List of substrates found:

ALK  ErbB3  IKB-alpha  Insulin receptor substrate 1  PI3-kinase p85-alpha subunit  CSFR-1  CTLA-4  Tyrosine-protein phosphatase, non-receptor type 6  SYK  PDGF-R alpha  Gab1  Gab2  SLP-76  FCGR2B  c-kit  LAT  FAK  Insulin receptor substrate 2  CBL E3 ubiquitin protein ligase  EGFR  Epo-R  IGF1-R  IL-7R alpha  RET  CD136  PDGF-R beta  IL-1R-1  c-met  TIE2 (TEK)  CD28  VEGFR-1  Src  TRKA  Insulin R  TRKB  Erzin  CD19 


Substrate: ALK (Receptor tyrosine kinase)
Seq-ID: Q9UM73 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1359 DPPKNCPGPVYRIMTQCWQHQ - 18083107
HTP
1.00
PIK3R1 SH2 TyrKc
0.42
- medium

Substrate: ErbB3 (Receptor tyrosine kinase)
Seq-ID: P21860 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1199 EEEDEDEEYEYMNRRRRHSPP - 9516479
LTP
1.00
GRB7 SH2;
PIK3R1 SH2
-
0.92
- medium
Y 1276 QRDGGGPGGDYAAMGACPASE - 11546794
LTP
0.31
PIK3R1 SH2 -
0.76
- medium
Y 1289 MGACPASEQGYEEMRAFQGPG - 11546794
LTP
0.12
PIK3R1 SH2 -
0.67
- medium

Substrate: IKB-alpha (Major histocompatibility complex enhancer-binding protein MAD3)
Seq-ID: P25963 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 42 SGLDSMKDEEYEQMVKELQEI Lck 8797825
LTP
1.00
PIK3R1 SH2 -
0.55
--
Y 42 SGLDSMKDEEYEQMVKELQEI - 12432072
LTP
1.00
PIK3R1 SH2 -
0.55
--
Y 42 SGLDSMKDEEYEQMVKELQEI SRC 9792645
LTP
1.00
PIK3R1 SH2 -
0.55
--

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35568 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 612 DSSTLHTDDGYMPMSPGVAPV - 15001544
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.81
--
Y 612 DSSTLHTDDGYMPMSPGVAPV - 18083107
HTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.81
--
Y 632 VPSGRKGSGDYMPMSPKSVSA - 15001544
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.83
--
Y 632 VPSGRKGSGDYMPMSPKSVSA - 18083107
HTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.83
--
Y 662 RHPQRVDPNGYMMMSPSGGCS - 15592455
HTP
1.00
Fyn SH2;
MATK SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.77
--

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35569 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 608 DTSNLHTDDGYMPMSPGVAPV - 9395471
LTP
1.00
PIK3R1 SH2 -
0.80
--
Y 608 DTSNLHTDDGYMPMSPGVAPV - 15821749
LTP
1.00
PIK3R1 SH2 -
0.80
--

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35570 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 608 DSSNLHTDDGYMPMSPGVAPV INSR 7504175
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 608 DSSNLHTDDGYMPMSPGVAPV - 12220227
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 608 DSSNLHTDDGYMPMSPGVAPV IGF1R 11572799
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 608 DSSNLHTDDGYMPMSPGVAPV INSR 11572799
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 628 VPSNRKGNGDYMPMSPKSVSA INSR 7504175
LTP
1.00
PIK3R1 SH2 -
0.81
- medium
Y 628 VPSNRKGNGDYMPMSPKSVSA IGF1R 11572799
LTP
1.00
PIK3R1 SH2 -
0.81
- medium
Y 628 VPSNRKGNGDYMPMSPKSVSA INSR 11572799
LTP
1.00
PIK3R1 SH2 -
0.81
- medium
Y 939 APREETGSEEYMNMDLGPGRR INSR 7504175
LTP
1.00
PIK3R1 SH2 -
0.87
- medium
Y 939 APREETGSEEYMNMDLGPGRR IGF1R 11572799
LTP
1.00
PIK3R1 SH2 -
0.87
- medium
Y 939 APREETGSEEYMNMDLGPGRR INSR 11572799
LTP
1.00
PIK3R1 SH2 -
0.87
- medium

Substrate: PI3-kinase p85-alpha subunit (Adaptor molecule. Phopshatidylinositol 3-kinase regulatory alpha subunit.)
Seq-ID: P27986 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16109   ARAF_HUMAN
MINT-17501   SHC1_HUMAN
MINT-19009   CDC42_HUMAN
MINT-56732   KSYK_HUMAN
MINT-56734   KSYK_MOUSE
MINT-65974   GRB2_HUMAN
MINT-66003   LCK_HUMAN
MINT-68496   GAB2_HUMAN
MINT-68500   CBL_HUMAN
MINT-68735   IRS1_HUMAN
MINT-74606   EGFR_HUMAN
MINT-74610   ERBB2_HUMAN
MINT-74617   ERBB3_HUMAN
MINT-1893011   GAB1_HUMAN
MINT-2840114   TLR3_HUMAN
MINT-3378272   SEPT2_HUMAN
MINT-6762880   IRS1_RAT
MINT-7103574   FLT3_HUMAN
MINT-7103638   MK08_HUMAN
MINT-7103655   CRKL_HUMAN
MINT-7251262   ICAL_HUMAN
MINT-7251286   SNX17_HUMAN
MINT-7251334   DAB2_HUMAN
MINT-7251346   CDC27_HUMAN
MINT-7251370   FLNA_HUMAN
MINT-7251382   SYNJ2_HUMAN
MINT-7251406   CSDE1_HUMAN
MINT-7251418   ABL1_HUMAN
MINT-7251430   SUV92_HUMAN
MINT-7251442   VP13A_HUMAN
MINT-7251454   FLNB_HUMAN
MINT-7251526   SOS1_HUMAN
MINT-7251538   ASAP2_HUMAN
MINT-7251550   LIPA3_HUMAN
MINT-7251562   AKAP2_HUMAN
MINT-7251574   ARHGB_HUMAN
MINT-7251598   PHAR2_HUMAN
MINT-7251610   DLGP4_HUMAN
MINT-7251622   ELK3_HUMAN
MINT-7251658   BRCA1_HUMAN
MINT-7251706   CKAP5_HUMAN
MINT-7251718   RRAS_HUMAN
MINT-7251730   ECT2_HUMAN
MINT-7251754   TPX2_HUMAN
MINT-7251766   JAK2_HUMAN
MINT-7251778   ASAP1_HUMAN
MINT-7251790   FLNC_HUMAN
MINT-7251802   DNLI3_HUMAN
MINT-7251814   TGON2_HUMAN
MINT-7251838   SHAN2_HUMAN
MINT-7251850   KI13A_HUMAN
MINT-7251862   ABL2_HUMAN
MINT-7251886   BRPF3_HUMAN
MINT-7251898   SH3K1_HUMAN
MINT-7251934   MYRIP_HUMAN
MINT-7251982   DAG1_HUMAN
MINT-7251994   STF1_HUMAN
MINT-7252006   P3C2B_HUMAN
MINT-7252018   SNX8_HUMAN
MINT-7252030   BRD4_HUMAN
MINT-7252078   MINT_HUMAN
MINT-7252126   PLCG2_HUMAN
MINT-7252150   MAP4_HUMAN
MINT-7252174   MYLK_HUMAN
MINT-7252186   PEBP1_HUMAN
MINT-7252234   CAF1A_HUMAN
MINT-7252258   DTBP1_HUMAN
MINT-7252270   NELFB_HUMAN
MINT-7252282   AKAP6_HUMAN
MINT-7252294   FANCA_HUMAN
MINT-7252318   GHR_HUMAN
MINT-7252330   M4K1_HUMAN
MINT-7252342   RPGF1_HUMAN
MINT-7296136   SRC_HUMAN
MINT-7306624   LCP2_HUMAN
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 688 GYGFAEPYNLYSSLKELVLHY - 9461588
LTP
1.00
PIK3R1 SH2 SH2
0.19
1H9O 15.72%
Y 688 GYGFAEPYNLYSSLKELVLHY - 11337495
LTP
1.00
PIK3R1 SH2 SH2
0.19
1H9O 15.72%

Substrate: CSFR-1 (Macrophage colony stimulating factor I receptor)
Seq-ID: P07333 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 723 SGFSSQGVDTYVEMRPVSTSS - N.N.
LTP
1.00
PIK3R1 SH2 TyrKc
0.46
- low

Substrate: CTLA-4 (CD152 antigen)
Seq-ID: P16410 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 201 KKRSPLTTGVYVKMPPTEPEC JAK2 10842319
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.37
- low
Y 201 KKRSPLTTGVYVKMPPTEPEC TXK 9813138
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.37
- low

Substrate: Tyrosine-protein phosphatase, non-receptor type 6 (Protein tyrosine phosphatase containing SH2 domains)
Seq-ID: P29350 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 564 RTSSKHKEDVYENLHTKNKRE - 12468540
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low
Y 564 RTSSKHKEDVYENLHTKNKRE Lck 8114715
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low
Y 564 RTSSKHKEDVYENLHTKNKRE Abl 8692915
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low
Y 564 RTSSKHKEDVYENLHTKNKRE - 14757045
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low
Y 564 RTSSKHKEDVYENLHTKNKRE SRC 14699166
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low
Y 564 RTSSKHKEDVYENLHTKNKRE Lck 10488096
LTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low
Y 564 RTSSKHKEDVYENLHTKNKRE - 18083107
HTP
0.31
PIK3R1 SH2;
SH3BP2 SH2
-
0.72
- low

Substrate: SYK (Spleen tyrosine kinase )
Seq-ID: P43405 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 323 RQESTVSFNPYEPELAPWAAD - 16497976
HTP
0.80
CBLB SH2;
CBL PTB;
PIK3R1 SH2
-
0.51
--
Y 323 RQESTVSFNPYEPELAPWAAD - 18083107
HTP
0.80
CBLB SH2;
CBL PTB;
PIK3R1 SH2
-
0.51
--

Substrate: PDGF-R alpha (Receptor tyrosine kinase)
Seq-ID: P16234 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 731 VILSFENNGDYMDMKQADTTQ - 11818394
LTP
1.00
PIK3R1 SH2 TyrKc
0.29
- medium
Y 742 MDMKQADTTQYVPMLERKEVS - 11818394
LTP
1.00
PIK3R1 SH2 TyrKc
0.39
- medium

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 447 SVSSEELDENYVPMNPNSPPR INSR 10978177
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2
-
0.83
- low
Y 447 SVSSEELDENYVPMNPNSPPR EGFR 9890893
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2
-
0.83
- low
Y 447 SVSSEELDENYVPMNPNSPPR Met 10734310
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2
-
0.83
- low
Y 472 SFTEPIQEANYVPMTPGTFDF INSR 10978177
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.54
- low
Y 472 SFTEPIQEANYVPMTPGTFDF EGFR 9890893
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.54
- low
Y 472 SFTEPIQEANYVPMTPGTFDF Met 10734310
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.54
- low
Y 589 SSDSHDSEENYVPMNPNLSSE INSR 10978177
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.89
- low
Y 589 SSDSHDSEENYVPMNPNLSSE EGFR 9890893
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.89
- low
Y 589 SSDSHDSEENYVPMNPNLSSE Met 10734310
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.89
- low

Substrate: Gab2 (Adaptor molecule)
Seq-ID: Q9Z1S8 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 441 RSNSASSDDNYVPMNPGSSTL - 9885561
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 441 RSNSASSDDNYVPMNPGSSTL - 11334882
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 465 ERPGDNSQSVYIPMSPGPHHF - 9885561
LTP
0.15
PIK3R1 SH2 -
0.78
- medium
Y 465 ERPGDNSQSVYIPMSPGPHHF - 11334882
LTP
0.15
PIK3R1 SH2 -
0.78
- medium
Y 573 STDSGDSEENYVPMQNPVSAS - 9885561
LTP
0.93
PIK3R1 SH2 -
0.85
- medium
Y 573 STDSGDSEENYVPMQNPVSAS - 11334882
LTP
0.93
PIK3R1 SH2 -
0.85
- medium

Substrate: SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)
Seq-ID: Q13094 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 113 GGWSSFEEDDYESPNDDQDGE - 8892604
LTP
0.99
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.92
- medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 9047237
LTP
0.99
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.92
- medium
Y 113 GGWSSFEEDDYESPNDDQDGE SYK 15388330
LTP
0.99
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.92
- medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 12817019
LTP
0.99
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.92
- medium
Y 113 GGWSSFEEDDYESPNDDQDGE Lck 8702662
LTP
0.99
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.92
- medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 8702662
LTP
0.99
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.92
- medium
Y 128 DDQDGEDDGDYESPNEEEEAP - 8892604
LTP
0.30
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.98
- medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 9047237
LTP
0.30
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.98
- medium
Y 128 DDQDGEDDGDYESPNEEEEAP SYK 15388330
LTP
0.30
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.98
- medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 12817019
LTP
0.30
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.98
- medium
Y 128 DDQDGEDDGDYESPNEEEEAP Lck 8702662
LTP
0.30
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.98
- medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 8702662
LTP
0.30
ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2
-
0.98
- medium

Substrate: FCGR2B (protein binding)
Seq-ID: P31994 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 292 DKVGAENTITYSLLMHPDALE Lyn 8756631
LTP
1.00
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.42
- low
Y 292 DKVGAENTITYSLLMHPDALE BLK 8756631
LTP
1.00
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.42
- low

Substrate: c-kit (Receptor tyrosine kinase)
Seq-ID: P10721 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 721 ESSCSDSTNEYMDMKPGVSYV - N.N.
LTP
1.00
MATK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
TyrKc
0.36
--
Y 721 ESSCSDSTNEYMDMKPGVSYV - 9038210
LTP
1.00
MATK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
TyrKc
0.36
--
Y 900 LSPEHAPAEMYDIMKTCWDAD SRC_group 12878163
LTP
1.00
PIK3R1 SH2 TyrKc
0.24
1T46 16.16%
Y 900 LSPEHAPAEMYDIMKTCWDAD SRC 12878163
LTP
1.00
PIK3R1 SH2 TyrKc
0.24
1T46 16.16%

Substrate: LAT (Adaptor molecule involved in the TCR signal pathway)
Seq-ID: O43561 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 220 AEASLDGSREYVNVSQELHPG - 15659558
HTP
1.00
GRAP2 SH2;
GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
VAV1 SH2
-
0.71
- medium

Substrate: FAK (Focal adhesion kinase)
Seq-ID: Q05397 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 397 HAVSVSETDDYAEIIDEEDTY FAK 7509446
LTP
1.00
Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2
-
0.49
--
Y 397 HAVSVSETDDYAEIIDEEDTY - 17192257
HTP
1.00
Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2
-
0.49
--
Y 397 HAVSVSETDDYAEIIDEEDTY - 18083107
HTP
1.00
Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2
-
0.49
--

Substrate: Insulin receptor substrate 2 (Adaptor molecule)
Seq-ID: Q9Y4H2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 653 SSSNLGADDGYMPMTPGAALA - 16497976
HTP
1.00
PIK3R1 SH2 -
0.60
- medium
Y 653 SSSNLGADDGYMPMTPGAALA - 18083107
HTP
1.00
PIK3R1 SH2 -
0.60
- medium
Y 675 SGSGSCRSDDYMPMSPASVSA - 16497976
HTP
1.00
PIK3R1 SH2 -
0.59
- medium
Y 675 SGSGSCRSDDYMPMSPASVSA - 18083107
HTP
1.00
PIK3R1 SH2 -
0.59
- medium
Y 675 SGSGSCRSDDYMPMSPASVSA - 18669648
HTP
1.00
PIK3R1 SH2 -
0.59
- medium
Y 742 PAESSPEDSGYMRMWCGSKLS - 18083107
HTP
1.00
PIK3R1 SH2 -
0.49
- medium
Y 823 PYTCGGDSDQYVLMSSPVGRI - 16497976
HTP
0.47
PIK3R1 SH2 -
0.46
- medium
Y 823 PYTCGGDSDQYVLMSSPVGRI - 18083107
HTP
0.47
PIK3R1 SH2 -
0.46
- medium

Substrate: CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID: P22681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 371 IKVTQEQYELYCEMGSTFQLC - 10635327
LTP
1.00
PIK3R1 SH2 -
0.11
1FBV 5.24%
Y 371 IKVTQEQYELYCEMGSTFQLC INSR 11997497
LTP
1.00
PIK3R1 SH2 -
0.11
1FBV 5.24%
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA SYK 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA Yes 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 10934191
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9890970
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 12604776
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 15922744
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 944 PQPPICTIDVYMIMVKCWMID SRC 11983694
LTP
1.00
PIK3R1 SH2;
Src SH2
TyrKc
0.05
3BEL 16.16%
Y 1092 IDDTFLPVPEYINQSVPKRPA EGFR 8845374
LTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 15302935
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 17081983
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 18083107
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 504 IPAAEPLPPSYVACS       - 10579919
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low
Y 504 IPAAEPLPPSYVACS       - 7559499
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low
Y 504 IPAAEPLPPSYVACS       - 9573010
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low

Substrate: IGF1-R (Receptor tyrosine kinase)
Seq-ID: P08069 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1346 LRASFDERQPYAHMNGGRKNE IGF1R 8550552
LTP
1.00
Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.63
--

Substrate: IL-7R alpha (Cytokin receptor)
Seq-ID: P16871 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 449 TSLGSNQEEAYVTMSSFYQNQ - 7719938
LTP
1.00
PIK3R1 SH2;
STAT5 SH2
-
0.40
- medium

Substrate: RET (Probable receptor with tyrosine-protein kinase activity; important for development.)
Seq-ID: P07949 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1062 LPSTWIENKLYGMSDPNWPGE - 11470823
LTP
0.19
FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2
-
0.43
--
Y 1062 LPSTWIENKLYGMSDPNWPGE RET 14711813
LTP
0.19
FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2
-
0.43
--
Y 1062 LPSTWIENKLYGMSDPNWPGE RET 14981541
LTP
0.19
FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2
-
0.43
--

Substrate: CD136 (Receptor tyrosine kinase)
Seq-ID: Q04912 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1353 QIVSALLGDHYVQLPATYMNL RON 10871856
LTP
1.00
GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
SHC1 SH2
-
0.21
- low
Y 1360 GDHYVQLPATYMNLGPSTSHE RON 10871856
LTP
1.00
GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
SHC1 SH2
-
0.40
- low

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 579 IESVSSDGHEYIYVDPMQLPY PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2
-
0.15
- medium
Y 581 SVSSDGHEYIYVDPMQLPYDS PDGFR_beta 8617789
LTP
1.00
Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2
-
0.16
- medium
Y 740 VSLTGESDGGYMDMSKDESVD PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2
TyrKc
0.45
- medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2
TyrKc
0.29
- medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_group 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2
TyrKc
0.29
- medium
Y 1009 RSPLDTSSVLYTAVQPNEGDN PDGFR_beta 8195171
LTP
0.02
NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2
-
0.61
- medium
Y 1021 AVQPNEGDNDYIIPLPDPKPE PDGFR_beta 12062403
LTP
1.00
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2
-
0.75
- medium

Substrate: IL-1R-1 (interleukin-1 receptor, type I precursor (IL-1R-1) (p80) (from PhosphoBase))
Seq-ID: P14778 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 496 VLLELEKIQDYEKMPESIKFI - 9821957
LTP
1.00
PIK3R1 SH2 TIR
0.14
- low

Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID: P08581 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1313 LQPEYCPDPLYEVMLKCWHPK - 7708691
LTP
0.97
PIK3R1 SH2;
STAT3 SH2
TyrKc
0.10
3F66 15.28%
Y 1313 LQPEYCPDPLYEVMLKCWHPK - 10069803
LTP
0.97
PIK3R1 SH2;
STAT3 SH2
TyrKc
0.10
3F66 15.28%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 12475979
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9444958
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9252406
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 7513258
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7731718
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7687741
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9826708
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 12475979
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9444958
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9252406
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 7513258
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7731718
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 8662889
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7961992
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7687741
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9826708
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%

Substrate: TIE2 (TEK) (PTK receptor for angiopoietin 1)
Seq-ID: Q02763 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 897 NLLGACEHRGYLYLAIEYAPH - 11080633
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
TyrKc
0.05
1FVR 36.24%
Y 897 NLLGACEHRGYLYLAIEYAPH - 11513602
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
TyrKc
0.05
1FVR 36.24%
Y 1102 LNRMLEERKTYVNTTLYEKFT - 10521483
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%
Y 1102 LNRMLEERKTYVNTTLYEKFT - 9632797
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%
Y 1102 LNRMLEERKTYVNTTLYEKFT TIE2 12082108
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%
Y 1108 ERKTYVNTTLYEKFTYAGIDC TIE2 10521483
LTP
0.08
DOK_group PTB;
GRB14 SH2;
PIK3R1 SH2
-
0.11
1FVR 76.42%
Y 1108 ERKTYVNTTLYEKFTYAGIDC TIE2 12665569
LTP
0.08
DOK_group PTB;
GRB14 SH2;
PIK3R1 SH2
-
0.11
1FVR 76.42%
Y 1113 VNTTLYEKFTYAGIDCSAEEA TIE2 10521483
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.12
1FVR 15.72%
Y 1113 VNTTLYEKFTYAGIDCSAEEA - 12665569
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.12
1FVR 15.72%

Substrate: CD28 (Involved in T cell activation)
Seq-ID: P10747 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 191 SKRSRLLHSDYMNMTPRRPGP Lck 8992971
LTP
0.95
GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2
-
0.44
- medium
Y 191 SKRSRLLHSDYMNMTPRRPGP ITK 8992971
LTP
0.95
GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2
-
0.44
- medium
Y 191 SKRSRLLHSDYMNMTPRRPGP - 16094384
HTP
0.95
GRAP2 SH2;
GRB2 SH2;
ITK SH2;
PIK3R1 SH2
-
0.44
- medium

Substrate: VEGFR-1 (Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity.)
Seq-ID: P17948 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1169 QANVQQDGKDYIPINAILTGN - 11513746
LTP
1.00
PIK3R1 SH2;
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low
Y 1169 QANVQQDGKDYIPINAILTGN - 9299537
LTP
1.00
PIK3R1 SH2;
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low
Y 1213 FNSGSSDDVRYVNAFKFMSLE FLT1 11513746
LTP
1.00
GRB2 SH2;
NCK SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.20
- low
Y 1213 FNSGSSDDVRYVNAFKFMSLE FLT1 9722576
LTP
1.00
GRB2 SH2;
NCK SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.20
- low
Y 1213 FNSGSSDDVRYVNAFKFMSLE - 9600074
LTP
1.00
GRB2 SH2;
NCK SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.20
- low

Substrate: Src (Proto-oncogene tyrosine-protein kinase Src)
Seq-ID: P12931 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14765   DDR2_HUMAN
MINT-15459   CAV1_HUMAN
MINT-46002   CTNB1_MOUSE
MINT-50376   RASH_HUMAN
MINT-62340   KPCD_HUMAN
MINT-62342   CDCP1_HUMAN
MINT-65953   DYN1_HUMAN
MINT-65954   DYN2_HUMAN
MINT-68512   PDC6I_HUMAN
MINT-74753   ERBB3_HUMAN
MINT-2792760   PAK2_HUMAN
MINT-2793013   ADA15_HUMAN
MINT-2840132   TLR3_HUMAN
MINT-3381308   FAK1_HUMAN
MINT-3381360   FYN_HUMAN
MINT-4051815   ADRB2_HUMAN
MINT-4961196   AFAD_HUMAN
MINT-4980122   SNIP_MOUSE
MINT-5210599   SNIP_HUMAN
MINT-6539730   CBL_HUMAN
MINT-6771405   FAK1_MOUSE
MINT-6794909   ACTS_HUMAN
MINT-6795322   ACTN1_HUMAN
MINT-6795447   PTN1_HUMAN
MINT-7035260   HNRPK_HUMAN
MINT-7040283   CBLB_HUMAN
MINT-7104422   BCAR1_HUMAN
MINT-7145938   RL10_HUMAN
MINT-7244986   ASAP1_HUMAN
MINT-7244998   FANCA_HUMAN
MINT-7245022   PHAR2_HUMAN
MINT-7245034   ABL1_HUMAN
MINT-7245058   DLGP4_HUMAN
MINT-7245070   SNX17_HUMAN
MINT-7245106   RTN4_HUMAN
MINT-7245118   ASAP2_HUMAN
MINT-7245142   E41L3_HUMAN
MINT-7245154   ICAL_HUMAN
MINT-7245214   FCG2B_HUMAN
MINT-7245226   FCG2C_HUMAN
MINT-7245334   SHAN2_HUMAN
MINT-7245346   SHRM2_HUMAN
MINT-7245358   DNLI3_HUMAN
MINT-7245370   EIF3D_HUMAN
MINT-7245406   HCN2_HUMAN
MINT-7245490   CKAP5_HUMAN
MINT-7245502   M4K1_HUMAN
MINT-7245538   RPP38_HUMAN
MINT-7245562   SP1_HUMAN
MINT-7245574   DOCK1_HUMAN
MINT-7245586   RLGPB_HUMAN
MINT-7245598   ABL2_HUMAN
MINT-7245610   CELR2_HUMAN
MINT-7245622   SOS1_HUMAN
MINT-7245634   AKAP6_HUMAN
MINT-7245670   DPOD1_HUMAN
MINT-7245682   DAG1_HUMAN
MINT-7245694   SNX3_HUMAN
MINT-7245730   KI67_HUMAN
MINT-7245742   CD97_HUMAN
MINT-7245754   RPGF1_HUMAN
MINT-7245778   ACAP1_HUMAN
MINT-7245790   PRIC3_HUMAN
MINT-7245814   AKAP2_HUMAN
MINT-7245826   RRAS_HUMAN
MINT-7296136   P85A_HUMAN
MINT-7296149   ACTB_HUMAN
MINT-7306598   LCP2_HUMAN
MINT-7552515   PTPRA_MOUSE
GO-Terms:
[show]
Conservation:

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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 530 EDYFTSTEPQYQPGENL     - 3103926
LTP
0.94
MOD_TYR_CSK
Csk SH2;
Fyn SH2;
Lck SH2;
PIK3R1 SH2;
Src SH2
-
0.46
1FMK 18.34%
Y 530 EDYFTSTEPQYQPGENL     Csk 12468645
LTP
0.94
MOD_TYR_CSK
Csk SH2;
Fyn SH2;
Lck SH2;
PIK3R1 SH2;
Src SH2
-
0.46
1FMK 18.34%
Y 530 EDYFTSTEPQYQPGENL     - 12387813
LTP
0.94
MOD_TYR_CSK
Csk SH2;
Fyn SH2;
Lck SH2;
PIK3R1 SH2;
Src SH2
-
0.46
1FMK 18.34%

Substrate: TRKA (Required for high affinity binding to nerve growth factor , neurotrophin-3 and neurotrophin-4/5r.)
Seq-ID: P04629 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 757 ERPRACPPEVYAIMRGCWQRE - 16319926
LTP
1.00
PIK3R1 SH2;
SH2D1A SH2
TyrKc
0.24
- medium

Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1355 GGSSLGFKRSYEEHIPYTHMN INSR 1321605
LTP
0.85
GRB10 SH2;
PIK3R1 SH2
-
0.50
--
Y 1361 FKRSYEEHIPYTHMNGGKKNG INSR 1321605
LTP
0.95
Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2;
SHC1 SH2
-
0.54
--

Substrate: TRKB (Receptor for brain-derived neurothrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5.)
Seq-ID: P15209 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 782 QRPRTCPQEVYELMLGCWQRE - 8226808
LTP
1.00
PIK3R1 SH2 TyrKc
0.18
- medium

Substrate: Erzin (Connection of cytoscheletro structure to plasma membrane)
Seq-ID: P15311 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 354 KEELMLRLQDYEEKTKKAERE EGFR 1382070
LTP
0.22
PIK3R1 SH2 COIL
0.49
--

Substrate: CD19 (Antigen of human B-lymphocytes)
Seq-ID: P15391 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 500 REATSLGSQSYEDMRGILYAA - 9190913
LTP
1.00
PIK3R1 SH2 -
0.73
- medium
Y 500 REATSLGSQSYEDMRGILYAA Lyn 10933394
LTP
1.00
PIK3R1 SH2 -
0.73
- medium
Y 531 GPNHEEDADSYENMDNPDGPD - 9190913
LTP
1.00
PIK3R1 SH2 -
0.97
- medium
Y 531 GPNHEEDADSYENMDNPDGPD Lyn 10933394
LTP
1.00
PIK3R1 SH2 -
0.97
- medium


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