a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

ALK  ErbB3  IKB-alpha  Insulin receptor substrate 1  PI3-kinase p85-alpha subunit  CSFR-1  CTLA-4  Tyrosine-protein phosphatase, non-receptor type 6  SYK  PDGF-R alpha  Gab1  Gab2  SLP-76  FCGR2B  c-kit  LAT  FAK  Insulin receptor substrate 2  CBL E3 ubiquitin protein ligase  EGFR  Epo-R  IGF1-R  IL-7R alpha  RET  CD136  PDGF-R beta  IL-1R-1  c-met  TIE2 (TEK)  CD28  VEGFR-1  Src  TRKA  Insulin R  TRKB  Erzin  CD19 

Substrate:	ALK (Receptor tyrosine kinase)
Seq-ID:	Q9UM73 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-48477   M3K3_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane receptor protein tyrosine kinase activity, ATP binding, protein binding integral to plasma membrane protein amino acid autophosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1359	DPPKNCPGPVYRIMTQCWQHQ	-	18083107	HTP	1.00		PIK3R1 SH2	TyrKc	0.42	-	medium

Substrate:	ErbB3 (Receptor tyrosine kinase)
Seq-ID:	P21860 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-61514   CSK_HUMAN MINT-61518   GRB2_HUMAN MINT-61520   P85B_HUMAN MINT-74430   ABL1_HUMAN MINT-74454   ABL2_HUMAN MINT-74500   CRK_HUMAN MINT-74505   CRKL_HUMAN MINT-74509   DAB1_HUMAN MINT-74510   DAPP1_HUMAN MINT-74534   FER_HUMAN MINT-74539   FGFR1_HUMAN MINT-74548   GRB7_HUMAN MINT-74550   HCK_HUMAN MINT-74559   ITK_HUMAN MINT-74563   JAK2_HUMAN MINT-74564   JAK3_HUMAN MINT-74569   SH2B3_HUMAN MINT-74588   NCK1_HUMAN MINT-74592   NCK2_HUMAN MINT-74617   P85A_HUMAN MINT-74672   P55G_HUMAN MINT-74682   PLCG1_HUMAN MINT-74688   PTK6_HUMAN MINT-74708   RASA1_HUMAN MINT-74714   RIN1_HUMAN MINT-74738   SHC1_HUMAN MINT-74753   SRC_HUMAN MINT-74775   KSYK_HUMAN MINT-74784   TENC1_HUMAN MINT-74788   TENS3_HUMAN MINT-74795   TXK_HUMAN MINT-74803   VAV2_HUMAN MINT-74806   ZAP70_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein heterodimerization activity, transmembrane receptor protein tyrosine kinase activity, receptor signaling protein tyrosine kinase activity, protein homodimerization activity, protein tyrosine kinase activator activity, ATP binding, growth factor binding receptor complex, basolateral plasma membrane, integral to plasma membrane, extracellular space protein amino acid phosphorylation, positive regulation of phosphoinositide 3-kinase cascade, negative regulation of signal transduction, phosphoinositide 3-kinase cascade, heart development, negative regulation of secretion, neuron apoptosis, negative regulation of neuron apoptosis, regulation of cell proliferation, negative regulation of cell adhesion, transmembrane receptor protein tyrosine kinase signaling pathway, cranial nerve development, wound healing, Schwann cell differentiation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1199	EEEDEDEEYEYMNRRRRHSPP	-	9516479	LTP	1.00		GRB7 SH2; PIK3R1 SH2	-	0.92	-	medium
Y	1276	QRDGGGPGGDYAAMGACPASE	-	11546794	LTP	0.31		PIK3R1 SH2	-	0.76	-	medium
Y	1289	MGACPASEQGYEEMRAFQGPG	-	11546794	LTP	0.12		PIK3R1 SH2	-	0.67	-	medium

Substrate:	IKB-alpha (Major histocompatibility complex enhancer-binding protein MAD3)
Seq-ID:	P25963 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-47837   REL_HUMAN MINT-47839   IKBB_HUMAN MINT-47840   ELP1_HUMAN MINT-47841   IKKA_HUMAN MINT-47842   IKKB_HUMAN MINT-47843   NEMO_HUMAN MINT-47845   MCM7_HUMAN MINT-48656   NFKB1_HUMAN MINT-48721   NFKB2_HUMAN MINT-48993   RELB_HUMAN MINT-64895   MED19_HUMAN MINT-6762163   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process nuclear localization sequence binding, identical protein binding, ubiquitin protein ligase binding, NF-kappaB binding cytosol, I-kappaB/NF-kappaB complex, nucleus positive regulation of gene-specific transcription from RNA polymerase II promoter, cytoplasmic sequestering of NF-kappaB, negative regulation of NF-kappaB transcription factor activity, apoptosis, anti-apoptosis, negative regulation of lipid storage, negative regulation of macrophage derived foam cell differentiation, positive regulation of cholesterol efflux, interspecies interaction between organisms, positive regulation of cellular protein metabolic process
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	42	SGLDSMKDEEYEQMVKELQEI	Lck	8797825	LTP	1.00		PIK3R1 SH2	-	0.55	-	-
Y	42	SGLDSMKDEEYEQMVKELQEI	-	12432072	LTP	1.00		PIK3R1 SH2	-	0.55	-	-
Y	42	SGLDSMKDEEYEQMVKELQEI	SRC	9792645	LTP	1.00		PIK3R1 SH2	-	0.55	-	-

Substrate:	Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID:	P35568 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-19010   INSR_HUMAN MINT-68735   P85A_HUMAN MINT-74551   EGFR_HUMAN MINT-74553   ERBB2_HUMAN MINT-3975430   1433S_HUMAN MINT-6628637   LT_SV40 MINT-6793745   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphoinositide 3-kinase binding, protein kinase C binding, insulin-like growth factor receptor binding, insulin receptor binding, transmembrane receptor protein tyrosine kinase docking protein activity, SH2 domain binding microsome, caveola, cytosol, insulin receptor complex, nucleus negative regulation of insulin receptor signaling pathway, glucose homeostasis, positive regulation of insulin receptor signaling pathway, positive regulation of fatty acid beta-oxidation, phosphoinositide 3-kinase cascade, negative regulation of insulin secretion, positive regulation of glycogen biosynthetic process, insulin receptor signaling pathway, positive regulation of glucose import, positive regulation of phosphoinositide 3-kinase activity
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	612	DSSTLHTDDGYMPMSPGVAPV	-	15001544	LTP	1.00		PIK3R1 SH2; PIK3R2 SH2	-	0.81	-	-
Y	612	DSSTLHTDDGYMPMSPGVAPV	-	18083107	HTP	1.00		PIK3R1 SH2; PIK3R2 SH2	-	0.81	-	-
Y	632	VPSGRKGSGDYMPMSPKSVSA	-	15001544	LTP	1.00		PIK3R1 SH2; PIK3R2 SH2	-	0.83	-	-
Y	632	VPSGRKGSGDYMPMSPKSVSA	-	18083107	HTP	1.00		PIK3R1 SH2; PIK3R2 SH2	-	0.83	-	-
Y	662	RHPQRVDPNGYMMMSPSGGCS	-	15592455	HTP	1.00		Fyn SH2; MATK SH2; PIK3R1 SH2; PTPN11 SH2	-	0.77	-	-

Substrate:	Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID:	P35569 [Mus musculus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	[show] MINT-58476   NUCL_MOUSE MINT-6381887   P85A_MOUSE MINT-6793439   PTN1_HUMAN MINT-6794075   INSR_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphoinositide 3-kinase binding, insulin-like growth factor receptor binding, insulin receptor binding, SH2 domain binding microsome, cytosol, nucleus positive regulation of mesenchymal cell proliferation, positive regulation of cell migration, protein kinase B signaling cascade, mammary gland development, insulin receptor signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	608	DTSNLHTDDGYMPMSPGVAPV	-	9395471	LTP	1.00		PIK3R1 SH2	-	0.80	-	-
Y	608	DTSNLHTDDGYMPMSPGVAPV	-	15821749	LTP	1.00		PIK3R1 SH2	-	0.80	-	-

Substrate:	Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID:	P35570 [Rattus norvegicus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	[show] MINT-45938   ITB2_HUMAN MINT-45939   ITB3_HUMAN MINT-60761   INSR_RAT MINT-6762786   GRB2_HUMAN MINT-6762811   PTN11_HUMAN MINT-6762830   PTPRA_HUMAN MINT-6762866   PTN1_HUMAN MINT-6762880   P85A_HUMAN MINT-6762904   CRK_HUMAN MINT-6795115   INSR_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphoinositide 3-kinase binding, protein kinase C binding, insulin-like growth factor receptor binding, insulin-like growth factor receptor activity, insulin receptor binding, transmembrane receptor protein tyrosine kinase docking protein activity, SH2 domain binding microsome, cytosol, insulin receptor complex, nucleus negative regulation of insulin receptor signaling pathway, negative regulation of somatostatin secretion, positive regulation of insulin receptor signaling pathway, negative regulation of insulin secretion, protein heterooligomerization, insulin receptor signaling pathway, positive regulation of phosphoinositide 3-kinase activity, positive regulation of phosphorylation, positive regulation of glucagon secretion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	608	DSSNLHTDDGYMPMSPGVAPV	INSR	7504175	LTP	1.00		PIK3R1 SH2	-	0.79	-	medium
Y	608	DSSNLHTDDGYMPMSPGVAPV	-	12220227	LTP	1.00		PIK3R1 SH2	-	0.79	-	medium
Y	608	DSSNLHTDDGYMPMSPGVAPV	IGF1R	11572799	LTP	1.00		PIK3R1 SH2	-	0.79	-	medium
Y	608	DSSNLHTDDGYMPMSPGVAPV	INSR	11572799	LTP	1.00		PIK3R1 SH2	-	0.79	-	medium
Y	628	VPSNRKGNGDYMPMSPKSVSA	INSR	7504175	LTP	1.00		PIK3R1 SH2	-	0.81	-	medium
Y	628	VPSNRKGNGDYMPMSPKSVSA	IGF1R	11572799	LTP	1.00		PIK3R1 SH2	-	0.81	-	medium
Y	628	VPSNRKGNGDYMPMSPKSVSA	INSR	11572799	LTP	1.00		PIK3R1 SH2	-	0.81	-	medium
Y	939	APREETGSEEYMNMDLGPGRR	INSR	7504175	LTP	1.00		PIK3R1 SH2	-	0.87	-	medium
Y	939	APREETGSEEYMNMDLGPGRR	IGF1R	11572799	LTP	1.00		PIK3R1 SH2	-	0.87	-	medium
Y	939	APREETGSEEYMNMDLGPGRR	INSR	11572799	LTP	1.00		PIK3R1 SH2	-	0.87	-	medium

Substrate:	PI3-kinase p85-alpha subunit (Adaptor molecule. Phopshatidylinositol 3-kinase regulatory alpha subunit.)
Seq-ID:	P27986 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16109   ARAF_HUMAN MINT-17501   SHC1_HUMAN MINT-19009   CDC42_HUMAN MINT-56732   KSYK_HUMAN MINT-56734   KSYK_MOUSE MINT-65974   GRB2_HUMAN MINT-66003   LCK_HUMAN MINT-68496   GAB2_HUMAN MINT-68500   CBL_HUMAN MINT-68735   IRS1_HUMAN MINT-74606   EGFR_HUMAN MINT-74610   ERBB2_HUMAN MINT-74617   ERBB3_HUMAN MINT-1893011   GAB1_HUMAN MINT-2840114   TLR3_HUMAN MINT-3378272   SEPT2_HUMAN MINT-6762880   IRS1_RAT MINT-7103574   FLT3_HUMAN MINT-7103638   MK08_HUMAN MINT-7103655   CRKL_HUMAN MINT-7251262   ICAL_HUMAN MINT-7251286   SNX17_HUMAN MINT-7251334   DAB2_HUMAN MINT-7251346   CDC27_HUMAN MINT-7251370   FLNA_HUMAN MINT-7251382   SYNJ2_HUMAN MINT-7251406   CSDE1_HUMAN MINT-7251418   ABL1_HUMAN MINT-7251430   SUV92_HUMAN MINT-7251442   VP13A_HUMAN MINT-7251454   FLNB_HUMAN MINT-7251526   SOS1_HUMAN MINT-7251538   ASAP2_HUMAN MINT-7251550   LIPA3_HUMAN MINT-7251562   AKAP2_HUMAN MINT-7251574   ARHGB_HUMAN MINT-7251598   PHAR2_HUMAN MINT-7251610   DLGP4_HUMAN MINT-7251622   ELK3_HUMAN MINT-7251658   BRCA1_HUMAN MINT-7251706   CKAP5_HUMAN MINT-7251718   RRAS_HUMAN MINT-7251730   ECT2_HUMAN MINT-7251754   TPX2_HUMAN MINT-7251766   JAK2_HUMAN MINT-7251778   ASAP1_HUMAN MINT-7251790   FLNC_HUMAN MINT-7251802   DNLI3_HUMAN MINT-7251814   TGON2_HUMAN MINT-7251838   SHAN2_HUMAN MINT-7251850   KI13A_HUMAN MINT-7251862   ABL2_HUMAN MINT-7251886   BRPF3_HUMAN MINT-7251898   SH3K1_HUMAN MINT-7251934   MYRIP_HUMAN MINT-7251982   DAG1_HUMAN MINT-7251994   STF1_HUMAN MINT-7252006   P3C2B_HUMAN MINT-7252018   SNX8_HUMAN MINT-7252030   BRD4_HUMAN MINT-7252078   MINT_HUMAN MINT-7252126   PLCG2_HUMAN MINT-7252150   MAP4_HUMAN MINT-7252174   MYLK_HUMAN MINT-7252186   PEBP1_HUMAN MINT-7252234   CAF1A_HUMAN MINT-7252258   DTBP1_HUMAN MINT-7252270   NELFB_HUMAN MINT-7252282   AKAP6_HUMAN MINT-7252294   FANCA_HUMAN MINT-7252318   GHR_HUMAN MINT-7252330   M4K1_HUMAN MINT-7252342   RPGF1_HUMAN MINT-7296136   SRC_HUMAN MINT-7306624   LCP2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process ErbB-3 class receptor binding, insulin-like growth factor receptor binding, phosphoinositide 3-kinase regulator activity, insulin binding, insulin receptor binding, insulin receptor substrate binding, phosphatidylinositol binding, protein phosphatase binding 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex phosphoinositide 3-kinase cascade, insulin-like growth factor receptor signaling pathway, phosphoinositide phosphorylation, interspecies interaction between organisms, positive regulation of establishment of protein localization in plasma membrane, insulin receptor signaling pathway, positive regulation of glucose import, growth hormone receptor signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	688	GYGFAEPYNLYSSLKELVLHY	-	9461588	LTP	1.00		PIK3R1 SH2	SH2	0.19	1H9O	15.72%
Y	688	GYGFAEPYNLYSSLKELVLHY	-	11337495	LTP	1.00		PIK3R1 SH2	SH2	0.19	1H9O	15.72%

Substrate:	CSFR-1 (Macrophage colony stimulating factor I receptor)
Seq-ID:	P07333 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process macrophage colony-stimulating factor receptor activity, protein homodimerization activity, ATP binding, cytokine binding receptor complex, integral to plasma membrane protein amino acid phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, multicellular organismal development, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	723	SGFSSQGVDTYVEMRPVSTSS	-	N.N.	LTP	1.00		PIK3R1 SH2	TyrKc	0.46	-	low

Substrate:	CTLA-4 (CD152 antigen)
Seq-ID:	P16410 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process external side of plasma membrane, integral to plasma membrane, Golgi apparatus, perinuclear region of cytoplasm, clathrin-coated endocytic vesicle negative regulation of regulatory T cell differentiation, immune response
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	201	KKRSPLTTGVYVKMPPTEPEC	JAK2	10842319	LTP	1.00		PIK3R1 SH2; PTPN11 SH2	-	0.37	-	low
Y	201	KKRSPLTTGVYVKMPPTEPEC	TXK	9813138	LTP	1.00		PIK3R1 SH2; PTPN11 SH2	-	0.37	-	low

Substrate:	Tyrosine-protein phosphatase, non-receptor type 6 (Protein tyrosine phosphatase containing SH2 domains)
Seq-ID:	P29350 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-56658   TFG_HUMAN MINT-73504   EPOR_HUMAN MINT-74919   FCG2B_HUMAN MINT-6761906   ESR1_HUMAN MINT-6793815   CAV1_HUMAN MINT-6799844   ROS_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein tyrosine phosphatase activity, protein binding cytosol, nucleus, membrane apoptosis, protein amino acid dephosphorylation, signal transduction, G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	564	RTSSKHKEDVYENLHTKNKRE	-	12468540	LTP	0.31		PIK3R1 SH2; SH3BP2 SH2	-	0.72	-	low
Y	564	RTSSKHKEDVYENLHTKNKRE	Lck	8114715	LTP	0.31		PIK3R1 SH2; SH3BP2 SH2	-	0.72	-	low
Y	564	RTSSKHKEDVYENLHTKNKRE	Abl	8692915	LTP	0.31		PIK3R1 SH2; SH3BP2 SH2	-	0.72	-	low
Y	564	RTSSKHKEDVYENLHTKNKRE	-	14757045	LTP	0.31		PIK3R1 SH2; SH3BP2 SH2	-	0.72	-	low
Y	564	RTSSKHKEDVYENLHTKNKRE	SRC	14699166	LTP	0.31		PIK3R1 SH2; SH3BP2 SH2	-	0.72	-	low
Y	564	RTSSKHKEDVYENLHTKNKRE	Lck	10488096	LTP	0.31		PIK3R1 SH2; SH3BP2 SH2	-	0.72	-	low
Y	564	RTSSKHKEDVYENLHTKNKRE	-	18083107	HTP	0.31		PIK3R1 SH2; SH3BP2 SH2	-	0.72	-	low

Substrate:	SYK (Spleen tyrosine kinase )
Seq-ID:	P43405 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-56730   LCK_HUMAN MINT-56732   P85A_HUMAN MINT-56739   FGR_HUMAN MINT-56749   P85B_HUMAN MINT-74763   EGFR_HUMAN MINT-74769   ERBB2_HUMAN MINT-74775   ERBB3_HUMAN MINT-74776   ERBB4_HUMAN MINT-6538977   CBL_HUMAN MINT-6621148   BLNK_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine kinase activity, ATP binding, integrin binding cytoplasm, T cell receptor complex protein complex assembly, organ morphogenesis, integrin-mediated signaling pathway, neutrophil chemotaxis, interspecies interaction between organisms, cell proliferation, leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	323	RQESTVSFNPYEPELAPWAAD	-	16497976	HTP	0.80		CBLB SH2; CBL PTB; PIK3R1 SH2	-	0.51	-	-
Y	323	RQESTVSFNPYEPELAPWAAD	-	18083107	HTP	0.80		CBLB SH2; CBL PTB; PIK3R1 SH2	-	0.51	-	-

Substrate:	PDGF-R alpha (Receptor tyrosine kinase)
Seq-ID:	P16234 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process platelet-derived growth factor alpha-receptor activity, vascular endothelial growth factor receptor activity, platelet-derived growth factor binding, protein homodimerization activity, platelet-derived growth factor receptor binding, ATP binding integral to plasma membrane positive regulation of DNA replication, positive regulation of fibroblast proliferation, cell activation, positive regulation of cell migration, protein amino acid autophosphorylation, peptidyl-tyrosine phosphorylation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	731	VILSFENNGDYMDMKQADTTQ	-	11818394	LTP	1.00		PIK3R1 SH2	TyrKc	0.29	-	medium
Y	742	MDMKQADTTQYVPMLERKEVS	-	11818394	LTP	1.00		PIK3R1 SH2	TyrKc	0.39	-	medium

Substrate:	Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID:	Q13480 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-58395   GRB2_HUMAN MINT-58403   GRAP2_HUMAN MINT-58404   MET_HUMAN MINT-68564   BMX_HUMAN MINT-1893011   P85A_HUMAN MINT-6169406   PTN11_HUMAN MINT-6169502   PAXI_HUMAN MINT-7971128   DLG4_RAT
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3/SH2 adaptor activity cytosol epidermal growth factor receptor signaling pathway, insulin receptor signaling pathway, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	447	SVSSEELDENYVPMNPNSPPR	INSR	10978177	LTP	1.00		PIK3R1 SH2; PIK3R2 SH2; PTPN11 SH2	-	0.83	-	low
Y	447	SVSSEELDENYVPMNPNSPPR	EGFR	9890893	LTP	1.00		PIK3R1 SH2; PIK3R2 SH2; PTPN11 SH2	-	0.83	-	low
Y	447	SVSSEELDENYVPMNPNSPPR	Met	10734310	LTP	1.00		PIK3R1 SH2; PIK3R2 SH2; PTPN11 SH2	-	0.83	-	low
Y	472	SFTEPIQEANYVPMTPGTFDF	INSR	10978177	LTP	1.00		PIK3R1 SH2; PIK3R2 SH2	-	0.54	-	low
Y	472	SFTEPIQEANYVPMTPGTFDF	EGFR	9890893	LTP	1.00		PIK3R1 SH2; PIK3R2 SH2	-	0.54	-	low
Y	472	SFTEPIQEANYVPMTPGTFDF	Met	10734310	LTP	1.00		PIK3R1 SH2; PIK3R2 SH2	-	0.54	-	low
Y	589	SSDSHDSEENYVPMNPNLSSE	INSR	10978177	LTP	1.00		PIK3R1 SH2; PTPN11 SH2	-	0.89	-	low
Y	589	SSDSHDSEENYVPMNPNLSSE	EGFR	9890893	LTP	1.00		PIK3R1 SH2; PTPN11 SH2	-	0.89	-	low
Y	589	SSDSHDSEENYVPMNPNLSSE	Met	10734310	LTP	1.00		PIK3R1 SH2; PTPN11 SH2	-	0.89	-	low

Substrate:	Gab2 (Adaptor molecule)
Seq-ID:	Q9Z1S8 [Mus musculus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3,4,5-trisphosphate binding, transmembrane receptor protein tyrosine kinase adaptor protein activity plasma membrane, cytoplasm positive regulation of cell proliferation, cell migration, integrin-mediated signaling pathway, phosphoinositide-mediated signaling, positive regulation of mast cell degranulation, osteoclast differentiation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	441	RSNSASSDDNYVPMNPGSSTL	-	9885561	LTP	1.00		PIK3R1 SH2	-	0.79	-	medium
Y	441	RSNSASSDDNYVPMNPGSSTL	-	11334882	LTP	1.00		PIK3R1 SH2	-	0.79	-	medium
Y	465	ERPGDNSQSVYIPMSPGPHHF	-	9885561	LTP	0.15		PIK3R1 SH2	-	0.78	-	medium
Y	465	ERPGDNSQSVYIPMSPGPHHF	-	11334882	LTP	0.15		PIK3R1 SH2	-	0.78	-	medium
Y	573	STDSGDSEENYVPMQNPVSAS	-	9885561	LTP	0.93		PIK3R1 SH2	-	0.85	-	medium
Y	573	STDSGDSEENYVPMQNPVSAS	-	11334882	LTP	0.93		PIK3R1 SH2	-	0.85	-	medium

Substrate:	SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)
Seq-ID:	Q13094 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-15244   FYB_HUMAN MINT-16513   SHC1_HUMAN MINT-16846   CBL_HUMAN MINT-17488   FCGR1_HUMAN MINT-59471   ITK_MOUSE MINT-59473   ITK_HUMAN MINT-59474   LCK_HUMAN MINT-2837400   PLCG1_BOVIN MINT-4302560   STAM1_HUMAN MINT-4302608   STAM2_HUMAN MINT-7041321   GRAP2_HUMAN MINT-7306527   NCK1_HUMAN MINT-7306585   SRC_CHICK MINT-7306598   SRC_HUMAN MINT-7306611   FYN_HUMAN MINT-7306624   P85A_HUMAN MINT-7306637   PLCG1_HUMAN MINT-7306657   GRB2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein binding cytosol immune response, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	113	GGWSSFEEDDYESPNDDQDGE	-	8892604	LTP	0.99		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.92	-	medium
Y	113	GGWSSFEEDDYESPNDDQDGE	ZAP70	9047237	LTP	0.99		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.92	-	medium
Y	113	GGWSSFEEDDYESPNDDQDGE	SYK	15388330	LTP	0.99		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.92	-	medium
Y	113	GGWSSFEEDDYESPNDDQDGE	ZAP70	12817019	LTP	0.99		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.92	-	medium
Y	113	GGWSSFEEDDYESPNDDQDGE	Lck	8702662	LTP	0.99		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.92	-	medium
Y	113	GGWSSFEEDDYESPNDDQDGE	ZAP70	8702662	LTP	0.99		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.92	-	medium
Y	128	DDQDGEDDGDYESPNEEEEAP	-	8892604	LTP	0.30		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.98	-	medium
Y	128	DDQDGEDDGDYESPNEEEEAP	ZAP70	9047237	LTP	0.30		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.98	-	medium
Y	128	DDQDGEDDGDYESPNEEEEAP	SYK	15388330	LTP	0.30		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.98	-	medium
Y	128	DDQDGEDDGDYESPNEEEEAP	ZAP70	12817019	LTP	0.30		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.98	-	medium
Y	128	DDQDGEDDGDYESPNEEEEAP	Lck	8702662	LTP	0.30		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.98	-	medium
Y	128	DDQDGEDDGDYESPNEEEEAP	ZAP70	8702662	LTP	0.30		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.98	-	medium

Substrate:	FCGR2B (protein binding)
Seq-ID:	P31994 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	[show] MINT-74919   PTN6_HUMAN MINT-74920   SHIP1_HUMAN MINT-7245214   SRC_HUMAN MINT-7247446   FYN_HUMAN MINT-7251178   NCK1_HUMAN MINT-7252786   PLCG1_HUMAN MINT-7254142   CRK_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process receptor activity, IgG binding plasma membrane, integral to membrane immune response, interspecies interaction between organisms
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	292	DKVGAENTITYSLLMHPDALE	Lyn	8756631	LTP	1.00		INPP5D SH2; Lyn SH2; PIK3R1 SH2; PTPN11 SH2; PTPN6 SH2; SHC1 SH2	-	0.42	-	low
Y	292	DKVGAENTITYSLLMHPDALE	BLK	8756631	LTP	1.00		INPP5D SH2; Lyn SH2; PIK3R1 SH2; PTPN11 SH2; PTPN6 SH2; SHC1 SH2	-	0.42	-	low

Substrate:	c-kit (Receptor tyrosine kinase)
Seq-ID:	P10721 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process receptor signaling protein tyrosine kinase activity, ATP binding, protein binding integral to membrane, extracellular space male gonad development, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	721	ESSCSDSTNEYMDMKPGVSYV	-	N.N.	LTP	1.00		MATK SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	TyrKc	0.36	-	-
Y	721	ESSCSDSTNEYMDMKPGVSYV	-	9038210	LTP	1.00		MATK SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	TyrKc	0.36	-	-
Y	900	LSPEHAPAEMYDIMKTCWDAD	SRC_group	12878163	LTP	1.00		PIK3R1 SH2	TyrKc	0.24	1T46	16.16%
Y	900	LSPEHAPAEMYDIMKTCWDAD	SRC	12878163	LTP	1.00		PIK3R1 SH2	TyrKc	0.24	1T46	16.16%

Substrate:	LAT (Adaptor molecule involved in the TCR signal pathway)
Seq-ID:	O43561 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-3382436   GRB2_HUMAN MINT-3382457   SOS1_MOUSE MINT-3382488   ZAP70_HUMAN MINT-6794135   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3/SH2 adaptor activity immunological synapse, integral to membrane, membrane raft calcium-mediated signaling, integrin-mediated signaling pathway, mast cell degranulation, regulation of T cell activation, Ras protein signal transduction
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	220	AEASLDGSREYVNVSQELHPG	-	15659558	HTP	1.00		GRAP2 SH2; GRB2 SH2; PIK3R1 SH2; PLCG1 SH2; VAV1 SH2	-	0.71	-	medium

Substrate:	FAK (Focal adhesion kinase)
Seq-ID:	Q05397 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-17602   LYN_HUMAN MINT-74938   BCAR1_HUMAN MINT-3381308   SRC_HUMAN MINT-6794892   PTN1_HUMAN MINT-7294020   P53_HUMAN MINT-7385708   SRC_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine kinase activity, ATP binding, SH2 domain binding, signal transducer activity focal adhesion, cytosol, cytoskeleton signal complex assembly, integrin-mediated signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	397	HAVSVSETDDYAEIIDEEDTY	FAK	7509446	LTP	1.00		Fyn SH2; GRB2 SH2; GRB7 SH2; NCK SH2; PIK3R1 SH2; Src SH2; STAT3 SH2	-	0.49	-	-
Y	397	HAVSVSETDDYAEIIDEEDTY	-	17192257	HTP	1.00		Fyn SH2; GRB2 SH2; GRB7 SH2; NCK SH2; PIK3R1 SH2; Src SH2; STAT3 SH2	-	0.49	-	-
Y	397	HAVSVSETDDYAEIIDEEDTY	-	18083107	HTP	1.00		Fyn SH2; GRB2 SH2; GRB7 SH2; NCK SH2; PIK3R1 SH2; Src SH2; STAT3 SH2	-	0.49	-	-

Substrate:	Insulin receptor substrate 2 (Adaptor molecule)
Seq-ID:	Q9Y4H2 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-18053   IGF1R_HUMAN MINT-18199   INSR_HUMAN MINT-50999   1433B_HUMAN MINT-3295882   1433Z_HUMAN MINT-3975441   1433S_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process signal transducer activity plasma membrane, cytosol negative regulation of kinase activity, positive regulation of insulin secretion, positive regulation of B cell proliferation, positive regulation of fatty acid beta-oxidation, response to glucose stimulus, lipid homeostasis, positive regulation of glycogen biosynthetic process, negative regulation of plasma membrane long-chain fatty acid transport, negative regulation of B cell apoptosis, insulin receptor signaling pathway, positive regulation of glucose import, glucose metabolic process
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	653	SSSNLGADDGYMPMTPGAALA	-	16497976	HTP	1.00		PIK3R1 SH2	-	0.60	-	medium
Y	653	SSSNLGADDGYMPMTPGAALA	-	18083107	HTP	1.00		PIK3R1 SH2	-	0.60	-	medium
Y	675	SGSGSCRSDDYMPMSPASVSA	-	16497976	HTP	1.00		PIK3R1 SH2	-	0.59	-	medium
Y	675	SGSGSCRSDDYMPMSPASVSA	-	18083107	HTP	1.00		PIK3R1 SH2	-	0.59	-	medium
Y	675	SGSGSCRSDDYMPMSPASVSA	-	18669648	HTP	1.00		PIK3R1 SH2	-	0.59	-	medium
Y	742	PAESSPEDSGYMRMWCGSKLS	-	18083107	HTP	1.00		PIK3R1 SH2	-	0.49	-	medium
Y	823	PYTCGGDSDQYVLMSSPVGRI	-	16497976	HTP	0.47		PIK3R1 SH2	-	0.46	-	medium
Y	823	PYTCGGDSDQYVLMSSPVGRI	-	18083107	HTP	0.47		PIK3R1 SH2	-	0.46	-	medium

Substrate:	CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID:	P22681 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-15516   LCK_HUMAN MINT-15716   CRK_HUMAN MINT-16022   CD2AP_HUMAN MINT-16347   LYN_HUMAN MINT-16846   LCP2_HUMAN MINT-17062   FCGR1_HUMAN MINT-17932   NCK1_HUMAN MINT-50666   FYN_HUMAN MINT-50717   ABL1_HUMAN MINT-50722   CRKL_HUMAN MINT-58331   ITCH_HUMAN MINT-60970   RET_HUMAN MINT-60973   EGFR_HUMAN MINT-60978   SHC1_HUMAN MINT-68500   P85A_HUMAN MINT-2837344   PLCG1_BOVIN MINT-4299918   ASAP1_HUMAN MINT-6169713   SPY1_HUMAN MINT-6170244   SH3G2_HUMAN MINT-6538940   SPY4_HUMAN MINT-6538977   KSYK_HUMAN MINT-6539587   MET_HUMAN MINT-6539601   SPY2_HUMAN MINT-6539646   VGFR1_HUMAN MINT-6539679   RON_HUMAN MINT-6539730   SRC_HUMAN MINT-7040249   GRB2_HUMAN MINT-7046364   ITSN1_HUMAN MINT-7103623   MK08_HUMAN MINT-7211864   ARHG7_HUMAN MINT-7214822   FYN_MOUSE MINT-7218352   SH3K1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3 domain binding, calcium ion binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, signal transducer activity, ubiquitin-protein ligase activity cytosol, nucleus epidermal growth factor receptor signaling pathway, positive regulation of receptor-mediated endocytosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	371	IKVTQEQYELYCEMGSTFQLC	-	10635327	LTP	1.00		PIK3R1 SH2	-	0.11	1FBV	5.24%
Y	371	IKVTQEQYELYCEMGSTFQLC	INSR	11997497	LTP	1.00		PIK3R1 SH2	-	0.11	1FBV	5.24%
Y	731	DCDQQIDSCTYEAMYNIQSQA	Fyn	9525940	LTP	0.29		CRKL SH2; CRK SH2; Lyn SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2	-	0.47	-	-
Y	731	DCDQQIDSCTYEAMYNIQSQA	SYK	9525940	LTP	0.29		CRKL SH2; CRK SH2; Lyn SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2	-	0.47	-	-
Y	731	DCDQQIDSCTYEAMYNIQSQA	Yes	9525940	LTP	0.29		CRKL SH2; CRK SH2; Lyn SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2	-	0.47	-	-
Y	731	DCDQQIDSCTYEAMYNIQSQA	-	10934191	LTP	0.29		CRKL SH2; CRK SH2; Lyn SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2	-	0.47	-	-
Y	731	DCDQQIDSCTYEAMYNIQSQA	Fyn	9890970	LTP	0.29		CRKL SH2; CRK SH2; Lyn SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2	-	0.47	-	-
Y	731	DCDQQIDSCTYEAMYNIQSQA	-	12604776	LTP	0.29		CRKL SH2; CRK SH2; Lyn SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2	-	0.47	-	-
Y	731	DCDQQIDSCTYEAMYNIQSQA	-	15922744	LTP	0.29		CRKL SH2; CRK SH2; Lyn SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2	-	0.47	-	-

Substrate:	EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID:	P00533 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16802   GRB10_HUMAN MINT-50935   1433Z_HUMAN MINT-51101   ANXA1_HUMAN MINT-51490   ARBK1_HUMAN MINT-60973   CBL_HUMAN MINT-61486   CRKL_HUMAN MINT-61487   CSK_HUMAN MINT-61490   STA5B_HUMAN MINT-61540   GRB2_HUMAN MINT-68514   PDC6I_HUMAN MINT-74427   ABL1_HUMAN MINT-74438   ABL2_HUMAN MINT-74460   ANS1A_HUMAN MINT-74469   APBB1_HUMAN MINT-74479   DP13A_HUMAN MINT-74487   BMX_HUMAN MINT-74497   CRK_HUMAN MINT-74535   FES_HUMAN MINT-74551   IRS1_HUMAN MINT-74555   IRS4_HUMAN MINT-74562   JAK2_HUMAN MINT-74566   SH2B3_HUMAN MINT-74572   JIP1_HUMAN MINT-74587   NCK1_HUMAN MINT-74593   NUMB_HUMAN MINT-74594   NUMBL_HUMAN MINT-74606   P85A_HUMAN MINT-74630   P85B_HUMAN MINT-74659   P55G_HUMAN MINT-74678   PLCG1_HUMAN MINT-74685   PLCG2_HUMAN MINT-74687   PTK6_HUMAN MINT-74689   PTN11_HUMAN MINT-74711   RASA1_HUMAN MINT-74717   SH2B1_HUMAN MINT-74720   SH22A_HUMAN MINT-74732   SHC1_HUMAN MINT-74746   SLAP1_HUMAN MINT-74763   KSYK_HUMAN MINT-74790   TLN1_HUMAN MINT-74807   ZAP70_HUMAN MINT-1788719   ERBB2_HUMAN MINT-6169667   ESR1_HUMAN MINT-6170031   SOS1_MOUSE MINT-6170198   SH3G2_HUMAN MINT-6170268   SH3K1_HUMAN MINT-6793358   PTN1_HUMAN MINT-7980526   TM1L1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process epidermal growth factor receptor activity, protein heterodimerization activity, identical protein binding, receptor signaling protein tyrosine kinase activity, double-stranded DNA binding, ATP binding, protein phosphatase binding, actin filament binding, MAP/ERK kinase kinase activity Shc-EGFR complex, endosome, basolateral plasma membrane, integral to membrane, extracellular space, nucleus activation of phospholipase C activity, protein insertion into membrane, response to UV-A, positive regulation of nitric oxide biosynthetic process, positive regulation of cell migration, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, positive regulation of catenin protein nuclear translocation, regulation of nitric-oxide synthase activity, positive regulation of protein kinase B signaling cascade, ossification, positive regulation of epithelial cell proliferation, activation of phospholipase A2 activity by calcium-mediated signaling, cell-cell adhesion, regulation of peptidyl-tyrosine phosphorylation, positive regulation of phosphorylation, positive regulation of MAP kinase activity, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	944	PQPPICTIDVYMIMVKCWMID	SRC	11983694	LTP	1.00		PIK3R1 SH2; Src SH2	TyrKc	0.05	3BEL	16.16%
Y	1092	IDDTFLPVPEYINQSVPKRPA	EGFR	8845374	LTP	0.05		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; STAT3 SH2	-	0.57	-	-
Y	1092	IDDTFLPVPEYINQSVPKRPA	-	15302935	HTP	0.05		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; STAT3 SH2	-	0.57	-	-
Y	1092	IDDTFLPVPEYINQSVPKRPA	-	17081983	HTP	0.05		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; STAT3 SH2	-	0.57	-	-
Y	1092	IDDTFLPVPEYINQSVPKRPA	-	18083107	HTP	0.05		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; STAT3 SH2	-	0.57	-	-

Substrate:	Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID:	P19235 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-73504   PTN6_HUMAN MINT-74896   PTN6_MOUSE MINT-6794748   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process erythropoietin receptor activity extracellular region, integral to plasma membrane
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	504	IPAAEPLPPSYVACS	-	10579919	LTP	0.67		INPP5D SH2; Lyn SH2; PIK3R1 SH2; PLCG2 SH2; STAT5 SH2	-	0.34	-	low
Y	504	IPAAEPLPPSYVACS	-	7559499	LTP	0.67		INPP5D SH2; Lyn SH2; PIK3R1 SH2; PLCG2 SH2; STAT5 SH2	-	0.34	-	low
Y	504	IPAAEPLPPSYVACS	-	9573010	LTP	0.67		INPP5D SH2; Lyn SH2; PIK3R1 SH2; PLCG2 SH2; STAT5 SH2	-	0.34	-	low

Substrate:	IGF1-R (Receptor tyrosine kinase)
Seq-ID:	P08069 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-15644   GRB10_HUMAN MINT-18053   IRS2_HUMAN MINT-1774754   ARHGC_MOUSE MINT-1774976   ARHGC_HUMAN MINT-6800783   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphoinositide 3-kinase binding, identical protein binding, insulin-like growth factor receptor activity, insulin binding, metal ion binding, insulin receptor binding, insulin receptor substrate binding, ATP binding, insulin-like growth factor I binding microsome, integral to plasma membrane positive regulation of DNA replication, positive regulation of cell proliferation, positive regulation of cell migration, anti-apoptosis, phosphoinositide 3-kinase cascade, phosphoinositide-mediated signaling, immune response, protein amino acid autophosphorylation, insulin receptor signaling pathway, protein tetramerization
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1346	LRASFDERQPYAHMNGGRKNE	IGF1R	8550552	LTP	1.00		Csk SH2; GRB10 SH2; PIK3R1 SH2; PTPN11 SH2	-	0.63	-	-

Substrate:	IL-7R alpha (Cytokin receptor)
Seq-ID:	P16871 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process antigen binding, interleukin-7 receptor activity extracellular region, integral to membrane regulation of DNA recombination
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	449	TSLGSNQEEAYVTMSSFYQNQ	-	7719938	LTP	1.00		PIK3R1 SH2; STAT5 SH2	-	0.40	-	medium

Substrate:	RET (Probable receptor with tyrosine-protein kinase activity; important for development.)
Seq-ID:	P07949 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-60970   CBL_HUMAN MINT-60975   GRB2_HUMAN MINT-60981   SHC1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process calcium ion binding, transmembrane receptor protein tyrosine kinase activity, ATP binding integral to membrane protein amino acid phosphorylation, posterior midgut development, homophilic cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1062	LPSTWIENKLYGMSDPNWPGE	-	11470823	LTP	0.19		FRS2 PTB; IRS1 PTB; PIK3R1 SH2; SHC1 PTB; SHC1 SH2; SHC3 PTB; SHC3 SH2	-	0.43	-	-
Y	1062	LPSTWIENKLYGMSDPNWPGE	RET	14711813	LTP	0.19		FRS2 PTB; IRS1 PTB; PIK3R1 SH2; SHC1 PTB; SHC1 SH2; SHC3 PTB; SHC3 SH2	-	0.43	-	-
Y	1062	LPSTWIENKLYGMSDPNWPGE	RET	14981541	LTP	0.19		FRS2 PTB; IRS1 PTB; PIK3R1 SH2; SHC1 PTB; SHC1 SH2; SHC3 PTB; SHC3 SH2	-	0.43	-	-

Substrate:	CD136 (Receptor tyrosine kinase)
Seq-ID:	Q04912 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-6539679   CBL_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process macrophage colony-stimulating factor receptor activity, ATP binding, protein binding integral to plasma membrane positive regulation of cell proliferation, protein amino acid phosphorylation, cellular component movement, single fertilization, transmembrane receptor protein tyrosine kinase signaling pathway, multicellular organismal development, defense response
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1353	QIVSALLGDHYVQLPATYMNL	RON	10871856	LTP	1.00		GRB2 SH2; PIK3R1 SH2; PLCG1 SH2; SHC1 SH2	-	0.21	-	low
Y	1360	GDHYVQLPATYMNLGPSTSHE	RON	10871856	LTP	1.00		GRB2 SH2; PIK3R1 SH2; PLCG1 SH2; SHC1 SH2	-	0.40	-	low

Substrate:	PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID:	P09619 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-2832596   NHRF2_HUMAN MINT-2832984   PTEN_HUMAN MINT-2833042   NHRF1_HUMAN MINT-6762380   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process vascular endothelial growth factor receptor activity, platelet-derived growth factor binding, platelet activating factor receptor activity, platelet-derived growth factor receptor binding, ATP binding, platelet-derived growth factor beta-receptor activity integral to plasma membrane positive regulation of cell proliferation, positive regulation of cell migration, protein amino acid autophosphorylation, peptidyl-tyrosine phosphorylation, cell chemotaxis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	579	IESVSSDGHEYIYVDPMQLPY	PDGFR_beta	8195171	LTP	1.00		Fyn SH2; PIK3R1 SH2; PLCG1 SH2; PTPN11 SH2; RASA_group SH2; SHC1 SH2; SHC_group SH2; SLA SH2; Src SH2; STAT5 SH2; YES1 SH2	-	0.15	-	medium
Y	581	SVSSDGHEYIYVDPMQLPYDS	PDGFR_beta	8617789	LTP	1.00		Fyn SH2; PIK3R1 SH2; PLCG1 SH2; PTPN11 SH2; RASA_group SH2; SLA SH2; Src SH2; STAT5 SH2; YES1 SH2	-	0.16	-	medium
Y	740	VSLTGESDGGYMDMSKDESVD	PDGFR_beta	8195171	LTP	1.00		Fyn SH2; NCK SH2; PIK3R1 SH2; PLCG1 SH2; RASA_group SH2; SHC1 SH2; SHC_group SH2	TyrKc	0.45	-	medium
Y	751	MDMSKDESVDYVPMLDMKGDV	PDGFR_beta	8195171	LTP	1.00		Fyn SH2; NCK SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2; RASA_group SH2; SHC1 SH2; SHC_group SH2; Src SH2	TyrKc	0.29	-	medium
Y	751	MDMSKDESVDYVPMLDMKGDV	PDGFR_group	8195171	LTP	1.00		Fyn SH2; NCK SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2; RASA_group SH2; SHC1 SH2; SHC_group SH2; Src SH2	TyrKc	0.29	-	medium
Y	1009	RSPLDTSSVLYTAVQPNEGDN	PDGFR_beta	8195171	LTP	0.02		NCK SH2; PIK3R1 SH2; PLCG1 SH2; PTPN11 SH2	-	0.61	-	medium
Y	1021	AVQPNEGDNDYIIPLPDPKPE	PDGFR_beta	12062403	LTP	1.00		PIK3R1 SH2; PLCG1 SH2; PTPN11 SH2	-	0.75	-	medium

Substrate:	IL-1R-1 (interleukin-1 receptor, type I precursor (IL-1R-1) (p80) (from PhosphoBase))
Seq-ID:	P14778 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process platelet-derived growth factor receptor binding, interleukin-1, Type I, activating receptor activity integral to plasma membrane innate immune response, response to interleukin-1, interleukin-1-mediated signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	496	VLLELEKIQDYEKMPESIKFI	-	9821957	LTP	1.00		PIK3R1 SH2	TIR	0.14	-	low

Substrate:	c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID:	P08581 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-18299   RANB9_HUMAN MINT-58374   GAB1_MOUSE MINT-58404   GAB1_HUMAN MINT-6539587   CBL_HUMAN MINT-6787689   PTN1_HUMAN MINT-6798640   PTN11_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process hepatocyte growth factor receptor activity, ATP binding, protein binding integral to plasma membrane, basal plasma membrane protein amino acid phosphorylation, multicellular organismal development, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1313	LQPEYCPDPLYEVMLKCWHPK	-	7708691	LTP	0.97		PIK3R1 SH2; STAT3 SH2	TyrKc	0.10	3F66	15.28%
Y	1313	LQPEYCPDPLYEVMLKCWHPK	-	10069803	LTP	0.97		PIK3R1 SH2; STAT3 SH2	TyrKc	0.10	3F66	15.28%
Y	1349	AIFSTFIGEHYVHVNATYVNV	Met	12475979	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	-	9444958	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	-	9252406	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	-	7513258	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	Met	7731718	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	Met	7687741	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	-	9826708	LTP	1.00		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	12475979	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	9444958	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	9252406	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	7513258	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7731718	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	8662889	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7961992	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7687741	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	9826708	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%

Substrate:	TIE2 (TEK) (PTK receptor for angiopoietin 1)
Seq-ID:	Q02763 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane receptor protein tyrosine kinase activity, ATP binding, protein binding basolateral plasma membrane, integral to plasma membrane, cell surface, microvillus, apical plasma membrane, membrane raft positive regulation of ERK1 and ERK2 cascade, protein amino acid phosphorylation, protein oligomerization, cell-cell signaling, positive regulation of protein kinase B signaling cascade, regulation of cell proliferation, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	897	NLLGACEHRGYLYLAIEYAPH	-	11080633	LTP	1.00		PIK3R1 SH2; PTPN11 SH2	TyrKc	0.05	1FVR	36.24%
Y	897	NLLGACEHRGYLYLAIEYAPH	-	11513602	LTP	1.00		PIK3R1 SH2; PTPN11 SH2	TyrKc	0.05	1FVR	36.24%
Y	1102	LNRMLEERKTYVNTTLYEKFT	-	10521483	LTP	1.00		GRB2 SH2; GRB7 SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	-	0.15	1FVR	3.49%
Y	1102	LNRMLEERKTYVNTTLYEKFT	-	9632797	LTP	1.00		GRB2 SH2; GRB7 SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	-	0.15	1FVR	3.49%
Y	1102	LNRMLEERKTYVNTTLYEKFT	TIE2	12082108	LTP	1.00		GRB2 SH2; GRB7 SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	-	0.15	1FVR	3.49%
Y	1108	ERKTYVNTTLYEKFTYAGIDC	TIE2	10521483	LTP	0.08		DOK_group PTB; GRB14 SH2; PIK3R1 SH2	-	0.11	1FVR	76.42%
Y	1108	ERKTYVNTTLYEKFTYAGIDC	TIE2	12665569	LTP	0.08		DOK_group PTB; GRB14 SH2; PIK3R1 SH2	-	0.11	1FVR	76.42%
Y	1113	VNTTLYEKFTYAGIDCSAEEA	TIE2	10521483	LTP	1.00		PIK3R1 SH2; PTPN11 SH2	-	0.12	1FVR	15.72%
Y	1113	VNTTLYEKFTYAGIDCSAEEA	-	12665569	LTP	1.00		PIK3R1 SH2; PTPN11 SH2	-	0.12	1FVR	15.72%

Substrate:	CD28 (Involved in T cell activation)
Seq-ID:	P10747 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process identical protein binding, SH3/SH2 adaptor activity, coreceptor activity external side of plasma membrane, cytosol, integral to plasma membrane regulatory T cell differentiation, humoral immune response, positive regulation of anti-apoptosis, regulation of defense response to virus by virus, positive regulation of interleukin-2 biosynthetic process, positive regulation of viral genome replication, cell surface receptor linked signaling pathway, cytokine biosynthetic process, positive regulation of mitosis, positive regulation of T cell proliferation, positive regulation of translation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	191	SKRSRLLHSDYMNMTPRRPGP	Lck	8992971	LTP	0.95		GRAP2 SH2; GRB2 SH2; ITK SH2; PIK3R1 SH2	-	0.44	-	medium
Y	191	SKRSRLLHSDYMNMTPRRPGP	ITK	8992971	LTP	0.95		GRAP2 SH2; GRB2 SH2; ITK SH2; PIK3R1 SH2	-	0.44	-	medium
Y	191	SKRSRLLHSDYMNMTPRRPGP	-	16094384	HTP	0.95		GRAP2 SH2; GRB2 SH2; ITK SH2; PIK3R1 SH2	-	0.44	-	medium

Substrate:	VEGFR-1 (Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity.)
Seq-ID:	P17948 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-6177086   LDLR_HUMAN MINT-6539646   CBL_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process vascular endothelial growth factor receptor activity, ATP binding, growth factor binding cytoplasm, integral to plasma membrane, extracellular space positive regulation of vascular endothelial growth factor receptor signaling pathway, female pregnancy, peptidyl-tyrosine phosphorylation, cell differentiation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1169	QANVQQDGKDYIPINAILTGN	-	11513746	LTP	1.00		PIK3R1 SH2; PLCG1 SH2; PLCG2 SH2; PLCG_group SH2	-	0.30	-	low
Y	1169	QANVQQDGKDYIPINAILTGN	-	9299537	LTP	1.00		PIK3R1 SH2; PLCG1 SH2; PLCG2 SH2; PLCG_group SH2	-	0.30	-	low
Y	1213	FNSGSSDDVRYVNAFKFMSLE	FLT1	11513746	LTP	1.00		GRB2 SH2; NCK SH2; PIK3R1 SH2; PTPN11 SH2	-	0.20	-	low
Y	1213	FNSGSSDDVRYVNAFKFMSLE	FLT1	9722576	LTP	1.00		GRB2 SH2; NCK SH2; PIK3R1 SH2; PTPN11 SH2	-	0.20	-	low
Y	1213	FNSGSSDDVRYVNAFKFMSLE	-	9600074	LTP	1.00		GRB2 SH2; NCK SH2; PIK3R1 SH2; PTPN11 SH2	-	0.20	-	low

Substrate:	Src (Proto-oncogene tyrosine-protein kinase Src)
Seq-ID:	P12931 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-14765   DDR2_HUMAN MINT-15459   CAV1_HUMAN MINT-46002   CTNB1_MOUSE MINT-50376   RASH_HUMAN MINT-62340   KPCD_HUMAN MINT-62342   CDCP1_HUMAN MINT-65953   DYN1_HUMAN MINT-65954   DYN2_HUMAN MINT-68512   PDC6I_HUMAN MINT-74753   ERBB3_HUMAN MINT-2792760   PAK2_HUMAN MINT-2793013   ADA15_HUMAN MINT-2840132   TLR3_HUMAN MINT-3381308   FAK1_HUMAN MINT-3381360   FYN_HUMAN MINT-4051815   ADRB2_HUMAN MINT-4961196   AFAD_HUMAN MINT-4980122   SNIP_MOUSE MINT-5210599   SNIP_HUMAN MINT-6539730   CBL_HUMAN MINT-6771405   FAK1_MOUSE MINT-6794909   ACTS_HUMAN MINT-6795322   ACTN1_HUMAN MINT-6795447   PTN1_HUMAN MINT-7035260   HNRPK_HUMAN MINT-7040283   CBLB_HUMAN MINT-7104422   BCAR1_HUMAN MINT-7145938   RL10_HUMAN MINT-7244986   ASAP1_HUMAN MINT-7244998   FANCA_HUMAN MINT-7245022   PHAR2_HUMAN MINT-7245034   ABL1_HUMAN MINT-7245058   DLGP4_HUMAN MINT-7245070   SNX17_HUMAN MINT-7245106   RTN4_HUMAN MINT-7245118   ASAP2_HUMAN MINT-7245142   E41L3_HUMAN MINT-7245154   ICAL_HUMAN MINT-7245214   FCG2B_HUMAN MINT-7245226   FCG2C_HUMAN MINT-7245334   SHAN2_HUMAN MINT-7245346   SHRM2_HUMAN MINT-7245358   DNLI3_HUMAN MINT-7245370   EIF3D_HUMAN MINT-7245406   HCN2_HUMAN MINT-7245490   CKAP5_HUMAN MINT-7245502   M4K1_HUMAN MINT-7245538   RPP38_HUMAN MINT-7245562   SP1_HUMAN MINT-7245574   DOCK1_HUMAN MINT-7245586   RLGPB_HUMAN MINT-7245598   ABL2_HUMAN MINT-7245610   CELR2_HUMAN MINT-7245622   SOS1_HUMAN MINT-7245634   AKAP6_HUMAN MINT-7245670   DPOD1_HUMAN MINT-7245682   DAG1_HUMAN MINT-7245694   SNX3_HUMAN MINT-7245730   KI67_HUMAN MINT-7245742   CD97_HUMAN MINT-7245754   RPGF1_HUMAN MINT-7245778   ACAP1_HUMAN MINT-7245790   PRIC3_HUMAN MINT-7245814   AKAP2_HUMAN MINT-7245826   RRAS_HUMAN MINT-7296136   P85A_HUMAN MINT-7296149   ACTB_HUMAN MINT-7306598   LCP2_HUMAN MINT-7552515   PTPRA_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3/SH2 adaptor activity, non-membrane spanning protein tyrosine kinase activity, ATP binding, integrin binding, SH2 domain binding caveola, cytosol protein amino acid phosphorylation, regulation of bone resorption, signal complex assembly, regulation of vascular permeability, response to interleukin-1, interspecies interaction between organisms, Ras protein signal transduction, positive regulation of integrin activation, intracellular protein kinase cascade
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	530	EDYFTSTEPQYQPGENL	-	3103926	LTP	0.94	MOD_TYR_CSK	Csk SH2; Fyn SH2; Lck SH2; PIK3R1 SH2; Src SH2	-	0.46	1FMK	18.34%
Y	530	EDYFTSTEPQYQPGENL	Csk	12468645	LTP	0.94	MOD_TYR_CSK	Csk SH2; Fyn SH2; Lck SH2; PIK3R1 SH2; Src SH2	-	0.46	1FMK	18.34%
Y	530	EDYFTSTEPQYQPGENL	-	12387813	LTP	0.94	MOD_TYR_CSK	Csk SH2; Fyn SH2; Lck SH2; PIK3R1 SH2; Src SH2	-	0.46	1FMK	18.34%

Substrate:	TRKA (Required for high affinity binding to nerve growth factor , neurotrophin-3 and neurotrophin-4/5r.)
Seq-ID:	P04629 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-6793941   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane receptor protein tyrosine kinase activity, neurotrophin receptor activity, ATP binding endosome, integral to plasma membrane activation of adenylate cyclase activity, Ras protein signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	757	ERPRACPPEVYAIMRGCWQRE	-	16319926	LTP	1.00		PIK3R1 SH2; SH2D1A SH2	TyrKc	0.24	-	medium

Substrate:	Insulin R (Receptor tyrosine kinase)
Seq-ID:	P06213 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16516   GRB10_HUMAN MINT-16842   MD2L1_HUMAN MINT-18199   IRS2_HUMAN MINT-19010   IRS1_HUMAN MINT-73466   GRB10_MOUSE MINT-6793537   INSR_RAT MINT-6794075   IRS1_MOUSE MINT-6794090   INSR_MOUSE MINT-6794946   PTN1_HUMAN MINT-6795115   IRS1_RAT
GO-Terms:	[show] Molecular Function Cellular Component Biological Process insulin-like growth factor receptor binding, insulin binding, PTB domain binding, GTP binding, metal ion binding, insulin receptor substrate binding, ATP binding, insulin-like growth factor I binding, insulin receptor activity, SH2 domain binding, phosphoinositide 3-kinase binding, insulin-like growth factor II binding, receptor signaling protein tyrosine kinase activity microsome, caveola, insulin receptor complex, endosome membrane positive regulation of glycolysis, positive regulation of MAPKKK cascade, positive regulation of developmental growth, regulation of embryonic development, heart morphogenesis, positive regulation of cell migration, carbohydrate metabolic process, protein heterotetramerization, positive regulation of protein kinase B signaling cascade, protein amino acid autophosphorylation, activation of MAPK activity, positive regulation of glycogen biosynthetic process, positive regulation of mitosis, peptidyl-tyrosine phosphorylation, positive regulation of glucose import, positive regulation of respiratory burst, activation of protein kinase B activity, G-protein coupled receptor protein signaling pathway, positive regulation of DNA replication, positive regulation of protein amino acid phosphorylation, positive regulation of cell proliferation, glucose homeostasis, positive regulation of nitric oxide biosynthetic process, transformation of host cell by virus, regulation of gene-specific transcription
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1355	GGSSLGFKRSYEEHIPYTHMN	INSR	1321605	LTP	0.85		GRB10 SH2; PIK3R1 SH2	-	0.50	-	-
Y	1361	FKRSYEEHIPYTHMNGGKKNG	INSR	1321605	LTP	0.95		Csk SH2; GRB10 SH2; PIK3R1 SH2; PTPN11 SH2; SHC1 SH2	-	0.54	-	-

Substrate:	TRKB (Receptor for brain-derived neurothrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5.)
Seq-ID:	P15209 [Mus musculus]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane receptor protein tyrosine kinase activity, ATP binding cytosol, integral to plasma membrane, terminal button regulation of metabolic process, feeding behavior, vasculogenesis, glutamate secretion, mechanoreceptor differentiation, retinal rod cell development
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	782	QRPRTCPQEVYELMLGCWQRE	-	8226808	LTP	1.00		PIK3R1 SH2	TyrKc	0.18	-	medium

Substrate:	Erzin (Connection of cytoscheletro structure to plasma membrane)
Seq-ID:	P15311 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-73250   TB10A_HUMAN MINT-73254   PLCB3_HUMAN MINT-73256   NHRF1_HUMAN MINT-3318887   1433Z_HUMAN MINT-6380786   FES_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process cell adhesion molecule binding, actin filament binding filopodium, cortical cytoskeleton, actin filament, cytosol, ruffle membrane, microvillus membrane, extrinsic to membrane, apical plasma membrane membrane to membrane docking, regulation of cell shape, actin filament bundle assembly, cytoskeletal anchoring at plasma membrane, leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	354	KEELMLRLQDYEEKTKKAERE	EGFR	1382070	LTP	0.22		PIK3R1 SH2	COIL	0.49	-	-

Substrate:	CD19 (Antigen of human B-lymphocytes)
Seq-ID:	P15391 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process receptor signaling protein activity, protein binding integral to plasma membrane cellular defense response
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	500	REATSLGSQSYEDMRGILYAA	-	9190913	LTP	1.00		PIK3R1 SH2	-	0.73	-	medium
Y	500	REATSLGSQSYEDMRGILYAA	Lyn	10933394	LTP	1.00		PIK3R1 SH2	-	0.73	-	medium
Y	531	GPNHEEDADSYENMDNPDGPD	-	9190913	LTP	1.00		PIK3R1 SH2	-	0.97	-	medium
Y	531	GPNHEEDADSYENMDNPDGPD	Lyn	10933394	LTP	1.00		PIK3R1 SH2	-	0.97	-	medium