List of substrates found:

ALK  ErbB3  IKB-alpha  Insulin receptor substrate 1  PI3-kinase p85-alpha subunit  CSFR-1  CTLA-4  Tyrosine-protein phosphatase, non-receptor type 6  SYK  PDGF-R alpha  Gab1  Gab2  SLP-76  FCGR2B  c-kit  LAT  FAK  Insulin receptor substrate 2  CBL E3 ubiquitin protein ligase  EGFR  Epo-R  IGF1-R  IL-7R alpha  RET  CD136  PDGF-R beta  IL-1R-1  c-met  TIE2 (TEK)  CD28  VEGFR-1  Src  TRKA  Insulin R  TRKB  Erzin  CD19 


Substrate: ALK (Receptor tyrosine kinase)
Seq-ID: Q9UM73 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1359 DPPKNCPGPVYRIMTQCWQHQ - 18083107
HTP
1.00
PIK3R1 SH2 TyrKc
0.42
- medium

Substrate: ErbB3 (Receptor tyrosine kinase)
Seq-ID: P21860 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1199 EEEDEDEEYEYMNRRRRHSPP - 9516479
LTP
1.00
GRB7 SH2;
PIK3R1 SH2
-
0.92
- medium
Y 1276 QRDGGGPGGDYAAMGACPASE - 11546794
LTP
0.31
PIK3R1 SH2 -
0.76
- medium
Y 1289 MGACPASEQGYEEMRAFQGPG - 11546794
LTP
0.12
PIK3R1 SH2 -
0.67
- medium

Substrate: IKB-alpha (Major histocompatibility complex enhancer-binding protein MAD3)
Seq-ID: P25963 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 42 SGLDSMKDEEYEQMVKELQEI Lck 8797825
LTP
1.00
PIK3R1 SH2 -
0.55
--
Y 42 SGLDSMKDEEYEQMVKELQEI - 12432072
LTP
1.00
PIK3R1 SH2 -
0.55
--
Y 42 SGLDSMKDEEYEQMVKELQEI SRC 9792645
LTP
1.00
PIK3R1 SH2 -
0.55
--

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35568 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 612 DSSTLHTDDGYMPMSPGVAPV - 15001544
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.81
--
Y 612 DSSTLHTDDGYMPMSPGVAPV - 18083107
HTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.81
--
Y 632 VPSGRKGSGDYMPMSPKSVSA - 15001544
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.83
--
Y 632 VPSGRKGSGDYMPMSPKSVSA - 18083107
HTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.83
--
Y 662 RHPQRVDPNGYMMMSPSGGCS - 15592455
HTP
1.00
Fyn SH2;
MATK SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.77
--

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35569 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 608 DTSNLHTDDGYMPMSPGVAPV - 9395471
LTP
1.00
PIK3R1 SH2 -
0.80
--
Y 608 DTSNLHTDDGYMPMSPGVAPV - 15821749
LTP
1.00
PIK3R1 SH2 -
0.80
--

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35570 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 608 DSSNLHTDDGYMPMSPGVAPV INSR 7504175
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 608 DSSNLHTDDGYMPMSPGVAPV - 12220227
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 608 DSSNLHTDDGYMPMSPGVAPV IGF1R 11572799
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 608 DSSNLHTDDGYMPMSPGVAPV INSR 11572799
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 628 VPSNRKGNGDYMPMSPKSVSA INSR 7504175
LTP
1.00
PIK3R1 SH2 -
0.81
- medium
Y 628 VPSNRKGNGDYMPMSPKSVSA IGF1R 11572799
LTP
1.00
PIK3R1 SH2 -
0.81
- medium
Y 628 VPSNRKGNGDYMPMSPKSVSA INSR 11572799
LTP
1.00
PIK3R1 SH2 -
0.81
- medium
Y 939 APREETGSEEYMNMDLGPGRR INSR 7504175
LTP
1.00
PIK3R1 SH2 -
0.87
- medium
Y 939 APREETGSEEYMNMDLGPGRR IGF1R 11572799
LTP
1.00
PIK3R1 SH2 -
0.87
- medium
Y 939 APREETGSEEYMNMDLGPGRR INSR 11572799
LTP
1.00
PIK3R1 SH2 -
0.87
- medium

Substrate: PI3-kinase p85-alpha subunit (Adaptor molecule. Phopshatidylinositol 3-kinase regulatory alpha subunit.)
Seq-ID: P27986 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16109   ARAF_HUMAN
MINT-17501   SHC1_HUMAN
MINT-19009   CDC42_HUMAN
MINT-56732   KSYK_HUMAN
MINT-56734   KSYK_MOUSE
MINT-65974   GRB2_HUMAN
MINT-66003   LCK_HUMAN
MINT-68496   GAB2_HUMAN
MINT-68500   CBL_HUMAN
MINT-68735   IRS1_HUMAN
MINT-74606   EGFR_HUMAN
MINT-74610   ERBB2_HUMAN
MINT-74617   ERBB3_HUMAN
MINT-1893011   GAB1_HUMAN
MINT-2840114   TLR3_HUMAN
MINT-3378272   SEPT2_HUMAN
MINT-6762880   IRS1_RAT
MINT-7103574   FLT3_HUMAN
MINT-7103638   MK08_HUMAN
MINT-7103655   CRKL_HUMAN
MINT-7251262   ICAL_HUMAN
MINT-7251286   SNX17_HUMAN
MINT-7251334   DAB2_HUMAN
MINT-7251346   CDC27_HUMAN
MINT-7251370   FLNA_HUMAN
MINT-7251382   SYNJ2_HUMAN
MINT-7251406   CSDE1_HUMAN
MINT-7251418   ABL1_HUMAN
MINT-7251430   SUV92_HUMAN
MINT-7251442   VP13A_HUMAN
MINT-7251454   FLNB_HUMAN
MINT-7251526   SOS1_HUMAN
MINT-7251538   ASAP2_HUMAN
MINT-7251550   LIPA3_HUMAN
MINT-7251562   AKAP2_HUMAN
MINT-7251574   ARHGB_HUMAN
MINT-7251598   PHAR2_HUMAN
MINT-7251610   DLGP4_HUMAN
MINT-7251622   ELK3_HUMAN
MINT-7251658   BRCA1_HUMAN
MINT-7251706   CKAP5_HUMAN
MINT-7251718   RRAS_HUMAN
MINT-7251730   ECT2_HUMAN
MINT-7251754   TPX2_HUMAN
MINT-7251766   JAK2_HUMAN
MINT-7251778   ASAP1_HUMAN
MINT-7251790   FLNC_HUMAN
MINT-7251802   DNLI3_HUMAN
MINT-7251814   TGON2_HUMAN
MINT-7251838   SHAN2_HUMAN
MINT-7251850   KI13A_HUMAN
MINT-7251862   ABL2_HUMAN
MINT-7251886   BRPF3_HUMAN
MINT-7251898   SH3K1_HUMAN
MINT-7251934   MYRIP_HUMAN
MINT-7251982   DAG1_HUMAN
MINT-7251994   STF1_HUMAN
MINT-7252006   P3C2B_HUMAN
MINT-7252018   SNX8_HUMAN
MINT-7252030   BRD4_HUMAN
MINT-7252078   MINT_HUMAN
MINT-7252126   PLCG2_HUMAN
MINT-7252150   MAP4_HUMAN
MINT-7252174   MYLK_HUMAN
MINT-7252186   PEBP1_HUMAN
MINT-7252234   CAF1A_HUMAN
MINT-7252258   DTBP1_HUMAN
MINT-7252270   NELFB_HUMAN
MINT-7252282   AKAP6_HUMAN
MINT-7252294   FANCA_HUMAN
MINT-7252318   GHR_HUMAN
MINT-7252330   M4K1_HUMAN
MINT-7252342   RPGF1_HUMAN
MINT-7296136   SRC_HUMAN
MINT-7306624   LCP2_HUMAN
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 688 GYGFAEPYNLYSSLKELVLHY - 9461588
LTP
1.00
PIK3R1 SH2 SH2
0.19
1H9O 15.72%
Y 688 GYGFAEPYNLYSSLKELVLHY - 11337495
LTP
1.00
PIK3R1 SH2 SH2
0.19
1H9O 15.72%

Substrate: CSFR-1 (Macrophage colony stimulating factor I receptor)
Seq-ID: P07333 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 723 SGFSSQGVDTYVEMRPVSTSS - N.N.
LTP
1.00
PIK3R1 SH2 TyrKc
0.46
- low

Substrate: CTLA-4 (CD152 antigen)
Seq-ID: P16410 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 201 KKRSPLTTGVYVKMPPTEPEC JAK2 10842319
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.37
- low
Y 201 KKRSPLTTGVYVKMPPTEPEC TXK 9813138
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.37
- low

Substrate: Tyrosine-protein phosphatase, non-receptor type 6 (Protein tyrosine phosphatase containing SH2 domains)
Seq-ID: P29350 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 564 RTSSKHKEDVYENLHTKNKRE - 12468540
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low
Y 564 RTSSKHKEDVYENLHTKNKRE Lck 8114715
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low
Y 564 RTSSKHKEDVYENLHTKNKRE Abl 8692915
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low
Y 564 RTSSKHKEDVYENLHTKNKRE - 14757045
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low
Y 564 RTSSKHKEDVYENLHTKNKRE SRC 14699166
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low
Y 564 RTSSKHKEDVYENLHTKNKRE Lck 10488096
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low
Y 564 RTSSKHKEDVYENLHTKNKRE - 18083107
HTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low

Substrate: SYK (Spleen tyrosine kinase )
Seq-ID: P43405 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 323 RQESTVSFNPYEPELAPWAAD - 16497976
HTP
0.80
CBLB SH2;
CBL PTB;
PIK3R1 SH2
-
0.51
--
Y 323 RQESTVSFNPYEPELAPWAAD - 18083107
HTP
0.80
CBLB SH2;
CBL PTB;
PIK3R1 SH2
-
0.51
--

Substrate: PDGF-R alpha (Receptor tyrosine kinase)
Seq-ID: P16234 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 731 VILSFENNGDYMDMKQADTTQ - 11818394
LTP
1.00
PIK3R1 SH2 TyrKc
0.29
- medium
Y 742 MDMKQADTTQYVPMLERKEVS - 11818394
LTP
1.00
PIK3R1 SH2 TyrKc
0.39
- medium

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 447 SVSSEELDENYVPMNPNSPPR INSR 10978177
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2
-
0.83
- low
Y 447 SVSSEELDENYVPMNPNSPPR EGFR 9890893
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2
-
0.83
- low
Y 447 SVSSEELDENYVPMNPNSPPR Met 10734310
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2
-
0.83
- low
Y 472 SFTEPIQEANYVPMTPGTFDF INSR 10978177
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.54
- low
Y 472 SFTEPIQEANYVPMTPGTFDF EGFR 9890893
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.54
- low
Y 472 SFTEPIQEANYVPMTPGTFDF Met 10734310
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.54
- low
Y 589 SSDSHDSEENYVPMNPNLSSE INSR 10978177
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.89
- low
Y 589 SSDSHDSEENYVPMNPNLSSE EGFR 9890893
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.89
- low
Y 589 SSDSHDSEENYVPMNPNLSSE Met 10734310
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.89
- low

Substrate: Gab2 (Adaptor molecule)
Seq-ID: Q9Z1S8 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 441 RSNSASSDDNYVPMNPGSSTL - 9885561
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 441 RSNSASSDDNYVPMNPGSSTL - 11334882
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 465 ERPGDNSQSVYIPMSPGPHHF - 9885561
LTP
0.15
PIK3R1 SH2 -
0.78
- medium
Y 465 ERPGDNSQSVYIPMSPGPHHF - 11334882
LTP
0.15
PIK3R1 SH2 -
0.78
- medium
Y 573 STDSGDSEENYVPMQNPVSAS - 9885561
LTP
0.93
PIK3R1 SH2 -
0.85
- medium
Y 573 STDSGDSEENYVPMQNPVSAS - 11334882
LTP
0.93
PIK3R1 SH2 -
0.85
- medium

Substrate: SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)
Seq-ID: Q13094 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 113 GGWSSFEEDDYESPNDDQDGE - 8892604
LTP
0.99
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.92
- medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 9047237
LTP
0.99
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.92
- medium
Y 113 GGWSSFEEDDYESPNDDQDGE SYK 15388330
LTP
0.99
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.92
- medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 12817019
LTP
0.99
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.92
- medium
Y 113 GGWSSFEEDDYESPNDDQDGE Lck 8702662
LTP
0.99
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.92
- medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 8702662
LTP
0.99
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.92
- medium
Y 128 DDQDGEDDGDYESPNEEEEAP - 8892604
LTP
0.30
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.98
- medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 9047237
LTP
0.30
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.98
- medium
Y 128 DDQDGEDDGDYESPNEEEEAP SYK 15388330
LTP
0.30
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.98
- medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 12817019
LTP
0.30
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.98
- medium
Y 128 DDQDGEDDGDYESPNEEEEAP Lck 8702662
LTP
0.30
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.98
- medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 8702662
LTP
0.30
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.98
- medium

Substrate: FCGR2B (protein binding)
Seq-ID: P31994 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 292 DKVGAENTITYSLLMHPDALE Lyn 8756631
LTP
1.00
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.42
- low
Y 292 DKVGAENTITYSLLMHPDALE BLK 8756631
LTP
1.00
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.42
- low

Substrate: c-kit (Receptor tyrosine kinase)
Seq-ID: P10721 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 721 ESSCSDSTNEYMDMKPGVSYV - N.N.
LTP
1.00
MATK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
TyrKc
0.36
--
Y 721 ESSCSDSTNEYMDMKPGVSYV - 9038210
LTP
1.00
MATK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
TyrKc
0.36
--
Y 900 LSPEHAPAEMYDIMKTCWDAD SRC_group 12878163
LTP
1.00
PIK3R1 SH2 TyrKc
0.24
1T46 16.16%
Y 900 LSPEHAPAEMYDIMKTCWDAD SRC 12878163
LTP
1.00
PIK3R1 SH2 TyrKc
0.24
1T46 16.16%

Substrate: LAT (Adaptor molecule involved in the TCR signal pathway)
Seq-ID: O43561 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 220 AEASLDGSREYVNVSQELHPG - 15659558
HTP
1.00
GRAP2 SH2;
GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
VAV1 SH2
-
0.71
- medium

Substrate: FAK (Focal adhesion kinase)
Seq-ID: Q05397 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 397 HAVSVSETDDYAEIIDEEDTY FAK 7509446
LTP
1.00
Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2
-
0.49
--
Y 397 HAVSVSETDDYAEIIDEEDTY - 17192257
HTP
1.00
Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2
-
0.49
--
Y 397 HAVSVSETDDYAEIIDEEDTY - 18083107
HTP
1.00
Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2
-
0.49
--

Substrate: Insulin receptor substrate 2 (Adaptor molecule)
Seq-ID: Q9Y4H2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 653 SSSNLGADDGYMPMTPGAALA - 16497976
HTP
1.00
PIK3R1 SH2 -
0.60
- medium
Y 653 SSSNLGADDGYMPMTPGAALA - 18083107
HTP
1.00
PIK3R1 SH2 -
0.60
- medium
Y 675 SGSGSCRSDDYMPMSPASVSA - 16497976
HTP
1.00
PIK3R1 SH2 -
0.59
- medium
Y 675 SGSGSCRSDDYMPMSPASVSA - 18083107
HTP
1.00
PIK3R1 SH2 -
0.59
- medium
Y 675 SGSGSCRSDDYMPMSPASVSA - 18669648
HTP
1.00
PIK3R1 SH2 -
0.59
- medium
Y 742 PAESSPEDSGYMRMWCGSKLS - 18083107
HTP
1.00
PIK3R1 SH2 -
0.49
- medium
Y 823 PYTCGGDSDQYVLMSSPVGRI - 16497976
HTP
0.47
PIK3R1 SH2 -
0.46
- medium
Y 823 PYTCGGDSDQYVLMSSPVGRI - 18083107
HTP
0.47
PIK3R1 SH2 -
0.46
- medium

Substrate: CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID: P22681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 371 IKVTQEQYELYCEMGSTFQLC - 10635327
LTP
1.00
PIK3R1 SH2 -
0.11
1FBV 5.24%
Y 371 IKVTQEQYELYCEMGSTFQLC INSR 11997497
LTP
1.00
PIK3R1 SH2 -
0.11
1FBV 5.24%
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA SYK 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA Yes 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 10934191
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9890970
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 12604776
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 15922744
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 944 PQPPICTIDVYMIMVKCWMID SRC 11983694
LTP
1.00
PIK3R1 SH2;
Src SH2
TyrKc
0.05
3BEL 16.16%
Y 1092 IDDTFLPVPEYINQSVPKRPA EGFR 8845374
LTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 15302935
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 17081983
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 18083107
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 504 IPAAEPLPPSYVACS       - 10579919
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low
Y 504 IPAAEPLPPSYVACS       - 7559499
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low
Y 504 IPAAEPLPPSYVACS       - 9573010
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low

Substrate: IGF1-R (Receptor tyrosine kinase)
Seq-ID: P08069 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1346 LRASFDERQPYAHMNGGRKNE IGF1R 8550552
LTP
1.00
Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.63
--

Substrate: IL-7R alpha (Cytokin receptor)
Seq-ID: P16871 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 449 TSLGSNQEEAYVTMSSFYQNQ - 7719938
LTP
1.00
PIK3R1 SH2;
STAT5 SH2
-
0.40
- medium

Substrate: RET (Probable receptor with tyrosine-protein kinase activity; important for development.)
Seq-ID: P07949 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1062 LPSTWIENKLYGMSDPNWPGE - 11470823
LTP
0.19
FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2
-
0.43
--
Y 1062 LPSTWIENKLYGMSDPNWPGE RET 14711813
LTP
0.19
FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2
-
0.43
--
Y 1062 LPSTWIENKLYGMSDPNWPGE RET 14981541
LTP
0.19
FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2
-
0.43
--

Substrate: CD136 (Receptor tyrosine kinase)
Seq-ID: Q04912 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1353 QIVSALLGDHYVQLPATYMNL RON 10871856
LTP
1.00
GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
SHC1 SH2
-
0.21
- low
Y 1360 GDHYVQLPATYMNLGPSTSHE RON 10871856
LTP
1.00
GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
SHC1 SH2
-
0.40
- low

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 579 IESVSSDGHEYIYVDPMQLPY PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2
-
0.15
- medium
Y 581 SVSSDGHEYIYVDPMQLPYDS PDGFR_beta 8617789
LTP
1.00
Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2
-
0.16
- medium
Y 740 VSLTGESDGGYMDMSKDESVD PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2
TyrKc
0.45
- medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2
TyrKc
0.29
- medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_group 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2
TyrKc
0.29
- medium
Y 1009 RSPLDTSSVLYTAVQPNEGDN PDGFR_beta 8195171
LTP
0.02
NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2
-
0.61
- medium
Y 1021 AVQPNEGDNDYIIPLPDPKPE PDGFR_beta 12062403
LTP
1.00
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2
-
0.75
- medium

Substrate: IL-1R-1 (interleukin-1 receptor, type I precursor (IL-1R-1) (p80) (from PhosphoBase))
Seq-ID: P14778 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 496 VLLELEKIQDYEKMPESIKFI - 9821957
LTP
1.00
PIK3R1 SH2 TIR
0.14
- low

Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID: P08581 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1313 LQPEYCPDPLYEVMLKCWHPK - 7708691
LTP
0.97
PIK3R1 SH2;
STAT3 SH2
TyrKc
0.10
3F66 15.28%
Y 1313 LQPEYCPDPLYEVMLKCWHPK - 10069803
LTP
0.97
PIK3R1 SH2;
STAT3 SH2
TyrKc
0.10
3F66 15.28%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 12475979
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9444958
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9252406
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 7513258
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7731718
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7687741
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9826708
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 12475979
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9444958
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9252406
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 7513258
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7731718
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 8662889
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7961992
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7687741
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9826708
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%

Substrate: TIE2 (TEK) (PTK receptor for angiopoietin 1)
Seq-ID: Q02763 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 897 NLLGACEHRGYLYLAIEYAPH - 11080633
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
TyrKc
0.05
1FVR 36.24%
Y 897 NLLGACEHRGYLYLAIEYAPH - 11513602
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
TyrKc
0.05
1FVR 36.24%
Y 1102 LNRMLEERKTYVNTTLYEKFT - 10521483
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%
Y 1102 LNRMLEERKTYVNTTLYEKFT - 9632797
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%
Y 1102 LNRMLEERKTYVNTTLYEKFT TIE2 12082108
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%
Y 1108 ERKTYVNTTLYEKFTYAGIDC TIE2 10521483
LTP
0.08
DOK_group PTB;
GRB14 SH2;
PIK3R1 SH2
-
0.11
1FVR 76.42%
Y 1108 ERKTYVNTTLYEKFTYAGIDC TIE2 12665569
LTP
0.08
DOK_group PTB;
GRB14 SH2;
PIK3R1 SH2
-
0.11
1FVR 76.42%
Y 1113 VNTTLYEKFTYAGIDCSAEEA TIE2 10521483
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.12
1FVR 15.72%
Y 1113 VNTTLYEKFTYAGIDCSAEEA - 12665569
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.12
1FVR 15.72%

Substrate: CD28 (Involved in T cell activation)
Seq-ID: P10747 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 191 SKRSRLLHSDYMNMTPRRPGP Lck 8992971
LTP
0.95
GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2
-
0.44
- medium
Y 191 SKRSRLLHSDYMNMTPRRPGP ITK 8992971
LTP
0.95
GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2
-
0.44
- medium
Y 191 SKRSRLLHSDYMNMTPRRPGP - 16094384
HTP
0.95
GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2
-
0.44
- medium

Substrate: VEGFR-1 (Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity.)
Seq-ID: P17948 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1169 QANVQQDGKDYIPINAILTGN - 11513746
LTP
1.00
PIK3R1 SH2;
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low
Y 1169 QANVQQDGKDYIPINAILTGN - 9299537
LTP
1.00
PIK3R1 SH2;
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low
Y 1213 FNSGSSDDVRYVNAFKFMSLE FLT1 11513746
LTP
1.00
GRB2 SH2;
NCK SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.20
- low
Y 1213 FNSGSSDDVRYVNAFKFMSLE FLT1 9722576
LTP
1.00
GRB2 SH2;
NCK SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.20
- low
Y 1213 FNSGSSDDVRYVNAFKFMSLE - 9600074
LTP
1.00
GRB2 SH2;
NCK SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.20
- low

Substrate: Src (Proto-oncogene tyrosine-protein kinase Src)
Seq-ID: P12931 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14765   DDR2_HUMAN
MINT-15459   CAV1_HUMAN
MINT-46002   CTNB1_MOUSE
MINT-50376   RASH_HUMAN
MINT-62340   KPCD_HUMAN
MINT-62342   CDCP1_HUMAN
MINT-65953   DYN1_HUMAN
MINT-65954   DYN2_HUMAN
MINT-68512   PDC6I_HUMAN
MINT-74753   ERBB3_HUMAN
MINT-2792760   PAK2_HUMAN
MINT-2793013   ADA15_HUMAN
MINT-2840132   TLR3_HUMAN
MINT-3381308   FAK1_HUMAN
MINT-3381360   FYN_HUMAN
MINT-4051815   ADRB2_HUMAN
MINT-4961196   AFAD_HUMAN
MINT-4980122   SNIP_MOUSE
MINT-5210599   SNIP_HUMAN
MINT-6539730   CBL_HUMAN
MINT-6771405   FAK1_MOUSE
MINT-6794909   ACTS_HUMAN
MINT-6795322   ACTN1_HUMAN
MINT-6795447   PTN1_HUMAN
MINT-7035260   HNRPK_HUMAN
MINT-7040283   CBLB_HUMAN
MINT-7104422   BCAR1_HUMAN
MINT-7145938   RL10_HUMAN
MINT-7244986   ASAP1_HUMAN
MINT-7244998   FANCA_HUMAN
MINT-7245022   PHAR2_HUMAN
MINT-7245034   ABL1_HUMAN
MINT-7245058   DLGP4_HUMAN
MINT-7245070   SNX17_HUMAN
MINT-7245106   RTN4_HUMAN
MINT-7245118   ASAP2_HUMAN
MINT-7245142   E41L3_HUMAN
MINT-7245154   ICAL_HUMAN
MINT-7245214   FCG2B_HUMAN
MINT-7245226   FCG2C_HUMAN
MINT-7245334   SHAN2_HUMAN
MINT-7245346   SHRM2_HUMAN
MINT-7245358   DNLI3_HUMAN
MINT-7245370   EIF3D_HUMAN
MINT-7245406   HCN2_HUMAN
MINT-7245490   CKAP5_HUMAN
MINT-7245502   M4K1_HUMAN
MINT-7245538   RPP38_HUMAN
MINT-7245562   SP1_HUMAN
MINT-7245574   DOCK1_HUMAN
MINT-7245586   RLGPB_HUMAN
MINT-7245598   ABL2_HUMAN
MINT-7245610   CELR2_HUMAN
MINT-7245622   SOS1_HUMAN
MINT-7245634   AKAP6_HUMAN
MINT-7245670   DPOD1_HUMAN
MINT-7245682   DAG1_HUMAN
MINT-7245694   SNX3_HUMAN
MINT-7245730   KI67_HUMAN
MINT-7245742   CD97_HUMAN
MINT-7245754   RPGF1_HUMAN
MINT-7245778   ACAP1_HUMAN
MINT-7245790   PRIC3_HUMAN
MINT-7245814   AKAP2_HUMAN
MINT-7245826   RRAS_HUMAN
MINT-7296136   P85A_HUMAN
MINT-7296149   ACTB_HUMAN
MINT-7306598   LCP2_HUMAN
MINT-7552515   PTPRA_MOUSE
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 530 EDYFTSTEPQYQPGENL     - 3103926
LTP
0.94
MOD_TYR_CSK
Csk SH2;
Fyn SH2;
Lck SH2;
PIK3R1 SH2;
Src SH2
-
0.46
1FMK 18.34%
Y 530 EDYFTSTEPQYQPGENL     Csk 12468645
LTP
0.94
MOD_TYR_CSK
Csk SH2;
Fyn SH2;
Lck SH2;
PIK3R1 SH2;
Src SH2
-
0.46
1FMK 18.34%
Y 530 EDYFTSTEPQYQPGENL     - 12387813
LTP
0.94
MOD_TYR_CSK
Csk SH2;
Fyn SH2;
Lck SH2;
PIK3R1 SH2;
Src SH2
-
0.46
1FMK 18.34%

Substrate: TRKA (Required for high affinity binding to nerve growth factor , neurotrophin-3 and neurotrophin-4/5r.)
Seq-ID: P04629 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 757 ERPRACPPEVYAIMRGCWQRE - 16319926
LTP
1.00
PIK3R1 SH2;
SH2D1A SH2
TyrKc
0.24
- medium

Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1355 GGSSLGFKRSYEEHIPYTHMN INSR 1321605
LTP
0.85
GRB10 SH2;
PIK3R1 SH2
-
0.50
--
Y 1361 FKRSYEEHIPYTHMNGGKKNG INSR 1321605
LTP
0.95
Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2;
SHC1 SH2
-
0.54
--

Substrate: TRKB (Receptor for brain-derived neurothrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5.)
Seq-ID: P15209 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 782 QRPRTCPQEVYELMLGCWQRE - 8226808
LTP
1.00
PIK3R1 SH2 TyrKc
0.18
- medium

Substrate: Erzin (Connection of cytoscheletro structure to plasma membrane)
Seq-ID: P15311 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 354 KEELMLRLQDYEEKTKKAERE EGFR 1382070
LTP
0.22
PIK3R1 SH2 COIL
0.49
--

Substrate: CD19 (Antigen of human B-lymphocytes)
Seq-ID: P15391 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 500 REATSLGSQSYEDMRGILYAA - 9190913
LTP
1.00
PIK3R1 SH2 -
0.73
- medium
Y 500 REATSLGSQSYEDMRGILYAA Lyn 10933394
LTP
1.00
PIK3R1 SH2 -
0.73
- medium
Y 531 GPNHEEDADSYENMDNPDGPD - 9190913
LTP
1.00
PIK3R1 SH2 -
0.97
- medium
Y 531 GPNHEEDADSYENMDNPDGPD Lyn 10933394
LTP
1.00
PIK3R1 SH2 -
0.97
- medium


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