Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Amyloid-like protein 2
Anaphase promoting complex subunit 1
APC8
Apoptosis inhibitor survivin
BAD
cAMP response element modulator
Casein kinase II, alpha chain
Casein kinase, II beta
Caspase 9
cdc25A
cdc25B
cdc25c
Cell division cycle protein 27 homolog
CHK1
Cut like 1
Cytokeratin 8
DEAD-box protein 3, X-chromosomal
DNA replication licensing factor MCM3
DNA replication licensing factor MCM4
DNA topoisomerase II, alpha
Drp1
E2F-1
ECT2 protein
EGFR
Epsin 1
FANCG
Flap endonuclease-1
Forkhead box protein M1
Golgin 95
GTPase activating protein Ran 1
Hamartin
Histone acetyltransferase HTATIP
HMG-I(Y)
HMGI-C
Inner centromere protein
Inositol 1,4,5-trisphosphate receptor type 1
IREB2
Kinesin-like protein KIF11
Kinesin-like protein KIF22
Lamin B receptor
LATS1
MAP2K1
Microtubule-associated protein 4
Myogenic factor 3
Neural interleukin 16 protein
NPM
NSFL1C
Nuclear pore membrane glycoprotein POM210
Origin recognition complex subunit 1
p53
Parathyroid hormone related protein
PBK
Peroxiredoxin 1
PIK3C2A
PITPNM1
Plectin 1
PP1A
Protein C10orf3
PTPN2
Rad9
Rap1GAP
Raptor
Ras-related protein Rab-5B
Replication factor-A protein 2
Ribonucleotide reductase M2 subunit
Ribosomal protein S6 kinase 1
RPB1
Sam68
Securin
Separin
Serine/threonine-protein kinase PAK 1
SIRT2
SREBP1
Synapsin-3
TK1
Transcription factor jun-B
TTD nonphotosensitive 1 protein
Tyrosine-protein phosphatase, non-receptor type 1
Ubiquitin activating enzyme 1
Ubiquitin-conjugating enzyme E2 A
Vimentin
WEE 1 tyrosine kinase

Substrate:

Amyloid-like protein 2 (Integral membrane protein)

Seq-ID:

Q06481 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-60793 Z512B_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
serine-type endopeptidase inhibitor activity, DNA binding, identical protein binding	plasma membrane, integral to membrane, nucleus	G-protein coupled receptor protein signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	736	HGIVEVDPMLTPEERHLNKMQ	CDK1	9109675	LTP	0.92	MOD_ProDKin_1	-	APP_amyloid	0.46	-	low

Substrate:

Anaphase promoting complex subunit 1 (Cell cycle control protein)

Seq-ID:

Q9H1A4 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	cytosol, anaphase-promoting complex, nucleoplasm	cell division, positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, protein K11-linked ubiquitination, negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, mitosis, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	291	VVLKFSEQGGTPQNVATSSSL	CDK1	14657031	LTP	0.09		-	-	0.55	-	medium
S	355	SNMAALSRAHSPALGVHSFSG	CDK1	14657031	LTP	1.00		-	-	0.38	-	medium
S	377	QRFNISSHNQSPKRHSISHSP	CDK1	14657031	LTP	0.21	MOD_CDK_SPxK_1	-	-	0.67	-	medium
T	530	TMSNTMPRPSTPLDGVSTPKP	CDK1	14657031	LTP	0.14		-	-	0.70	-	medium
T	537	RPSTPLDGVSTPKPLSKLLGS	CDK1	14657031	HTP	0.07		-	-	0.46	-	medium
S	555	LGSLDEVVLLSPVPELRDSSK	CDK1	14657031	HTP	1.00		-	-	0.26	-	medium
S	688	TRNFDFEGSLSPVIAPKKARP	CDK1	14657031	LTP	0.27	MOD_PLK	-	-	0.27	-	medium

Substrate:

APC8 (Cell cycle control protein)

Seq-ID:

Q9UJX2 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-66993 RBPMS_HUMAN
MINT-67439 T22D4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
binding, ubiquitin-protein ligase activity	cytosol, anaphase-promoting complex, nucleoplasm	cell division, positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, G1 phase of mitotic cell cycle, protein K11-linked ubiquitination, negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, mitotic metaphase/anaphase transition, regulation of exit from mitosis, mitotic metaphase plate congression, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, regulation of mitotic metaphase/anaphase transition

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	556	QILQLRNQGETPTTEVPAPFF	CDK1	14657031	LTP	0.00		-	-	0.39	-	medium
T	576	FLPASLSANNTPTRRVSPLNL	CDK1	14657031	HTP	0.65	MOD_CDK_SPxK_1	-	-	0.36	-	medium

Substrate:

Apoptosis inhibitor survivin (Adapter molecule)

Seq-ID:

O15392 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-77929   INCE_HUMAN
MINT-4055407   XPO1_HUMAN
MINT-4509524   BOREA_HUMAN
MINT-4509558   AURKB_HUMAN
MINT-7969366   BECN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cobalt ion binding, cysteine-type endopeptidase inhibitor activity, protein heterodimerization activity, identical protein binding, protein homodimerization activity, metal ion binding, cofactor binding, caspase inhibitor activity, Ran GTPase binding, microtubule binding, chaperone binding, zinc ion binding	spindle, chromosome, centromeric region, midbody, chromosome passenger complex, spindle microtubule, cytoplasm, cytosol, centriole, cytoplasmic microtubule, interphase microtubule organizing center, nuclear chromosome	cytokinesis, positive regulation of mitotic cell cycle, apoptosis, anti-apoptosis, chromosome segregation, establishment of chromosome localization, negative regulation of caspase activity, positive regulation of exit from mitosis, mitosis, spindle checkpoint, G2/M transition of mitotic cell cycle, protein complex localization, cell division

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	34	NWPFLEGCACTPERMAEAGFI	CDK1	11861764	LTP	1.00	MOD_CDK_SPxK_1	-	BIR	0.19	2RAW	10.96%
T	34	NWPFLEGCACTPERMAEAGFI	CDK1	11069302	LTP	1.00	MOD_CDK_SPxK_1	-	BIR	0.19	2RAW	10.96%

Substrate:

BAD (Bcl2-antagonist of cell death (BAD) (Bcl-2 binding component 6) (Bcl- XL/Bcl-2 associated death promoter) (Bcl-2-like 8 protein))

Seq-ID:

O35147 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase B binding, protein phosphatase 2B binding	cytosol, mitochondrial outer membrane	response to amino acid stimulus, response to hypoxia, response to hydrogen peroxide, response to organic cyclic substance, apoptosis, response to drug, response to oleic acid, response to progesterone stimulus, response to estradiol stimulus, response to glucose stimulus, response to calcium ion, response to testosterone stimulus, induction of apoptosis, response to glucocorticoid stimulus, response to ethanol

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	129	EEDEGMEEELSPFRGRSRSAP	CDK1	12049737	LTP	0.47	MOD_CDK_SPxK_1	-	Bcl-2_BAD	0.86	-	medium

Substrate:

cAMP response element modulator (Transcription factor)

Seq-ID:

P27699 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, protein dimerization activity, sequence-specific DNA binding transcription factor activity	transcription factor complex	transcription, spermatogenesis, regulation of transcription, DNA-dependent, glycosphingolipid metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	268	ALPQGVVMAASPGSLHSPQQL	CDK1	8404858	LTP	0.71	-	-	0.63	-	medium
S	268	ALPQGVVMAASPGSLHSPQQL	CDK1	8114763	LTP	0.71	-	-	0.63	-	medium
S	274	VMAASPGSLHSPQQLAEEATR	CDK1	8404858	LTP	0.00	-	-	0.70	-	medium
S	274	VMAASPGSLHSPQQLAEEATR	CDK1	8114763	LTP	0.00	-	-	0.70	-	medium

Substrate:

Casein kinase II, alpha chain (casein kinase II, alpha chain (CKII) (EC 2.7.1.37) (from PhosphoBase))

Seq-ID:

P68400 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14550   ENPL_HUMAN
MINT-15215   UB2R1_HUMAN
MINT-15821   PIN1_HUMAN
MINT-17591   TCP4_HUMAN
MINT-50090   TF65_HUMAN
MINT-50947   1433B_HUMAN
MINT-51176   XRCC4_HUMAN
MINT-51183   XRCC1_HUMAN
MINT-62785   CSK2B_HUMAN
MINT-63998   ZHX1_HUMAN
MINT-1779097   KAP2_BOVIN
MINT-3372672   PACS1_HUMAN
MINT-3975397   1433S_HUMAN
MINT-4791613   HIF1A_HUMAN
MINT-4961111   KANK2_HUMAN
MINT-6628644   LT_SV40
MINT-6628799   VE7_HPV16
MINT-6744190   PTN1_HUMAN
MINT-6805408   MDC1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, protein N-terminus binding	plasma membrane, Sin3 complex, NuRD complex	protein amino acid phosphorylation, signal transduction, Wnt receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	344	MGSSSMPGGSTPVSSANMMSG	CDK1	7592773	LTP	0.62	-	-	0.64	-	-
T	344	MGSSSMPGGSTPVSSANMMSG	CDK1	7592773	LTP	0.62	-	-	0.64	-	-
T	360	NMMSGISSVPTPSPLGPLAGS	CDK1	7592773	LTP	-	-	-	0.56	-	-
T	360	NMMSGISSVPTPSPLGPLAGS	CDK1	7592773	LTP	-	-	-	0.56	-	-
S	362	MSGISSVPTPSPLGPLAGSPV	CDK1	7592773	LTP	-	-	-	0.54	-	-
S	362	MSGISSVPTPSPLGPLAGSPV	CDK1	7592773	LTP	-	-	-	0.54	-	-
S	370	TPSPLGPLAGSPVIAAANPLG	CDK1	7592773	LTP	0.60	-	-	0.54	-	-
S	370	TPSPLGPLAGSPVIAAANPLG	CDK1	7592773	LTP	0.60	-	-	0.54	-	-

Substrate:

Casein kinase, II beta (Casein kinase II beta chain)

Seq-ID:

P67870 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-51394   CHK1_HUMAN
MINT-62783   CSK22_HUMAN
MINT-62784   LYN_HUMAN
MINT-62785   CSK21_HUMAN
MINT-62787   RL5_HUMAN
MINT-62789   MBD4_HUMAN
MINT-2857838   COIL_HUMAN
MINT-3372614   PACS1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase regulator activity, identical protein binding, protein domain specific binding, transcription factor binding, receptor binding	protein kinase CK2 complex, cytoplasm	negative regulation of cell proliferation, Wnt receptor signaling pathway, adiponectin-mediated signaling pathway, cellular protein complex assembly, regulation of DNA binding

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	209	LQLQAASNFKSPVKTIR	CDK1	7578274	LTP	0.30	MOD_CDK_SPxK_1	-	-	0.33	-	-
S	209	LQLQAASNFKSPVKTIR	CDK1	1939094	LTP	0.30	MOD_CDK_SPxK_1	-	-	0.33	-	-
S	209	LQLQAASNFKSPVKTIR	CDK1	12551973	LTP	0.30	MOD_CDK_SPxK_1	-	-	0.33	-	-

Substrate:

Caspase 9 (Cysteine protease)

Seq-ID:

P55211 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15372   APAF_HUMAN
MINT-18815   CASP3_HUMAN
MINT-25026   XIAP_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
enzyme activator activity, cysteine-type endopeptidase activity, protein binding	cytosol	proteolysis, activation of caspase activity by cytochrome c

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	125	IRKPEVLRPETPRPVDIGSGG	CDK1	17466630	LTP	0.08	MOD_ProDKin_1	-	-	0.56	-	-

Substrate:

cdc25A (Dual specificity phosphatase)

Seq-ID:

P30304 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15591 CHK2_HUMAN
MINT-3294407 1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, protein binding	nucleoplasm	regulation of cyclin-dependent protein kinase activity, cell division, protein amino acid dephosphorylation, mitosis, DNA replication, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	18	PHRRRLLFACSPPPASQPVVK	CDK1	12411508	LTP	0.22		-	-	0.54	-	high
S	116	HSLPQKLLGCSPALKRSHSDS	CDK1	12411508	LTP	1.00		-	M-inducer_phosp	0.51	-	high

Substrate:

cdc25B (Dual specificity phosphatase)

Seq-ID:

P30305 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19329   1433Z_HUMAN
MINT-19330   1433F_HUMAN
MINT-25122   1433B_HUMAN
MINT-51069   1433S_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, protein binding	cytosol, microtubule organizing center, nucleoplasm	positive regulation of cell proliferation, cell division, protein amino acid dephosphorylation, mitosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	160	QSMPVRLLGHSPVLRNITNSQ	CDK1	12107172	LTP	1.00		-	M-inducer_phosp	0.55	-	medium

Substrate:

cdc25c (M-phase inducer phosphatase 3)

Seq-ID:

P30307 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16690 PLK1_HUMAN
MINT-3294433 1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, WW domain binding	cytosol, nucleoplasm	regulation of cyclin-dependent protein kinase activity, cell division, traversing start control point of mitotic cell cycle, protein amino acid dephosphorylation, regulation of mitosis, mitosis, interspecies interaction between organisms, DNA replication, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	48	SFTVCPDVPRTPVGKFLGDSA	CDK1	8119945	LTP	0.19		PIN1 WW	-	0.44	-	low
T	67	SANLSILSGGTPKRCLDLSNL	CDK1	8119945	LTP	0.24	MOD_CDK_SPxK_1	PIN1 WW	-	0.40	-	low
S	122	MNHDQHLMKCSPAQLLCSTPN	CDK1	8119945	LTP	0.06		-	M-inducer_phosp	0.49	-	low
T	130	KCSPAQLLCSTPNGLDRGHRK	CDK1	8119945	LTP	0.20		PLK1 PBD	M-inducer_phosp	0.55	-	low
S	168	LVDSEMKYLGSPITTVPKLDK	CDK1	8119945	LTP	1.00		-	M-inducer_phosp	0.53	-	low
S	214	AKVSRSGLYRSPSMPENLNRP	CDK1	8119945	LTP	1.00		-	M-inducer_phosp	0.67	-	low

Substrate:

Cell division cycle protein 27 homolog (Cell cycle control protein)

Seq-ID:

P30260 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-7244026   ABL1_HUMAN
MINT-7246846   FYN_HUMAN
MINT-7250398   NCK1_HUMAN
MINT-7251346   P85A_HUMAN
MINT-7974880   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	centrosome, spindle microtubule, cytosol, anaphase-promoting complex, nucleoplasm	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, protein K11-linked ubiquitination, negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, mitotic metaphase/anaphase transition, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	205	HRQPETVLTETPQDTIELNRL	CDK1	14657031	HTP	0.27	-	-	0.64	-	medium
T	289	TPSFGILPLETPSPGDGSYLQ	CDK1	14657031	HTP	0.80	-	-	0.61	-	medium
T	343	FSQSGNSREVTPILAQTQSSG	CDK1	14657031	HTP	0.48	-	-	0.75	-	medium
S	364	PQTSTTPQVLSPTITSPPNAL	CDK1	14657031	HTP	0.28	-	-	0.84	-	medium
T	446	IISEGKISTITPQIQAFNLQK	CDK1	14657031	HTP	0.07	-	-	0.33	-	medium

Substrate:

CHK1 (Serine/threonine-protein kinase Chk1)

Seq-ID:

O14757 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-51394   CSK2B_HUMAN
MINT-1958329   P53_HUMAN
MINT-4793746   RB_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, protein binding	condensed nuclear chromosome, microtubule organizing center, nucleoplasm	protein amino acid phosphorylation, regulation of cyclin-dependent protein kinase activity, senescence, DNA repair, reciprocal meiotic recombination, negative regulation of cell proliferation, DNA damage checkpoint, gamete generation, DNA replication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	301	SKHIQSNLDFSPVNSASSEEN	CDK1	16629900	LTP	0.29		-	-	0.46	-	-

Substrate:

Cut like 1 (Transcription regulatory protein)

Seq-ID:

P39880 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13924   RB_HUMAN
MINT-64663   BIN1_HUMAN
MINT-64665   RECQ5_HUMAN
MINT-64666   RNZ2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity	nucleus	transcription, negative regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1237	SVGTEYSQGASPQPQHQLKKP	CDK1	11584018	LTP	0.07		-	-	0.79	-	medium
S	1270	KRAYQQKPYPSPKTIEDLATQ	CDK1	11584018	LTP	1.00		-	HOX	0.67	-	medium

Substrate:

Cytokeratin 8 (keratin, type II cytoskeletal 8 (cytokeratin 8) (K8) (CK8) (from PhosphoBase))

Seq-ID:

P05787 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-51056   RAF1_HUMAN
MINT-61555   GRB2_HUMAN
MINT-2984733   ZO1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural molecule activity, protein binding	cytoplasm, keratin filament	cytoskeleton organization, interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	432	GLSSAYGGLTSPGLSYSLGSS	CDK1	9524113	LTP	0.40	MOD_ProDKin_1	-	-	0.31	-	low
S	432	GLSSAYGGLTSPGLSYSLGSS	CDK1	9054461	LTP	0.40	MOD_ProDKin_1	-	-	0.31	-	low
S	432	GLSSAYGGLTSPGLSYSLGSS	CDK1	9054461	LTP	0.40	MOD_ProDKin_1	-	-	0.31	-	low

Substrate:

DEAD-box protein 3, X-chromosomal (RNA binding protein)

Seq-ID:

O00571 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48749   NFKB2_HUMAN
MINT-48849   M3K14_HUMAN
MINT-60828   Z512B_HUMAN
MINT-73033   WBP4_HUMAN
MINT-3296972   1433Z_HUMAN
MINT-6948107   TBK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, ATP-dependent RNA helicase activity, RNA binding, ATP binding, protein binding	cytoplasm, nuclear speck	interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	204	NIELTRYTRPTPVQKHAIPII	CDK1	16280325	LTP	1.00		-	DEXDc	0.44	2I4I	27.40%
T	323	LERGCHLLVATPGRLVDMMER	CDK1	16280325	LTP	1.00	MOD_CDK_SPxK_1	-	DEXDc	0.21	2I4I	6.16%

Substrate:

DNA replication licensing factor MCM3 (DNA binding protein)

Seq-ID:

P25206 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, nucleoside-triphosphatase activity, ATP binding	nucleus	transcription, regulation of transcription, cell cycle, DNA-dependent DNA replication initiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	112	LEGSFGSKHVSPRTLTSCFLS	CDK1	18524952	LTP	0.24		-	MCM	0.13	-	medium
T	719	EAETQMPQVHTPKTDDSQEKT	CDK1	18524952	LTP	0.42		-	-	0.91	-	medium

Substrate:

DNA replication licensing factor MCM4 (DNA binding protein)

Seq-ID:

P49717 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleoside-triphosphatase activity, ATP binding, single-stranded DNA binding, protein binding	nucleus	transcription, regulation of transcription, DNA unwinding involved in replication, DNA-dependent DNA replication initiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	7	MSSPASTPSRRSSRRGR	CDK1	16519687	LTP	0.30	MOD_CDK_SPxK_1	-	-	0.95	-	medium
S	32	QSLRSEESRSSPNRRRRGEDS	CDK1	16519687	LTP	0.90	MOD_CDK_SPxK_1	-	-	0.96	-	medium
S	87	LAIPLDFDVSSPLTYGTPSSR	CDK1	16519687	LTP	1.00		-	-	0.57	-	medium
T	109	EGTPRSGVRGTPVRQRPDLGS	CDK1	16519687	LTP	0.25	MOD_CDK_SPxK_1	-	-	0.84	-	medium

Substrate:

DNA topoisomerase II, alpha (DNA topoisomerase II alpha)

Seq-ID:

P11388 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-15316 PIN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C binding, DNA topoisomerase (ATP-hydrolyzing) activity, protein heterodimerization activity, protein C-terminus binding, protein homodimerization activity, DNA-dependent ATPase activity, chromatin binding, histone deacetylase binding, ATP binding, ubiquitin binding, drug binding	DNA topoisomerase complex (ATP-hydrolyzing), cytoplasm, chromosome, nucleoplasm	DNA repair, chromosome segregation, phosphoinositide-mediated signaling, positive regulation of apoptosis, DNA ligation, apoptotic chromosome condensation, DNA topological change, DNA replication, positive regulation of retroviral genome replication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1213	KKTQMAEVLPSPRGQRVIPRI	CDK1	7635160	LTP	0.91	MOD_ProDKin_1	-	-	0.70	-	-
S	1247	KKIKNENTEGSPQEDGVELEG	CDK1	7635160	LTP	0.20	MOD_ProDKin_1	-	-	0.82	-	-
S	1354	DDEDFVPSDASPPKTKTSPKL	CDK1	7635160	LTP	0.04	MOD_CDK_SPxK_1	-	-	0.87	-	-
S	1361	SDASPPKTKTSPKLSNKELKP	CDK1	7635160	LTP	0.24	MOD_ProDKin_1	-	-	0.89	-	-
S	1393	DVKGSVPLSSSPPATHFPDET	CDK1	7635160	LTP	0.19	MOD_ProDKin_1	-	-	0.86	-	-

Substrate:

Drp1 (GTPase)

Seq-ID:

O35303 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
GTPase activity, GTP binding, protein binding	microsome, mitochondrion, cytosol, peroxisome, membrane, endomembrane system

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	635	KSKPIPIMPASPQKGHAVNLL	CDK1	17301055	LTP	0.92	MOD_CDK_SPxK_1	-	-	0.61	-	low

Substrate:

E2F-1 (Transcription factor)

Seq-ID:

Q01094 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19370   TOPB1_HUMAN
MINT-73331   VE7_HPV16
MINT-4793665   RB_HUMAN
MINT-6804982   MCPH1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription corepressor activity, sequence-specific DNA binding transcription factor activity	mitochondrion	transcription, G1 phase of mitotic cell cycle, apoptosis, mRNA stabilization, negative regulation of transcription from RNA polymerase II promoter, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	332	NRATDSATIVSPPPSSPPSSL	CDK1	8087847	LTP	0.21		-	-	0.87	-	medium
S	337	SATIVSPPPSSPPSSLTTDPS	CDK1	8087847	LTP	0.15		-	-	0.86	-	medium

Substrate:

ECT2 protein (Unclassified)

Seq-ID:

Q9H8V3 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-6166634   RGAP1_HUMAN
MINT-7250722   NCK1_HUMAN
MINT-7251730   P85A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
Rho guanyl-nucleotide exchange factor activity, signal transducer activity, protein binding	cytosol	induction of apoptosis by extracellular signals, positive regulation of I-kappaB kinase/NF-kappaB cascade, apoptosis, regulation of Rho protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	342	KKSVSMLSLNTPNSNRKRRRL	CDK1	16170345	LTP	1.00		-	-	0.58	-	low
T	413	KSCTKSSKSSTPVPSKQSARW	CDK1	16247472	LTP	0.71		-	-	0.64	-	low
T	815	KVTRAFSFSKTPKRALRRALM	CDK1	16247472	LTP	0.98	MOD_CDK_SPxK_1	-	-	0.40	-	low

Substrate:

EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)

Seq-ID:

P00533 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
epidermal growth factor receptor activity, protein heterodimerization activity, identical protein binding, receptor signaling protein tyrosine kinase activity, double-stranded DNA binding, ATP binding, protein phosphatase binding, actin filament binding, MAP/ERK kinase kinase activity	Shc-EGFR complex, endosome, basolateral plasma membrane, integral to membrane, extracellular space, nucleus	activation of phospholipase C activity, protein insertion into membrane, response to UV-A, positive regulation of nitric oxide biosynthetic process, positive regulation of cell migration, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, positive regulation of catenin protein nuclear translocation, regulation of nitric-oxide synthase activity, positive regulation of protein kinase B signaling cascade, ossification, positive regulation of epithelial cell proliferation, activation of phospholipase A2 activity by calcium-mediated signaling, cell-cell adhesion, regulation of peptidyl-tyrosine phosphorylation, positive regulation of phosphorylation, positive regulation of MAP kinase activity, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1026	YLIPQQGFFSSPSTSRTPLLS	CDK1	8360196	LTP	0.23		-	-	0.42	-	-

Substrate:

Epsin 1 (Adapter molecule)

Seq-ID:

Q9Y6I3 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-6179958 EPS15_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
lipid binding	plasma membrane, cytoplasm, coated pit, nucleus	endocytosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	357	APAFSDPWGGSPAKPSTNGTT	CDK1	10764745	LTP	0.48	MOD_CDK_SPxK_1	-	-	0.90	-	medium

Substrate:

FANCG (damaged DNA binding)

Seq-ID:

O15287 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19440   FANCA_HUMAN
MINT-45827   FANCE_HUMAN
MINT-68101   K1C19_HUMAN
MINT-7231852   SPTA2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
damaged DNA binding, protein binding	mitochondrion, nucleus	DNA repair, cell cycle checkpoint, mitochondrion organization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	387	SSEPRFSPPPSPPGPCMPEVF	CDK1	15367677	LTP	0.97		-	-	0.63	-	low

Substrate:

Flap endonuclease-1 (Deoxyribonuclease)

Seq-ID:

P39748 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-63719 EF1G_HUMAN
MINT-63857 GDIR1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
double-stranded DNA specific exodeoxyribonuclease activity, 5`-flap endonuclease activity, 5`-3` exonuclease activity, double-stranded DNA binding, damaged DNA binding, ribonuclease H activity, protein binding	mitochondrion, nucleus	DNA replication, removal of RNA primer, UV protection, phosphoinositide-mediated signaling, double-strand break repair

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	187	TEDMDCLTFGSPVLMRHLTAS	CDK1	12853968	LTP	0.83		-	XPGI	0.29	1UL1	0.00%

Substrate:

Forkhead box protein M1 (Transcription factor)

Seq-ID:

Q08050-2 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-73149 VE7_HPV16

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, protein binding	nucleus	positive regulation of cell proliferation, transcription from RNA polymerase II promoter, regulation of cell growth, transcription, regulation of cell cycle arrest, cell cycle, regulation of Ras protein signal transduction, negative regulation of stress-activated MAPK cascade, negative regulation of cell aging, regulation of cell proliferation, regulation of transcription, DNA-dependent, regulation of oxygen and reactive oxygen species metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	596	PIKETLPISSTPSKSVLPRTP	CDK1	15024056	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.69	-	medium

Substrate:

Golgin 95 (Structural protein)

Seq-ID:

Q08379 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-61271   RUSC2_HUMAN
MINT-66414   ABLM1_HUMAN
MINT-67616   TRI29_HUMAN
MINT-7263700   AKAP9_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	Golgi cisterna membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	25	KKLREYQQRNSPGVPTGAKKK	CDK1	9753325	LTP	1.00		-	-	0.84	-	medium

Substrate:

GTPase activating protein Ran 1 (GTPase activating protein)

Seq-ID:

P46060 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-3380510 SUMO1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
Ran GTPase activator activity, protein binding	condensed chromosome kinetochore, nuclear membrane, spindle pole, soluble fraction, nuclear pore	signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	409	QQRGQGEKSATPSRKILDPNT	CDK1	15037602	LTP	0.93	MOD_CDK_SPxK_1	-	RanGAP1_C	0.89	-	-

Substrate:

Hamartin (Implicated as a tumor suppressor)

Seq-ID:

Q92574 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16238 TSC2_HUMAN
MINT-50948 1433B_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
chaperone binding, protein N-terminus binding	TSC1-TSC2 complex, lamellipodium, cell cortex, membrane	regulation of phosphoprotein phosphatase activity, negative regulation of protein ubiquitination, negative regulation of cell proliferation, negative regulation of TOR signaling cascade, activation of Rho GTPase activity, cell-matrix adhesion, negative regulation of translation, regulation of stress fiber assembly, response to insulin stimulus, rRNA export from nucleus, positive regulation of focal adhesion assembly

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	417	VHISLPQATVTPPRKEERMDS	CDK1	14551205	LTP	0.04	MOD_CDK_SPxK_1	-	Hamartin	0.80	-	low
S	584	TSLETSIFTPSPCKIPPPTRV	CDK1	14551205	LTP	1.00	MOD_CDK_SPxK_1	-	Hamartin	0.58	-	low
T	1047	GSSSSSSELSTPEKPPHQRAG	CDK1	14551205	LTP	0.03	MOD_CDK_SPxK_1	-	-	0.91	-	low

Substrate:

Histone acetyltransferase HTATIP (Enzyme: Acyltransferase)

Seq-ID:

Q92993 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16136   ANDR_HUMAN
MINT-63068   PDCD5_HUMAN
MINT-63283   SNAPN_HUMAN
MINT-63303   ARI2_HUMAN
MINT-63507   ZNF24_HUMAN
MINT-63520   SYN1_HUMAN
MINT-63577   SAT1_HUMAN
MINT-63661   HNRH3_HUMAN
MINT-63677   CSTF2_HUMAN
MINT-63963   SMD2_HUMAN
MINT-64117   RED_HUMAN
MINT-64193   MD2BP_HUMAN
MINT-64887   CA174_HUMAN
MINT-65256   CK5P2_HUMAN
MINT-65557   CBX8_HUMAN
MINT-3978756   BARD1_HUMAN
MINT-3980540   G3P_HUMAN
MINT-3980744   CA103_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription repressor activity, transcription repressor binding, histone acetyltransferase activity, metal ion binding, androgen receptor binding, chromatin binding, transcription coactivator activity	Piccolo NuA4 histone acetyltransferase complex, NuA4 histone acetyltransferase complex, chromatin, nucleolus, perinuclear region of cytoplasm	negative regulation of interleukin-2 production, negative regulation of gene-specific transcription from RNA polymerase II promoter, transcription, regulation of growth, positive regulation of transcription, DNA-dependent, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, chromatin assembly or disassembly, androgen receptor signaling pathway, histone acetylation, interspecies interaction between organisms, double-strand break repair

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	90	KNGLPGSRPGSPEREVPASAQ	CDK1	12468530	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.87	-	medium

Substrate:

HMG-I(Y) (high mobility group protein HMG-Y (from PhosphoBase))

Seq-ID:

P17096 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-49728 SP1_HUMAN
MINT-49733 CEBPB_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
AT DNA binding, peroxisome proliferator activated receptor binding, ligand-dependent nuclear receptor transcription coactivator activity, enzyme binding, sequence-specific DNA binding transcription factor activity, retinoid X receptor binding	chromatin, cytosol, transcription factor complex	provirus integration, protein complex assembly, transcription, DNA unwinding involved in replication, nucleosome disassembly, initiation of viral infection, interspecies interaction between organisms, loss of chromatin silencing

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	53	GSQKEPSEVPTPKRPRGRPKG	CDK1	1939057	LTP	-	MOD_CDK_SPxK_1	-	-	0.97	-	medium
T	78	GAAKTRKTTTTPGRKPRGRPK	CDK1	1939057	LTP	-	MOD_CDK_SPxK_1	-	-	0.96	-	medium

Substrate:

HMGI-C (Transcription factor)

Seq-ID:

P52926 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
AT DNA binding, protein binding	chromatin, nucleus	chromatin organization, transcription, cell division, regulation of growth, mitosis, regulation of transcription, DNA-dependent, multicellular organismal development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	44	KQQQEPTGEPSPKRPRGRPKG	CDK1	10636877	LTP	0.61	MOD_CDK_SPxK_1	-	-	0.99	-	medium
S	59	RGRPKGSKNKSPSKAAQKKAE	CDK1	10636877	LTP	0.61	MOD_CDK_SPxK_1	-	-	0.97	-	medium

Substrate:

Inner centromere protein (Cell cycle control protein)

Seq-ID:

Q9WU62 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	central element, spindle, condensed chromosome kinetochore, midbody, cytoplasm, centromeric heterochromatin, microtubule	cytokinesis, chromosome segregation, mitosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	59	FSNEPELMPKTPSQKNRRKKR	CDK1	16378098	LTP	1.00		-	-	0.83	-	medium
T	388	PRSATKIAISTPTSKPAAAGQ	CDK1	16378098	LTP	0.05		-	-	0.80	-	medium

Substrate:

Inositol 1,4,5-trisphosphate receptor type 1 (inositol 1,4,5-trisphosphate-binding protein type 1 receptor (from PhosphoBase))

Seq-ID:

P11881 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity, phosphoinositide binding, protein binding	nuclear inner membrane, sarcoplasmic reticulum, microsome, integral to membrane, nucleolus, endoplasmic reticulum membrane, calcineurin complex, postsynaptic density	response to hypoxia, endoplasmic reticulum calcium ion homeostasis, post-embryonic development, voluntary musculoskeletal movement

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	421	EKPVMLKIGTSPLKEDKEAFA	CDK1	14635192	LTP	0.84	MOD_CDK_SPxK_1	-	MIR	0.41	1N4K	6.56%
T	799	HVDRDPQEQVTPVKYARLWSE	CDK1	14635192	LTP	0.95	MOD_CDK_SPxK_1	-	-	0.28	-	-

Substrate:

IREB2 (Iron regulatory protein)

Seq-ID:

P48200 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
4 iron, 4 sulfur cluster binding, metal ion binding, protein binding

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	157	GGDLQKAGKLSPLKVQPKKLP	CDK1	18574241	LTP	-	MOD_CDK_SPxK_1	-	Aconitase	0.50	-	low

Substrate:

Kinesin-like protein KIF11 (sin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor interacting protein 5) (TRIP5) (Kinesin-like protein 1))

Seq-ID:

P52732 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-48095 IKKE_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase binding, microtubule motor activity, ATP binding	spindle, chromatin remodeling complex, microtubule, kinesin complex	cell division, microtubule-based movement, spindle assembly involved in mitosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	926	DLKLDIPTGTTPQRKSYLYPS	CDK1	9235942	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.48	-	medium
T	926	DLKLDIPTGTTPQRKSYLYPS	CDK1	8548803	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.48	-	medium

Substrate:

Kinesin-like protein KIF22 (DNA binding protein)

Seq-ID:

Q14807 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7254936 CRK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, microtubule motor activity, ATP binding, protein binding	kinetochore, nucleus, microtubule	DNA repair, microtubule-based movement, mitosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	463	QGSQGAPLLSTPKRERMVLMK	CDK1	12727876	LTP	0.10	MOD_CDK_SPxK_1	-	-	0.67	-	-

Substrate:

Lamin B receptor (lamin B receptor (from PhosphoBase))

Seq-ID:

Q14739 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-50938 1433B_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, DNA binding, lamin binding, chromo shadow domain binding, delta14-sterol reductase activity	integral to nuclear inner membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	71	RQRKGGSTSSSPSRRRGSRSR	CDK1	14718546	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.88	-	medium

Substrate:

LATS1 (serine/threonine kinase)

Seq-ID:

O95835 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, protein kinase binding, ATP binding	spindle pole, microtubule organizing center	negative regulation of cyclin-dependent protein kinase activity, protein amino acid phosphorylation, cell division, cytoplasmic sequestering of protein, regulation of actin filament polymerization, positive regulation of peptidyl-serine phosphorylation, hippo signaling cascade, negative regulation of canonical Wnt receptor signaling pathway, mitosis, sister chromatid segregation, G2/M transition of mitotic cell cycle, hormone-mediated signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	613	GDKEKKQITTSPITVRKNKKD	CDK1	12372621	LTP	1.00		-	-	0.81	-	medium

Substrate:

MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1))

Seq-ID:

Q02750 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16002   KSR1_MOUSE
MINT-3391583   M3K1_HUMAN
MINT-4300484   MK01_HUMAN
MINT-7014370   RAF1_HUMAN
MINT-7014390   MK03_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, MAP kinase kinase activity, ATP binding, protein tyrosine kinase activity	cytosol	senescence, negative regulation of cell proliferation, cell cycle arrest, chemotaxis, Ras protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	286	GCQVEGDAAETPPRPRTPGRP	CDK1	11684694	LTP	0.12	MOD_CDK_SPxK_1	-	S_TKc	0.74	-	-

Substrate:

Microtubule-associated protein 4 (Cytoskeletal protein)

Seq-ID:

P27816 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-63440   ENOG_HUMAN
MINT-3390055   KC1D_RAT
MINT-7251058   NCK1_HUMAN
MINT-7252150   P85A_HUMAN
MINT-7252894   PLCG1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural molecule activity, protein binding	microtubule associated complex, microtubule	negative regulation of microtubule depolymerization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	696	TTPPNKELPPSPEKKTKPLAT	CDK1	9398320	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.94	-	medium
S	787	ADAKAPEKRASPSKPASAPAS	CDK1	9398320	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.91	-	medium

Substrate:

Myogenic factor 3 (Transcription factor)

Seq-ID:

P10085 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-50074 CREB1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity, RNA polymerase II transcription factor activity, enhancer binding, transcription factor binding	transcription factor complex	transcription, regulation of alternative nuclear mRNA splicing, via spliceosome, myoblast cell fate determination, positive regulation of skeletal muscle tissue regeneration, striated muscle cell differentiation, skeletal muscle tissue development, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	200	EHYSGDSDASSPRSNCSDGMM	CDK1	10082583	LTP	1.00		-	-	0.76	-	medium
S	200	EHYSGDSDASSPRSNCSDGMM	CDK1	10942602	LTP	1.00		-	-	0.76	-	medium

Substrate:

Myogenic factor 3 (Transcription factor)

Seq-ID:

P15172 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15523 SRF_HUMAN
MINT-61952 SMAD4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
RNA polymerase II transcription factor activity, enhancer binding, transcription coactivator activity		protein amino acid phosphorylation, transcription, skeletal muscle tissue development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	5	MELLSPPLRDVDLTA	CDK1	14749395	LTP	0.11		-	BASIC	0.45	-	-
S	200	EHYSGDSDASSPRSNCSDGMM	CDK1	14749395	LTP	1.00		-	-	0.76	-	-

Substrate:

Neural interleukin 16 protein (Cytokine)

Seq-ID:

ENSP00000347528 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cytokine activity	cytoplasm, extracellular space, nucleus	transcription, regulation of transcription, immune response, interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	757	EEGTQGHPDGTPPKLDTANGT	CDK1	12450396	LTP	-	MOD_CDK_SPxK_1	-	-	0.95	-	medium

Substrate:

NPM (nucleophosmin (nucleolar phosphoprotein B23) (from PhosphoBase))

Seq-ID:

P06748 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48882   M3K14_HUMAN
MINT-74886   P53_HUMAN
MINT-75016   PTBP1_HUMAN
MINT-75017   SFRS1_HUMAN
MINT-3089429   E2AK2_HUMAN
MINT-3296152   1433Z_HUMAN
MINT-4544864   AP2A_HUMAN
MINT-4544899   HDAC1_HUMAN
MINT-4544944   HDAC2_HUMAN
MINT-6541788   SENP3_HUMAN
MINT-7041169   HABP4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
Tat protein binding, histone binding, ribosomal small subunit binding, protein heterodimerization activity, ribosomal large subunit binding, protein homodimerization activity, unfolded protein binding, transcription coactivator activity, NF-kappaB binding	spindle pole centrosome	response to stress, negative regulation of cell proliferation, negative regulation of centrosome duplication, nucleosome assembly, anti-apoptosis, cell aging, signal transduction, protein oligomerization, intracellular protein transport, centrosome cycle, interspecies interaction between organisms, positive regulation of NF-kappaB transcription factor activity, ribosome assembly

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	199	KAPVKKSIRDTPAKNAQKSNQ	CDK1	12058066	LTP	1.00	MOD_CDK_SPxK_1	-	Nucleoplasmin	0.83	-	-
T	199	KAPVKKSIRDTPAKNAQKSNQ	CDK1	15190079	LTP	1.00	MOD_CDK_SPxK_1	-	Nucleoplasmin	0.83	-	-
T	234	GQESFKKQEKTPKTPKGPSSV	CDK1	14670079	LTP	0.97		-	-	0.86	-	-
T	237	SFKKQEKTPKTPKGPSSVEDI	CDK1	14670079	LTP	1.00		-	-	0.85	-	-

Substrate:

NSFL1C (Unclassified)

Seq-ID:

Q9UNZ2 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
lipid binding, protein binding	chromosome, nucleus, Golgi stack

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	140	GAVAVERVTKSPGETSKPRPF	CDK1	12810701	LTP	0.10		-	-	0.75	-	-

Substrate:

Nuclear pore membrane glycoprotein POM210 (Transport/cargo protein)

Seq-ID:

Q9QY81 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	nuclear membrane, endoplasmic reticulum membrane, nuclear pore	transmembrane transport, protein transport, mRNA transport

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1880	RKASPPSGLWSPAYASH	CDK1	8672508	LTP	1.00		-	-	0.34	-	medium

Substrate:

Origin recognition complex subunit 1 (DNA binding protein)

Seq-ID:

Q13415 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50403   CDC6_HUMAN
MINT-50425   CDT1_HUMAN
MINT-2831892   TERF2_HUMAN
MINT-7243690   ABL1_HUMAN
MINT-7245886   FYN_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, nucleoside-triphosphatase activity, ATP binding, protein binding	origin recognition complex, cytosol	DNA-dependent DNA replication initiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	258	SQQTSCASLDSPGRIKRKVAF	CDK1	11931757	LTP	-	MOD_CDK_SPxK_1	-	-	0.58	-	medium
S	273	KRKVAFSEITSPSKRSQPDKL	CDK1	11931757	LTP	0.13	MOD_CDK_SPxK_1	-	-	0.69	-	medium
T	375	EAKAQNEATSTPHRIRRKSSV	CDK1	11931757	LTP	0.20	MOD_CDK_SPxK_1	-	-	0.81	-	medium

Substrate:

p53 (Cellular tumor antigen p53)

Seq-ID:

P10361 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
RNA polymerase II transcription factor activity, ubiquitin protein ligase binding, DNA strand annealing activity, copper ion binding, ATP binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, transcription repressor activity, sequence-specific DNA binding, protein C-terminus binding	cytosol, transcription factor complex, nucleolus, soluble fraction, endoplasmic reticulum, mitochondrion, chromatin	positive regulation of gene-specific transcription from RNA polymerase II promoter, response to amino acid stimulus, response to oxidative stress, response to drug, response to vitamin B3, cell cycle, positive regulation of apoptosis, negative regulation of smooth muscle cell proliferation, response to cytokine stimulus, response to X-ray, response to tumor cell, regulation of intracellular pH, response to caffeine, nucleotide-excision repair, response to retinoic acid, wound healing, multicellular organismal development, response to hyperoxia, positive regulation of leukocyte migration, response to metal ion, response to UV, transcription, negative regulation of cell growth, positive regulation of cell cycle, activation of caspase activity by cytochrome c, cell aging

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	313	KRALPTSTSSSPQQKKKPLDG	CDK1	7862459	LTP	0.95		-	-	0.78	-	medium

Substrate:

Parathyroid hormone related protein (Peptide hormone)

Seq-ID:

P12272 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
hormone activity	cytoplasm, extracellular space, nucleus	epidermis development, positive regulation of cAMP biosynthetic process, positive regulation of cell proliferation, negative regulation of cell proliferation, skeletal system development, cell-cell signaling, regulation of gene expression, female pregnancy, negative regulation of chondrocyte differentiation, activation of adenylate cyclase activity by G-protein signaling pathway, cAMP metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	108	DDEGRYLTQETNKVETYKEQP	CDK1	10373465	LTP	1.00		-	Parathyroid	0.64	-	low

Substrate:

PBK (ATP binding, protein binding)

Seq-ID:

Q96KB5 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19323   ARAF_HUMAN
MINT-72835   DLG1_HUMAN
MINT-1792581   MBP_HUMAN
MINT-1792672   CDC2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, protein binding		protein amino acid phosphorylation, mitosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	9	MEGISNFKTPSKLSEKKKS	CDK1	15541388	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.43	-	low

Substrate:

Peroxiredoxin 1 (Involved in redox regulation of the cell)

Seq-ID:

Q06830 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-64057   G3P_HUMAN
MINT-3296237   1433Z_HUMAN
MINT-3373635   ADRM1_HUMAN
MINT-5115288   THIO_HUMAN
MINT-7213827   ABL1_HUMAN
MINT-7266561   PTEN_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
thioredoxin peroxidase activity, protein binding	mitochondrion, melanosome, nucleus	hydrogen peroxide catabolic process, oxidation reduction, cell redox homeostasis, skeletal system development, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	90	SHFCHLAWVNTPKKQGGLGPM	CDK1	11986303	LTP	0.76	MOD_CDK_SPxK_1	-	AhpC-TSA	0.23	2RII	26.03%

Substrate:

PIK3C2A (phosphatidylinositol 3-kinase activity)

Seq-ID:

O00443 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7971086 DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide binding, 1-phosphatidylinositol-3-kinase activity, phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, protein binding	plasma membrane, phosphoinositide 3-kinase complex, clathrin-coated vesicle, Golgi apparatus, nucleus	phosphatidylinositol biosynthetic process, phosphoinositide-mediated signaling, cell communication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	259	TDSKVSNLQVSPKSEDISKFD	CDK1	12719431	LTP	0.18		-	-	0.40	-	low

Substrate:

PITPNM1 (Cell cycle control protein)

Seq-ID:

O00562 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphatidylinositol transporter activity, metal ion binding	lipid particle, membrane fraction, endoplasmic reticulum membrane, Golgi cisterna membrane	brain development, phototransduction, lipid metabolic process, protein transport

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	287	EARSAASNTGTPDGPEAPPGP	CDK1	15125835	LTP	0.09		-	-	0.95	-	low
S	382	NSNDFIDAFASPVEAEGTPEP	CDK1	15125835	LTP	0.41		-	-	0.68	-	low

Substrate:

Plectin 1 (Anchor protein)

Seq-ID:

Q15149 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-61558   GRB2_HUMAN
MINT-62106   SMAD9_HUMAN
MINT-2985088   ZO1_HUMAN
MINT-7234326   ITB4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural constituent of muscle, actin binding	plasma membrane, cytosol, cytoskeleton	hemidesmosome assembly

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	4539	YLTGGLIEPDTPGRVPLDEAL	CDK1	8626512	LTP	0.01	MOD_CDK_SPxK_1	-	PLEC	0.50	-	medium

Substrate:

PP1A (ser/thr protein phosphatase PP1-alpha 1 catalytic subunit (from PhosphoBase))

Seq-ID:

P62136 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48444   M3K3_HUMAN
MINT-62187   NOM1_HUMAN
MINT-62188   PP1R8_HUMAN
MINT-62189   PP1RA_HUMAN
MINT-62194   ASPP2_HUMAN
MINT-62195   STAM1_HUMAN
MINT-62197   KI18A_HUMAN
MINT-62199   NEB2_HUMAN
MINT-62200   PLCL2_HUMAN
MINT-62201   CASC5_HUMAN
MINT-62203   ASPP1_HUMAN
MINT-62204   MPP10_HUMAN
MINT-62205   ZFY16_HUMAN
MINT-62206   P53_HUMAN
MINT-4544575   AXN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
metal ion binding, protein serine/threonine phosphatase activity, protein phosphatase type 1 regulator activity, protein binding	cytosol, MLL5-L complex, nucleolus	cell division, cell cycle, protein amino acid dephosphorylation, glycogen metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	320	SGLNPGGRPITPPRNSAKAKK	CDK1	9122166	LTP	0.65	MOD_CDK_SPxK_1	-	-	0.70	-	medium

Substrate:

Protein C10orf3 (unclassified)

Seq-ID:

Q53EZ4 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-6173387   TS101_HUMAN
MINT-6173438   HGS_HUMAN
MINT-6175173   PDC6I_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	centriole	cell division, mitosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	425	ETENREKVAASPKSPTAALNE	CDK1	16198290	LTP	0.85		-	-	0.65	-	medium
S	428	NREKVAASPKSPTAALNESLV	CDK1	16198290	LTP	0.68		-	-	0.55	-	medium

Substrate:

PTPN2 (Tyrosine-protein phosphatase non-receptor type 2)

Seq-ID:

P17706-2 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	cytoplasm	protein amino acid dephosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	304	KEDLSPAFDHSPNKIMTEKYN	CDK1	15030318	LTP	0.32	MOD_CDK_SPxK_1	-	-	0.58	-	medium

Substrate:

Rad9 (Cell cycle checkpoint control protein (RAD9))

Seq-ID:

Q99638 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-3379418 TOPB1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, exodeoxyribonuclease III activity, protein kinase binding, 3`-5` exonuclease activity, histone deacetylase binding	nucleus	DNA repair, DNA damage checkpoint, DNA replication checkpoint, DNA replication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	277	DTDSHSQDLGSPERHQPVPQL	CDK1	12734188	LTP	0.12	MOD_CDK_SPxK_1	-	-	0.89	-	-
T	292	QPVPQLQAHSTPHPDDFANDD	CDK1	12734188	LTP	0.12		-	-	0.84	-	-
S	328	GSRVLPSISLSPGPQPPKSPG	CDK1	12734188	LTP	0.09		-	-	0.89	-	-
S	336	SLSPGPQPPKSPGPHSEEEDE	CDK1	12734188	LTP	0.05		-	-	0.98	-	-
T	355	DEAEPSTVPGTPPPKKFRSLF	CDK1	12734188	LTP	0.17		-	-	0.84	-	-

Substrate:

Rap1GAP (GTPase activating protein)

Seq-ID:

P47736 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-3308267 1433Z_HUMAN
MINT-6543629 RAP1B_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein homodimerization activity, GTPase activator activity, Ras GTPase binding	Golgi membrane	signal transduction, regulation of Ras GTPase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	484	AGISLIVPGKSPTRKKSGPFG	CDK1	1406653	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.68	-	low

Substrate:

Raptor (Unclassified)

Seq-ID:

Q8N122 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-6549354 4EBP1_HUMAN
MINT-7556099 FRAP_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein complex binding	TORC1 complex, cytosol	positive regulation of TOR signaling cascade, regulation of cell size, cellular response to nutrient levels

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	696	IEEEKNYALPSPATTEGGSLT	CDK1	20169205	LTP	0.09		-	-	0.57	-	medium
T	706	SPATTEGGSLTPVRDSPCTPR	CDK1	20169205	LTP	0.03	MOD_CDK_SPxK_1	-	-	0.68	-	medium

Substrate:

Ras-related protein Rab-5B (GTPase)

Seq-ID:

P61020 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
GTPase activity, GTP binding, GTP-dependent protein binding	plasma membrane, membrane fraction, early endosome membrane, melanosome	protein transport, small GTPase mediated signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	123	TWVKELQRQASPSIVIALAGN	CDK1	10403367	LTP	0.42		-	RAB	0.23	2HEI	41.80%

Substrate:

Replication factor-A protein 2 (DNA binding protein)

Seq-ID:

P15927 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-69732 LT_SV40

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
single-stranded DNA binding, protein binding	nucleoplasm, DNA replication factor A complex	nucleotide-excision repair, DNA damage removal, nucleotide-excision repair, DNA gap filling, DNA-dependent DNA replication, DNA recombination

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	23	SYGGAGGYTQSPGGFGSPAPS	CDK1	9295339	LTP	0.22	-	-	0.61	-	-
S	29	GYTQSPGGFGSPAPSQAEKKS	CDK1	9295339	LTP	0.21	-	-	0.72	-	-
S	29	GYTQSPGGFGSPAPSQAEKKS	CDK1	9139719	LTP	0.21	-	-	0.72	-	-

Substrate:

Ribonucleotide reductase M2 subunit (Cell cycle control protein)

Seq-ID:

P31350 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transition metal ion binding, ribonucleoside-diphosphate reductase activity	cytoplasm	oxidation reduction, deoxyribonucleotide biosynthetic process, DNA replication, deoxyribonucleoside diphosphate metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	20	PITDPQQLQLSPLKGLSLVDK	CDK1	9990288	LTP	0.30	MOD_CDK_SPxK_1	-	-	0.45	-	medium

Substrate:

Ribosomal protein S6 kinase 1 (p70 S6 kinase)

Seq-ID:

P23443 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14377   PDPK1_HUMAN
MINT-14953   4EBP1_MOUSE
MINT-15213   AKT1_HUMAN
MINT-15292   CDC42_HUMAN
MINT-51122   COASY_HUMAN
MINT-74872   TAU_HUMAN
MINT-74874   TAU_HUMAN
MINT-3390512   PDK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP binding, protein kinase activity, protein binding	cell junction, cytoplasm, cytosol, synapse, mitochondrial outer membrane, synaptosome, nucleus	TOR signaling cascade, negative regulation of apoptosis, positive regulation of mitotic cell cycle, apoptosis, G1/S transition of mitotic cell cycle, phosphoinositide-mediated signaling, positive regulation of translational initiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	394	SKFTRQTPVDSPDDSTLSESA	CDK1	12586835	LTP	0.98		-	S_TK_X	0.70	-	low
S	434	EKFSFEPKIRSPRRFIGSPRT	CDK1	12586835	LTP	0.44	MOD_CDK_SPxK_1	-	-	0.49	-	low
T	444	SPRRFIGSPRTPVSPVKFSPG	CDK1	12586835	LTP	0.38	MOD_CDK_SPxK_1	-	-	0.50	-	low
S	447	RFIGSPRTPVSPVKFSPGDFW	CDK1	12586835	LTP	0.41	MOD_CDK_SPxK_1	-	-	0.48	-	low
S	447	RFIGSPRTPVSPVKFSPGDFW	CDK1	11914378	LTP	0.41	MOD_CDK_SPxK_1	-	-	0.48	-	low

Substrate:

RPB1 (RNA polymerase)

Seq-ID:

P08775 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7277744 ELOA1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA-directed RNA polymerase activity, DNA binding, metal ion binding	DNA-directed RNA polymerase II, core complex	transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1616	GGYTPQSPSYSPTSPSYSPTS	CDK1	1899239	LTP	0.89		-	RNA_pol_Rpb1_R	0.71	-	medium
S	1619	TPQSPSYSPTSPSYSPTSPSY	CDK1	1899239	LTP	0.93		-	RNA_pol_Rpb1_R	0.68	-	medium

Substrate:

Sam68 (Adapter molecule)

Seq-ID:

Q07666 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15408   FYN_HUMAN
MINT-16809   SRC_CHICK
MINT-17535   LYN_HUMAN
MINT-56721   FNBP4_HUMAN
MINT-56723   WBP4_HUMAN
MINT-56729   ANM1_HUMAN
MINT-61611   SMAD2_HUMAN
MINT-62828   CD2B2_HUMAN
MINT-65549   STUB1_HUMAN
MINT-7051501   HCK_HUMAN
MINT-7212471   LCK_HUMAN
MINT-7300587   VAV_HUMAN
MINT-7300603   VAV_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, transcription repressor activity, DNA binding, SH3/SH2 adaptor activity, RNA binding	nucleus, membrane	mRNA processing, transcription, cell cycle arrest, regulation of RNA export from nucleus, cell surface receptor linked signaling pathway, cell proliferation, G2/M transition of mitotic cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	317	GPPRGALVRGTPVRGAITRGA	CDK1	9315091	LTP	0.11	MOD_CDK_SPxK_1	-	-	0.59	-	low

Substrate:

Securin (Transcription regulatory protein)

Seq-ID:

O95997 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, cysteine-type endopeptidase inhibitor activity, sequence-specific DNA binding transcription factor activity	cytosol, nucleus	chromosome organization, transcription from RNA polymerase II promoter, cell division, DNA repair, chromosome segregation, spermatogenesis, mitosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	165	LEKLFQLGPPSPVKMPSPPWE	CDK1	10656688	LTP	1.00	MOD_CDK_SPxK_1	-	Securin	0.54	-	low

Substrate:

Separin (Cysteine protease)

Seq-ID:

Q14674 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cysteine-type peptidase activity, protein binding	centrosome, nucleus	positive regulation of mitotic metaphase/anaphase transition, proteolysis, cytokinesis, apoptosis, mitotic sister chromatid segregation, negative regulation of sister chromatid cohesion, establishment of mitotic spindle localization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1126	PGPIAPSTNSSPVLKTKPQPI	CDK1	11747808	LTP	0.15	MOD_ProDKin_1	-	-	0.64	-	medium

Substrate:

Serine/threonine-protein kinase PAK 1 (Ser/Thr protein kinase family)

Seq-ID:

O88643 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19486 ARHG7_HUMAN
MINT-19793 NCK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding	focal adhesion, axon, growth cone	dendrite development, protein amino acid phosphorylation, neuromuscular junction development, receptor clustering

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	212	TRSVIEPLPVTPTRDVATSPI	CDK1	12176333	LTP	0.13	MOD_CDK_SPxK_1	-	-	0.68	-	-

Substrate:

SIRT2 (protein binding)

Seq-ID:

Q8IXJ6 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
NAD binding, NAD-dependent histone deacetylase activity, histone deacetylase binding, transcription factor binding, tubulin deacetylase activity, ubiquitin binding, zinc ion binding, histone acetyltransferase binding	cytoplasm, chromatin silencing complex, microtubule	cell division, histone deacetylation, regulation of phosphorylation, negative regulation of striated muscle tissue development, protein amino acid ADP-ribosylation, mitosis, regulation of exit from mitosis, chromatin silencing at rDNA, chromatin silencing at telomere, response to redox state

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	368	AGVPNPSTSASPKKSPPPAKD	CDK1	17488717	LTP	0.05	MOD_CDK_SPxK_1	-	-	0.93	-	medium

Substrate:

SREBP1 (Transcription factor)

Seq-ID:

P36956 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-2863379 ATX1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sterol response element binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, protein binding	Golgi membrane, ER to Golgi transport vesicle membrane, integral to membrane, nuclear envelope, endoplasmic reticulum membrane, nucleus, endoplasmic reticulum	cellular response to starvation, transcription, regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, cholesterol metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	439	PSDAGSPFQSSPLSLGSRGSG	CDK1	16880739	LTP	1.00		-	-	0.72	-	medium

Substrate:

Synapsin-3 (Unclassified)

Seq-ID:

O14994 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
catalytic activity, ATP binding	cell junction, synaptic vesicle membrane	neurotransmitter secretion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	470	RLSPQGQQPLSPQSGSPQQQR	CDK1	14732590	LTP	0.23	MOD_ProDKin_1	-	-	0.99	-	medium

Substrate:

TK1 (thymidine kinase activity)

Seq-ID:

P04183 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-63364   G3P_HUMAN
MINT-63365   P53_HUMAN
MINT-63367   TLE1_HUMAN
MINT-63371   SETB1_HUMAN
MINT-63375   CC90B_HUMAN
MINT-63376   CA103_HUMAN
MINT-3296457   1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP binding, thymidine kinase activity	cytoplasm	DNA replication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	13	CINLPTVLPGSPSKTRGQIQV	CDK1	9575153	LTP	0.86	MOD_CDK_SPxK_1	-	-	0.28	-	-

Substrate:

Transcription factor jun-B (Transcription factor)

Seq-ID:

P24898 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, protein heterodimerization activity, transcription activator activity, double-stranded DNA binding, sequence-specific DNA binding transcription factor activity	nucleus	response to corticosterone stimulus, transcription from RNA polymerase II promoter, response to organic cyclic substance, response to cAMP, response to drug, response to progesterone stimulus, cellular response to hormone stimulus, response to cytokine stimulus, response to mechanical stimulus, response to peptide hormone stimulus, positive regulation of transcription from RNA polymerase II promoter during mitosis, response to light stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	23	DSYAAAGYGRSPGSLSLHDYK	CDK1	10790372	LTP	0.14	-	Jun	0.40	-	low
T	150	LDDLHKMNHVTPPNVSLGASG	CDK1	10790372	LTP	0.03	-	Jun	0.72	-	low
S	186	PPVYTNLSSYSPASAPSGGSG	CDK1	10790372	LTP	0.18	-	Jun	0.71	-	low

Substrate:

TTD nonphotosensitive 1 protein (unclassified)

Seq-ID:

Q8TAP9 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	microtubule organizing center, nucleus	cell division, mitosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	93	PGGYPGSYSRSPAGSQQQFGY	CDK1	17310276	LTP	1.00	-	-	0.81	-	medium
S	104	PAGSQQQFGYSPGQQQTHPQG	CDK1	17310276	LTP	1.00	-	-	0.95	-	medium
T	120	THPQGSPRTSTPFGSGRVREK	CDK1	17310276	LTP	1.00	-	-	0.93	-	medium

Substrate:

Tyrosine-protein phosphatase, non-receptor type 1 (Protein tyrosine phosphatase 1B)

Seq-ID:

P18031 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-51115   PPIP1_HUMAN
MINT-73489   CADH2_HUMAN
MINT-6744190   CSK21_HUMAN
MINT-6761890   GSK3B_HUMAN
MINT-6761899   ESR1_HUMAN
MINT-6762163   IKBA_HUMAN
MINT-6762380   PGFRB_HUMAN
MINT-6762549   PAXI_MOUSE
MINT-6762573   FAK1_MOUSE
MINT-6762866   IRS1_RAT
MINT-6763504   BCAR1_MOUSE
MINT-6763556   INSR_RAT
MINT-6764602   JAK2_HUMAN
MINT-6764613   STAT3_HUMAN
MINT-6764665   TRPV6_HUMAN
MINT-6764866   CAV1_HUMAN
MINT-6765163   PIAS1_HUMAN
MINT-6765185   SUMO1_HUMAN
MINT-6765318   CTND1_MOUSE
MINT-6765333   LPP_MOUSE
MINT-6765355   SRC8_MOUSE
MINT-6765370   ZO1_MOUSE
MINT-6765383   PLCG1_MOUSE
MINT-6765422   DOK1_MOUSE
MINT-6765439   EGFR_MOUSE
MINT-6765460   PGFRB_MOUSE
MINT-6787689   MET_HUMAN
MINT-6787710   ABL1_HUMAN
MINT-6793324   B3AT_HUMAN
MINT-6793358   EGFR_HUMAN
MINT-6793387   CAN1_HUMAN
MINT-6793394   CAN2_HUMAN
MINT-6793439   IRS1_MOUSE
MINT-6793452   INSR_MOUSE
MINT-6793484   BCAR1_HUMAN
MINT-6793722   AKT1_MOUSE
MINT-6793745   IRS1_HUMAN
MINT-6793782   TYK2_HUMAN
MINT-6793941   NTRK1_HUMAN
MINT-6793957   NTRK3_HUMAN
MINT-6793973   LTK_HUMAN
MINT-6793989   STA5A_HUMAN
MINT-6794005   STA5B_HUMAN
MINT-6794135   LAT_HUMAN
MINT-6794748   EPOR_HUMAN
MINT-6794792   GRB2_HUMAN
MINT-6794817   ITB3_HUMAN
MINT-6794878   ACTS_HUMAN
MINT-6794892   FAK1_HUMAN
MINT-6794946   INSR_HUMAN
MINT-6794972   KPCG_HUMAN
MINT-6795050   JAK2_MOUSE
MINT-6795199   SRC8_HUMAN
MINT-6795447   SRC_HUMAN
MINT-6796717   PLD2_HUMAN
MINT-6797067   CLK2_HUMAN
MINT-6797829   GHR_HUMAN
MINT-6799814   ROS_HUMAN
MINT-6800783   IGF1R_HUMAN
MINT-7972220   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, zinc ion binding	cytosol, endoplasmic reticulum membrane	negative regulation of insulin receptor signaling pathway, signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	386	GGSLRGAQAASPAKGEPSLPE	CDK1	8491187	LTP	0.00	MOD_CDK_SPxK_1	-	-	0.75	-	-

Substrate:

Ubiquitin activating enzyme 1 (Ubiquitin proteasome system protein)

Seq-ID:

P22314 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-72666   HS90B_HUMAN
MINT-2863889   TAF9_HUMAN
MINT-3318217   1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP binding, ligase activity, small protein activating enzyme activity, protein binding		protein modification process, cell death

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	4	MSSSPLSKKRRVSG	CDK1	7673335	LTP	0.15		-	-	0.74	-	medium
S	835	RLEELKATLPSPDKLPGFKMY	CDK1	7724583	LTP	0.22	MOD_CDK_SPxK_1	-	-	0.35	-	medium

Substrate:

Ubiquitin-conjugating enzyme E2 A (Ubiquitin proteasome system protein)

Seq-ID:

P49459 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ubiquitin protein ligase binding, ATP binding, ubiquitin-protein ligase activity		positive regulation of cell proliferation, regulation of protein metabolic process, response to UV, protein autoubiquitination, histone H2A ubiquitination, postreplication repair, protein K11-linked ubiquitination, protein K48-linked ubiquitination, ubiquitin-dependent protein catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	120	QSLLDEPNPNSPANSQAAQLY	CDK1	11953320	LTP	1.00		-	UBCc	0.63	-	medium

Substrate:

Vimentin (vimentin (from PhosphoBase))

Seq-ID:

P08670 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48218   NEMO_HUMAN
MINT-48335   M3K1_HUMAN
MINT-48490   M3K3_HUMAN
MINT-48555   NFKB1_HUMAN
MINT-49072   RIPK2_HUMAN
MINT-49446   TNR1B_HUMAN
MINT-51249   SMAD3_HUMAN
MINT-63478   FABP4_HUMAN
MINT-63483   CREB1_HUMAN
MINT-63519   SYN1_HUMAN
MINT-64054   RAD51_HUMAN
MINT-64131   TIF1B_HUMAN
MINT-64137   NFAC2_HUMAN
MINT-64185   CASP8_HUMAN
MINT-64286   STX1A_HUMAN
MINT-64820   Q86V38_HUMAN
MINT-64930   SIRT6_HUMAN
MINT-64945   CA103_HUMAN
MINT-64988   PAIRB_HUMAN
MINT-65109   FUBP1_HUMAN
MINT-65490   TARA_HUMAN
MINT-65741   PUF60_HUMAN
MINT-65855   SRRT_HUMAN
MINT-65878   NS1BP_HUMAN
MINT-66105   MYST2_HUMAN
MINT-66208   ABLM1_HUMAN
MINT-66844   K1C20_HUMAN
MINT-66894   GFAP_HUMAN
MINT-67503   PDLI1_HUMAN
MINT-67553   PSA1_HUMAN
MINT-67944   GOPC_HUMAN
MINT-2515544   SYUA_HUMAN
MINT-2791056   RD23A_HUMAN
MINT-2791422   RD23B_HUMAN
MINT-2985160   ZO1_HUMAN
MINT-3297793   1433Z_HUMAN
MINT-3979536   CHD3_HUMAN
MINT-3979774   ZHX1_HUMAN
MINT-3980301   SETB1_HUMAN
MINT-3980318   NFL_HUMAN
MINT-3980438   ING5_HUMAN
MINT-3980472   PPHLN_HUMAN
MINT-3980489   UT14A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein C-terminus binding, structural constituent of cytoskeleton	intermediate filament, cytosol	cellular component movement, interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	56	PSTSRSLYASSPGGVYATRSS	CDK1	7983050	LTP	0.61	MOD_ProDKin_1	-	Filament_head	0.48	-	-

Substrate:

WEE 1 tyrosine kinase (Dual specificity kinase)

Seq-ID:

P30291 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50988   1433B_HUMAN
MINT-3295375   1433Z_HUMAN
MINT-3975741   1433S_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, non-membrane spanning protein tyrosine kinase activity, ATP binding, protein binding	nucleoplasm	protein amino acid phosphorylation, cell division, mitosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	123	SWEEEGFGSSSPVKSPAAPYF	CDK1	15070733	LTP	0.54	MOD_CDK_SPxK_1	-	-	0.73	-	medium
S	123	SWEEEGFGSSSPVKSPAAPYF	CDK1	16085715	LTP	0.54	MOD_CDK_SPxK_1	-	-	0.73	-	medium