a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Acetylcholine receptor protein, delta chain  Ras GTPase-activating protein 1  Microtubule associated protein 2  Bcr  Insulin receptor substrate 1  Integrin beta 3  CSFR-1  FGFR-3  G-CSF-R  Ptpn11  R-PTP-alpha  c-kit  LAT  FAK  Insulin receptor substrate 2  CBL E3 ubiquitin protein ligase  P130Cas  ErbB4  EGFR  Shc  RET  CD136  PYK2  PDGF-R beta  LAT2  c-met  TIE2 (TEK)  CD28  VEGFR-1  SIT Protein  DOK3  Amyloid beta A4 protein  Beta-2 adrenergic receptor  TRKA  Insulin R  CD19  ErbB2 

Substrate:	Acetylcholine receptor protein, delta chain (Acetylcholine receptor)
Seq-ID:	P02718 [Torpedo californica]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process nicotinic acetylcholine-activated cation-selective channel activity, receptor activity cell junction, integral to membrane, postsynaptic membrane
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	393	SVGYISKAQEYFNIKSRSELM	-	1721053	LTP	0.37		GRB2 SH2	Neur_chan_memb	0.14	-	medium
Y	393	SVGYISKAQEYFNIKSRSELM	-	9185541	LTP	0.37		GRB2 SH2	Neur_chan_memb	0.14	-	medium

Substrate:	Ras GTPase-activating protein 1 (Ras p21 activator protein (GAP))
Seq-ID:	P20936 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-74708   ERBB3_HUMAN MINT-74709   ERBB4_HUMAN MINT-74711   EGFR_HUMAN MINT-74712   ERBB2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process potassium channel inhibitor activity, Ras GTPase activator activity, glycoprotein binding, GTPase binding, receptor binding cytoplasm intracellular signaling pathway, cytokinesis, regulation of actin filament polymerization, positive regulation of anti-apoptosis, regulation of cell shape, signal transduction, negative regulation of cell-matrix adhesion, vasculogenesis, negative regulation of neuron apoptosis, regulation of small GTPase mediated signal transduction, regulation of RNA metabolic process, embryo development
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	615	KLPVKHFTNPYCNIYLNSVQV	-	15592455	HTP	1.00		GRB2 SH2	C2	0.11	-	low
Y	615	KLPVKHFTNPYCNIYLNSVQV	-	18083107	HTP	1.00		GRB2 SH2	C2	0.11	-	low

Substrate:	Microtubule associated protein 2 (Cytoskeletal protein)
Seq-ID:	P11137 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-50652   FYN_HUMAN MINT-50656   GRB2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process beta-dystroglycan binding, structural molecule activity, calmodulin binding cytoplasm, microtubule associated complex, microtubule negative regulation of microtubule depolymerization
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	67	AFGEHGSQGTYSNTKENGING	Fyn	15536091	LTP	1.00		GRB2 SH2	-	0.85	-	medium
Y	67	AFGEHGSQGTYSNTKENGING	Lyn	15536091	LTP	1.00		GRB2 SH2	-	0.85	-	medium

Substrate:	Bcr (Breakpoint cluster region protein)
Seq-ID:	P11274 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-69534   AT2B1_HUMAN MINT-69536   CLH1_HUMAN MINT-69537   CFTR_HUMAN MINT-69540   ZO2_HUMAN MINT-69542   RGS12_HUMAN MINT-4961172   AFAD_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process Rho guanyl-nucleotide exchange factor activity, protein serine/threonine kinase activity, ATP binding, GTPase activator activity intracellular protein amino acid phosphorylation, signal transduction, regulation of Rho protein signal transduction
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	177	QPGADAEKPFYVNVEFHHERG	Fes	8955135	LTP	0.75		ABL1 SH2; FES SH2; GRAP SH2; GRB2 SH2; PTPN11 SH2	-	0.68	-	medium
Y	177	QPGADAEKPFYVNVEFHHERG	Fes	10405761	LTP	0.75		ABL1 SH2; FES SH2; GRAP SH2; GRB2 SH2; PTPN11 SH2	-	0.68	-	medium
Y	177	QPGADAEKPFYVNVEFHHERG	-	12522270	HTP	0.75		ABL1 SH2; FES SH2; GRAP SH2; GRB2 SH2; PTPN11 SH2	-	0.68	-	medium
Y	177	QPGADAEKPFYVNVEFHHERG	-	9178913	LTP	0.75		ABL1 SH2; FES SH2; GRAP SH2; GRB2 SH2; PTPN11 SH2	-	0.68	-	medium
Y	177	QPGADAEKPFYVNVEFHHERG	-	12124177	LTP	0.75		ABL1 SH2; FES SH2; GRAP SH2; GRB2 SH2; PTPN11 SH2	-	0.68	-	medium
Y	177	QPGADAEKPFYVNVEFHHERG	-	9407116	LTP	0.75		ABL1 SH2; FES SH2; GRAP SH2; GRB2 SH2; PTPN11 SH2	-	0.68	-	medium
Y	177	QPGADAEKPFYVNVEFHHERG	Abl	16912036	LTP	0.75		ABL1 SH2; FES SH2; GRAP SH2; GRB2 SH2; PTPN11 SH2	-	0.68	-	medium
Y	177	QPGADAEKPFYVNVEFHHERG	HCK	16912036	LTP	0.75		ABL1 SH2; FES SH2; GRAP SH2; GRB2 SH2; PTPN11 SH2	-	0.68	-	medium
Y	177	QPGADAEKPFYVNVEFHHERG	-	18083107	HTP	0.75		ABL1 SH2; FES SH2; GRAP SH2; GRB2 SH2; PTPN11 SH2	-	0.68	-	medium
Y	246	SESSCGVDGDYEDAELNPRFL	Fes	8955135	LTP	1.00		ABL1 SH2; GRB10 SH2; GRB2 SH2	-	0.57	-	medium
Y	276	GSRPPWPPLEYQPYQSIYVGG	Fes	8955135	LTP	0.00		ABL1 SH2; GRB10 SH2; GRB2 SH2; SHC1 SH2; SHC_group SH2	-	0.58	-	medium
Y	279	PPWPPLEYQPYQSIYVGGMME	Fes	8955135	LTP	1.00		ABL1 SH2; GRB10 SH2; GRB2 SH2; SHC1 SH2; SHC_group SH2	-	0.58	-	medium
Y	283	PLEYQPYQSIYVGGMMEGEGK	Fes	8955135	LTP	1.00		ABL1 SH2; GRB10 SH2; GRB2 SH2; SHC1 SH2; SHC_group SH2	-	0.61	-	medium

Substrate:	Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID:	P35568 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-19010   INSR_HUMAN MINT-68735   P85A_HUMAN MINT-74551   EGFR_HUMAN MINT-74553   ERBB2_HUMAN MINT-3975430   1433S_HUMAN MINT-6628637   LT_SV40 MINT-6793745   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphoinositide 3-kinase binding, protein kinase C binding, insulin-like growth factor receptor binding, insulin receptor binding, transmembrane receptor protein tyrosine kinase docking protein activity, SH2 domain binding microsome, caveola, cytosol, insulin receptor complex, nucleus negative regulation of insulin receptor signaling pathway, glucose homeostasis, positive regulation of insulin receptor signaling pathway, positive regulation of fatty acid beta-oxidation, phosphoinositide 3-kinase cascade, negative regulation of insulin secretion, positive regulation of glycogen biosynthetic process, insulin receptor signaling pathway, positive regulation of glucose import, positive regulation of phosphoinositide 3-kinase activity
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	896	HPPEPKSPGEYVNIEFGSDQS	-	11259577	LTP	1.00		GRB2 SH2; PTPN11 SH2	-	0.76	-	-

Substrate:	Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID:	P35570 [Rattus norvegicus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	[show] MINT-45938   ITB2_HUMAN MINT-45939   ITB3_HUMAN MINT-60761   INSR_RAT MINT-6762786   GRB2_HUMAN MINT-6762811   PTN11_HUMAN MINT-6762830   PTPRA_HUMAN MINT-6762866   PTN1_HUMAN MINT-6762880   P85A_HUMAN MINT-6762904   CRK_HUMAN MINT-6795115   INSR_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphoinositide 3-kinase binding, protein kinase C binding, insulin-like growth factor receptor binding, insulin-like growth factor receptor activity, insulin receptor binding, transmembrane receptor protein tyrosine kinase docking protein activity, SH2 domain binding microsome, cytosol, insulin receptor complex, nucleus negative regulation of insulin receptor signaling pathway, negative regulation of somatostatin secretion, positive regulation of insulin receptor signaling pathway, negative regulation of insulin secretion, protein heterooligomerization, insulin receptor signaling pathway, positive regulation of phosphoinositide 3-kinase activity, positive regulation of phosphorylation, positive regulation of glucagon secretion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	895	HPPEPKSPGEYVNIEFGSGQP	INSR	7504175	LTP	1.00		GRB2 SH2	-	0.80	-	medium
Y	895	HPPEPKSPGEYVNIEFGSGQP	IGF1R	8530377	LTP	1.00		GRB2 SH2	-	0.80	-	medium
Y	895	HPPEPKSPGEYVNIEFGSGQP	INSR	8530377	LTP	1.00		GRB2 SH2	-	0.80	-	medium

Substrate:	Integrin beta 3 (Platelet membrane glycoprotein IIIa)
Seq-ID:	P05106 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-25081   ITAV_HUMAN MINT-45900   EPS8_HUMAN MINT-45905   RBGP1_HUMAN MINT-45913   GULP1_HUMAN MINT-45916   RGS12_HUMAN MINT-45923   DAB1_MOUSE MINT-45928   DAB2_MOUSE MINT-45939   IRS1_RAT MINT-45952   TLN1_MOUSE MINT-45957   JIP1_HUMAN MINT-45960   LIN10_CAEEL MINT-61480   TENC1_HUMAN MINT-61568   DOK1_MOUSE MINT-61569   NUMB_MOUSE MINT-1795026   TLN1_HUMAN MINT-6794817   PTN1_HUMAN MINT-7384376   SRC_MOUSE MINT-7384444   LYN_HUMAN MINT-7384460   YES_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process receptor activity, vascular endothelial growth factor receptor 2 binding, identical protein binding, platelet-derived growth factor receptor binding, cell adhesion molecule binding integrin complex, alphav-beta3 integrin-vitronectin complex, platelet alpha granule membrane positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of endothelial cell proliferation, regulation of bone resorption, blood coagulation, negative regulation of lipid transport, tube development, activation of protein kinase activity, integrin-mediated signaling pathway, positive regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of lipid storage, negative regulation of macrophage derived foam cell differentiation, cell-matrix adhesion, interspecies interaction between organisms, smooth muscle cell migration, negative regulation of lipoprotein metabolic process, angiogenesis involved in wound healing, positive regulation of endothelial cell migration, negative regulation of low-density lipoprotein receptor biosynthetic process
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	773	AKWDTANNPLYKEATSTFTNI	-	8631894	LTP	1.00		GRB2 SH2; PTPN11 SH2; SHC1 PTB; TLN1 PTB	Integrin_b_cyt	0.26	-	-
Y	773	AKWDTANNPLYKEATSTFTNI	SRC	15699036	LTP	1.00		GRB2 SH2; PTPN11 SH2; SHC1 PTB; TLN1 PTB	Integrin_b_cyt	0.26	-	-
Y	773	AKWDTANNPLYKEATSTFTNI	-	18088087	HTP	1.00		GRB2 SH2; PTPN11 SH2; SHC1 PTB; TLN1 PTB	Integrin_b_cyt	0.26	-	-
Y	773	AKWDTANNPLYKEATSTFTNI	SRC	18398066	LTP	1.00		GRB2 SH2; PTPN11 SH2; SHC1 PTB; TLN1 PTB	Integrin_b_cyt	0.26	-	-

Substrate:	CSFR-1 (Macrophage colony stimulating factor I receptor)
Seq-ID:	P07333 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process macrophage colony-stimulating factor receptor activity, protein homodimerization activity, ATP binding, cytokine binding receptor complex, integral to plasma membrane protein amino acid phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, multicellular organismal development, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	699	PGQDPEGGVDYKNIHLEKKYV	-	N.N.	LTP	1.00		GRAP2 SH2; GRB2 SH2	TyrKc	0.45	-	low

Substrate:	FGFR-3 (Receptor tyrosine kinase)
Seq-ID:	P22607 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process identical protein binding, fibroblast growth factor binding, fibroblast growth factor receptor activity, ATP binding integral to plasma membrane positive regulation of cell proliferation, protein amino acid phosphorylation, MAPKKK cascade, cell growth, JAK-STAT cascade, skeletal system development
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	724	DKPANCTHDLYMIMRECWHAA	FGFR3	11294897	LTP	1.00		GRB2 SH2; SHC1 SH2	TyrKc	0.23	-	medium

Substrate:	G-CSF-R (Granulocyte colony stimulating factor receptor)
Seq-ID:	P40223 [Mus musculus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process cytokine receptor activity integral to membrane neutrophil chemotaxis, cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	788	LGGPTPSPKSYENIWFHSRPQ	-	8608222	LTP	1.00		GRB2 SH2; PTPN11 SH2; SHC_group SH2	-	0.60	-	medium

Substrate:	Ptpn11 (Protein-tyrosine phosphatase, non-receptor type 11)
Seq-ID:	Q06124 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-50695   CATA_HUMAN MINT-61523   ERBB4_HUMAN MINT-61552   GRB2_HUMAN MINT-74689   EGFR_HUMAN MINT-74691   ERBB2_HUMAN MINT-74885   DDR1_HUMAN MINT-6169406   GAB1_HUMAN MINT-6169440   PAXI_HUMAN MINT-6762811   IRS1_RAT MINT-6793881   CAV1_HUMAN MINT-6798640   MET_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine phosphatase activity cytosol
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	304	DGDPNEPVSDYINANIIMPEF	-	12531430	LTP	1.00		GRB2 SH2	PTPc	0.45	3B7O	0.44%
Y	546	EQKSKRKGHEYTNIKYSLADQ	-	11684012	LTP	1.00		GRB2 SH2	-	0.51	-	-
Y	546	EQKSKRKGHEYTNIKYSLADQ	PDGFR_beta	8041791	LTP	1.00		GRB2 SH2	-	0.51	-	-
Y	546	EQKSKRKGHEYTNIKYSLADQ	-	12531430	LTP	1.00		GRB2 SH2	-	0.51	-	-
Y	546	EQKSKRKGHEYTNIKYSLADQ	-	12721296	LTP	1.00		GRB2 SH2	-	0.51	-	-

Substrate:	R-PTP-alpha (Receptor tyrosine phosphatase)
Seq-ID:	P18433 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-6762830   IRS1_RAT
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane receptor protein tyrosine phosphatase activity integral to plasma membrane protein amino acid dephosphorylation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	588	PVKRGEENTDYVNASFIDGYR	-	7518772	LTP	1.00		GRB2 SH2	PTPc	0.33	1P15	1.31%
Y	798	VQEYIDAFSDYANFK	-	11923305	LTP	1.00		GRB2 SH2; Src SH2	-	0.07	-	-
Y	798	VQEYIDAFSDYANFK	-	17507376	LTP	1.00		GRB2 SH2; Src SH2	-	0.07	-	-
Y	798	VQEYIDAFSDYANFK	-	18083107	HTP	1.00		GRB2 SH2; Src SH2	-	0.07	-	-

Substrate:	c-kit (Receptor tyrosine kinase)
Seq-ID:	P10721 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process receptor signaling protein tyrosine kinase activity, ATP binding, protein binding integral to membrane, extracellular space male gonad development, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	703	KQEDHAEAALYKNLLHSKESS	Kit	10377264	LTP	1.00		GRB2 SH2	TyrKc	0.30	-	-
Y	936	KQISESTNHIYSNLANCSPNR	Kit	10377264	LTP	1.00		GRB2 SH2; GRB7 SH2; PLCG1 SH2	-	0.38	-	-
Y	936	KQISESTNHIYSNLANCSPNR	-	18083107	HTP	1.00		GRB2 SH2; GRB7 SH2; PLCG1 SH2	-	0.38	-	-

Substrate:	LAT (Adaptor molecule involved in the TCR signal pathway)
Seq-ID:	O43561 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-3382436   GRB2_HUMAN MINT-3382457   SOS1_MOUSE MINT-3382488   ZAP70_HUMAN MINT-6794135   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3/SH2 adaptor activity immunological synapse, integral to membrane, membrane raft calcium-mediated signaling, integrin-mediated signaling pathway, mast cell degranulation, regulation of T cell activation, Ras protein signal transduction
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	220	AEASLDGSREYVNVSQELHPG	-	15659558	HTP	1.00		GRAP2 SH2; GRB2 SH2; PIK3R1 SH2; PLCG1 SH2; VAV1 SH2	-	0.71	-	medium

Substrate:	LAT (Adaptor molecule involved in the TCR signal pathway)
Seq-ID:	O54957 [Mus musculus]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3/SH2 adaptor activity, receptor signaling protein activity integral to plasma membrane, immunological synapse calcium-mediated signaling, integrin-mediated signaling pathway, gene expression, cellular defense response, inflammatory response, mast cell degranulation, regulation of T cell activation, Ras protein signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	175	SAFSVESCEDYVNVPESEESA	-	10811803	LTP	1.00		GRAP2 SH2; GRB2 SH2; VAV_group SH2	-	0.71	-	low
Y	175	SAFSVESCEDYVNVPESEESA	ZAP70	11368773	LTP	1.00		GRAP2 SH2; GRB2 SH2; VAV_group SH2	-	0.71	-	low
Y	195	AEASLDGSREYVNVSPEQQPV	-	10811803	LTP	1.00		GRAP2 SH2; GRB2 SH2; VAV_group SH2	-	0.83	-	low
Y	195	AEASLDGSREYVNVSPEQQPV	ZAP70	11368773	LTP	1.00		GRAP2 SH2; GRB2 SH2; VAV_group SH2	-	0.83	-	low
Y	235	EGVDGEEAPDYENLQELN	-	10811803	LTP	1.00		GRB2 SH2; VAV_group SH2	-	0.90	-	low
Y	235	EGVDGEEAPDYENLQELN	ZAP70	11368773	LTP	1.00		GRB2 SH2; VAV_group SH2	-	0.90	-	low

Substrate:	FAK (Focal adhesion kinase)
Seq-ID:	Q05397 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-17602   LYN_HUMAN MINT-74938   BCAR1_HUMAN MINT-3381308   SRC_HUMAN MINT-6794892   PTN1_HUMAN MINT-7294020   P53_HUMAN MINT-7385708   SRC_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine kinase activity, ATP binding, SH2 domain binding, signal transducer activity focal adhesion, cytosol, cytoskeleton signal complex assembly, integrin-mediated signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	397	HAVSVSETDDYAEIIDEEDTY	FAK	7509446	LTP	1.00		Fyn SH2; GRB2 SH2; GRB7 SH2; NCK SH2; PIK3R1 SH2; Src SH2; STAT3 SH2	-	0.49	-	-
Y	397	HAVSVSETDDYAEIIDEEDTY	-	17192257	HTP	1.00		Fyn SH2; GRB2 SH2; GRB7 SH2; NCK SH2; PIK3R1 SH2; Src SH2; STAT3 SH2	-	0.49	-	-
Y	397	HAVSVSETDDYAEIIDEEDTY	-	18083107	HTP	1.00		Fyn SH2; GRB2 SH2; GRB7 SH2; NCK SH2; PIK3R1 SH2; Src SH2; STAT3 SH2	-	0.49	-	-
Y	925	ANLDRSNDKVYENVTGLVKAV	-	12370821	LTP	1.00		GRB2 SH2; STAT3 SH2	Focal_AT	0.45	1K04	39.30%
Y	925	ANLDRSNDKVYENVTGLVKAV	-	7997267	LTP	1.00		GRB2 SH2; STAT3 SH2	Focal_AT	0.45	1K04	39.30%

Substrate:	Insulin receptor substrate 2 (Adaptor molecule)
Seq-ID:	Q9Y4H2 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-18053   IGF1R_HUMAN MINT-18199   INSR_HUMAN MINT-50999   1433B_HUMAN MINT-3295882   1433Z_HUMAN MINT-3975441   1433S_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process signal transducer activity plasma membrane, cytosol negative regulation of kinase activity, positive regulation of insulin secretion, positive regulation of B cell proliferation, positive regulation of fatty acid beta-oxidation, response to glucose stimulus, lipid homeostasis, positive regulation of glycogen biosynthetic process, negative regulation of plasma membrane long-chain fatty acid transport, negative regulation of B cell apoptosis, insulin receptor signaling pathway, positive regulation of glucose import, glucose metabolic process
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	919	LPPEPKSPGEYINIDFGEPGA	-	18669648	HTP	1.00		GRB2 SH2	-	0.77	-	medium

Substrate:	CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID:	P22681 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-15516   LCK_HUMAN MINT-15716   CRK_HUMAN MINT-16022   CD2AP_HUMAN MINT-16347   LYN_HUMAN MINT-16846   LCP2_HUMAN MINT-17062   FCGR1_HUMAN MINT-17932   NCK1_HUMAN MINT-50666   FYN_HUMAN MINT-50717   ABL1_HUMAN MINT-50722   CRKL_HUMAN MINT-58331   ITCH_HUMAN MINT-60970   RET_HUMAN MINT-60973   EGFR_HUMAN MINT-60978   SHC1_HUMAN MINT-68500   P85A_HUMAN MINT-2837344   PLCG1_BOVIN MINT-4299918   ASAP1_HUMAN MINT-6169713   SPY1_HUMAN MINT-6170244   SH3G2_HUMAN MINT-6538940   SPY4_HUMAN MINT-6538977   KSYK_HUMAN MINT-6539587   MET_HUMAN MINT-6539601   SPY2_HUMAN MINT-6539646   VGFR1_HUMAN MINT-6539679   RON_HUMAN MINT-6539730   SRC_HUMAN MINT-7040249   GRB2_HUMAN MINT-7046364   ITSN1_HUMAN MINT-7103623   MK08_HUMAN MINT-7211864   ARHG7_HUMAN MINT-7214822   FYN_MOUSE MINT-7218352   SH3K1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3 domain binding, calcium ion binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, signal transducer activity, ubiquitin-protein ligase activity cytosol, nucleus epidermal growth factor receptor signaling pathway, positive regulation of receptor-mediated endocytosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	552	LPPPPPPDRPYSVGAESRPQR	-	15951569	HTP	0.04		Fyn SH2; GRB2 SH2	-	0.94	-	-

Substrate:	P130Cas (Adaptor molecule. Contain 15 YxxP motifs. )
Seq-ID:	P56945 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-74936   PTN12_HUMAN MINT-74938   FAK1_HUMAN MINT-3974941   1433S_HUMAN MINT-6174734   ACTB_HUMAN MINT-6763936   CRK_HUMAN MINT-6793484   PTN1_HUMAN MINT-7104353   CDC42_HUMAN MINT-7104422   SRC_HUMAN MINT-7104436   ACK1_HUMAN MINT-7247002   FYN_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3 domain binding, protein kinase binding, protein phosphatase binding, signal transducer activity focal adhesion, membrane fraction, cytosol, ruffle regulation of cell growth, B cell receptor signaling pathway, cell division, positive regulation of cell migration, nerve growth factor receptor signaling pathway, cell migration, integrin-mediated signaling pathway, epidermal growth factor receptor signaling pathway, actin filament organization, regulation of apoptosis, platelet-derived growth factor receptor signaling pathway, T cell receptor signaling pathway, cell adhesion, insulin receptor signaling pathway, cell proliferation, G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	653	FTSQDSPDGQYENSEGGWMED	SRC	11604500	LTP	1.00		GRB2 SH2; Src SH2	-	0.75	-	medium
Y	653	FTSQDSPDGQYENSEGGWMED	-	8670206	LTP	1.00		GRB2 SH2; Src SH2	-	0.75	-	medium
Y	653	FTSQDSPDGQYENSEGGWMED	-	12480533	LTP	1.00		GRB2 SH2; Src SH2	-	0.75	-	medium

Substrate:	ErbB4 (protein binding, protein heterodimerization activity)
Seq-ID:	Q15303 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-61523   PTN11_HUMAN MINT-61524   STA5B_HUMAN MINT-61525   CRKL_HUMAN MINT-61526   P85B_HUMAN MINT-61534   GRB2_HUMAN MINT-61535   NCK2_HUMAN MINT-61536   SHC1_HUMAN MINT-74431   ABL1_HUMAN MINT-74458   ABL2_HUMAN MINT-74463   ANS1A_HUMAN MINT-74709   RASA1_HUMAN MINT-74776   KSYK_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane receptor protein tyrosine kinase activity, receptor signaling protein tyrosine kinase activity, ATP binding, protein binding basolateral plasma membrane, integral to membrane, nucleus transcription, regulation of transcription, transmembrane receptor protein tyrosine kinase signaling pathway, peptidyl-tyrosine phosphorylation, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1188	GDLQALDNPEYHNASNGPPKA	-	8617750	LTP	0.10		GRB2 SH2	-	0.83	-	-
Y	1242	KAKKAFDNPDYWNHSLPPRST	-	8617750	LTP	1.00		GRB2 SH2	-	0.57	-	-

Substrate:	EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID:	P00533 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16802   GRB10_HUMAN MINT-50935   1433Z_HUMAN MINT-51101   ANXA1_HUMAN MINT-51490   ARBK1_HUMAN MINT-60973   CBL_HUMAN MINT-61486   CRKL_HUMAN MINT-61487   CSK_HUMAN MINT-61490   STA5B_HUMAN MINT-61540   GRB2_HUMAN MINT-68514   PDC6I_HUMAN MINT-74427   ABL1_HUMAN MINT-74438   ABL2_HUMAN MINT-74460   ANS1A_HUMAN MINT-74469   APBB1_HUMAN MINT-74479   DP13A_HUMAN MINT-74487   BMX_HUMAN MINT-74497   CRK_HUMAN MINT-74535   FES_HUMAN MINT-74551   IRS1_HUMAN MINT-74555   IRS4_HUMAN MINT-74562   JAK2_HUMAN MINT-74566   SH2B3_HUMAN MINT-74572   JIP1_HUMAN MINT-74587   NCK1_HUMAN MINT-74593   NUMB_HUMAN MINT-74594   NUMBL_HUMAN MINT-74606   P85A_HUMAN MINT-74630   P85B_HUMAN MINT-74659   P55G_HUMAN MINT-74678   PLCG1_HUMAN MINT-74685   PLCG2_HUMAN MINT-74687   PTK6_HUMAN MINT-74689   PTN11_HUMAN MINT-74711   RASA1_HUMAN MINT-74717   SH2B1_HUMAN MINT-74720   SH22A_HUMAN MINT-74732   SHC1_HUMAN MINT-74746   SLAP1_HUMAN MINT-74763   KSYK_HUMAN MINT-74790   TLN1_HUMAN MINT-74807   ZAP70_HUMAN MINT-1788719   ERBB2_HUMAN MINT-6169667   ESR1_HUMAN MINT-6170031   SOS1_MOUSE MINT-6170198   SH3G2_HUMAN MINT-6170268   SH3K1_HUMAN MINT-6793358   PTN1_HUMAN MINT-7980526   TM1L1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process epidermal growth factor receptor activity, protein heterodimerization activity, identical protein binding, receptor signaling protein tyrosine kinase activity, double-stranded DNA binding, ATP binding, protein phosphatase binding, actin filament binding, MAP/ERK kinase kinase activity Shc-EGFR complex, endosome, basolateral plasma membrane, integral to membrane, extracellular space, nucleus activation of phospholipase C activity, protein insertion into membrane, response to UV-A, positive regulation of nitric oxide biosynthetic process, positive regulation of cell migration, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, positive regulation of catenin protein nuclear translocation, regulation of nitric-oxide synthase activity, positive regulation of protein kinase B signaling cascade, ossification, positive regulation of epithelial cell proliferation, activation of phospholipase A2 activity by calcium-mediated signaling, cell-cell adhesion, regulation of peptidyl-tyrosine phosphorylation, positive regulation of phosphorylation, positive regulation of MAP kinase activity, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1092	IDDTFLPVPEYINQSVPKRPA	EGFR	8845374	LTP	0.05		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; STAT3 SH2	-	0.57	-	-
Y	1092	IDDTFLPVPEYINQSVPKRPA	-	15302935	HTP	0.05		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; STAT3 SH2	-	0.57	-	-
Y	1092	IDDTFLPVPEYINQSVPKRPA	-	17081983	HTP	0.05		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; STAT3 SH2	-	0.57	-	-
Y	1092	IDDTFLPVPEYINQSVPKRPA	-	18083107	HTP	0.05		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; STAT3 SH2	-	0.57	-	-
Y	1110	RPAGSVQNPVYHNQPLNPAPS	EGFR	8845374	LTP	1.00		GRB2 SH2; PLCG1 SH2; RASA_group SH2; SHC1 PTB; Src SH2; STAT3 SH2	-	0.80	-	-
Y	1110	RPAGSVQNPVYHNQPLNPAPS	-	15302935	HTP	1.00		GRB2 SH2; PLCG1 SH2; RASA_group SH2; SHC1 PTB; Src SH2; STAT3 SH2	-	0.80	-	-
Y	1172	SHQISLDNPDYQQDFFPKEAK	EGFR	8845374	LTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 PTB; SHC3 PTB; Src SH2; VAV2 SH2	-	0.67	-	-
Y	1172	SHQISLDNPDYQQDFFPKEAK	-	15302935	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 PTB; SHC3 PTB; Src SH2; VAV2 SH2	-	0.67	-	-
Y	1172	SHQISLDNPDYQQDFFPKEAK	-	17081983	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 PTB; SHC3 PTB; Src SH2; VAV2 SH2	-	0.67	-	-
Y	1172	SHQISLDNPDYQQDFFPKEAK	-	18083107	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 PTB; SHC3 PTB; Src SH2; VAV2 SH2	-	0.67	-	-
Y	1197	FKGSTAENAEYLRVAPQSSEF	EGFR	8845374	LTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 SH2; SHC3 SH2; Src SH2	-	0.54	-	-
Y	1197	FKGSTAENAEYLRVAPQSSEF	-	15302935	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 SH2; SHC3 SH2; Src SH2	-	0.54	-	-
Y	1197	FKGSTAENAEYLRVAPQSSEF	-	17081983	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 SH2; SHC3 SH2; Src SH2	-	0.54	-	-
Y	1197	FKGSTAENAEYLRVAPQSSEF	-	18083107	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 SH2; SHC3 SH2; Src SH2	-	0.54	-	-

Substrate:	Shc ( Adaptor molecule)
Seq-ID:	P29353 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-13959   DDR2_HUMAN MINT-14688   GAB2_HUMAN MINT-15243   LYN_HUMAN MINT-15425   FYN_HUMAN MINT-15946   FCGR1_HUMAN MINT-16179   SHIP1_HUMAN MINT-16513   LCP2_HUMAN MINT-17269   SRC_CHICK MINT-17501   P85A_HUMAN MINT-49636   CADH5_HUMAN MINT-49637   VGFR2_HUMAN MINT-49660   A4_HUMAN MINT-60978   CBL_HUMAN MINT-60980   ZAP70_HUMAN MINT-60981   RET_HUMAN MINT-61536   ERBB4_HUMAN MINT-61537   GRB2_HUMAN MINT-74732   EGFR_HUMAN MINT-74737   ERBB2_HUMAN MINT-74738   ERBB3_HUMAN MINT-1782423   SOS1_HUMAN MINT-2738306   JAK2_MOUSE MINT-7714840   IQGA1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process epidermal growth factor receptor binding, insulin-like growth factor receptor binding, insulin receptor binding, phospholipid binding, transmembrane receptor protein tyrosine kinase adaptor protein activity mitochondrial matrix, Shc-EGFR complex, cytosol positive regulation of DNA replication, positive regulation of cell proliferation, regulation of growth, regulation of epidermal growth factor receptor activity, epidermal growth factor receptor signaling pathway, activation of MAPK activity, Ras protein signal transduction, insulin receptor signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	349	EEEEEPPDHQYYNDFPGKEPP	-	11075717	LTP	1.00		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.86	-	-
Y	349	EEEEEPPDHQYYNDFPGKEPP	-	9121430	LTP	1.00		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.86	-	-
Y	349	EEEEEPPDHQYYNDFPGKEPP	SYK	9710204	LTP	1.00		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.86	-	-
Y	349	EEEEEPPDHQYYNDFPGKEPP	ZAP70	9710204	LTP	1.00		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.86	-	-
Y	349	EEEEEPPDHQYYNDFPGKEPP	-	10891441	LTP	1.00		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.86	-	-
Y	349	EEEEEPPDHQYYNDFPGKEPP	-	11687594	LTP	1.00		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.86	-	-
Y	349	EEEEEPPDHQYYNDFPGKEPP	-	15592455	HTP	1.00		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.86	-	-
Y	349	EEEEEPPDHQYYNDFPGKEPP	FLT4	9927207	LTP	1.00		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.86	-	-
Y	350	EEEEPPDHQYYNDFPGKEPPL	-	11075717	LTP	1.00		GRB2 SH2; INPP5D SH2	-	0.85	-	-
Y	350	EEEEPPDHQYYNDFPGKEPPL	-	9121430	LTP	1.00		GRB2 SH2; INPP5D SH2	-	0.85	-	-
Y	350	EEEEPPDHQYYNDFPGKEPPL	SYK	9710204	LTP	1.00		GRB2 SH2; INPP5D SH2	-	0.85	-	-
Y	350	EEEEPPDHQYYNDFPGKEPPL	ZAP70	9710204	LTP	1.00		GRB2 SH2; INPP5D SH2	-	0.85	-	-
Y	350	EEEEPPDHQYYNDFPGKEPPL	-	15592455	HTP	1.00		GRB2 SH2; INPP5D SH2	-	0.85	-	-
Y	350	EEEEPPDHQYYNDFPGKEPPL	FLT4	9927207	LTP	1.00		GRB2 SH2; INPP5D SH2	-	0.85	-	-
Y	427	PGRELFDDPSYVNVQNLDKAR	-	11075717	LTP	0.99		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.62	-	-
Y	427	PGRELFDDPSYVNVQNLDKAR	SYK	9710204	LTP	0.99		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.62	-	-
Y	427	PGRELFDDPSYVNVQNLDKAR	ZAP70	9710204	LTP	0.99		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.62	-	-
Y	427	PGRELFDDPSYVNVQNLDKAR	-	8610109	LTP	0.99		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.62	-	-
Y	427	PGRELFDDPSYVNVQNLDKAR	-	9741627	LTP	0.99		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.62	-	-
Y	427	PGRELFDDPSYVNVQNLDKAR	-	12522270	HTP	0.99		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.62	-	-
Y	427	PGRELFDDPSYVNVQNLDKAR	-	15592455	HTP	0.99		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.62	-	-
Y	427	PGRELFDDPSYVNVQNLDKAR	FLT4	9927207	LTP	0.99		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.62	-	-
Y	427	PGRELFDDPSYVNVQNLDKAR	-	18083107	HTP	0.99		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.62	-	-
Y	427	PGRELFDDPSYVNVQNLDKAR	-	18669648	HTP	0.99		GRAP2 SH2; GRB2 SH2; INPP5D SH2	-	0.62	-	-

Substrate:	RET (Probable receptor with tyrosine-protein kinase activity; important for development.)
Seq-ID:	P07949 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-60970   CBL_HUMAN MINT-60975   GRB2_HUMAN MINT-60981   SHC1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process calcium ion binding, transmembrane receptor protein tyrosine kinase activity, ATP binding integral to membrane protein amino acid phosphorylation, posterior midgut development, homophilic cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1090	ADGTNTGFPRYPNDSVYANWM	RET	14711813	LTP	0.16		GRB2 SH2	-	0.41	-	-
Y	1096	GFPRYPNDSVYANWMLSPSAA	-	11470823	LTP	1.00		GRB2 SH2	-	0.33	-	-
Y	1096	GFPRYPNDSVYANWMLSPSAA	RET	8621380	LTP	1.00		GRB2 SH2	-	0.33	-	-
Y	1096	GFPRYPNDSVYANWMLSPSAA	RET	14711813	LTP	1.00		GRB2 SH2	-	0.33	-	-

Substrate:	CD136 (Receptor tyrosine kinase)
Seq-ID:	Q04912 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-6539679   CBL_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process macrophage colony-stimulating factor receptor activity, ATP binding, protein binding integral to plasma membrane positive regulation of cell proliferation, protein amino acid phosphorylation, cellular component movement, single fertilization, transmembrane receptor protein tyrosine kinase signaling pathway, multicellular organismal development, defense response
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1353	QIVSALLGDHYVQLPATYMNL	RON	10871856	LTP	1.00		GRB2 SH2; PIK3R1 SH2; PLCG1 SH2; SHC1 SH2	-	0.21	-	low
Y	1360	GDHYVQLPATYMNLGPSTSHE	RON	10871856	LTP	1.00		GRB2 SH2; PIK3R1 SH2; PLCG1 SH2; SHC1 SH2	-	0.40	-	low

Substrate:	PYK2 (Focal adhesion kinase 2)
Seq-ID:	Q14289 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-68515   PDC6I_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine kinase activity, ATP binding, signal transducer activity positive regulation of cell proliferation, signal complex assembly, apoptosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	881	ANLDRTDDLVYLNVMELVRAV	-	10880513	LTP	1.00		GRB2 SH2; PTPN11 SH2	Focal_AT	0.23	3GM1	24.02%

Substrate:	PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID:	P09619 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-2832596   NHRF2_HUMAN MINT-2832984   PTEN_HUMAN MINT-2833042   NHRF1_HUMAN MINT-6762380   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process vascular endothelial growth factor receptor activity, platelet-derived growth factor binding, platelet activating factor receptor activity, platelet-derived growth factor receptor binding, ATP binding, platelet-derived growth factor beta-receptor activity integral to plasma membrane positive regulation of cell proliferation, positive regulation of cell migration, protein amino acid autophosphorylation, peptidyl-tyrosine phosphorylation, cell chemotaxis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	716	DKRRPPSAELYSNALPVGLPL	PDGFR_beta	8940081	LTP	1.00		GRB2 SH2; GRB7 SH2	TyrKc	0.46	-	medium
Y	716	DKRRPPSAELYSNALPVGLPL	PDGFR_beta	7935391	LTP	1.00		GRB2 SH2; GRB7 SH2	TyrKc	0.46	-	medium
Y	775	DIESSNYMAPYDNYVPSAPER	PDGFR_beta	8940081	LTP	1.00		GRB2 SH2; GRB7 SH2; STAT5 SH2	TyrKc	0.34	-	medium

Substrate:	LAT2 (protein binding, SH2 domain binding)
Seq-ID:	Q9GZY6 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	MINT-2864170   UBQL4_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH2 domain binding plasma membrane, integral to membrane, membrane raft B cell receptor signaling pathway, calcium-mediated signaling, mast cell degranulation, B cell activation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	136	KPPEDDDANSYENVLICKQKT	-	14722116	LTP	1.00		GRB2 SH2	-	0.63	-	medium
Y	193	SPEEDEESEDYQNSASIHQWR	-	14722116	LTP	1.00		GRB2 SH2	-	0.84	-	medium
Y	233	SPDEEDGEPDYVNGEVAATEA	-	14722116	LTP	1.00		GRB2 SH2	-	0.90	-	medium

Substrate:	c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID:	P08581 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-18299   RANB9_HUMAN MINT-58374   GAB1_MOUSE MINT-58404   GAB1_HUMAN MINT-6539587   CBL_HUMAN MINT-6787689   PTN1_HUMAN MINT-6798640   PTN11_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process hepatocyte growth factor receptor activity, ATP binding, protein binding integral to plasma membrane, basal plasma membrane protein amino acid phosphorylation, multicellular organismal development, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1349	AIFSTFIGEHYVHVNATYVNV	Met	12475979	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	-	9444958	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	-	9252406	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	-	7513258	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	Met	7731718	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	Met	7687741	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	-	9826708	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	12475979	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	9444958	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	9252406	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	7513258	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7731718	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	8662889	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7961992	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7687741	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	9826708	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%

Substrate:	TIE2 (TEK) (PTK receptor for angiopoietin 1)
Seq-ID:	Q02763 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane receptor protein tyrosine kinase activity, ATP binding, protein binding basolateral plasma membrane, integral to plasma membrane, cell surface, microvillus, apical plasma membrane, membrane raft positive regulation of ERK1 and ERK2 cascade, protein amino acid phosphorylation, protein oligomerization, cell-cell signaling, positive regulation of protein kinase B signaling cascade, regulation of cell proliferation, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1102	LNRMLEERKTYVNTTLYEKFT	-	10521483	LTP	1.00		GRB2 SH2; GRB7 SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	-	0.15	1FVR	3.49%
Y	1102	LNRMLEERKTYVNTTLYEKFT	-	9632797	LTP	1.00		GRB2 SH2; GRB7 SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	-	0.15	1FVR	3.49%
Y	1102	LNRMLEERKTYVNTTLYEKFT	TIE2	12082108	LTP	1.00		GRB2 SH2; GRB7 SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	-	0.15	1FVR	3.49%

Substrate:	CD28 (Involved in T cell activation)
Seq-ID:	P10747 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process identical protein binding, SH3/SH2 adaptor activity, coreceptor activity external side of plasma membrane, cytosol, integral to plasma membrane regulatory T cell differentiation, humoral immune response, positive regulation of anti-apoptosis, regulation of defense response to virus by virus, positive regulation of interleukin-2 biosynthetic process, positive regulation of viral genome replication, cell surface receptor linked signaling pathway, cytokine biosynthetic process, positive regulation of mitosis, positive regulation of T cell proliferation, positive regulation of translation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	191	SKRSRLLHSDYMNMTPRRPGP	Lck	8992971	LTP	0.95		GRAP2 SH2; GRB2 SH2; ITK SH2; PIK3R1 SH2	-	0.44	-	medium
Y	191	SKRSRLLHSDYMNMTPRRPGP	ITK	8992971	LTP	0.95		GRAP2 SH2; GRB2 SH2; ITK SH2; PIK3R1 SH2	-	0.44	-	medium
Y	191	SKRSRLLHSDYMNMTPRRPGP	-	16094384	HTP	0.95		GRAP2 SH2; GRB2 SH2; ITK SH2; PIK3R1 SH2	-	0.44	-	medium

Substrate:	VEGFR-1 (Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity.)
Seq-ID:	P17948 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-6177086   LDLR_HUMAN MINT-6539646   CBL_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process vascular endothelial growth factor receptor activity, ATP binding, growth factor binding cytoplasm, integral to plasma membrane, extracellular space positive regulation of vascular endothelial growth factor receptor signaling pathway, female pregnancy, peptidyl-tyrosine phosphorylation, cell differentiation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1213	FNSGSSDDVRYVNAFKFMSLE	FLT1	11513746	LTP	1.00		GRB2 SH2; NCK SH2; PIK3R1 SH2; PTPN11 SH2	-	0.20	-	low
Y	1213	FNSGSSDDVRYVNAFKFMSLE	FLT1	9722576	LTP	1.00		GRB2 SH2; NCK SH2; PIK3R1 SH2; PTPN11 SH2	-	0.20	-	low
Y	1213	FNSGSSDDVRYVNAFKFMSLE	-	9600074	LTP	1.00		GRB2 SH2; NCK SH2; PIK3R1 SH2; PTPN11 SH2	-	0.20	-	low

Substrate:	SIT Protein (Adapter molecule)
Seq-ID:	Q9Y3P8 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process kinase binding, SH2 domain binding integral to plasma membrane signal transduction, regulation of T cell activation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	90	SGESVEEVPLYGNLHYLQTGR	-	11433379	LTP	-		GRB2 SH2	-	0.39	-	medium
Y	90	SGESVEEVPLYGNLHYLQTGR	-	15144186	HTP	-		GRB2 SH2	-	0.39	-	medium
Y	90	SGESVEEVPLYGNLHYLQTGR	-	15592455	HTP	-		GRB2 SH2	-	0.39	-	medium
Y	188	RARASFPDQAYANSQPAAS	-	10209036	LTP	-		GRB2 SH2	-	0.71	-	medium
Y	188	RARASFPDQAYANSQPAAS	-	15144186	HTP	-		GRB2 SH2	-	0.71	-	medium
Y	188	RARASFPDQAYANSQPAAS	-	15592455	HTP	-		GRB2 SH2	-	0.71	-	medium

Substrate:	DOK3 (Docking proteins interact with receptor tyrosine kinases)
Seq-ID:	Q7L591 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-4329711   SHIP1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process insulin receptor binding plasma membrane, cytoplasm
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	432	GSRSPTTSPIYHNGQDLSWPG	-	16497976	HTP	1.00		GRB2 SH2	-	0.81	-	medium

Substrate:	Amyloid beta A4 protein (Cell surface receptor)
Seq-ID:	P05067 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-14547   JIP1_HUMAN MINT-49648   APBB1_RAT MINT-49659   GRB2_HUMAN MINT-49660   SHC1_HUMAN MINT-49984   ABL1_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process serine-type endopeptidase inhibitor activity, DNA binding, acetylcholine receptor binding, identical protein binding, metal ion binding, heparin binding extracellular region, dendritic shaft, integral to plasma membrane, coated pit, cell surface, Golgi apparatus, platelet alpha granule lumen, axon, dendritic spine dendrite development, G2 phase of mitotic cell cycle, positive regulation of mitotic cell cycle, regulation of multicellular organism growth, regulation of epidermal growth factor receptor activity, ionotropic glutamate receptor signaling pathway, mRNA polyadenylation, collateral sprouting in the absence of injury, adult locomotory behavior, extracellular matrix organization, Notch signaling pathway, regulation of translation, visual learning, neuron apoptosis, axon midline choice point recognition, cell adhesion, neuron remodeling, mating behavior, endocytosis, axon cargo transport, cellular copper ion homeostasis, protein amino acid phosphorylation, regulation of synapse structure and activity
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	757	RHLSKMQQNGYENPTYKFFEQ	-	11279131	LTP	1.00		ABL1 SH2; GRB2 SH2; SHC1 SH2	APP_amyloid	0.38	-	-
Y	757	RHLSKMQQNGYENPTYKFFEQ	-	18083107	HTP	1.00		ABL1 SH2; GRB2 SH2; SHC1 SH2	APP_amyloid	0.38	-	-

Substrate:	Beta-2 adrenergic receptor (Protein G coupled receptor)
Seq-ID:	P04274 [Mesocricetus auratus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein homodimerization activity, norepinephrine binding, beta2-adrenergic receptor activity plasma membrane, receptor complex, integral to membrane positive regulation of MAPKKK cascade, receptor-mediated endocytosis, activation of adenylate cyclase activity, desensitization of G-protein coupled receptor protein signaling pathway by arrestin
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	350	LCLRRSSSKAYGNGYSSNSNG	-	8521811	LTP	0.10		GRB2 SH2	-	0.30	-	medium
Y	350	LCLRRSSSKAYGNGYSSNSNG	INSR	8557631	LTP	0.10		GRB2 SH2	-	0.30	-	medium

Substrate:	TRKA (Required for high affinity binding to nerve growth factor , neurotrophin-3 and neurotrophin-4/5r.)
Seq-ID:	P04629 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-6793941   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane receptor protein tyrosine kinase activity, neurotrophin receptor activity, ATP binding endosome, integral to plasma membrane activation of adenylate cyclase activity, Ras protein signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	496	LQGHIIENPQYFSDACVHHIK	TRKA	11159935	LTP	1.00		FRS2 PTB; GRB2 SH2; PLCG1 SH2; SHC1 PTB; SHC1 SH2	-	0.16	-	medium
Y	496	LQGHIIENPQYFSDACVHHIK	TRKA	8155326	LTP	1.00		FRS2 PTB; GRB2 SH2; PLCG1 SH2; SHC1 PTB; SHC1 SH2	-	0.16	-	medium

Substrate:	Insulin R (Receptor tyrosine kinase)
Seq-ID:	P06213 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16516   GRB10_HUMAN MINT-16842   MD2L1_HUMAN MINT-18199   IRS2_HUMAN MINT-19010   IRS1_HUMAN MINT-73466   GRB10_MOUSE MINT-6793537   INSR_RAT MINT-6794075   IRS1_MOUSE MINT-6794090   INSR_MOUSE MINT-6794946   PTN1_HUMAN MINT-6795115   IRS1_RAT
GO-Terms:	[show] Molecular Function Cellular Component Biological Process insulin-like growth factor receptor binding, insulin binding, PTB domain binding, GTP binding, metal ion binding, insulin receptor substrate binding, ATP binding, insulin-like growth factor I binding, insulin receptor activity, SH2 domain binding, phosphoinositide 3-kinase binding, insulin-like growth factor II binding, receptor signaling protein tyrosine kinase activity microsome, caveola, insulin receptor complex, endosome membrane positive regulation of glycolysis, positive regulation of MAPKKK cascade, positive regulation of developmental growth, regulation of embryonic development, heart morphogenesis, positive regulation of cell migration, carbohydrate metabolic process, protein heterotetramerization, positive regulation of protein kinase B signaling cascade, protein amino acid autophosphorylation, activation of MAPK activity, positive regulation of glycogen biosynthetic process, positive regulation of mitosis, peptidyl-tyrosine phosphorylation, positive regulation of glucose import, positive regulation of respiratory burst, activation of protein kinase B activity, G-protein coupled receptor protein signaling pathway, positive regulation of DNA replication, positive regulation of protein amino acid phosphorylation, positive regulation of cell proliferation, glucose homeostasis, positive regulation of nitric oxide biosynthetic process, transformation of host cell by virus, regulation of gene-specific transcription
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	992	RQPDGPLGPLYASSNPEYLSA	INSR	1658004	LTP	1.00		GRB2 SH2	-	0.33	-	-
Y	1011	SASDVFPCSVYVPDEWEVSRE	INSR	12707268	LTP	0.06		GRB2 SH2	-	0.11	1IR3	77.98%

Substrate:	CD19 (Antigen of human B-lymphocytes)
Seq-ID:	P15391 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process receptor signaling protein activity, protein binding integral to plasma membrane cellular defense response
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	348	PPPGSGPQNQYGNVLSLPTPT	-	10706702	LTP	1.00		GRB2 SH2	-	0.78	-	medium
Y	378	AAGLGGTAPSYGNPSSDVQAD	-	10706702	LTP	1.00		GRB2 SH2; VAV_group SH2	-	0.71	-	medium

Substrate:	ErbB2 (Receptor tyrosine kinase)
Seq-ID:	P04626 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-61505   P85B_HUMAN MINT-74429   ABL1_HUMAN MINT-74444   ABL2_HUMAN MINT-74462   ANS1A_HUMAN MINT-74470   APBB1_HUMAN MINT-74486   BLNK_HUMAN MINT-74488   BMX_HUMAN MINT-74498   CRK_HUMAN MINT-74502   CRKL_HUMAN MINT-74508   DAB1_HUMAN MINT-74512   DOK1_HUMAN MINT-74521   SPT6H_HUMAN MINT-74533   FER_HUMAN MINT-74538   FGR_HUMAN MINT-74540   GRAP2_HUMAN MINT-74542   GRB2_HUMAN MINT-74544   GRB7_HUMAN MINT-74553   IRS1_HUMAN MINT-74556   IRS4_HUMAN MINT-74558   ITK_HUMAN MINT-74561   JAK1_HUMAN MINT-74567   SH2B3_HUMAN MINT-74575   JIP1_HUMAN MINT-74582   MATK_HUMAN MINT-74590   NCK2_HUMAN MINT-74610   P85A_HUMAN MINT-74664   P55G_HUMAN MINT-74680   PLCG1_HUMAN MINT-74686   PLCG2_HUMAN MINT-74691   PTN11_HUMAN MINT-74712   RASA1_HUMAN MINT-74713   RIN1_HUMAN MINT-74722   SH22A_HUMAN MINT-74723   SH23A_HUMAN MINT-74724   3BP2_HUMAN MINT-74737   SHC1_HUMAN MINT-74747   SLAP1_HUMAN MINT-74755   STAT1_HUMAN MINT-74756   STAT3_HUMAN MINT-74769   KSYK_HUMAN MINT-74777   TEC_HUMAN MINT-74781   TENC1_HUMAN MINT-74786   TENS3_HUMAN MINT-74793   TLN1_HUMAN MINT-74794   TXK_HUMAN MINT-74802   VAV2_HUMAN MINT-1788719   EGFR_HUMAN MINT-1901925   LAP2_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process epidermal growth factor receptor activity, ErbB-3 class receptor binding, protein heterodimerization activity, DNA binding, protein C-terminus binding, identical protein binding, receptor signaling protein tyrosine kinase activity, ATP binding, protein phosphatase binding receptor complex, integral to membrane, nucleus, perinuclear region of cytoplasm regulation of angiogenesis, transcription, regulation of transcription, phosphoinositide 3-kinase cascade, phosphoinositide-mediated signaling, heart development, positive regulation of cell adhesion, protein amino acid autophosphorylation, positive regulation of epithelial cell proliferation, wound healing, positive regulation of MAP kinase activity, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1139	APLTCSPQPEYVNQPDVRPQP	ErbB2	11500516	LTP	1.00		GRB2 SH2; GRB7 SH2; Src SH2; STAT3 SH2	-	0.85	-	low
Y	1221	PAFSPAFDNLYYWDQDPPERG	ErbB2	11500516	LTP	0.19		GRB2 SH2; SHC1 SH2; SHC_group SH2	-	0.67	-	low