
PLC gamma 1
PLD2
Pleckstrin
PPP1R14D
Presenilin 1
PtdInsTP
PTGIR
R-PTP-alpha
Raf1
RGS7
Rhodopsin
Ribosomal protein S6 kinase 2
Serine/threonine-protein kinase 11
SH3 domain-binding protein 2
SNAP23
SPN
SRF
TACSTD2
TBXA2R
Transient receptor potential cation channel subfamily V member 6
Troponin I, cardiac muscle
TRPC3
Tyrosine-protein phosphatase, non-receptor type 1
Tyrosine-protein phosphatase, non-receptor type 12
Tyrosine-protein phosphatase, non-receptor type 6
Vimentin
Vinculin

Substrate:

AhR (Transcription factor)

Seq-ID:

P30561 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, protein heterodimerization activity, ligand-dependent nuclear receptor activity, sequence-specific DNA binding transcription factor activity	cytoplasm, transcription factor complex	transcription from RNA polymerase II promoter, response to stress, apoptosis, cell cycle, prostate gland development, positive regulation of RNA polymerase II transcriptional preinitiation complex assembly, xenobiotic metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	35	IPAEGIKSNPSKRHRDRLNTE	PKC_alpha	15063792	LTP	1.00		-	HLH	0.66	-	low

Substrate:

AhR (Transcription factor)

Seq-ID:

P35869 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
Hsp90 protein binding, ligand-dependent nuclear receptor activity, transcription factor binding, sequence-specific DNA binding transcription factor activity	cytoplasm, nucleus	transcription from RNA polymerase II promoter, response to stress, apoptosis, cell cycle, response to xenobiotic stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	12	NSSSANITYASRKRRKPVQKT	PKC_alpha	15063792	LTP	0.23		-	-	0.62	-	low
S	36	IPAEGIKSNPSKRHRDRLNTE	PKC_alpha	15063792	LTP	1.00		-	HLH	0.67	-	low

Substrate:

Alpha adducin (Structural protein)

Seq-ID:

P35611 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-72730 RFX1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
spectrin binding, protein heterodimerization activity, protein homodimerization activity, metal ion binding, transcription factor binding, calmodulin binding, actin filament binding	plasma membrane, cytosol, F-actin capping protein complex, nucleus	positive regulation of protein binding, actin filament bundle assembly, barbed-end actin filament capping

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	716	GSDGSPGKSPSKKKKKFRTPS	PKC_alpha	9679146	LTP	1.00	-	-	0.84	-	medium
S	726	SKKKKKFRTPSFLKKSKKKSD	PKC_alpha	9679146	LTP	0.13	-	-	0.79	-	medium
S	726	SKKKKKFRTPSFLKKSKKKSD	PKC_alpha	15611095	LTP	0.13	-	-	0.79	-	medium

Substrate:

ATP-sensitive inward rectifier potassium channel 11 (Potassium channel protein)

Seq-ID:

Q61743 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
potassium ion binding, ATP binding, ATP-activated inward rectifier potassium channel activity	ATP-sensitive potassium channel complex	potassium ion import

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	180	KTAQAHRRAETLIFSKHAVIT	PKC_alpha	10908656	LTP	1.00		-	IRK	0.08	-	low

Substrate:

Beta adducin (Anchor protein)

Seq-ID:

P35612 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
spectrin binding, protein heterodimerization activity, protein homodimerization activity, metal ion binding, calmodulin binding, actin filament binding	plasma membrane, cytoplasm, F-actin capping protein complex	positive regulation of protein binding, actin filament bundle assembly, barbed-end actin filament capping

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	703	SPEGSPSKSPSKKKKKFRTPS	PKC_alpha	8810272	LTP	0.95		-	-	0.82	-	medium

Substrate:

Beta-ARK-1 (Beta-adrenergic receptor kinase)

Seq-ID:

P25098 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-51490   EGFR_HUMAN
MINT-3376147   MDM2_HUMAN
MINT-6608788   GIT1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
G-protein coupled receptor kinase activity, ATP binding, Edg-2 lysophosphatidic acid receptor binding, alpha-2A adrenergic receptor binding, beta-adrenergic receptor kinase activity, signal transducer activity	cytosol, soluble fraction	negative regulation of striated muscle contraction, desensitization of G-protein coupled receptor protein signaling pathway, positive regulation of catecholamine secretion, muscarinic acetylcholine receptor signaling pathway, tachykinin receptor signaling pathway, peptidyl-serine phosphorylation, cardiac muscle contraction, negative regulation of the force of heart contraction by chemical signal

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	29	KSKATPAARASKKILLPEPSI	PKC_alpha	11042191	LTP	0.26		-	-	0.36	1OMW	130.33%

Substrate:

BK-2 receptor (B2 bradykinin receptor)

Seq-ID:

P30411 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, phosphoinositide phospholipase C activity, protease binding, bradykinin receptor activity, type 1 angiotensin receptor binding	endosome, integral to plasma membrane	arachidonic acid secretion, regulation of vasoconstriction, regulation of vascular permeability, inflammatory response, smooth muscle contraction, transmembrane receptor protein tyrosine kinase signaling pathway, elevation of cytosolic calcium ion concentration

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	373	MENSMGTLRTSISVERQIHKL	PKC_alpha	11517230	LTP	1.00		-	-	0.24	-	low

Substrate:

BNC1 (transcription factor activity)

Seq-ID:

Q01954 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
zinc ion binding, sequence-specific DNA binding transcription factor activity	cytoplasm, nucleus	epidermis development, positive regulation of cell proliferation, transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	541	ALPKKKSRKSSMPIKIEKEAV	PKC_alpha	9223293	LTP	1.00		-	-	0.63	-	medium

Substrate:

c-kit (Receptor tyrosine kinase)

Seq-ID:

P10721 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor signaling protein tyrosine kinase activity, ATP binding, protein binding	integral to membrane, extracellular space	male gonad development, transmembrane receptor protein tyrosine kinase signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	741	VVPTKADKRRSVRIGSYIERD	PKC_alpha	7539802	LTP	1.00	-	TyrKc	0.30	-	-
S	746	ADKRRSVRIGSYIERDVTPAI	PKC_alpha	7539802	LTP	0.11	-	TyrKc	0.31	3G0E	8.20%
S	821	FGLARDIKNDSNYVVKGNARL	PKC_alpha	7539802	LTP	1.00	-	TyrKc	0.17	1T46	90.16%
S	959	PVVDHSVRINSVGSTASSSQP	PKC_alpha	7539802	LTP	0.24	-	-	0.45	-	-

Substrate:

C22orf19 (n.a.)

Seq-ID:

Q13769 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-6800052 THOC1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
RNA binding, protein binding	cytoplasm, THO complex part of transcription export complex	mRNA processing, intronless viral mRNA export from host nucleus, RNA splicing, cell differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	5	MSSESSKKRKPKVIR	PKC_alpha	15221008	LTP	0.08		-	-	0.70	-	low
S	6	MSSESSKKRKPKVIRS	PKC_alpha	15221008	LTP	0.00		-	-	0.69	-	low

Substrate:

Calcium sensing receptor (G protein coupled receptor)

Seq-ID:

P41180 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
G-protein coupled receptor activity, phosphoinositide phospholipase C activity	integral to plasma membrane	calcium-mediated signaling, anatomical structure morphogenesis, cellular calcium ion homeostasis, chemosensory behavior, ossification, detection of calcium ion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	888	AHAFKVAARATLRRSNVSRKR	PKC_alpha	9694886	LTP	0.09		-	-	0.30	-	medium
T	888	AHAFKVAARATLRRSNVSRKR	PKC_alpha	12409307	LTP	0.09		-	-	0.30	-	medium

Substrate:

CD226 (Receptor involved in intercellular adhesion)

Seq-ID:

Q15762 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, protein kinase binding, cell adhesion molecule binding, integrin binding	integral to plasma membrane, cell surface, membrane raft	positive regulation of immunoglobulin mediated immune response, positive regulation of mast cell activation, positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target, cell recognition, cell adhesion, positive regulation of Fc receptor mediated stimulatory signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	329	EDIYVNYPTFSRRPKTRV	PKC_alpha	9712030	LTP	0.14		-	-	0.38	-	medium

Substrate:

CD44 (CD antigen)

Seq-ID:

P16070 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, collagen binding, receptor signaling protein activity, hyaluronic acid binding	integral to plasma membrane	positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of ERK1 and ERK2 cascade, negative regulation of apoptosis, positive regulation of peptidyl-serine phosphorylation, negative regulation of DNA damage response, signal transduction by p53 class mediator, cell-matrix adhesion, cell-cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	672	LILAVCIAVNSRRRCGQKKKL	PKC_alpha	12032545	LTP	1.00		-	TRANS	0.23	-	-

Substrate:

CD5 (T-cell surface glycoprotein CD5 precursor (Lymphocyte glycoprotein T1/Leu-1) (Lymphocyte antigen CD5))

Seq-ID:

P06127 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
scavenger receptor activity	integral to plasma membrane	cell recognition, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	434	NQNMSFHRNHTATVRSHAENP	PKC_alpha	11123317	LTP	1.00		-	-	0.67	-	medium
T	436	NMSFHRNHTATVRSHAENPTA	PKC_alpha	11123317	LTP	1.00		-	-	0.66	-	medium

Substrate:

CD71 (transferrin receptor protein (antigen CD71) (p90) (from PhosphoBase))

Seq-ID:

P02786 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48105   IKKE_HUMAN
MINT-50059   RANB9_HUMAN
MINT-3319281   1433Z_HUMAN
MINT-7183598   SH3B4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
peptidase activity, transferrin receptor activity	endosome, integral to plasma membrane, coated pit, melanosome	cellular iron ion homeostasis, proteolysis, interspecies interaction between organisms, endocytosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	24	GGEPLSYTRFSLARQVDGDNS	PKC_alpha	3013873	LTP	1.00	-	-	0.34	-	low
S	24	GGEPLSYTRFSLARQVDGDNS	PKC_alpha	3013873	LTP	1.00	-	-	0.34	-	low
S	24	GGEPLSYTRFSLARQVDGDNS	PKC_alpha	3119581	LTP	1.00	-	-	0.34	-	low

Substrate:

CD88 (G protein coupled receptor)

Seq-ID:

P21730 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
C5a anaphylatoxin receptor activity	integral to plasma membrane	activation of phospholipase C activity, cellular defense response, immune response, activation of MAPK activity, elevation of cytosolic calcium ion concentration, sensory perception of chemical stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	314	GQGFQGRLRKSLPSLLRNVLT	PKC_alpha	7642584	LTP	1.00	-	-	0.09	-	medium
S	317	FQGRLRKSLPSLLRNVLTEES	PKC_alpha	7642584	LTP	0.28	-	-	0.11	-	medium
S	332	VLTEESVVRESKSFTRSTVDT	PKC_alpha	7642584	LTP	0.15	-	-	0.27	-	medium
S	334	TEESVVRESKSFTRSTVDTMA	PKC_alpha	7642584	LTP	0.22	-	-	0.30	-	medium
S	338	VVRESKSFTRSTVDTMAQKTQ	PKC_alpha	7642584	LTP	0.32	-	-	0.33	-	medium

Substrate:

CFTR (cystic fibrosis transmembrane conductance regulator (CFTR) (from PhosphoBase))

Seq-ID:

P13569 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-60075   NHRF1_MOUSE
MINT-69537   BCR_HUMAN
MINT-73263   NHRF3_MOUSE
MINT-1783772   GOPC_HUMAN
MINT-1787402   NHRF2_HUMAN
MINT-1794992   CALX_HUMAN
MINT-1796681   NHRF1_HUMAN
MINT-7218998   UBP19_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
channel-conductance-controlling ATPase activity, ATP-binding and phosphorylation-dependent chloride channel activity, ATP binding, enzyme binding, PDZ domain binding	early endosome membrane, basolateral plasma membrane, chloride channel complex, apical plasma membrane	respiratory gaseous exchange

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	686	PVSWTETKKQSFKQTGEFGEK	PKC_alpha	1377674	LTP	0.90		-	-	0.52	-	-
S	686	PVSWTETKKQSFKQTGEFGEK	PKC_alpha	1377674	LTP	0.90		-	-	0.52	-	-

Substrate:

CGK 1 alpha (cGMP-dependent protein kinase, alpha isoenzyme (from PhosphoBase))

Seq-ID:

Q13976 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-7289566 BMPR2_HUMAN
MINT-7289576 SMAD4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cGMP binding, ATP binding, cGMP-dependent protein kinase activity		protein amino acid phosphorylation, actin cytoskeleton organization, signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	59	VPSTHIGPRTTRAQGISAEPQ	PKC_alpha	12609995	LTP	0.37		-	-	0.64	-	medium

Substrate:

CPI-17 (Inhibitor of PPP1CA)

Seq-ID:

Q96A00 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-16604 KC1A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoprotein phosphatase inhibitor activity, protein binding	cytoplasm	regulation of phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	38	GGLQKRHARVTVKYDRRELQR	PKC_alpha	12604330	LTP	1.00	MOD_PKA_2	-	PP1_inhibitor	0.51	-	medium
T	38	GGLQKRHARVTVKYDRRELQR	PKC_alpha	15003508	LTP	1.00	MOD_PKA_2	-	PP1_inhibitor	0.51	-	medium

Substrate:

CREB-binding protein (Transcription regulatory protein)

Seq-ID:

P45481 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-24802   NCOA3_HUMAN
MINT-72894   LT_SV40
MINT-4979712   CREB1_MOUSE
MINT-7264037   STAT1_HUMAN
MINT-7264052   STAT2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, histone acetyltransferase activity, chromatin binding, MyoD binding, transcription coactivator activity, zinc ion binding	outer kinetochore of condensed chromosome, transcription factor complex, histone acetyltransferase complex	transcription, positive regulation of transcription factor activity, N-terminal peptidyl-lysine acetylation, histone acetylation, positive regulation of transcription from RNA polymerase II promoter, germ-line stem cell maintenance

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	436	CPVCLPLKNASDKRNQQTILG	PKC_alpha	11463380	LTP	0.27		-	-	0.47	-	-

Substrate:

Cytohesin 2 (Guanine nucleotide exchange factor)

Seq-ID:

Q99418 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-3976039 1433S_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ARF guanyl-nucleotide exchange factor activity, protein binding	plasma membrane, membrane fraction, intracellular	actin cytoskeleton organization, regulation of ARF protein signal transduction, endocytosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	392	EMLAARKKRISVKKKQEQP	PKC_alpha	10531036	LTP	0.21		-	-	0.47	-	medium

Substrate:

DGKD (diacylglycerol binding, diacylglycerol kinase activity)

Seq-ID:

Q16760 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, protein homodimerization activity, metal ion binding, diacylglycerol kinase activity, diacylglycerol binding, ATP binding	plasma membrane, cytoplasmic membrane-bounded vesicle	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, diacylglycerol metabolic process, cell growth, protein transport, epidermal growth factor receptor signaling pathway, response to organic substance, protein homooligomerization, multicellular organismal development, endocytosis, second-messenger-mediated signaling

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	66	KEGMLTKQNNSFQRSKRRYFK	PKC_alpha	15228384	LTP	1.00		-	PH	0.49	-	low
S	70	LTKQNNSFQRSKRRYFKLRGR	PKC_alpha	15228384	LTP	0.00		-	PH	0.48	-	low

Substrate:

E1A-associated protein p300 (Transcription regulatory protein)

Seq-ID:

Q09472 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13681   P73_HUMAN
MINT-17787   GATA4_MOUSE
MINT-50178   TF65_HUMAN
MINT-69559   VE7_HPV16
MINT-2584615   TF2B_HUMAN
MINT-2831131   ABL1_HUMAN
MINT-2982535   HIPK2_HUMAN
MINT-2982660   RUNX1_HUMAN
MINT-2983397   CDK2_HUMAN
MINT-4790867   ITF2_HUMAN
MINT-4791678   HIF1A_HUMAN
MINT-4979756   CREB1_MOUSE
MINT-5209851   CREB1_HUMAN
MINT-6628502   LT_SV40
MINT-6665134   E1A_ADE05
MINT-6743403   STRAP_HUMAN
MINT-7263630   P53_HUMAN
MINT-7943702   SENP3_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
histone acetyltransferase activity, beta-catenin binding, transcription coactivator activity, zinc ion binding	cytoplasm	transcription, response to hypoxia, histone H4 acetylation, apoptosis, positive regulation of transcription factor activity, cell cycle, N-terminal peptidyl-lysine acetylation, interspecies interaction between organisms, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	89	KQLSELLRSGSSPNLNMGVGG	PKC_alpha	12590608	LTP	0.79		-	-	0.74	-	medium

Substrate:

EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)

Seq-ID:

P00533 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
epidermal growth factor receptor activity, protein heterodimerization activity, identical protein binding, receptor signaling protein tyrosine kinase activity, double-stranded DNA binding, ATP binding, protein phosphatase binding, actin filament binding, MAP/ERK kinase kinase activity	Shc-EGFR complex, endosome, basolateral plasma membrane, integral to membrane, extracellular space, nucleus	activation of phospholipase C activity, protein insertion into membrane, response to UV-A, positive regulation of nitric oxide biosynthetic process, positive regulation of cell migration, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, positive regulation of catenin protein nuclear translocation, regulation of nitric-oxide synthase activity, positive regulation of protein kinase B signaling cascade, ossification, positive regulation of epithelial cell proliferation, activation of phospholipase A2 activity by calcium-mediated signaling, cell-cell adhesion, regulation of peptidyl-tyrosine phosphorylation, positive regulation of phosphorylation, positive regulation of MAP kinase activity, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	678	MRRRHIVRKRTLRRLLQEREL	PKC_alpha	6090944	LTP	1.00		-	-	0.28	-	-
T	678	MRRRHIVRKRTLRRLLQEREL	PKC_alpha	1860884	LTP	1.00		-	-	0.28	-	-

Substrate:

eIF-4E (eukaryotic translation initation factor 4E (eIF-4E) (from PhosphoBase))

Seq-ID:

P63073 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-1899476 EIF3B_MOUSE
MINT-1954700 IF4G1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
translation initiation factor activity, RNA binding, protein binding	mRNA cap binding complex, cytoplasm

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	209	SHADTATKSGSTTKNRFVV	PKC_alpha	8662663	LTP	0.96		-	IF4E	0.45	1IPB	50.82%

Substrate:

EMK1 (Serine/threonine kinase)

Seq-ID:

Q7KZI7 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48484   M3K3_HUMAN
MINT-51527   1433B_HUMAN
MINT-3294883   1433Z_HUMAN
MINT-3975077   1433S_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding, protein binding	plasma membrane	protein amino acid phosphorylation, response to oxidative stress, establishment or maintenance of epithelial cell apical/basal polarity, cell differentiation, multicellular organismal development, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	596	NFPRGVSSRSTFHAGQLRQVR	PKC_alpha	15324659	LTP	0.94		-	-	0.75	-	-

Substrate:

FGF2 (protein binding)

Seq-ID:

P09038 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
fibroblast growth factor receptor binding, heparin binding, growth factor activity	extracellular space	branching involved in ureteric bud morphogenesis, positive regulation of cell fate specification, positive regulation of ERK1 and ERK2 cascade, positive regulation of blood vessel endothelial cell migration, positive regulation of cardiac muscle cell proliferation, negative regulation of cell death, negative regulation of blood vessel endothelial cell migration, activation of MAPK activity, chondroblast differentiation, chemotaxis, cell migration involved in sprouting angiogenesis, Ras protein signal transduction, positive regulation of cell division, fibroblast growth factor receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	73	QLQAEERGVVSIKGVCANRYL	PKC_alpha	2541433	LTP	0.32		-	FGF	0.19	1BFG	5.74%

Substrate:

GluR-1 (Extracellular ligand gated channel)

Seq-ID:

P42261 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-18147 KAPCA_HUMAN
MINT-49811 CXCR2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
kainate selective glutamate receptor activity, extracellular-glutamate-gated ion channel activity	endocytic vesicle membrane, cell junction, endoplasmic reticulum membrane, postsynaptic membrane	synaptic transmission

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	849	MKGFCLIPQQSINEAIRTSTL	PKC_alpha	18305116	LTP	0.52		-	-	0.27	-	low
S	849	MKGFCLIPQQSINEAIRTSTL	PKC_alpha	14973229	LTP	0.52		-	-	0.27	-	low

Substrate:

Glutamate [NMDA] receptor subunit epsilon 2 (Extracellular ligand gated channel)

Seq-ID:

Q13224 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-1900702 DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
N-methyl-D-aspartate selective glutamate receptor activity, zinc ion binding, glycine binding	N-methyl-D-aspartate selective glutamate receptor complex, cell junction, outer membrane-bounded periplasmic space, postsynaptic membrane	response to ethanol

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1303	KNRNKLRRQHSYDTFVDLQKE	PKC_alpha	11306676	LTP	1.00		-	NMDAR2_C	0.57	-	low
S	1323	EEAALAPRSVSLKDKGRFMDG	PKC_alpha	11306676	LTP	1.00		-	NMDAR2_C	0.53	-	low

Substrate:

GMF-beta (Glia maturation factor)

Seq-ID:

P60983 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
enzyme activator activity, protein kinase inhibitor activity, growth factor activity, actin binding, signal transducer activity	intracellular	nervous system development, protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	72	PERQPRFIVYSYKYQHDDGRV	PKC_alpha	9030586	LTP	0.96		-	ADF	0.22	-	medium

Substrate:

GNG12 (unclassified)

Seq-ID:

Q9DAS9 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
signal transducer activity	heterotrimeric G-protein complex	G-protein coupled receptor protein signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	2	MSSKTASTNSIA	PKC_alpha	7493986	LTP	-		-	-	0.41	-	medium
S	2	MSSKTASTNSIA	PKC_alpha	9492299	LTP	-		-	-	0.41	-	medium

Substrate:

Gz-alpha (G protein)

Seq-ID:

P19086 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
GTPase activity, GTP binding, receptor signaling protein activity	plasma membrane, nuclear envelope, endoplasmic reticulum

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	16	SSEEKEAARRSRRIDRHLRSE	PKC_alpha	9166747	LTP	1.00	-	G_alpha	0.65	-	medium
S	16	SSEEKEAARRSRRIDRHLRSE	PKC_alpha	10531372	LTP	1.00	-	G_alpha	0.65	-	medium
S	16	SSEEKEAARRSRRIDRHLRSE	PKC_alpha	8429024	LTP	1.00	-	G_alpha	0.65	-	medium
S	27	RRIDRHLRSESQRQRREIKLL	PKC_alpha	9166747	LTP	0.00	-	G_alpha	0.42	-	medium
S	27	RRIDRHLRSESQRQRREIKLL	PKC_alpha	10531372	LTP	0.00	-	G_alpha	0.42	-	medium
S	27	RRIDRHLRSESQRQRREIKLL	PKC_alpha	8429024	LTP	0.00	-	G_alpha	0.42	-	medium

Substrate:

HRH1 (G-protein coupled receptor activity, histamine receptor activity)

Seq-ID:

P35367 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
histamine receptor activity	integral to plasma membrane	inflammatory response, activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	396	YIKFTWKRLRSHSRQYVSGLH	PKC_alpha	15107581	LTP	0.22	-	7tm_1	0.12	-	medium
S	398	KFTWKRLRSHSRQYVSGLHMN	PKC_alpha	15107581	LTP	1.00	-	7tm_1	0.19	-	medium
S	398	KFTWKRLRSHSRQYVSGLHMN	PKC_alpha	10101032	LTP	1.00	-	7tm_1	0.19	-	medium
T	478	YPLCNENFKKTFKRILHIRS	PKC_alpha	15107581	LTP	1.00	-	7TM_GPCR_Srsx	0.03	-	medium

Substrate:

Insulin R (Receptor tyrosine kinase)

Seq-ID:

P06213 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16516   GRB10_HUMAN
MINT-16842   MD2L1_HUMAN
MINT-18199   IRS2_HUMAN
MINT-19010   IRS1_HUMAN
MINT-73466   GRB10_MOUSE
MINT-6793537   INSR_RAT
MINT-6794075   IRS1_MOUSE
MINT-6794090   INSR_MOUSE
MINT-6794946   PTN1_HUMAN
MINT-6795115   IRS1_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
insulin-like growth factor receptor binding, insulin binding, PTB domain binding, GTP binding, metal ion binding, insulin receptor substrate binding, ATP binding, insulin-like growth factor I binding, insulin receptor activity, SH2 domain binding, phosphoinositide 3-kinase binding, insulin-like growth factor II binding, receptor signaling protein tyrosine kinase activity	microsome, caveola, insulin receptor complex, endosome membrane	positive regulation of glycolysis, positive regulation of MAPKKK cascade, positive regulation of developmental growth, regulation of embryonic development, heart morphogenesis, positive regulation of cell migration, carbohydrate metabolic process, protein heterotetramerization, positive regulation of protein kinase B signaling cascade, protein amino acid autophosphorylation, activation of MAPK activity, positive regulation of glycogen biosynthetic process, positive regulation of mitosis, peptidyl-tyrosine phosphorylation, positive regulation of glucose import, positive regulation of respiratory burst, activation of protein kinase B activity, G-protein coupled receptor protein signaling pathway, positive regulation of DNA replication, positive regulation of protein amino acid phosphorylation, positive regulation of cell proliferation, glucose homeostasis, positive regulation of nitric oxide biosynthetic process, transformation of host cell by virus, regulation of gene-specific transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1062	TRVAVKTVNESASLRERIEFL	PKC_alpha	7926007	LTP	1.00	-	TyrKc	0.28	1IR3	88.52%
S	1064	VAVKTVNESASLRERIEFLNE	PKC_alpha	7926007	LTP	0.99	-	TyrKc	0.26	1IR3	45.90%
T	1375	NGGKKNGRILTLPRSNPS	PKC_alpha	2110001	LTP	0.21	-	-	0.74	-	-

Substrate:

Integrin beta 2 (Adhesion molecule)

Seq-ID:

P05107 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16748   CSN3_HUMAN
MINT-45894   SHC1_MOUSE
MINT-45897   EPS8_HUMAN
MINT-45904   RBGP1_HUMAN
MINT-45912   GULP1_HUMAN
MINT-45917   NUMB_MOUSE
MINT-45924   DAB1_MOUSE
MINT-45938   IRS1_RAT
MINT-45944   DOK1_MOUSE
MINT-45953   TLN1_MOUSE
MINT-45956   JIP1_HUMAN
MINT-50069   RANB9_HUMAN
MINT-4652127   RADI_HUMAN
MINT-4652150   CYH1_HUMAN
MINT-7226098   ABL1_HUMAN
MINT-7226365   TLN2_HUMAN
MINT-7226634   VAV_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, protein kinase binding, glycoprotein binding	integrin complex	apoptosis, integrin-mediated signaling pathway, regulation of cell shape, inflammatory response, cell-cell signaling, neutrophil chemotaxis, cell-matrix adhesion, regulation of peptidyl-tyrosine phosphorylation, leukocyte cell-cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	745	YRRFEKEKLKSQWNNDNPLFK	PKC_alpha	11700305	LTP	0.13		-	Integrin_b_cyt	0.32	-	-
T	758	NNDNPLFKSATTTVMNPKFAE	PKC_alpha	11700305	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Integrin_b_cyt	0.35	2JF1	93.15%

Substrate:

IPP1 (protein phosphatase inhibitor 1 (IPP-1) (from PhosphoBase))

Seq-ID:

P19103 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoprotein phosphatase inhibitor activity		signal transduction, glycogen metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	65	IPNPLLKSTLSMSPRQRKKMT	PKC_alpha	16772299	LTP	0.08		-	DARPP-32	0.88	-	medium

Substrate:

Iron-responsive element binding protein 1 (iron-responsive element binding protein (IRE-BP) (from PhosphoBase))

Seq-ID:

P21399 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
4 iron, 4 sulfur cluster binding, iron-responsive element binding, metal ion binding, aconitate hydratase activity, protein binding	cytosol, Golgi apparatus, endoplasmic reticulum	tricarboxylic acid cycle, citrate metabolic process, response to iron(II) ion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	138	IQVDFNRRADSLQKNQDLEFE	PKC_alpha	8262977	LTP	0.41	-	Aconitase	0.36	2B3X	0.00%
S	711	LTPREFNSYGSRRGNDAVMAR	PKC_alpha	15263083	LTP	1.00	-	Aconitase_C	0.42	2B3X	0.82%
S	711	LTPREFNSYGSRRGNDAVMAR	PKC_alpha	8262977	LTP	1.00	-	Aconitase_C	0.42	2B3X	0.82%

Substrate:

ITGB4 (protein binding)

Seq-ID:

P16144 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-51381   FLNA_HUMAN
MINT-2860098   ATX1_HUMAN
MINT-7234326   PLEC1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, protein binding	integrin complex	hemidesmosome assembly, integrin-mediated signaling pathway, cell-matrix adhesion, cell communication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1356	FLMYSDDVLRSPSGSQRPSVS	PKC_alpha	15121854	LTP	1.00	-	-	0.62	-	-
S	1360	SDDVLRSPSGSQRPSVSDDTG	PKC_alpha	15121854	LTP	1.00	-	-	0.73	-	-
S	1364	LRSPSGSQRPSVSDDTGCGWK	PKC_alpha	15121854	LTP	1.00	-	-	0.69	-	-

Substrate:

ITGB4BP (protein binding)

Seq-ID:

P56537 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
translation initiation factor activity, ribosome binding, protein binding	cytoplasm, nucleolus	mature ribosome assembly

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	235	NEAQPSTIATSMRDSLIDSLT	PKC_alpha	14654845	LTP	0.17		-	-	0.36	-	medium

Substrate:

KCNC4 (voltage-gated potassium channel activity)

Seq-ID:

Q03721 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
voltage-gated potassium channel activity, protein binding	voltage-gated potassium channel complex	synaptic transmission

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	8	MISSVCVSSYRGRKSGNK	PKC_alpha	9649584	LTP	1.00	-	-	0.42	-	-
S	9	MISSVCVSSYRGRKSGNKP	PKC_alpha	9649584	LTP	1.00	-	-	0.44	-	-
S	15	VCVSSYRGRKSGNKPPSKTCL	PKC_alpha	9649584	LTP	0.25	-	-	0.47	-	-
S	21	RGRKSGNKPPSKTCLKEEMAK	PKC_alpha	9649584	LTP	1.00	-	-	0.60	-	-

Substrate:

Lamin A/C (lamin A (70 kD lamin) (from PhosphoBase))

Seq-ID:

P48678 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural molecule activity, protein binding	lamin filament, nuclear envelope	nuclear envelope organization, sterol regulatory element binding protein nuclear translocation, ventricular cardiac muscle cell development, positive regulation of cell aging

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	652	LVTRSYLLGNSSPRSQSSQNC	PKC_alpha	8477740	LTP	-		-	-	0.53	-	-

Substrate:

Lipocortin I (annexinI) ( Ca++, phospholipids and actin-binding protein)

Seq-ID:

P04083 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-51101 EGFR_HUMAN
MINT-3297886 1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium-dependent phospholipid binding, calcium ion binding, phospholipase A2 inhibitor activity, protein binding, bridging, structural molecule activity, receptor binding	extracellular region, cilium, cytoplasm, basolateral plasma membrane, cornified envelope, nucleus	positive regulation of vesicle fusion, lipid metabolic process, keratinocyte differentiation, anti-apoptosis, cellular component movement, signal transduction, inflammatory response, cell surface receptor linked signaling pathway, peptide cross-linking

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	27	EEQEYVQTVKSSKGGPGSAVS	PKC_alpha	2457390	LTP	0.13		-	-	0.57	-	-

Substrate:

Lipocortin II (annexinII) (Calcium-regulated membrane -binding protein)

Seq-ID:

P07355 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-3297866 1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium-dependent phospholipid binding, calcium ion binding, cytoskeletal protein binding, phospholipase inhibitor activity	basement membrane, melanosome, soluble fraction	positive regulation of vesicle fusion, skeletal system development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	26	DHSTPPSAYGSVKAYTNFDAE	PKC_alpha	2946940	LTP	-		-	-	0.47	1W7B	17.21%

Substrate:

MARCKS (Protein kinase C substrate)

Seq-ID:

P29966 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calmodulin binding, actin filament binding	actin cytoskeleton, membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	159	ETPKKKKKRFSFKKSFKLSGF	PKC_alpha	1650359	LTP	1.00		-	MARCKS	0.52	-	low
S	163	KKKKRFSFKKSFKLSGFSFKK	PKC_alpha	1650359	LTP	1.00		-	MARCKS	0.41	-	low

Substrate:

Myosin-9 (myosin heavy chain, nonmuscle type A (NMMHC-A) (from PhosphoBase))

Seq-ID:

P35579 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48057   IKKA_HUMAN
MINT-48117   IKKE_HUMAN
MINT-48214   NEMO_HUMAN
MINT-48485   M3K3_HUMAN
MINT-48678   NFKB1_HUMAN
MINT-49070   RIPK2_HUMAN
MINT-49443   TNR1B_HUMAN
MINT-72662   HS90B_HUMAN
MINT-6699369   TRPM7_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein homodimerization activity, microfilament motor activity, actin-dependent ATPase activity, protein anchor, ATP binding, ADP binding, calmodulin binding, actin filament binding	uropod, actomyosin contractile ring, stress fiber, cytosol, myosin complex, nucleus, ruffle, cleavage furrow	angiogenesis, cytokinesis, membrane protein ectodomain proteolysis, actin cytoskeleton reorganization, platelet formation, protein transport, integrin-mediated signaling pathway, blood vessel endothelial cell migration, regulation of cell shape, monocyte differentiation, actin filament-based movement, leukocyte migration

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1916	TADAMNREVSSLKNKLRRGDL	PKC_alpha	1899200	LTP	0.80		-	COIL	0.65	-	medium
S	1916	TADAMNREVSSLKNKLRRGDL	PKC_alpha	9545325	LTP	0.80		-	COIL	0.65	-	medium

Substrate:

Neuronal membrane glycoprotein M6-a (Ion channel, other)

Seq-ID:

P51674 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	cell surface, integral to membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	10	MEENMEEGQTQKGCFECCIK	PKC_alpha	12359212	LTP	0.10		-	-	0.09	-	high

Substrate:

Neutrophil cytosol factor 1 (Neutrophil cytosol factor 1)

Seq-ID:

P14598 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-58638   TF65_HUMAN
MINT-66383   TRIM9_HUMAN
MINT-74863   ACTB_HUMAN
MINT-3973484   KPCA_HUMAN
MINT-3973536   KPCD_HUMAN
MINT-7135171   GNAI2_HUMAN
MINT-7300360   NCF4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, phosphoinositide binding, GTPase activity, GTP binding, electron carrier activity	cytosol, NADPH oxidase complex, soluble fraction	protein targeting to membrane, superoxide anion generation, cellular defense response, innate immune response, cell communication, respiratory burst

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	303	QIKRGAPPRRSSIRNAHSIHQ	PKC_alpha	8626435	LTP	1.00	MOD_PKA_1	-	-	0.76	1NG2	44.26%
S	303	QIKRGAPPRRSSIRNAHSIHQ	PKC_alpha	7520867	LTP	1.00	MOD_PKA_1	-	-	0.76	1NG2	44.26%
S	304	IKRGAPPRRSSIRNAHSIHQR	PKC_alpha	8626435	LTP	0.09		-	-	0.77	1NG2	57.38%
S	304	IKRGAPPRRSSIRNAHSIHQR	PKC_alpha	7520867	LTP	0.09		-	-	0.77	1NG2	57.38%
S	315	IRNAHSIHQRSRKRLSQDAYR	PKC_alpha	8626435	LTP	0.77		-	-	0.66	1NG2	86.89%
S	320	SIHQRSRKRLSQDAYRRNSVR	PKC_alpha	8626435	LTP	1.00	MOD_PKA_1	-	-	0.59	1NG2	58.20%
S	320	SIHQRSRKRLSQDAYRRNSVR	PKC_alpha	7520867	LTP	1.00	MOD_PKA_1	-	-	0.59	1NG2	58.20%
S	328	RLSQDAYRRNSVRFLQQRRRQ	PKC_alpha	8626435	LTP	0.99	MOD_PKA_1	-	-	0.56	1NG2	0.00%
S	328	RLSQDAYRRNSVRFLQQRRRQ	PKC_alpha	7520867	LTP	0.99	MOD_PKA_1	-	-	0.56	1NG2	0.00%
S	348	QARPGPQSPGSPLEEERQTQR	PKC_alpha	8626435	LTP	0.81	MOD_CK2_1	-	p47_phox_C	0.94	-	-
S	359	PLEEERQTQRSKPQPAVPPRP	PKC_alpha	8626435	LTP	0.71	MOD_PKA_2	-	p47_phox_C	0.94	-	-
S	370	KPQPAVPPRPSADLILNRCSE	PKC_alpha	8626435	LTP	1.00	MOD_PKA_2	-	p47_phox_C	0.80	-	-

Substrate:

Neutrophil cytosol factor 4 (Enzyme: Oxidase)

Seq-ID:

Q15080 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7300360 NCF1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein dimerization activity, phosphoinositide binding	cytosol, NADPH oxidase complex	oxidation reduction, immune response, cell communication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	154	PQALRRLRPRTRKVKSVSPQG	PKC_alpha	9804763	LTP	1.00	-	-	0.47	-	-
T	154	PQALRRLRPRTRKVKSVSPQG	PKC_alpha	15035643	LTP	1.00	-	-	0.47	-	-
S	315	LMVRQARGLPSQKRLFPWKLH	PKC_alpha	9804763	LTP	1.00	-	PB1	0.15	2DYB	90.98%

Substrate:

NFE2L2 (Transcription factor)

Seq-ID:

Q60795 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-19697 ARRB1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, protein dimerization activity, transcription activator activity, sequence-specific DNA binding transcription factor activity	cytosol, nucleus	regulation of embryonic development, transcription, positive regulation of transcription, DNA-dependent, endoplasmic reticulum unfolded protein response

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	40	LGVSREVFDFSQRQKDYELEK	PKC_alpha	12947090	LTP	0.22		-	-	0.33	-	medium

Substrate:

NHERF-1 (Membrane bound ligand)

Seq-ID:

O14745 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19912   PAG1_HUMAN
MINT-72743   YAP1_HUMAN
MINT-72749   YES_HUMAN
MINT-73246   RHG17_HUMAN
MINT-73249   TB10A_HUMAN
MINT-73251   PLCB3_HUMAN
MINT-73256   EZRI_HUMAN
MINT-1796624   P2RY1_HUMAN
MINT-1796656   ADRB2_HUMAN
MINT-1796681   CFTR_HUMAN
MINT-2832448   PTEN_HUMAN
MINT-2832839   PTEN_MOUSE
MINT-2832864   PGFRB_MOUSE
MINT-2833042   PGFRB_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
beta-2 adrenergic receptor binding, PDZ domain binding	filopodium, cytoplasm, intracellular membrane-bounded organelle, microvillus, actin cytoskeleton, apical plasma membrane, ruffle, endomembrane system	protein complex assembly, regulation of sodium:hydrogen antiporter activity, Wnt receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	162	PRLCTMKKGPSGYGFNLHSDK	PKC_alpha	12881487	LTP	0.81		-	PDZ	0.57	2OZF	92.62%

Substrate:

Nitric-oxide synthase, endothelial (Nitric-oxide synthase, endothelial)

Seq-ID:

P29473 [Bos taurus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
NADP or NADPH binding, FAD binding, calmodulin binding, nitric-oxide synthase activity, FMN binding	caveola, cytoskeleton, Golgi apparatus	blood coagulation, oxidation reduction, anti-apoptosis, positive regulation of guanylate cyclase activity, arginine catabolic process, nitric oxide biosynthetic process, mitochondrion organization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	497	TKGAGITRKKTFKEVANAVKI	PKC_alpha	12869534	LTP	0.05		-	-	0.31	-	-

Substrate:

p21 (Cyclin-dependent kinase inhibitor 1 (p21))

Seq-ID:

P38936 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50392   CC45L_HUMAN
MINT-50407   CDC6_HUMAN
MINT-50418   CDK4_HUMAN
MINT-50421   CDK6_HUMAN
MINT-50432   CCNB2_HUMAN
MINT-50437   CCND1_HUMAN
MINT-50441   CCND3_HUMAN
MINT-50445   GEMI_HUMAN
MINT-50660   CCNB1_HUMAN
MINT-73322   VE7_HPV16
MINT-73323   CDK2_HUMAN
MINT-1774121   SKP2_HUMAN
MINT-1780042   MCM7_HUMAN
MINT-1891378   P53_HUMAN
MINT-2635177   CCNE1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cyclin-dependent protein kinase inhibitor activity, metal ion binding	cytosol, cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, PCNA-p21 complex	cellular response to extracellular stimulus, positive regulation of fibroblast proliferation, senescence, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, negative regulation of cell proliferation, negative regulation of cell growth, cell cycle arrest, G1/S transition of mitotic cell cycle, induction of apoptosis by intracellular signals, Ras protein signal transduction, G2/M transition of mitotic cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	145	GDSQGRKRRQTSMTDFYHSKR	PKC_alpha	15001356	LTP	0.19	MOD_PKB_1	-	-	0.69	-	medium
S	146	DSQGRKRRQTSMTDFYHSKRR	PKC_alpha	10753973	LTP	0.03	MOD_PKB_1	-	-	0.65	-	medium

Substrate:

PEBP1 (phosphatidylethanolamine binding)

Seq-ID:

P30086 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-63641   STC2_HUMAN
MINT-3389607   RAF1_HUMAN
MINT-7252186   P85A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
serine-type endopeptidase inhibitor activity, phosphatidylethanolamine binding, ATP binding

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	153	GDHRGKFKVASFRKKYELRAP	PKC_alpha	14654844	LTP	0.23		-	PBP	0.29	1BD9	62.30%

Substrate:

PITPNA (phosphatidylcholine transporter activity, phosphatidylinositol transporter activity)

Seq-ID:

P53810 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
lipid binding	cytoplasm	transport

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	166	KAEEDPAKFKSVKTGRGPLGP	PKC_alpha	10801835	LTP	1.00		-	IP_trans	0.49	1KCM	2.46%

Substrate:

PITPNA (phosphatidylcholine transporter activity, phosphatidylinositol transporter activity)

Seq-ID:

Q00169 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphatidylinositol transporter activity, phosphatidylcholine transmembrane transporter activity, protein binding	cytoplasm, nucleus	lipid metabolic process, visual perception

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	165	KAEEDPAKFKSIKTGRGPLGP	PKC_alpha	15322105	LTP	1.00		-	IP_trans	0.48	1KCM	2.46%

Substrate:

PKC alpha (Serine/threonine kinase)

Seq-ID:

P17252 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-62532   RBP1_HUMAN
MINT-2490678   RAC1_HUMAN
MINT-2833162   BRAF_HUMAN
MINT-2833275   KPCE_HUMAN
MINT-2833291   KS6A2_HUMAN
MINT-3973484   NCF1_HUMAN
MINT-4298329   NUMB_DROME
MINT-4300836   INADL_HUMAN
MINT-4507294   JAK1_HUMAN
MINT-4507312   TYK2_HUMAN
MINT-4507332   IF2A_HUMAN
MINT-4507367   JAK2_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
histone kinase activity (H3-T6 specific), ATP binding, enzyme binding, zinc ion binding	plasma membrane, cytosol, endoplasmic reticulum	induction of apoptosis by extracellular signals, response to interleukin-1

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	657	NIDQSDFEGFSYVNPQFVHPI	PKC_alpha	8856079	LTP	0.84		-	S_TK_X	0.23	-	-

Substrate:

PKC mu (Serine/threonine kinase)

Seq-ID:

Q15139 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C activity, metal ion binding, ATP binding, protein binding	cytosol, integral to plasma membrane	protein amino acid phosphorylation, signal transduction, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	738	FGFARIIGEKSFRRSVVGTPA	PKC_alpha	15383279	LTP	1.00	-	S_TKc	0.08	-	medium
S	738	FGFARIIGEKSFRRSVVGTPA	PKC_alpha	11948398	LTP	1.00	-	S_TKc	0.08	-	medium
S	742	RIIGEKSFRRSVVGTPAYLAP	PKC_alpha	15383279	LTP	1.00	-	S_TKc	0.12	-	medium
S	742	RIIGEKSFRRSVVGTPAYLAP	PKC_alpha	11948398	LTP	1.00	-	S_TKc	0.12	-	medium

Substrate:

PLAU (Urokinase-type plasminogen activator)

Seq-ID:

P00749 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
serine-type endopeptidase activity	plasma membrane, cell surface, extracellular space	proteolysis, blood coagulation, regulation of cell adhesion mediated by integrin, signal transduction, regulation of receptor activity, chemotaxis, fibrinolysis, regulation of smooth muscle cell migration

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	158	VHDCADGKKPSSPPEELKFQC	PKC_alpha	9765311	LTP	0.76		-	-	0.35	-	-
S	323	CEITGFGKENSTDYLYPEQLK	PKC_alpha	9765311	LTP	0.16		-	Tryp_SPc	0.28	1GJ7	41.80%

Substrate:

PLC gamma 1 (Major substrate for eparin binding growth factor)

Seq-ID:

P19174 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19688   RBP2_MOUSE
MINT-74678   EGFR_HUMAN
MINT-74680   ERBB2_HUMAN
MINT-74682   ERBB3_HUMAN
MINT-7146767   AKT1_HUMAN
MINT-7229970   RAC1_HUMAN
MINT-7231507   PLD1_HUMAN
MINT-7252402   ICAL_HUMAN
MINT-7252438   TRAIP_HUMAN
MINT-7252450   SNX17_HUMAN
MINT-7252486   ASAP2_HUMAN
MINT-7252498   ARHGB_HUMAN
MINT-7252534   ASAP1_HUMAN
MINT-7252546   RRAS_HUMAN
MINT-7252558   M4K1_HUMAN
MINT-7252594   GHR_HUMAN
MINT-7252618   RGS7_HUMAN
MINT-7252642   CKAP5_HUMAN
MINT-7252666   JAK2_HUMAN
MINT-7252678   SOS1_HUMAN
MINT-7252690   FLNB_HUMAN
MINT-7252714   FLNA_HUMAN
MINT-7252738   ABL1_HUMAN
MINT-7252750   SUV92_HUMAN
MINT-7252762   SC24B_HUMAN
MINT-7252786   FCG2B_HUMAN
MINT-7252798   FCG2C_HUMAN
MINT-7252810   PHAR2_HUMAN
MINT-7252846   FANCA_HUMAN
MINT-7252858   TGON2_HUMAN
MINT-7252882   CAF1A_HUMAN
MINT-7252894   MAP4_HUMAN
MINT-7252954   SHAN2_HUMAN
MINT-7252966   DNLI3_HUMAN
MINT-7252978   NELFB_HUMAN
MINT-7253038   DTBP1_HUMAN
MINT-7253050   ABL2_HUMAN
MINT-7253062   AKAP2_HUMAN
MINT-7253086   FLNC_HUMAN
MINT-7253122   MINT_HUMAN
MINT-7253146   LIPA4_HUMAN
MINT-7253158   ADNP_HUMAN
MINT-7306637   LCP2_HUMAN
MINT-7309951   SCRB2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide phospholipase C activity, receptor signaling protein activity	plasma membrane, cytosol	interspecies interaction between organisms, phospholipid catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1248	QLFHGRAREGSFESRYQQPFE	PKC_alpha	1370476	LTP	0.94		-	-	0.40	-	medium

Substrate:

PLD2 (Phospholipase D2)

Seq-ID:

O14939 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-6173922 COF1_HUMAN
MINT-6796717 PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
NAPE-specific phospholipase D activity, phosphoinositide binding, phospholipase D activity		cell communication, cytoskeleton organization, small GTPase mediated signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	243	WSKRWLVVKDSFLLYMCLETG	PKC_alpha	15979581	LTP	1.00		-	PH	0.02	-	low
T	252	DSFLLYMCLETGAISFVQLFD	PKC_alpha	15979581	LTP	0.17		-	PH	0.01	-	low

Substrate:

Pleckstrin (pleckstrin (platelet p47 protein) (from PhosphoBase))

Seq-ID:

P08567 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphatidylinositol-3,4-bisphosphate binding, protein kinase C binding, protein homodimerization activity	extracellular region, membrane fraction, cytosol, ruffle membrane, soluble fraction	negative regulation of calcium-mediated signaling, vesicle docking involved in exocytosis, cortical actin cytoskeleton organization, negative regulation of inositol phosphate biosynthetic process, positive regulation of actin filament depolymerization, actin cytoskeleton reorganization, positive regulation of actin filament bundle assembly, integrin-mediated signaling pathway, protein kinase C signaling cascade, inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway, protein secretion by platelet, hemopoietic progenitor cell differentiation, positive regulation of platelet activation, platelet aggregation, phosphoinositide metabolic process, positive regulation of inositol-polyphosphate 5-phosphatase activity, positive regulation of integrin activation, regulation of cell diameter, ruffle organization, thrombin receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	113	IEGGQKFARKSTRRSIRLPET	PKC_alpha	8615792	LTP	1.00		-	-	0.37	-	medium
S	117	QKFARKSTRRSIRLPETIDLG	PKC_alpha	8615792	LTP	1.00		-	-	0.31	-	medium

Substrate:

PPP1R14D (Protein phosphatase)

Seq-ID:

Q9NXH3 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoprotein phosphatase inhibitor activity, protein binding	cytoplasm	regulation of phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	58	IPRSRRPSRLTVKYDRGQLQR	PKC_alpha	12974676	LTP	1.00	MOD_PKA_1	-	PP1_inhibitor	0.54	-	low

Substrate:

Presenilin 1 (Presenilin 1 (PS-1) (S182 protein))

Seq-ID:

P49768 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14193   PKP4_HUMAN
MINT-15987   FLNB_HUMAN
MINT-16205   B2CL1_HUMAN
MINT-17726   FLNA_HUMAN
MINT-49819   CADH1_HUMAN
MINT-2837737   GSK3B_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium channel activity, beta-catenin binding, endopeptidase activity, PDZ domain binding	centrosome, Golgi membrane, smooth endoplasmic reticulum, integral to plasma membrane, cell surface, kinetochore, nuclear outer membrane, endoplasmic reticulum membrane, rough endoplasmic reticulum, gamma-secretase complex	induction of apoptosis by extracellular signals, membrane protein ectodomain proteolysis, anti-apoptosis, Notch receptor processing, membrane protein intracellular domain proteolysis, Notch signaling pathway, amyloid precursor protein catabolic process, cell-cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	346	FSEEWEAQRDSHLGPHRSTPE	PKC_alpha	14576165	LTP	0.24		-	PSN	0.62	-	medium

Substrate:

PtdInsTP (Transporter activity)

Seq-ID:

P53811 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
lipid binding	Golgi apparatus	in utero embryonic development, transport

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	165	KADEDPALFHSVKTKRGPLGP	PKC_alpha	11953429	LTP	1.00		-	IP_trans	0.40	2A1L	0.82%
S	262	KELETMRKKGSVRGTSAADA	PKC_alpha	11953429	LTP	0.26		-	-	0.56	2A1L	77.87%

Substrate:

PTGIR (Prostacyclin receptor)

Seq-ID:

P43119 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
G-protein coupled receptor activity	integral to plasma membrane	cell-cell signaling, G-protein signaling, coupled to cyclic nucleotide second messenger

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	328	DSQTPLSQLASGRRDPRAPSA	PKC_alpha	9722557	LTP	0.10		-	-	0.62	-	low

Substrate:

R-PTP-alpha (Receptor tyrosine phosphatase)

Seq-ID:

P18052 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7552515 SRC_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity	integral to membrane	protein amino acid phosphorylation, protein amino acid dephosphorylation, insulin receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	180	KYKQAGSHSNSFRLSNGRTED	PKC_alpha	7537734	LTP	0.62		-	-	0.56	-	-
S	204	QSVPLLARSPSTNRKYPPLPV	PKC_alpha	7537734	LTP	1.00		-	-	0.49	-	-

Substrate:

Raf1 (RAF proto-oncogene serine/threonine-protein kinase)

Seq-ID:

Q99N57 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, metal ion binding, receptor signaling protein activity, ATP binding, protein binding	plasma membrane, cytosol	protein amino acid phosphorylation, apoptosis, nerve growth factor receptor signaling pathway, cytoskeleton organization, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	499	LATVKSRWSGSQQVEQPTGSV	PKC_alpha	8321321	LTP	1.00		-	STYKc	0.33	-	medium

Substrate:

RGS7 (GTPase activating protein)

Seq-ID:

P49802 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-7252618 PLCG1_HUMAN
MINT-7254286 CRK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
signal transducer activity, protein binding	heterotrimeric G-protein complex	negative regulation of signal transduction, regulation of G-protein coupled receptor protein signaling pathway, G-protein coupled receptor protein signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	434	EHIYKLMKSDSYPRFIRSSAY	PKC_alpha	12077120	LTP	1.00		YWHAB 14-3-3; YWHAQ 14-3-3	RGS	0.22	2A72	52.46%

Substrate:

Rhodopsin (G protein coupled receptor)

Seq-ID:

P15409 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
G-protein coupled receptor activity, photoreceptor activity, metal ion binding	plasma membrane, photoreceptor outer segment membrane, photoreceptor inner segment membrane, integral to membrane	protein amino acid phosphorylation, protein-chromophore linkage

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	334	GKNPLGDDDASATASKTETSQ	PKC_alpha	12809555	LTP	0.57		-	-	0.47	-	medium
S	338	LGDDDASATASKTETSQVAPA	PKC_alpha	12809555	LTP	0.56		-	-	0.48	-	medium

Substrate:

Ribosomal protein S6 kinase 2 (Ser/Thr protein kinase family)

Seq-ID:

Q9UBS0 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15495   EF2K_HUMAN
MINT-51121   COASY_HUMAN
MINT-2833483   RS6_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding	nucleoplasm	positive regulation of translational initiation, translation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	473	PIRPPSGTKKSKRGRGRPGR	PKC_alpha	12529391	LTP	0.11		-	-	0.94	-	medium

Substrate:

Serine/threonine-protein kinase 11 (Serine/threonine protein kinase 11)

Seq-ID:

Q9WTK7 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, LRR domain binding, ATP binding	cytoplasm, nucleus	protein amino acid phosphorylation, regulation of Wnt receptor signaling pathway, cell cycle arrest, canonical Wnt receptor signaling pathway, regulation of protein kinase B signaling cascade, negative regulation of epithelial cell proliferation involved in prostate gland development, tissue homeostasis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	431	VCSSNKIRRLSACKQQ	PKC_alpha	16407220	LTP	0.16	MOD_PKA_1	-	-	0.37	-	low

Substrate:

SH3 domain-binding protein 2 (Adaptor molecule)

Seq-ID:

P78314 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17097   1433T_HUMAN
MINT-74724   ERBB2_HUMAN
MINT-4549720   VAV_HUMAN
MINT-4563345   DBNL_HUMAN
MINT-4563367   SH3K1_HUMAN
MINT-7301276   VAV2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, SH3/SH2 adaptor activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	225	PAFSDMPRAHSFTSKGPGPLL	PKC_alpha	12501243	LTP	1.00		-	-	0.79	-	medium

Substrate:

SNAP23 (Membrane transport protein)

Seq-ID:

O00161 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-17055 TLK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	cell junction, plasma membrane enriched fraction, synapse, specific granule, synaptosome, azurophil granule	protein transport, post-Golgi vesicle-mediated transport, vesicle targeting, cellular membrane fusion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	23	AHQITDESLESTRRILGLAIE	PKC_alpha	12930825	LTP	1.00	-	t_SNARE	0.48	-	low
T	24	HQITDESLESTRRILGLAIES	PKC_alpha	12930825	LTP	1.00	-	t_SNARE	0.48	-	low
S	161	EMEENLTQVGSILGNLKDMAL	PKC_alpha	12930825	LTP	1.00	-	t_SNARE	0.48	-	low

Substrate:

SPN (bacterial binding, transmembrane receptor activity)

Seq-ID:

P16150 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
bacterial cell surface binding, transmembrane receptor activity	integral to plasma membrane, extracellular space	defense response to bacterium, establishment or maintenance of cell polarity, cellular defense response, immune response, positive regulation of tumor necrosis factor biosynthetic process, chemotaxis, negative regulation of cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	351	TLTTFFGRRKSRQGSLAMEEL	PKC_alpha	2530225	LTP	1.00		-	-	0.51	-	medium

Substrate:

SRF (Serum response factor)

Seq-ID:

P11831 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-15523 MYOD1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein homodimerization activity, specific RNA polymerase II transcription factor activity, transcription factor binding, sequence-specific DNA binding transcription factor activity, serum response element binding	cytoplasm, nucleus	senescence, transcription, positive regulation of cell differentiation, neuron development, regulation of smooth muscle cell differentiation, response to hormone stimulus, response to toxin, positive regulation of transcription via serum response element binding, response to cytokine stimulus, heart looping, positive regulation of smooth muscle contraction, cell migration involved in sprouting angiogenesis, muscle cell homeostasis, trophectodermal cell differentiation, angiogenesis involved in wound healing, positive regulation of transcription initiation from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	159	EFIDNKLRRYTTFSKRKTGIM	PKC_alpha	12809504	LTP	0.74		-	MADS	0.38	1K6O	50.68%

Substrate:

TACSTD2 (receptor activity)

Seq-ID:

P09758 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity	cytosol, integral to plasma membrane	visual perception, cell surface receptor linked signaling pathway, response to stimulus, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	303	AVLVITNRRKSGKYKKVEIKE	PKC_alpha	7635574	LTP	0.07		-	-	0.15	-	medium

Substrate:

TBXA2R (receptor activity, rhodopsin-like receptor activity)

Seq-ID:

ENSP00000248419 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
guanyl-nucleotide exchange factor activity, thromboxane A2 receptor activity, protein binding	integral to plasma membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	399	GVQLLPFEPPTGKALSRKD	PKC_alpha	15100160	LTP	0.00		-	-	0.39	-	low

Substrate:

Transient receptor potential cation channel subfamily V member 6 (Membrane transport protein)

Seq-ID:

Q9H1D0 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-6764665 PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium channel activity, calmodulin binding	integral to plasma membrane	regulation of calcium ion-dependent exocytosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	702	SANWERLRQGTLRRDLRGIIN	PKC_alpha	11248124	LTP	0.93		-	-	0.29	-	medium

Substrate:

Troponin I, cardiac muscle (troponin I, cardiac muscle (from PhosphoBase))

Seq-ID:

P48787 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
actin binding		regulation of systemic arterial blood pressure by ischemic conditions, cellular calcium ion homeostasis, vasculogenesis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	43	EPHAKKKSKISASRKLQLKTL	PKC_alpha	7592712	LTP	1.00	-	-	0.53	-	-
S	45	HAKKKSKISASRKLQLKTLML	PKC_alpha	7592712	LTP	1.00	-	-	0.46	-	-
T	144	YDLRGKFKRPTLRRVRISADA	PKC_alpha	7592712	LTP	0.05	-	Troponin	0.35	-	-

Substrate:

TRPC3 (protein binding, store-operated calcium channel activity)

Seq-ID:

Q13507 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
store-operated calcium channel activity, protein binding	integral to plasma membrane	phototransduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	712	TLPPPFSLVPSPKSFVYFIMR	PKC_alpha	15533987	LTP	1.00		-	TRANS	0.04	-	medium
S	712	TLPPPFSLVPSPKSFVYFIMR	PKC_alpha	16331690	LTP	1.00		-	TRANS	0.04	-	medium

Substrate:

Tyrosine-protein phosphatase, non-receptor type 1 (Protein tyrosine phosphatase 1B)

Seq-ID:

P18031 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-51115   PPIP1_HUMAN
MINT-73489   CADH2_HUMAN
MINT-6744190   CSK21_HUMAN
MINT-6761890   GSK3B_HUMAN
MINT-6761899   ESR1_HUMAN
MINT-6762163   IKBA_HUMAN
MINT-6762380   PGFRB_HUMAN
MINT-6762549   PAXI_MOUSE
MINT-6762573   FAK1_MOUSE
MINT-6762866   IRS1_RAT
MINT-6763504   BCAR1_MOUSE
MINT-6763556   INSR_RAT
MINT-6764602   JAK2_HUMAN
MINT-6764613   STAT3_HUMAN
MINT-6764665   TRPV6_HUMAN
MINT-6764866   CAV1_HUMAN
MINT-6765163   PIAS1_HUMAN
MINT-6765185   SUMO1_HUMAN
MINT-6765318   CTND1_MOUSE
MINT-6765333   LPP_MOUSE
MINT-6765355   SRC8_MOUSE
MINT-6765370   ZO1_MOUSE
MINT-6765383   PLCG1_MOUSE
MINT-6765422   DOK1_MOUSE
MINT-6765439   EGFR_MOUSE
MINT-6765460   PGFRB_MOUSE
MINT-6787689   MET_HUMAN
MINT-6787710   ABL1_HUMAN
MINT-6793324   B3AT_HUMAN
MINT-6793358   EGFR_HUMAN
MINT-6793387   CAN1_HUMAN
MINT-6793394   CAN2_HUMAN
MINT-6793439   IRS1_MOUSE
MINT-6793452   INSR_MOUSE
MINT-6793484   BCAR1_HUMAN
MINT-6793722   AKT1_MOUSE
MINT-6793745   IRS1_HUMAN
MINT-6793782   TYK2_HUMAN
MINT-6793941   NTRK1_HUMAN
MINT-6793957   NTRK3_HUMAN
MINT-6793973   LTK_HUMAN
MINT-6793989   STA5A_HUMAN
MINT-6794005   STA5B_HUMAN
MINT-6794135   LAT_HUMAN
MINT-6794748   EPOR_HUMAN
MINT-6794792   GRB2_HUMAN
MINT-6794817   ITB3_HUMAN
MINT-6794878   ACTS_HUMAN
MINT-6794892   FAK1_HUMAN
MINT-6794946   INSR_HUMAN
MINT-6794972   KPCG_HUMAN
MINT-6795050   JAK2_MOUSE
MINT-6795199   SRC8_HUMAN
MINT-6795447   SRC_HUMAN
MINT-6796717   PLD2_HUMAN
MINT-6797067   CLK2_HUMAN
MINT-6797829   GHR_HUMAN
MINT-6799814   ROS_HUMAN
MINT-6800783   IGF1R_HUMAN
MINT-7972220   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, zinc ion binding	cytosol, endoplasmic reticulum membrane	negative regulation of insulin receptor signaling pathway, signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	378	TEVRSRVVGGSLRGAQAASPA	PKC_alpha	8491187	LTP	0.06		-	-	0.63	-	-

Substrate:

Tyrosine-protein phosphatase, non-receptor type 12 (tyrosine phosphatase)

Seq-ID:

Q05209 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50149   PPIP1_HUMAN
MINT-50152   WASP_HUMAN
MINT-61770   GLHA_HUMAN
MINT-61771   TEX10_HUMAN
MINT-61772   RBM19_HUMAN
MINT-61775   UTRO_HUMAN
MINT-61778   BAT3_HUMAN
MINT-61825   SMAD5_HUMAN
MINT-74936   BCAR1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, non-membrane spanning protein tyrosine phosphatase activity	soluble fraction	protein amino acid dephosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	39	ARDFMRLRRLSTKYRTEKIYP	PKC_alpha	7909431	LTP	1.00	MOD_PKA_1	-	PTPc	0.22	-	medium
S	39	ARDFMRLRRLSTKYRTEKIYP	PKC_alpha	7520867	LTP	1.00	MOD_PKA_1	-	PTPc	0.22	-	medium
S	435	QIDKKLERNLSFEIKKVPLQE	PKC_alpha	7909431	LTP	1.00		-	-	0.55	-	medium
S	435	QIDKKLERNLSFEIKKVPLQE	PKC_alpha	7520867	LTP	1.00		-	-	0.55	-	medium

Substrate:

Tyrosine-protein phosphatase, non-receptor type 6 (Protein tyrosine phosphatase containing SH2 domains)

Seq-ID:

P29350 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-56658   TFG_HUMAN
MINT-73504   EPOR_HUMAN
MINT-74919   FCG2B_HUMAN
MINT-6761906   ESR1_HUMAN
MINT-6793815   CAV1_HUMAN
MINT-6799844   ROS_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, protein binding	cytosol, nucleus, membrane	apoptosis, protein amino acid dephosphorylation, signal transduction, G-protein coupled receptor protein signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	591	RSADKEKSKGSLKRK	PKC_alpha	15269224	LTP	1.00		-	-	0.78	-	low

Substrate:

Vimentin (vimentin (from PhosphoBase))

Seq-ID:

P20152 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19723 ARRB1_HUMAN
MINT-50699 KPCE_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	cytoplasm, type III intermediate filament, cell leading edge	intermediate filament-based process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	7	MSTRSVSSSSYRRMFGG	PKC_alpha	2500966	LTP	0.65		-	Filament_head	0.49	-	medium
S	7	MSTRSVSSSSYRRMFGG	PKC_alpha	2500966	LTP	0.65		-	Filament_head	0.49	-	medium
S	9	MSTRSVSSSSYRRMFGGSG	PKC_alpha	2500966	LTP	0.95		-	Filament_head	0.53	-	medium
S	10	MSTRSVSSSSYRRMFGGSGT	PKC_alpha	2500966	LTP	0.96		-	Filament_head	0.55	-	medium
S	25	FGGSGTSSRPSSNRSYVTTST	PKC_alpha	2500966	LTP	0.68	MOD_PKA_2	-	Filament_head	0.68	-	medium
S	25	FGGSGTSSRPSSNRSYVTTST	PKC_alpha	2500966	LTP	0.68	MOD_PKA_2	-	Filament_head	0.68	-	medium

Substrate:

Vinculin (Cytoskeletal protein)

Seq-ID:

P18206 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-61876   PR40A_HUMAN
MINT-68320   TRIP6_HUMAN
MINT-3318937   1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
beta-dystroglycan binding, cadherin binding, alpha-catenin binding, beta-catenin binding, structural molecule activity, actin binding	extracellular region, focal adhesion, costamere, cytosol	muscle contraction, protein localization at cell surface, apical junction assembly, cellular component movement, epithelial cell-cell adhesion, cell-matrix adhesion, morphogenesis of an epithelium, adherens junction assembly, negative regulation of cell migration, lamellipodium assembly

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1101	LVHNAQNLMQSVKETVREAEA	PKC_alpha	11741957	LTP	1.00		-	Vinculin	0.45	-	medium
S	1113	KETVREAEAASIKIRTDAGFT	PKC_alpha	11741957	LTP	1.00		-	Vinculin	0.34	-	medium