Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Actin filament-associated protein
ADAM 12
ADAM 15
Alpha enolase
ARAF
Beta-arrestin 1
Beta-catenin
BK-2 receptor
BMX
c-kit
C3G protein
Caveolin-1
Caveolin-2
CD227
CD33
CD91
CDC42
CDH2
CHRNA7
Clathrin heavy chain 1
Common beta c subunit
Connexin 43
CUGBP2
Cyclin dependent kinase inhibitor 1B
Disabled homolog 1
Dsrc64
Dystroglycan
EGFR
Erzin
Estrogen receptor alpha
FAK
GAST
Gelsolin
Glucocorticoid receptor DNA binding factor 1
Glutamate [NMDA] receptor subunit epsilon 2
Grb10
HLA-A1
hnRNPK
IGF1-R
IKB-alpha
Inositol polyphosphate 5-phosphatase
Integrin beta 3
KCNA3
Kcnb1
Lipocortin I (annexinI)
Lipocortin II (annexinII)
Middle T antigen
Nitric-oxide synthase, endothelial
P130Cas
PAK2
Paxillin
PDK1
PI3-kinase p85-alpha subunit
PIP5KIgamma
PKB-alpha
PKC delta
PKC iota
PKC mu
PL scramblase 1
PLC gamma 2
Protein zero related protein
PVRL2
RACK1
Raf1
Ras-related protein
RGS16
SH3-containing GRB2-like protein 1
Shc
Spectrin
Spry-2
Src
Src substrate cortactin
SRC-interacting protein
STAT 1
STAT 5
STAT 5B
Telomerase reverse transcriptase
TRIP6
Tyrosine-protein phosphatase, non-receptor type 6
WASF1

Substrate:

Actin filament-associated protein (Actin filament-associated protein)

Seq-ID:

ENSGALP00000036444 [Gallus gallus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, actin binding	cytoplasm, cytoskeleton

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	93	PLPTSSLPEGYYEEAVPLSPG	SRC	9655255	LTP	1.00	Src SH2	-	0.54	-	medium
Y	94	LPTSSLPEGYYEEAVPLSPGK	SRC	9655255	LTP	1.00	Src SH2	-	0.52	-	medium
Y	451	GSSTDPGALHYDYIDVEMTAS	SRC	9655255	LTP	1.00	Src SH2	-	0.33	-	medium
Y	453	STDPGALHYDYIDVEMTASVI	SRC	9655255	LTP	1.00	Src SH2	-	0.27	-	medium

Substrate:

ADAM 12 (Disintegrin and metalloproteinase domain 12)

Seq-ID:

Q61824 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, metalloendopeptidase activity, zinc ion binding	plasma membrane, integral to membrane	proteolysis, cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	901	HQVPRPSHNAYIK	SRC	11127814	LTP	0.00		-	-	0.71	-	medium

Substrate:

ADAM 15 (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15)

Seq-ID:

Q13444 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-2792372   LYN_HUMAN
MINT-2792392   YES_HUMAN
MINT-2792412   FYN_HUMAN
MINT-2792521   PACN3_HUMAN
MINT-2792601   ARHG7_HUMAN
MINT-2792621   ARHG6_HUMAN
MINT-2792641   NCK1_HUMAN
MINT-2792681   SRBS1_HUMAN
MINT-2792701   SH3R3_HUMAN
MINT-2792950   SNX33_HUMAN
MINT-2792970   SPD2A_HUMAN
MINT-2793013   SRC_HUMAN
MINT-7218089   HCK_HUMAN
MINT-7218109   LCK_HUMAN
MINT-7218139   GRB2_HUMAN
MINT-7218198   ABL1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, metalloendopeptidase activity, zinc ion binding	acrosomal vesicle, integral to membrane, flagellum, adherens junction, endomembrane system	proteolysis, angiogenesis, cell-matrix adhesion, collagen catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	715	LLVLVMLGASYWYRARLHQRL	SRC	11741929	LTP	0.30		-	TRANS	0.06	-	medium
Y	735	LCQLKGPTCQYRAAQSGPSER	SRC	11741929	LTP	0.13		-	-	0.46	-	medium

Substrate:

Alpha enolase (alpha enolase (from PhosphoBase))

Seq-ID:

P06733 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-49071   RIPK2_HUMAN
MINT-2858506   CBPC1_HUMAN
MINT-3304712   1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, transcription corepressor activity, phosphopyruvate hydratase activity, sequence-specific DNA binding transcription factor activity, serine-type endopeptidase activity	plasma membrane, M band, phosphopyruvate hydratase complex, nucleus	transcription, negative regulation of cell growth, negative regulation of transcription from RNA polymerase II promoter, glycolysis, response to virus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	44	AVPSGASTGIYEALELRDNDK	SRC	8578591	LTP	0.64		-	Enolase_N	0.36	2PSN	35.81%

Substrate:

ARAF (ATP binding, protein binding)

Seq-ID:

P10398 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16109   P85A_HUMAN
MINT-19316   PGTB2_HUMAN
MINT-19319   PRP6_HUMAN
MINT-19322   CSN3_HUMAN
MINT-19323   TOPK_HUMAN
MINT-3975364   1433S_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, metal ion binding, receptor signaling protein activity, ATP binding, protein binding		protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	301	VKNLGYRDSGYYWEVPPSEVQ	SRC	9020159	LTP	1.00		-	-	0.32	-	low
Y	302	KNLGYRDSGYYWEVPPSEVQL	SRC	9020159	LTP	1.00		-	-	0.30	-	low

Substrate:

Beta-arrestin 1 (Adapter molecule)

Seq-ID:

P49407 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19558   RTN3_MOUSE
MINT-19561   SON_MOUSE
MINT-19655   TOP2A_MOUSE
MINT-19697   NF2L2_MOUSE
MINT-19723   VIME_MOUSE
MINT-19787   ROA1_MOUSE
MINT-19799   MDM2_MOUSE
MINT-4791905   AGTR1_HUMAN
MINT-7263136   MK10_HUMAN
MINT-7263254   M3K5_HUMAN
MINT-7263269   MP2K4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
insulin-like growth factor receptor binding, ubiquitin protein ligase binding, enzyme inhibitor activity, GTPase activator activity, angiotensin receptor binding, transcription factor binding, promoter binding	plasma membrane, membrane fraction, pseudopodium, chromatin, cytoplasmic membrane-bounded vesicle, coated pit, soluble fraction, nucleus	positive regulation of ERK1 and ERK2 cascade, positive regulation of gene-specific transcription from RNA polymerase II promoter, negative regulation of interleukin-8 production, negative regulation of NF-kappaB transcription factor activity, histone H4 acetylation, negative regulation of protein ubiquitination, negative regulation of signal transduction, proteasomal ubiquitin-dependent protein catabolic process, protein ubiquitination, protein transport, post-Golgi vesicle-mediated transport, sensory perception, positive regulation of histone acetylation, G-protein coupled receptor internalization, positive regulation of Rho protein signal transduction, stress fiber assembly, negative regulation of interleukin-6 production, transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	54	DPEYLKERRVYVTLTCAFRYG	SRC	17456469	LTP	0.87		-	Arrestin_N	0.10	1G4M	3.06%

Substrate:

Beta-catenin (Adhesion molecule)

Seq-ID:

P35222 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-46005   CADH1_HUMAN
MINT-46006   CTNA1_HUMAN
MINT-49803   ANDR_HUMAN
MINT-49805   NCOA2_HUMAN
MINT-1779698   TF7L2_HUMAN
MINT-1792780   LAP2_HUMAN
MINT-1792796   PKP4_HUMAN
MINT-2839028   LAP2B_HUMAN
MINT-2839079   EMD_HUMAN
MINT-4085223   CADH5_HUMAN
MINT-4085261   PARD3_HUMAN
MINT-4085491   CADH2_HUMAN
MINT-4508051   GSK3B_HUMAN
MINT-4508065   ITF2_HUMAN
MINT-4508192   AXN1_HUMAN
MINT-4508216   ABL1_HUMAN
MINT-4508229   APC_HUMAN
MINT-6823807   HDAC1_HUMAN
MINT-7023862   NFKB1_HUMAN
MINT-7952417   TNIK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
R-SMAD binding, cadherin binding, androgen receptor binding, alpha-catenin binding, kinase binding, protein phosphatase binding, transcription coactivator activity, promoter binding, signal transducer activity, estrogen receptor binding, I-SMAD binding, protein C-terminus binding	Axin-APC-beta-catenin-GSK3B complex, catenin complex, transcription factor complex, perinuclear region of cytoplasm, cell cortex, protein-DNA complex, beta-catenin-TCF7L2 complex, centrosome, cell-substrate adherens junction, lateral plasma membrane	positive regulation of gene-specific transcription from RNA polymerase II promoter, patterning of blood vessels, protein localization at cell surface, positive regulation of heparan sulfate proteoglycan biosynthetic process, negative regulation of cell proliferation, cellular response to indole-3-methanol, response to drug, positive regulation of anti-apoptosis, positive regulation of apoptosis, canonical Wnt receptor signaling pathway, regulation of calcium ion import, androgen receptor signaling pathway, adherens junction assembly, regulation of fibroblast proliferation, epithelial to mesenchymal transition, regulation of smooth muscle cell proliferation, cell-cell adhesion, cellular response to growth factor stimulus, positive regulation of epithelial to mesenchymal transition, regulation of angiogenesis, endothelial tube morphogenesis, negative regulation of apoptosis, transcription, regulation of centriole-centriole cohesion, regulation of centromeric sister chromatid cohesion, response to estradiol stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	86	QEQVADIDGQYAMTRAQRVRA	SRC	11279024	LTP	0.18		-	-	0.45	-	-
Y	654	LHSRNEGVATYAAAVLFRMSE	SRC	11279024	LTP	0.98		-	ARM	0.28	1JDH	25.76%

Substrate:

BK-2 receptor (B2 bradykinin receptor)

Seq-ID:

P30411 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, phosphoinositide phospholipase C activity, protease binding, bradykinin receptor activity, type 1 angiotensin receptor binding	endosome, integral to plasma membrane	arachidonic acid secretion, regulation of vasoconstriction, regulation of vascular permeability, inflammatory response, smooth muscle contraction, transmembrane receptor protein tyrosine kinase signaling pathway, elevation of cytosolic calcium ion concentration

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	177	RMRGVRWAKLYSLVIWGCTLL	SRC	16226010	LTP	0.05		-	TRANS	0.01	-	low
Y	347	KRFRKKSWEVYQGVCQKGGCR	SRC	16226010	LTP	0.16		-	-	0.13	-	low

Substrate:

BMX (Tyrosine kinase)

Seq-ID:

P51813 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-68564   GAB1_HUMAN
MINT-68565   P53_HUMAN
MINT-74487   EGFR_HUMAN
MINT-74488   ERBB2_HUMAN
MINT-7254948   CRK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
metal ion binding, non-membrane spanning protein tyrosine kinase activity, ATP binding, signal transducer activity, protein binding	cytosol	protein amino acid phosphorylation, mesoderm development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	566	GMTRYVLDDQYVSSVGTKFPV	SRC	10688651	LTP	1.00		-	TyrKc	0.06	-	medium

Substrate:

c-kit (Receptor tyrosine kinase)

Seq-ID:

P10721 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor signaling protein tyrosine kinase activity, ATP binding, protein binding	integral to membrane, extracellular space	male gonad development, transmembrane receptor protein tyrosine kinase signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	900	LSPEHAPAEMYDIMKTCWDAD	SRC	12878163	LTP	1.00		PIK3R1 SH2	TyrKc	0.24	1T46	16.16%

Substrate:

C3G protein (Guanine nucleotide exchange factor)

Seq-ID:

Q13905 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14744   GRB2_HUMAN
MINT-7244206   ABL1_HUMAN
MINT-7245754   SRC_HUMAN
MINT-7247374   FYN_HUMAN
MINT-7250842   NCK1_HUMAN
MINT-7252342   P85A_HUMAN
MINT-7254430   CRK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
guanyl-nucleotide exchange factor activity, SH3 domain binding	endosome, cytosol	regulation of small GTPase mediated signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway, small GTPase mediated signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	504	QSTAPIPSVPYAPFAAILPFQ	SRC	15320955	LTP	0.23		-	-	0.42	-	low

Substrate:

Caveolin-1 (May act as a scaffolding protein within the caveolar membranes )

Seq-ID:

P49817 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-7307575 TRXR1_HUMAN
MINT-7307618 TRXR1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
peptidase activator activity	caveola, integral to membrane of membrane fraction, integral to plasma membrane, perinuclear region of cytoplasm, protein complex, cell cortex, endoplasmic reticulum, Golgi membrane	negative regulation of gene-specific transcription from RNA polymerase II promoter, positive regulation of vasoconstriction, inactivation of MAPK activity, negative regulation of tyrosine phosphorylation of Stat5 protein, cholesterol homeostasis, positive regulation of calcium ion transport into cytosol, lipid storage, mammary gland involution, vasoconstriction, negative regulation of nitric oxide biosynthetic process, negative regulation of canonical Wnt receptor signaling pathway, negative regulation of epithelial cell differentiation, positive regulation of metalloenzyme activity, response to calcium ion, negative regulation of MAPKKK cascade, lactation, vasculogenesis, calcium ion transport, skeletal muscle tissue development, T cell costimulation, triglyceride metabolic process, protein homooligomerization, negative regulation of endothelial cell proliferation, nitric oxide homeostasis, endocytosis, negative regulation of cytokine-mediated signaling pathway, regulation of smooth muscle contraction, membrane depolarization, regulation of fatty acid metabolic process, response to hypoxia, response to estrogen stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	14	GKYVDSEGHLYTVPIREQGNI	SRC	11075810	LTP	-		GRB7 SH2	Caveolin	0.30	-	low
Y	14	GKYVDSEGHLYTVPIREQGNI	SRC	8632005	LTP	-		GRB7 SH2	Caveolin	0.30	-	low

Substrate:

Caveolin-1 (May act as a scaffolding protein within the caveolar membranes )

Seq-ID:

Q03135 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14113   RASH_HUMAN
MINT-15459   SRC_HUMAN
MINT-50920   MDR1_HUMAN
MINT-6764866   PTN1_HUMAN
MINT-6793815   PTN6_HUMAN
MINT-6793823   PTEN_HUMAN
MINT-6793881   PTN11_HUMAN
MINT-7234712   SDPR_HUMAN
MINT-7234742   PRDBP_HUMAN
MINT-7307629   TRXR1_HUMAN
MINT-7309906   SCRB2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nitric-oxide synthase binding, protein complex scaffold, cholesterol binding, peptidase activator activity, receptor binding, protein binding	lipid particle, basolateral plasma membrane, caveola, perinuclear region of cytoplasm, apical plasma membrane, endoplasmic reticulum, Golgi membrane	cellular response to starvation, negative regulation of gene-specific transcription from RNA polymerase II promoter, positive regulation of vasoconstriction, inactivation of MAPK activity, maintenance of protein location in cell, regulation of blood coagulation, negative regulation of BMP signaling pathway, cholesterol homeostasis, positive regulation of calcium ion transport into cytosol, lipid storage, mammary gland involution, positive regulation of peptidyl-serine phosphorylation, negative regulation of canonical Wnt receptor signaling pathway, negative regulation of epithelial cell differentiation, positive regulation of metalloenzyme activity, negative regulation of peptidyl-serine phosphorylation, calcium ion transport, interspecies interaction between organisms, cytosolic calcium ion homeostasis, T cell costimulation, triglyceride metabolic process, protein homooligomerization, vesicle organization, negative regulation of endothelial cell proliferation, nitric oxide homeostasis, receptor internalization, caveola assembly, regulation of smooth muscle contraction, membrane depolarization, regulation of fatty acid metabolic process, response to hypoxia, response to estrogen stimulus, positive regulation of canonical Wnt receptor signaling pathway, response to progesterone stimulus, negative regulation of nitric oxide biosynthetic process, response to calcium ion, negative regulation of MAPKKK cascade, negative regulation of protein binding, vasculogenesis, skeletal muscle tissue development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	14	GKYVDSEGHLYTVPIREQGNI	SRC	12921535	LTP	0.69		Csk SH2	Caveolin	0.29	-	low

Substrate:

Caveolin-2 (Scaffolding protein)

Seq-ID:

P51636 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-64180 GOGB1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
D1 dopamine receptor binding, protein homodimerization activity	Golgi membrane, membrane fraction, caveola, integral to plasma membrane, extrinsic to internal side of plasma membrane, transport vesicle, nucleus, perinuclear region of cytoplasm	vesicle docking, endoplasmic reticulum organization, regulation of mitosis, positive regulation of dopamine receptor signaling pathway, skeletal muscle fiber development, vesicle fusion, negative regulation of endothelial cell proliferation, caveola assembly, mitochondrion organization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	19	DVQLFMDDDSYSHHSGLEYAD	SRC	12091389	LTP	0.09		-	Caveolin	0.13	-	low

Substrate:

Caveolin-2 (Scaffolding protein)

Seq-ID:

Q9WVC3 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
D1 dopamine receptor binding	Golgi membrane, caveola, extrinsic to internal side of plasma membrane, nucleus, perinuclear region of cytoplasm	vesicle docking, protein oligomerization, endoplasmic reticulum organization, positive regulation of dopamine receptor signaling pathway, skeletal muscle fiber development, vesicle fusion, negative regulation of endothelial cell proliferation, endocytosis, caveola assembly, mitochondrion organization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	19	DVQLFMADDAYSHHSGVDYAD	SRC	12091389	LTP	0.08		-	Caveolin	0.09	-	medium

Substrate:

CD227 (CD antigen)

Seq-ID:

P15941 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-2880967 ABL1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	extracellular region, cytoplasm, integral to plasma membrane, nucleus, apical plasma membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1229	VPPSSTDRSPYEKVSAGNGGS	SRC	11152665	LTP	0.00		-	-	0.54	-	low

Substrate:

CD33 (CD antigen)

Seq-ID:

P20138 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sugar binding, receptor activity	integral to plasma membrane	negative regulation of cell proliferation, cell-cell signaling, cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	340	PTVEMDEELHYASLNFHGMNP	SRC	10887109	LTP	1.00		PTPN11 SH2; PTPN6 SH2	-	0.54	-	low

Substrate:

CD91 (Cell surface receptor)

Seq-ID:

Q07954 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, calcium ion binding, lipid transporter activity, lipoprotein binding, lipoprotein receptor binding, apolipoprotein binding, protein complex binding	membrane fraction, integral to plasma membrane, coated pit, nucleus	lipid metabolic process, regulation of phospholipase A2 activity, negative regulation of Wnt receptor signaling pathway, positive regulation of cholesterol efflux, apoptotic cell clearance, multicellular organismal development, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	4507	DKPTNFTNPVYATLYMGGHGS	SRC	12789267	LTP	1.00		DAB1 PTB; GULP1 PTB; SHC1 PTB	-	0.41	-	low

Substrate:

CDC42 (GTPase activity, protein binding)

Seq-ID:

P60953 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14030   PAK1_HUMAN
MINT-14552   E2AK2_HUMAN
MINT-15292   KS6B1_HUMAN
MINT-15379   CIP4_HUMAN
MINT-18637   IQGA1_HUMAN
MINT-19009   P85A_HUMAN
MINT-25018   WASP_HUMAN
MINT-72703   WASL_HUMAN
MINT-3372015   ARHG7_HUMAN
MINT-6743356   VAV_HUMAN
MINT-7104353   BCAR1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
thioesterase binding, GTPase activity, GTP binding	plasma membrane, filopodium, cytosol	macrophage differentiation, actin cytoskeleton organization, positive regulation of pseudopodium assembly, establishment or maintenance of cell polarity, small GTPase mediated signal transduction, negative regulation of protein complex assembly

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	64	GLFDTAGQEDYDRLRPLSYPQ	SRC	14506284	LTP	0.96		-	RHO	0.32	1GZS	55.90%

Substrate:

CDH2 (cell adhesion molecule)

Seq-ID:

P15116 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, protein phosphatase binding, RPTP-like protein binding	lamellipodium, integral to membrane, synapse	cell migration, calcium-dependent cell-cell adhesion, blood vessel morphogenesis, heterophilic cell-cell adhesion, homophilic cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	852	AADNDPTAPPYDSLLVFDYEG	SRC	10502299	LTP	0.98		-	Cadherin_C	0.61	-	medium
Y	884	NSSSSGGDQDYDYLNDWGPRF	SRC	10502299	LTP	0.97		-	Cadherin_C	0.57	-	medium

Substrate:

CDH2 (cell adhesion molecule)

Seq-ID:

P19022 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-73489 PTN1_HUMAN
MINT-4085491 CTNB1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, alpha-catenin binding, beta-catenin binding, gamma-catenin binding	catenin complex, integral to membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	852	AADNDPTAPPYDSLLVFDYEG	SRC	16371504	LTP	0.98		-	Cadherin_C	0.62	-	medium
Y	884	NSSSSGGEQDYDYLNDWGPRF	SRC	16371504	LTP	0.97		-	Cadherin_C	0.58	-	medium

Substrate:

CHRNA7 (acetylcholine receptor activity, nicotinic acetylcholine-activated cation-se...)

Seq-ID:

P36544 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nicotinic acetylcholine-activated cation-selective channel activity, beta-amyloid binding, toxin binding, protein homodimerization activity, chloride channel regulator activity, acetylcholine receptor activity	cell junction, nicotinic acetylcholine-gated receptor-channel complex, postsynaptic membrane	positive regulation of cell proliferation, response to hypoxia, negative regulation of tumor necrosis factor production, cellular calcium ion homeostasis, activation of MAPK activity, positive regulation of angiogenesis, calcium ion transport, memory, response to nicotine

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	386	PPPASNGNLLYIGFRGLDGVH	SRC	16251431	LTP	1.00		-	Neur_chan_memb	0.11	-	low
Y	442	DLAKILEEVRYIANRFRCQDE	SRC	16251431	LTP	1.00		-	Neur_chan_memb	0.12	-	low

Substrate:

Clathrin heavy chain 1 (Structural protein)

Seq-ID:

Q00610 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48080   IKKB_HUMAN
MINT-48107   IKKE_HUMAN
MINT-48173   NEMO_HUMAN
MINT-48258   TANK_HUMAN
MINT-48433   M3K3_HUMAN
MINT-48547   NFKB1_HUMAN
MINT-48727   NFKB2_HUMAN
MINT-49001   RELB_HUMAN
MINT-49201   TAB2_HUMAN
MINT-49413   TNR1B_HUMAN
MINT-65733   ARMX3_HUMAN
MINT-69536   BCR_HUMAN
MINT-3320079   1433Z_HUMAN
MINT-3979927   KU70_HUMAN
MINT-6802128   MYB_HUMAN
MINT-7983349   TM1L1_HUMAN
MINT-7983409   ACK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural molecule activity, protein binding	clathrin coat of coated pit, spindle, melanosome, clathrin coat of trans-Golgi network vesicle	post-Golgi vesicle-mediated transport, intracellular protein transport, mitosis, transferrin transport, receptor internalization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1477	LNNLFITEEDYQALRTSIDAY	SRC	12237126	LTP	0.94		-	CLH	0.12	1B89	36.68%

Substrate:

Common beta c subunit (Cytokine recpetor common beta chain)

Seq-ID:

P26955 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cytokine receptor activity	integral to membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	595	QLPSFDFNGPYLGPPQSHSLP	SRC	16437163	LTP	1.00		SHC1 PTB	-	0.75	-	medium

Substrate:

Connexin 43 (Intercellular channel)

Seq-ID:

P08050 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-1791070 ZO1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, gap junction channel activity, PDZ domain binding	connexon complex, Golgi-associated vesicle membrane, early endosome, integral to plasma membrane, lysosome, fascia adherens, mitochondrial outer membrane, endoplasmic reticulum membrane, multivesicular body, membrane raft	positive regulation of protein catabolic process, ATP transport, response to pH, negative regulation of cell proliferation, apoptosis, vascular transport, gap junction assembly, protein oligomerization, cell-cell signaling, neuron projection morphogenesis, regulation of calcium ion transport, response to peptide hormone stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	247	KDRVKGRSDPYHATTGPLSPS	SRC	11514593	LTP	0.22		-	-	0.51	-	-
Y	265	SPSKDCGSPKYAYFNGCSSPT	SRC	11514593	LTP	0.09		-	-	0.26	-	-

Substrate:

CUGBP2 (RNA-binding protein)

Seq-ID:

Q792H5-3 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleotide binding, RNA binding	cytoplasm, nucleus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	39	EKELKELFEPYGAVYQINVLR	SRC	17855367	LTP	0.96		-	RRM	0.20	-	medium

Substrate:

Cyclin dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1))

Seq-ID:

P46527 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17680   AKT1_HUMAN
MINT-17889   1433T_HUMAN
MINT-63858   GDIR1_HUMAN
MINT-1779946   MCM7_HUMAN
MINT-3379700   CDK2_HUMAN
MINT-3379718   CDK4_HUMAN
MINT-7219650   GRB2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cyclin-dependent protein kinase inhibitor activity, transforming growth factor beta receptor, cytoplasmic mediator activity, protein binding	cytosol, nucleus	negative regulation of kinase activity, regulation of cyclin-dependent protein kinase activity, negative regulation of cell proliferation, negative regulation of cell growth, cell cycle arrest, G1/S transition of mitotic cell cycle, autophagic cell death, cellular response to lithium ion, induction of apoptosis, negative regulation of gene-specific transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	74	FQNHKPLEGKYEWQEVEKGSL	SRC	17254967	LTP	1.00	-	CDI	0.62	-	-
Y	88	EVEKGSLPEFYYRPPRPPKGA	SRC	17254967	LTP	1.00	-	-	0.68	1JSU	70.31%
Y	89	VEKGSLPEFYYRPPRPPKGAC	SRC	17254967	LTP	0.22	-	-	0.67	1JSU	36.68%

Substrate:

Disabled homolog 1 (Adapter molecule functioning in neural development)

Seq-ID:

P97318 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-45921   ITB7_HUMAN
MINT-45923   ITB3_HUMAN
MINT-45924   ITB2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phospholipid binding, SH2 domain binding	intracellular	positive regulation of protein kinase activity, cerebellum structural organization, radial glia guided migration of Purkinje cell, neuron migration, cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration, negative regulation of cell adhesion, small GTPase mediated signal transduction, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	198	ILEEDVEDPVYQYIVFEAGHE	SRC	11279201	LTP	1.00	-	-	0.33	-	medium
Y	220	IRDPETEENIYQVPTSQKKEG	SRC	11279201	LTP	0.20	-	-	0.71	-	medium
Y	232	VPTSQKKEGVYDVPKSQPNSQ	SRC	11279201	LTP	0.97	-	-	0.72	-	medium
Y	232	VPTSQKKEGVYDVPKSQPNSQ	SRC	15062102	LTP	0.97	-	-	0.72	-	medium

Substrate:

Dsrc64 (Tyrosine-protein kinase Src64B (from PhosphoBase))

Seq-ID:

P00528 [Drosophila melanogaster]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-40216   MMD4_DROME
MINT-41228   DTX_DROME
MINT-43437   ELOA1_DROME
MINT-43844   TBB1_DROME

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
non-membrane spanning protein tyrosine kinase activity, ATP binding, protein binding	germline ring canal	female germline ring canal stabilization, mushroom body development, parallel actin filament bundle assembly, JNK cascade, ovarian fusome organization, olfactory learning, female germline ring canal formation, actin assembly, germarium-derived female germ-line cyst encapsulation, regulation of actin polymerization or depolymerization, karyosome formation, peptidyl-tyrosine phosphorylation, dorsal closure, cellularization, salivary gland morphogenesis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	434	GLARVIADDEYCPKQGSRFPV	SRC	1281305	LTP	1.00		-	TyrKc	0.12	-	low

Substrate:

Dystroglycan (Adhesion molecule)

Seq-ID:

Q14118 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-18977   UTRO_HUMAN
MINT-7245682   SRC_HUMAN
MINT-7247422   FYN_HUMAN
MINT-7249366   NCK1_HUMAN
MINT-7251982   P85A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, structural constituent of muscle, laminin-1 binding, vinculin binding, actin binding, alpha-actinin binding, tubulin binding	filopodium, basement membrane, integral to membrane of membrane fraction, lamellipodium, cytoskeleton, integral to membrane, extracellular space, nucleoplasm, contractile ring	negative regulation of MAPKKK cascade, microtubule anchoring, negative regulation of cell migration, cytoskeletal anchoring at plasma membrane, negative regulation of protein kinase B signaling cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	892	NMTPYRSPPPYVPP	SRC	12795607	LTP	1.00		Csk SH2; Fyn SH2; NCK SH2; Src SH2	DAG1	0.77	-	medium

Substrate:

EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)

Seq-ID:

P00533 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
epidermal growth factor receptor activity, protein heterodimerization activity, identical protein binding, receptor signaling protein tyrosine kinase activity, double-stranded DNA binding, ATP binding, protein phosphatase binding, actin filament binding, MAP/ERK kinase kinase activity	Shc-EGFR complex, endosome, basolateral plasma membrane, integral to membrane, extracellular space, nucleus	activation of phospholipase C activity, protein insertion into membrane, response to UV-A, positive regulation of nitric oxide biosynthetic process, positive regulation of cell migration, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, positive regulation of catenin protein nuclear translocation, regulation of nitric-oxide synthase activity, positive regulation of protein kinase B signaling cascade, ossification, positive regulation of epithelial cell proliferation, activation of phospholipase A2 activity by calcium-mediated signaling, cell-cell adhesion, regulation of peptidyl-tyrosine phosphorylation, positive regulation of phosphorylation, positive regulation of MAP kinase activity, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	869	AKLLGAEEKEYHAEGGKVPIK	SRC	10075741	LTP	1.00	-	TyrKc	0.18	2EB2	17.03%
Y	915	WELMTFGSKPYDGIPASEISS	SRC	11983694	LTP	1.00	PLCG1 SH2; Src SH2	TyrKc	0.18	3BEL	8.30%
Y	944	PQPPICTIDVYMIMVKCWMID	SRC	11983694	LTP	1.00	PIK3R1 SH2; Src SH2	TyrKc	0.05	3BEL	16.16%
Y	1016	DMDDVVDADEYLIPQQGFFSS	SRC	8845374	LTP	1.00	CRK SH2; PLCG1 SH2; RASA_group SH2; Src SH2	-	0.41	1XKK	41.92%
Y	1125	LNPAPSRDPHYQDPHSTAVGN	SRC	8845374	LTP	1.00	PLCG1 SH2; RASA_group SH2; Src SH2	-	0.86	-	-
Y	1125	LNPAPSRDPHYQDPHSTAVGN	SRC	11983694	LTP	1.00	PLCG1 SH2; RASA_group SH2; Src SH2	-	0.86	-	-
Y	1125	LNPAPSRDPHYQDPHSTAVGN	SRC	10075741	LTP	1.00	PLCG1 SH2; RASA_group SH2; Src SH2	-	0.86	-	-

Substrate:

Erzin (Connection of cytoscheletro structure to plasma membrane)

Seq-ID:

P15311 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-73250   TB10A_HUMAN
MINT-73254   PLCB3_HUMAN
MINT-73256   NHRF1_HUMAN
MINT-3318887   1433Z_HUMAN
MINT-6380786   FES_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cell adhesion molecule binding, actin filament binding	filopodium, cortical cytoskeleton, actin filament, cytosol, ruffle membrane, microvillus membrane, extrinsic to membrane, apical plasma membrane	membrane to membrane docking, regulation of cell shape, actin filament bundle assembly, cytoskeletal anchoring at plasma membrane, leukocyte cell-cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	478	TAPPPPPPPVYEPVSYHVQES	SRC	15623525	LTP	0.04		-	ERM	0.88	-	-

Substrate:

Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )

Seq-ID:

P03372 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13786   BRCA1_HUMAN
MINT-50646   STA5A_HUMAN
MINT-50709   M3K1_HUMAN
MINT-5222241   NCOA1_HUMAN
MINT-6169667   EGFR_HUMAN
MINT-6614126   SMCA4_HUMAN
MINT-6614301   CHD3_HUMAN
MINT-6614361   MTA1_HUMAN
MINT-6614421   MTA2_HUMAN
MINT-6761899   PTN1_HUMAN
MINT-6761906   PTN6_HUMAN
MINT-7013584   PA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
beta-catenin binding, nitric-oxide synthase regulator activity, estrogen response element binding, steroid binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, estrogen receptor activity	chromatin remodeling complex	response to estradiol stimulus, transcription, DNA-dependent, regulation of transcription, DNA-dependent, positive regulation of retinoic acid receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	537	SMKCKNVVPLYDLLLEMLDAH	SRC	7539106	LTP	0.96		Src SH2	Hormone_recep	0.06	2IOG	27.07%

Substrate:

FAK (Focal adhesion kinase)

Seq-ID:

Q05397 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17602   LYN_HUMAN
MINT-74938   BCAR1_HUMAN
MINT-3381308   SRC_HUMAN
MINT-6794892   PTN1_HUMAN
MINT-7294020   P53_HUMAN
MINT-7385708   SRC_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
non-membrane spanning protein tyrosine kinase activity, ATP binding, SH2 domain binding, signal transducer activity	focal adhesion, cytosol, cytoskeleton	signal complex assembly, integrin-mediated signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	861	LQGPIGNQHIYQPVGKPDPAA	SRC	8941336	LTP	0.18		-	-	0.79	-	-
Y	861	LQGPIGNQHIYQPVGKPDPAA	SRC	11927607	LTP	0.18		-	-	0.79	-	-

Substrate:

GAST (gastrin precursor (from PhosphoBase))

Seq-ID:

P01350 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7212864 TRFE_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
hormone activity	extracellular region	signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	87	GPWLEEEEEAYGWMDFGRRSA	SRC	8578591	LTP	1.00		-	Gastrin	0.47	-	low

Substrate:

Gelsolin (Cytoskeletal protein)

Seq-ID:

P06396 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-24898 ACTS_HUMAN
MINT-4792996 VDAC1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, actin binding	cytosol, actin cytoskeleton	actin filament polymerization, actin filament severing, barbed-end actin filament capping

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	465	SNKVPVDPATYGQFYGGDSYI	SRC	10210201	LTP	1.00		-	GEL	0.30	1P8X	22.27%

Substrate:

Glucocorticoid receptor DNA binding factor 1 (Nuclear receptor)

Seq-ID:

Q9NRY4 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, transcription corepressor activity, Rho GTPase activator activity	cytosol, nucleus	transcription, signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1105	VKPRNEEENIYSVPHDSTQGK	SRC	9819392	LTP	1.00		-	-	0.70	-	low
Y	1105	VKPRNEEENIYSVPHDSTQGK	SRC	11309200	LTP	1.00		-	-	0.70	-	low

Substrate:

Glutamate [NMDA] receptor subunit epsilon 2 (Extracellular ligand gated channel)

Seq-ID:

Q00960 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-60072   DLG2_RAT
MINT-60074   DLG4_RAT
MINT-1890944   DLG4_MOUSE
MINT-1891205   INADL_MOUSE
MINT-2841984   KCC2A_MOUSE
MINT-3377699   SRC_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cell adhesion molecule binding, zinc ion binding, drug binding, D2 dopamine receptor binding, neurotransmitter binding, protein heterodimerization activity, ionotropic glutamate receptor binding, N-methyl-D-aspartate selective glutamate receptor activity, beta-catenin binding, extracellular-glutamate-gated ion channel activity	N-methyl-D-aspartate selective glutamate receptor complex, cell junction, synaptic cleft, flotillin complex, terminal button, postsynaptic membrane, postsynaptic density, Z disc, dendritic spine, presynaptic membrane, outer membrane-bounded periplasmic space	response to amphetamine, regulation of action potential, hippocampus development, long-term memory, response to growth hormone stimulus, response to magnesium ion, cellular response to organic cyclic substance, cellular response to amino acid stimulus, response to methylmercury, regulation of MAPKKK cascade, response to cytokine stimulus, response to fungicide, cellular response to lipid, response to electrical stimulus, regulation of long-term neuronal synaptic plasticity, cellular response to growth factor stimulus, cerebral cortex development, response to ethanol, associative learning, cellular response to dsRNA, rhythmic process, response to carbohydrate stimulus, cellular response to manganese ion, cellular response to protein stimulus, response to cocaine, cellular response to magnesium starvation, ionotropic glutamate receptor signaling pathway, positive regulation of glutamate secretion, receptor clustering, positive regulation of synaptic transmission, response to calcium ion, response to other organism, positive regulation of cell death

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1472	AFNGSSNGHVYEKLSSIESDV	SRC	11483655	LTP	1.00		-	NMDAR2_C	0.43	-	medium

Substrate:

Grb10 (Adapter molecule)

Seq-ID:

Q13322 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15644   IGF1R_HUMAN
MINT-16516   INSR_HUMAN
MINT-16802   EGFR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
insulin receptor binding, SH3/SH2 adaptor activity	plasma membrane, cytoplasm	negative regulation of glycogen biosynthetic process, negative regulation of insulin receptor signaling pathway, negative regulation of glucose import, positive regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of Wnt receptor signaling pathway, insulin receptor signaling pathway, positive regulation of phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	67	NDMNASLESLYSACSMQSDTV	SRC	10871840	LTP	0.81		Fyn SH2; Src SH2	-	0.50	-	low

Substrate:

HLA-A1 (MHC complex protein)

Seq-ID:

P30443 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
MHC class I receptor activity	MHC class I protein complex, integral to plasma membrane	immune response, interspecies interaction between organisms, antigen processing and presentation of peptide antigen via MHC class I

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	344	RKSSDRKGGSYTQAASSDSAQ	SRC	6304688	LTP	0.94		-	MHC_I_C	0.63	-	medium

Substrate:

hnRNPK (Ribonucleoprotein)

Seq-ID:

P61978 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-2859758   PCBP1_HUMAN
MINT-3296872   1433Z_HUMAN
MINT-6803834   ANM1_HUMAN
MINT-6803896   ANM3_HUMAN
MINT-7035260   SRC_HUMAN
MINT-7974306   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, RNA binding, protein binding	spliceosomal complex, cytoplasm, nucleoplasm, heterogeneous nuclear ribonucleoprotein complex	mRNA processing, signal transduction, interspecies interaction between organisms, RNA splicing

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	230	GRAQPYDPNFYDETYDYGGFT	SRC	12052863	LTP	0.93	-	-	0.41	-	-
Y	234	PYDPNFYDETYDYGGFTMMFD	SRC	12052863	LTP	0.94	-	-	0.36	-	-
Y	236	DPNFYDETYDYGGFTMMFDDR	SRC	12052863	LTP	0.81	-	-	0.37	-	-
Y	380	DYSYAGGRGSYGDLGGPIITT	SRC	12052863	LTP	0.86	-	-	0.45	-	-

Substrate:

IGF1-R (Receptor tyrosine kinase)

Seq-ID:

P08069 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15644   GRB10_HUMAN
MINT-18053   IRS2_HUMAN
MINT-1774754   ARHGC_MOUSE
MINT-1774976   ARHGC_HUMAN
MINT-6800783   PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide 3-kinase binding, identical protein binding, insulin-like growth factor receptor activity, insulin binding, metal ion binding, insulin receptor binding, insulin receptor substrate binding, ATP binding, insulin-like growth factor I binding	microsome, integral to plasma membrane	positive regulation of DNA replication, positive regulation of cell proliferation, positive regulation of cell migration, anti-apoptosis, phosphoinositide 3-kinase cascade, phosphoinositide-mediated signaling, immune response, protein amino acid autophosphorylation, insulin receptor signaling pathway, protein tetramerization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1161	IGDFGMTRDIYETDYYRKGGK	SRC	8940173	LTP	1.00	PTPN11 SH2	TyrKc	0.16	1P4O	3.49%
Y	1165	GMTRDIYETDYYRKGGKGLLP	SRC	8940173	LTP	1.00	PTPN11 SH2	TyrKc	0.16	1P4O	17.03%
Y	1166	MTRDIYETDYYRKGGKGLLPV	SRC	8940173	LTP	1.00	PTPN11 SH2	TyrKc	0.14	1P4O	24.45%

Substrate:

IGF1-R (Receptor tyrosine kinase)

Seq-ID:

Q60751 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-73467 GRB10_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide 3-kinase binding, insulin-like growth factor receptor activity, metal ion binding, insulin receptor substrate binding, ATP binding	integral to membrane	brain development, positive regulation of MAPKKK cascade, exocrine pancreas development, prostate gland epithelium morphogenesis, positive regulation of protein kinase B signaling cascade, negative regulation of MAPKKK cascade, protein amino acid autophosphorylation, mammary gland development, protein tetramerization, male sex determination, negative regulation of protein kinase B signaling cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	974	NNSRLGNGVLYASVNPEYFSA	SRC	8940173	LTP	1.00	-	-	0.17	-	medium
Y	981	GVLYASVNPEYFSAADVYVPD	SRC	8940173	LTP	1.00	-	-	0.07	-	medium
Y	1163	IGDFGMTRDIYETDYYRKGGK	SRC	8940173	LTP	1.00	-	TyrKc	0.16	-	medium
Y	1167	GMTRDIYETDYYRKGGKGLLP	SRC	8940173	LTP	1.00	-	TyrKc	0.15	-	medium
Y	1168	MTRDIYETDYYRKGGKGLLPV	SRC	8940173	LTP	1.00	-	TyrKc	0.14	-	medium
Y	1352	LRASFDERQPYAHMNGGRANE	SRC	8940173	LTP	1.00	-	-	0.66	-	medium

Substrate:

IKB-alpha (Major histocompatibility complex enhancer-binding protein MAD3)

Seq-ID:

P25963 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-47837   REL_HUMAN
MINT-47839   IKBB_HUMAN
MINT-47840   ELP1_HUMAN
MINT-47841   IKKA_HUMAN
MINT-47842   IKKB_HUMAN
MINT-47843   NEMO_HUMAN
MINT-47845   MCM7_HUMAN
MINT-48656   NFKB1_HUMAN
MINT-48721   NFKB2_HUMAN
MINT-48993   RELB_HUMAN
MINT-64895   MED19_HUMAN
MINT-6762163   PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nuclear localization sequence binding, identical protein binding, ubiquitin protein ligase binding, NF-kappaB binding	cytosol, I-kappaB/NF-kappaB complex, nucleus	positive regulation of gene-specific transcription from RNA polymerase II promoter, cytoplasmic sequestering of NF-kappaB, negative regulation of NF-kappaB transcription factor activity, apoptosis, anti-apoptosis, negative regulation of lipid storage, negative regulation of macrophage derived foam cell differentiation, positive regulation of cholesterol efflux, interspecies interaction between organisms, positive regulation of cellular protein metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	42	SGLDSMKDEEYEQMVKELQEI	SRC	9792645	LTP	1.00		PIK3R1 SH2	-	0.55	-	-

Substrate:

Inositol polyphosphate 5-phosphatase (Lipid phosphatase)

Seq-ID:

O15357 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-58385 GAB1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
actin binding, SH3 domain binding, SH2 domain binding	cytosol, actin cortical patch	actin filament organization, endocytosis, cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	986	PPKNSFNNPAYYVLEGVPHQL	SRC	12235291	LTP	1.00		SHC1 PTB	-	0.67	-	-
Y	987	PKNSFNNPAYYVLEGVPHQLL	SRC	12235291	LTP	0.08		-	-	0.66	-	medium

Substrate:

Integrin beta 3 (Platelet membrane glycoprotein IIIa)

Seq-ID:

P05106 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-25081   ITAV_HUMAN
MINT-45900   EPS8_HUMAN
MINT-45905   RBGP1_HUMAN
MINT-45913   GULP1_HUMAN
MINT-45916   RGS12_HUMAN
MINT-45923   DAB1_MOUSE
MINT-45928   DAB2_MOUSE
MINT-45939   IRS1_RAT
MINT-45952   TLN1_MOUSE
MINT-45957   JIP1_HUMAN
MINT-45960   LIN10_CAEEL
MINT-61480   TENC1_HUMAN
MINT-61568   DOK1_MOUSE
MINT-61569   NUMB_MOUSE
MINT-1795026   TLN1_HUMAN
MINT-6794817   PTN1_HUMAN
MINT-7384376   SRC_MOUSE
MINT-7384444   LYN_HUMAN
MINT-7384460   YES_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, vascular endothelial growth factor receptor 2 binding, identical protein binding, platelet-derived growth factor receptor binding, cell adhesion molecule binding	integrin complex, alphav-beta3 integrin-vitronectin complex, platelet alpha granule membrane	positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of endothelial cell proliferation, regulation of bone resorption, blood coagulation, negative regulation of lipid transport, tube development, activation of protein kinase activity, integrin-mediated signaling pathway, positive regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of lipid storage, negative regulation of macrophage derived foam cell differentiation, cell-matrix adhesion, interspecies interaction between organisms, smooth muscle cell migration, negative regulation of lipoprotein metabolic process, angiogenesis involved in wound healing, positive regulation of endothelial cell migration, negative regulation of low-density lipoprotein receptor biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	773	AKWDTANNPLYKEATSTFTNI	SRC	15699036	LTP	1.00	GRB2 SH2; PTPN11 SH2; SHC1 PTB; TLN1 PTB	Integrin_b_cyt	0.26	-	-
Y	773	AKWDTANNPLYKEATSTFTNI	SRC	18398066	LTP	1.00	GRB2 SH2; PTPN11 SH2; SHC1 PTB; TLN1 PTB	Integrin_b_cyt	0.26	-	-
Y	785	EATSTFTNITYRGT	SRC	8631894	LTP	0.98	PTPN11 SH2; SHC1 PTB; SYK SH2	Integrin_b_cyt	0.26	-	-

Substrate:

KCNA3 (delayed rectifier potassium channel activity, voltage-gated ion channel activity)

Seq-ID:

P22001 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-68490 DLG1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
delayed rectifier potassium channel activity	voltage-gated potassium channel complex

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	135	IDIFSEEIRFYQLGEEAMEKF	SRC	11812778	LTP	0.00		-	BTB	0.16	-	low
Y	447	RETEGEEQSQYMHVGSCQHLS	SRC	11812778	LTP	1.00		-	-	0.44	-	low

Substrate:

Kcnb1 (potassium channel)

Seq-ID:

P15387 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
delayed rectifier potassium channel activity, protein N-terminus binding, outward rectifier potassium channel activity	dendrite, dendrite membrane, voltage-gated potassium channel complex, neuronal cell body membrane, postsynaptic membrane	protein oligomerization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	128	ELDYWGIDEIYLESCCQARYH	SRC	12615930	LTP	1.00		-	BTB	0.05	-	medium

Substrate:

Lipocortin I (annexinI) ( Ca++, phospholipids and actin-binding protein)

Seq-ID:

P04083 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-51101 EGFR_HUMAN
MINT-3297886 1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium-dependent phospholipid binding, calcium ion binding, phospholipase A2 inhibitor activity, protein binding, bridging, structural molecule activity, receptor binding	extracellular region, cilium, cytoplasm, basolateral plasma membrane, cornified envelope, nucleus	positive regulation of vesicle fusion, lipid metabolic process, keratinocyte differentiation, anti-apoptosis, cellular component movement, signal transduction, inflammatory response, cell surface receptor linked signaling pathway, peptide cross-linking

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	21	AWFIENEEQEYVQTVKSSKGG	SRC	2457390	LTP	0.13		-	-	0.42	-	-

Substrate:

Lipocortin II (annexinII) (Calcium-regulated membrane -binding protein)

Seq-ID:

P04272 [Bos taurus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium-dependent phospholipid binding, calcium ion binding, cytoskeletal protein binding, phospholipase inhibitor activity	basement membrane, melanosome

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	24	EGDHSTPPSAYGSVKAYTNFD	SRC	2415974	LTP	0.35		-	-	0.48	1W7B	51.97%

Substrate:

Lipocortin II (annexinII) (Calcium-regulated membrane -binding protein)

Seq-ID:

P07355 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-3297866 1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium-dependent phospholipid binding, calcium ion binding, cytoskeletal protein binding, phospholipase inhibitor activity	basement membrane, melanosome, soluble fraction	positive regulation of vesicle fusion, skeletal system development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	24	EGDHSTPPSAYGSVKAYTNFD	SRC	2456953	LTP	-		-	-	0.47	1W7B	51.97%

Substrate:

Lipocortin II (annexinII) (Calcium-regulated membrane -binding protein)

Seq-ID:

P17785 [Gallus gallus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium-dependent phospholipid binding, calcium ion binding, cytoskeletal protein binding, phospholipase inhibitor activity	basement membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	24	EGDHSLPPSAYATVKAYSNFD	SRC	2143014	LTP	0.04		-	-	0.36	-	medium

Substrate:

Lipocortin II (annexinII) (Calcium-regulated membrane -binding protein)

Seq-ID:

P19620 [Sus scrofa]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium-dependent phospholipid binding, calcium ion binding, cytoskeletal protein binding, phospholipase inhibitor activity	basement membrane, melanosome

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	24	EGDHSTPASAYGSVKAYTNFD	SRC	2456953	LTP	0.35		-	-	0.41	1W7B	51.97%

Substrate:

Middle T antigen (Middle T antigen (from PhosphoBase))

Seq-ID:

P03079 [Hamster polyomavirus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
heat shock protein binding	integral to membrane, host cell membrane	interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	298	QETQAERENEYMPMAPQIHLY	SRC	8578591	LTP	0.03		-	-	0.64	-	medium
Y	324	PTHQEEEEPQYEEIPIYLELL	SRC	8578591	LTP	0.07		-	-	0.49	-	medium

Substrate:

Middle T antigen (Middle T antigen (from PhosphoBase))

Seq-ID:

P12906 [Murine polyomavirus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
heat shock protein binding	integral to membrane, host cell membrane	interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	250	RLPSLLSNPTYSVMRSHSFPP	SRC	8578591	LTP	0.00		-	-	0.37	-	medium
Y	315	LEPLEEEEEEYMPMEDLYLDI	SRC	8578591	LTP	1.00		-	-	0.43	-	medium

Substrate:

Nitric-oxide synthase, endothelial (Nitric-oxide synthase, endothelial)

Seq-ID:

P29473 [Bos taurus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
NADP or NADPH binding, FAD binding, calmodulin binding, nitric-oxide synthase activity, FMN binding	caveola, cytoskeleton, Golgi apparatus	blood coagulation, oxidation reduction, anti-apoptosis, positive regulation of guanylate cyclase activity, arginine catabolic process, nitric oxide biosynthetic process, mitochondrion organization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	83	VKNWELGSITYDTLCAQSQQD	SRC	16123043	LTP	0.16		-	-	0.42	1Q2O	30.13%

Substrate:

P130Cas (Adaptor molecule. Contain 15 YxxP motifs. )

Seq-ID:

P56945 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-74936   PTN12_HUMAN
MINT-74938   FAK1_HUMAN
MINT-3974941   1433S_HUMAN
MINT-6174734   ACTB_HUMAN
MINT-6763936   CRK_HUMAN
MINT-6793484   PTN1_HUMAN
MINT-7104353   CDC42_HUMAN
MINT-7104422   SRC_HUMAN
MINT-7104436   ACK1_HUMAN
MINT-7247002   FYN_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, protein kinase binding, protein phosphatase binding, signal transducer activity	focal adhesion, membrane fraction, cytosol, ruffle	regulation of cell growth, B cell receptor signaling pathway, cell division, positive regulation of cell migration, nerve growth factor receptor signaling pathway, cell migration, integrin-mediated signaling pathway, epidermal growth factor receptor signaling pathway, actin filament organization, regulation of apoptosis, platelet-derived growth factor receptor signaling pathway, T cell receptor signaling pathway, cell adhesion, insulin receptor signaling pathway, cell proliferation, G-protein coupled receptor protein signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	653	FTSQDSPDGQYENSEGGWMED	SRC	11604500	LTP	1.00		GRB2 SH2; Src SH2	-	0.75	-	medium

Substrate:

P130Cas (Adaptor molecule. Contain 15 YxxP motifs. )

Seq-ID:

Q61140 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19527   FYN_MOUSE
MINT-58759   LYN_MOUSE
MINT-6763504   PTN1_HUMAN
MINT-7303491   FAK1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding	focal adhesion, membrane fraction, cytoplasm, lamellipodium, ruffle	B cell receptor signaling pathway, positive regulation of cell migration, nerve growth factor receptor signaling pathway, cell migration, integrin-mediated signaling pathway, epidermal growth factor receptor signaling pathway, actin filament organization, platelet-derived growth factor receptor signaling pathway, cell adhesion, insulin receptor signaling pathway, G-protein coupled receptor protein signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	668	ENSEGGWMEDYDYVHLQGKEE	SRC	11604500	LTP	1.00		-	-	0.49	-	low

Substrate:

PAK2 (Protein Kinase C-related protein kinase)

Seq-ID:

Q13177 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-2792057   LYN_HUMAN
MINT-2792076   YES_HUMAN
MINT-2792095   FYN_HUMAN
MINT-2792128   SPD2A_HUMAN
MINT-2792760   SRC_HUMAN
MINT-2792779   HCK_HUMAN
MINT-2792817   ARHG6_HUMAN
MINT-2792855   VINEX_HUMAN
MINT-2792874   SRBS1_HUMAN
MINT-2792893   SH3R3_HUMAN
MINT-2792912   NCK1_HUMAN
MINT-2792931   GRB2_HUMAN
MINT-6541954   SRC8_HUMAN
MINT-7147251   ARHG7_HUMAN
MINT-7230086   RAC1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, identical protein binding, ATP binding	cytosol, nucleus, perinuclear region of cytoplasm, membrane	regulation of growth, apoptosis, signal transduction, protein amino acid autophosphorylation, interspecies interaction between organisms, negative regulation of protein kinase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	130	PQAVLDVLKFYDSNTVKQKYL	SRC	12215529	LTP	0.73		-	PBD	0.34	-	low

Substrate:

Paxillin (Cytoskeletal protein; component of focal adhesion.)

Seq-ID:

P49023 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-1953339   GIT1_HUMAN
MINT-1953360   GIT2_HUMAN
MINT-6169431   CSK_HUMAN
MINT-6169440   PTN11_HUMAN
MINT-6169502   GAB1_HUMAN
MINT-6763928   CRK_HUMAN
MINT-7145479   ASAP1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
beta-catenin binding, vinculin binding, zinc ion binding	focal adhesion, cytoplasm, microtubule associated complex, lamellipodium	muscle contraction, signal complex assembly, signal transduction, cell-matrix adhesion, cellular response to reactive oxygen species

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	40	PYSYPTGNHTYQEIAVPPPVP	SRC	11695992	LTP	0.93		CRK SH2; Src SH2	-	0.77	-	low
Y	88	HQQPQSSSPVYGSSAKTSSVS	SRC	11695992	LTP	0.90		Csk SH2	Paxillin	0.76	-	low

Substrate:

PDK1 (3-phosphoinositide dependent protein kinase-1; serine/threonine kinase)

Seq-ID:

O15530 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13835   AKT1_HUMAN
MINT-14377   KS6B1_HUMAN
MINT-15996   1433F_HUMAN
MINT-16333   1433T_HUMAN
MINT-17466   FRAP_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
3-phosphoinositide-dependent protein kinase activity, ATP binding, protein binding	plasma membrane, cytosol	intracellular signaling pathway, actin cytoskeleton organization, cellular response to insulin stimulus, positive regulation of establishment of protein localization in plasma membrane, negative regulation of protein kinase activity, peptidyl-threonine phosphorylation, activation of protein kinase B activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	9	MARTTSQLYDAVPIQSSVV	SRC	11481331	LTP	0.68	-	-	0.44	-	-
Y	373	PAMSEDDEDCYGNYDNLLSQF	SRC	11481331	LTP	1.00	-	-	0.28	-	-
Y	376	SEDDEDCYGNYDNLLSQFGCM	SRC	11481331	LTP	1.00	-	-	0.26	-	-

Substrate:

PI3-kinase p85-alpha subunit (Adaptor molecule. Phopshatidylinositol 3-kinase regulatory alpha subunit.)

Seq-ID:

P27986 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16109   ARAF_HUMAN
MINT-17501   SHC1_HUMAN
MINT-19009   CDC42_HUMAN
MINT-56732   KSYK_HUMAN
MINT-56734   KSYK_MOUSE
MINT-65974   GRB2_HUMAN
MINT-66003   LCK_HUMAN
MINT-68496   GAB2_HUMAN
MINT-68500   CBL_HUMAN
MINT-68735   IRS1_HUMAN
MINT-74606   EGFR_HUMAN
MINT-74610   ERBB2_HUMAN
MINT-74617   ERBB3_HUMAN
MINT-1893011   GAB1_HUMAN
MINT-2840114   TLR3_HUMAN
MINT-3378272   SEPT2_HUMAN
MINT-6762880   IRS1_RAT
MINT-7103574   FLT3_HUMAN
MINT-7103638   MK08_HUMAN
MINT-7103655   CRKL_HUMAN
MINT-7251262   ICAL_HUMAN
MINT-7251286   SNX17_HUMAN
MINT-7251334   DAB2_HUMAN
MINT-7251346   CDC27_HUMAN
MINT-7251370   FLNA_HUMAN
MINT-7251382   SYNJ2_HUMAN
MINT-7251406   CSDE1_HUMAN
MINT-7251418   ABL1_HUMAN
MINT-7251430   SUV92_HUMAN
MINT-7251442   VP13A_HUMAN
MINT-7251454   FLNB_HUMAN
MINT-7251526   SOS1_HUMAN
MINT-7251538   ASAP2_HUMAN
MINT-7251550   LIPA3_HUMAN
MINT-7251562   AKAP2_HUMAN
MINT-7251574   ARHGB_HUMAN
MINT-7251598   PHAR2_HUMAN
MINT-7251610   DLGP4_HUMAN
MINT-7251622   ELK3_HUMAN
MINT-7251658   BRCA1_HUMAN
MINT-7251706   CKAP5_HUMAN
MINT-7251718   RRAS_HUMAN
MINT-7251730   ECT2_HUMAN
MINT-7251754   TPX2_HUMAN
MINT-7251766   JAK2_HUMAN
MINT-7251778   ASAP1_HUMAN
MINT-7251790   FLNC_HUMAN
MINT-7251802   DNLI3_HUMAN
MINT-7251814   TGON2_HUMAN
MINT-7251838   SHAN2_HUMAN
MINT-7251850   KI13A_HUMAN
MINT-7251862   ABL2_HUMAN
MINT-7251886   BRPF3_HUMAN
MINT-7251898   SH3K1_HUMAN
MINT-7251934   MYRIP_HUMAN
MINT-7251982   DAG1_HUMAN
MINT-7251994   STF1_HUMAN
MINT-7252006   P3C2B_HUMAN
MINT-7252018   SNX8_HUMAN
MINT-7252030   BRD4_HUMAN
MINT-7252078   MINT_HUMAN
MINT-7252126   PLCG2_HUMAN
MINT-7252150   MAP4_HUMAN
MINT-7252174   MYLK_HUMAN
MINT-7252186   PEBP1_HUMAN
MINT-7252234   CAF1A_HUMAN
MINT-7252258   DTBP1_HUMAN
MINT-7252270   NELFB_HUMAN
MINT-7252282   AKAP6_HUMAN
MINT-7252294   FANCA_HUMAN
MINT-7252318   GHR_HUMAN
MINT-7252330   M4K1_HUMAN
MINT-7252342   RPGF1_HUMAN
MINT-7296136   SRC_HUMAN
MINT-7306624   LCP2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ErbB-3 class receptor binding, insulin-like growth factor receptor binding, phosphoinositide 3-kinase regulator activity, insulin binding, insulin receptor binding, insulin receptor substrate binding, phosphatidylinositol binding, protein phosphatase binding	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	phosphoinositide 3-kinase cascade, insulin-like growth factor receptor signaling pathway, phosphoinositide phosphorylation, interspecies interaction between organisms, positive regulation of establishment of protein localization in plasma membrane, insulin receptor signaling pathway, positive regulation of glucose import, growth hormone receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	607	WLGNENTEDQYSLVEDDEDLP	SRC	8385099	LTP	1.00		-	-	0.55	-	-

Substrate:

PIP5KIgamma (Lipid Kinase)

Seq-ID:

O70161 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-4329599 SYT1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
1-phosphatidylinositol-4-phosphate 5-kinase activity, ATP binding	focal adhesion, endomembrane system	phosphatidylinositol metabolic process, axonogenesis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	644	YFPTDERSWVYSPLHYSARPA	SRC	14691141	LTP	-		-	-	0.57	-	low

Substrate:

PKB-alpha (RAC-alpha serine/threonine kinase (EC 2.7.1.-) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT))

Seq-ID:

P31750 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-4049581   PDE3A_MOUSE
MINT-6175057   STK4_HUMAN
MINT-6793722   PTN1_HUMAN
MINT-6978911   HS90A_MOUSE
MINT-6978941   UBIQ_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding	plasma membrane, spindle, cytosol, lamellipodium, nucleus	response to food, glycogen cell development involved in embryonic placenta development, protein ubiquitination, regulation of neuron projection development, maternal placenta development, glycogen biosynthetic process, apoptotic mitochondrial changes, germ cell development, inflammatory response, insulin-like growth factor receptor signaling pathway, peptidyl-serine phosphorylation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, anagen, positive regulation of sodium ion transport, regulation of translation, labyrinthine layer blood vessel development, protein catabolic process, protein kinase B signaling cascade, glucose transport, insulin receptor signaling pathway, regulation of survival gene product expression

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	315	TMKTFCGTPEYLAPEVLEDND	SRC	11445557	LTP	1.00		-	S_TKc	0.25	-	medium
Y	326	LAPEVLEDNDYGRAVDWWGLG	SRC	11445557	LTP	1.00		-	S_TKc	0.10	-	medium

Substrate:

PKC delta (Protein kinase C, delta)

Seq-ID:

P09215 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase binding, metal ion binding, calcium-independent protein kinase C activity, ATP binding	membrane fraction, mitochondrion, nucleus, membrane	intracellular signaling pathway, positive regulation of MAPKKK cascade, cellular response to glucose starvation, response to amino acid stimulus, response to hypoxia, response to hydrogen peroxide, response to organic cyclic substance, aging, response to drug, response to heat, response to glucose stimulus, protein amino acid autophosphorylation, collagen metabolic process, aspartate transport, response to mechanical stimulus, cellular response to insulin stimulus, induction of apoptosis, positive regulation of glucose import, positive regulation of MAP kinase activity, response to ethanol

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	311	KPETPETVGIYQGFEKKTAVS	SRC	15961393	LTP	0.15		-	-	0.40	-	medium
Y	311	KPETPETVGIYQGFEKKTAVS	SRC	14970215	LTP	0.15		-	-	0.40	-	medium

Substrate:

PKC delta (Protein kinase C, delta)

Seq-ID:

P28867 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C activity, metal ion binding, insulin receptor substrate binding, ATP binding	cytoplasm, membrane	protein amino acid phosphorylation, negative regulation of insulin receptor signaling pathway, negative regulation of peptidyl-tyrosine phosphorylation, interleukin-10 production, B cell proliferation, immunoglobulin mediated immune response, interleukin-12 production

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	155	RGAIKQAKIHYIKNHEFIATF	SRC	10945993	LTP	0.37		-	-	0.11	-	low

Substrate:

PKC iota (Serine/threonine kinase)

Seq-ID:

P41743 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-66072 PAR6A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C activity, phospholipid binding, ATP binding, zinc ion binding, protein binding	endosome, polarisome, cytosol, nucleus	protein amino acid phosphorylation, protein targeting to membrane, vesicle-mediated transport, anti-apoptosis, establishment or maintenance of epithelial cell apical/basal polarity, secretion, cellular response to insulin stimulus, positive regulation of establishment of protein localization in plasma membrane, cellular membrane organization, positive regulation of glucose import, cell-cell junction organization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	256	DLLRVIGRGSYAKVLLVRLKK	SRC	11713277	LTP	-	S_TKc	0.09	1ZRZ	60.26%
Y	271	LVRLKKTDRIYAMKVVKKELV	SRC	11713277	LTP	-	S_TKc	0.17	1ZRZ	9.61%
Y	325	TESRLFFVIEYVNGGDLMFHM	SRC	11713277	LTP	-	S_TKc	0.04	1ZRZ	36.68%

Substrate:

PKC mu (Serine/threonine kinase)

Seq-ID:

Q15139 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C activity, metal ion binding, ATP binding, protein binding	cytosol, integral to plasma membrane	protein amino acid phosphorylation, signal transduction, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	95	VDQKFPECGFYGMYDKILLFR	SRC	17804414	LTP	0.72		-	-	0.03	-	medium

Substrate:

PL scramblase 1 (Erythrocytes phospholipid scramblase)

Seq-ID:

O15162 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-66053   CPSF6_HUMAN
MINT-66152   CRY1_HUMAN
MINT-66176   DTX2_HUMAN
MINT-66313   LASP1_HUMAN
MINT-66701   GNAI2_HUMAN
MINT-66739   K1683_HUMAN
MINT-66992   HXB6_HUMAN
MINT-67029   MED15_HUMAN
MINT-67190   NECP2_HUMAN
MINT-67221   F103A_HUMAN
MINT-67237   PLS4_HUMAN
MINT-67637   VASP_HUMAN
MINT-67716   BORG5_HUMAN
MINT-67916   TFG_HUMAN
MINT-67975   ILF3_HUMAN
MINT-68323   ZN638_HUMAN
MINT-2861816   ATN1_HUMAN
MINT-2861835   RERE_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, calcium ion binding, phospholipid scramblase activity	plasma membrane, integral to membrane	phospholipid scrambling, platelet activation, response to virus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	69	AGFPVPNQPVYNQPVYNQPVG	SRC	12871937	LTP	0.34		SHC PTB	-	0.51	-	low
Y	74	PNQPVYNQPVYNQPVGAAGVP	SRC	12871937	LTP	0.45		SHC PTB	-	0.45	-	low

Substrate:

PLC gamma 2 (Involved in transmembrane signaling)

Seq-ID:

P16885 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-60791   Z512B_HUMAN
MINT-74685   EGFR_HUMAN
MINT-74686   ERBB2_HUMAN
MINT-7252126   P85A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide phospholipase C activity, signal transducer activity, protein binding	plasma membrane	phospholipid catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	753	YNMERDINSLYDVSRMYVDPS	SRC	11606584	LTP	0.37		PLCG2 SH2	-	0.26	-	medium
Y	759	INSLYDVSRMYVDPSEINPSM	SRC	11606584	LTP	0.98		PLCG2 SH2	-	0.33	-	medium

Substrate:

Protein zero related protein (Immunoglobulin)

Seq-ID:

O95297 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural molecule activity, protein binding	integral to plasma membrane	cell-cell signaling, transmembrane receptor protein tyrosine kinase signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	241	PSGSHQGPVIYAQLDHSGGHH	SRC	11751924	LTP	1.00		PTPN11 SH2	-	0.48	-	low
Y	263	DKINKSESVVYADIRKN	SRC	11751924	LTP	0.11		PTPN11 SH2	-	0.37	-	low

Substrate:

PVRL2 (coreceptor activity)

Seq-ID:

P32507 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, protein homodimerization activity, cell adhesion molecule binding	zonula adherens, integral to membrane	spermatid development, homophilic cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	505	EDFLDKINPIYDALSYPSPSD	SRC	10962558	LTP	0.76		-	-	0.43	-	medium

Substrate:

RACK1 (Adapter molecule)

Seq-ID:

P63244 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48160 NEMO_HUMAN
MINT-68273 T22D4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein phosphatase binding, receptor binding	plasma membrane, neuronal cell body, cytoplasm

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	228	LWDLNEGKHLYTLDGGDIINA	SRC	12400005	LTP	0.95		-	WD40	0.09	-	-
Y	246	INALCFSPNRYWLCAATGPSI	SRC	12400005	LTP	1.00		-	WD40	0.04	-	-

Substrate:

Raf1 (RAF proto-oncogene serine/threonine-protein kinase)

Seq-ID:

P04049 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19324   KPYM_HUMAN
MINT-24923   RAP1A_HUMAN
MINT-45800   1433Z_HUMAN
MINT-51053   K1C19_HUMAN
MINT-51055   K1C18_HUMAN
MINT-51056   K2C8_HUMAN
MINT-56513   CNKR1_HUMAN
MINT-3389399   PAK1_HUMAN
MINT-3389607   PEBP1_HUMAN
MINT-3975386   1433S_HUMAN
MINT-6946517   RASH_HUMAN
MINT-7014370   MP2K1_HUMAN
MINT-7014449   AKT1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, metal ion binding, receptor signaling protein activity, ATP binding, protein binding	plasma membrane, cytosol, mitochondrial outer membrane	protein amino acid phosphorylation, negative regulation of cell proliferation, apoptosis, Ras protein signal transduction, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	341	RPRGQRDSSYYWEIEASEVML	SRC	10205168	LTP	0.91		-	-	0.37	-	medium

Substrate:

Ras-related protein (GTPase)

Seq-ID:

P10301 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-7245826   SRC_HUMAN
MINT-7247122   FYN_HUMAN
MINT-7251046   NCK1_HUMAN
MINT-7251718   P85A_HUMAN
MINT-7252546   PLCG1_HUMAN
MINT-7253338   GRB2_HUMAN
MINT-7254262   CRK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
GDP binding, GTPase activity, GTP binding, protein binding	plasma membrane, intracellular	Ras protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	66	SDYDPTIEDSYTKICSVDGIP	SRC	11682467	LTP	1.00		-	RAS	0.32	2FN4	17.03%

Substrate:

RGS16 (Regulator of G-protein signaling 16)

Seq-ID:

O15492 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
GTPase activator activity, calmodulin binding, signal transducer activity		negative regulation of signal transduction, visual perception, regulation of G-protein coupled receptor protein signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	168	KTRTLMEKDSYPRFLKSPAYR	SRC	12588871	LTP	1.00		-	RGS	0.34	2BT2	9.17%
Y	177	SYPRFLKSPAYRDLAAQASAA	SRC	12588871	LTP	1.00		Src SH2	RGS	0.29	2BT2	0.87%

Substrate:

SH3-containing GRB2-like protein 1 (Possible regulatory role in synaptic vesicle recycling)

Seq-ID:

Q99961 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-18018 SH3K1_HUMAN
MINT-7103074 KCMA1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
lipid binding, protein binding	early endosome membrane	central nervous system development, signal transduction, endocytosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	315	PLDQPSCKALYDFEPENDGEL	SRC	16054026	LTP	0.98		-	SH3	0.56	-	low

Substrate:

Shc ( Adaptor molecule)

Seq-ID:

P98083 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19712   Q80UM4_MOUSE
MINT-19720   TAXB1_MOUSE
MINT-19873   BRSK1_HUMAN
MINT-45893   ITB1_HUMAN
MINT-45894   ITB2_HUMAN
MINT-45896   ITB7_HUMAN
MINT-58379   GAB1_MOUSE
MINT-5226700   TGFR2_MOUSE
MINT-5226834   TGFR1_MOUSE
MINT-5226862   SOS1_MOUSE
MINT-7714902   IQGA1_HUMAN
MINT-7716148   IQGA1_MOUSE
MINT-7716165   PTN12_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	mitochondrial matrix	angiogenesis, regulation of growth, actin cytoskeleton reorganization, heart development, activation of MAPK activity, cell-cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	349	EEEEEPPDHQYYNDFPGKEPP	SRC	14963047	LTP	1.00		-	-	0.86	-	-

Substrate:

Spectrin (Cytoskeletal protein)

Seq-ID:

Q13813 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19442   FANCA_HUMAN
MINT-48101   IKKE_HUMAN
MINT-48416   M3K3_HUMAN
MINT-49194   TAB2_HUMAN
MINT-64161   TSSC4_HUMAN
MINT-65417   DDX24_HUMAN
MINT-72663   HS90B_HUMAN
MINT-2985122   ZO1_HUMAN
MINT-3318904   1433Z_HUMAN
MINT-7211761   EVL_HUMAN
MINT-7231852   FANCG_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, structural constituent of cytoskeleton, actin binding, calmodulin binding	membrane fraction, microtubule cytoskeleton, cytosol, spectrin	actin filament capping

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1176	EVQAVQQQEVYGMMPRDETDS	SRC	11971983	LTP	0.00		-	SPEC	0.63	-	medium

Substrate:

Spry-2 (Adaptor molecule)

Seq-ID:

O43597 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-6169734   GRB2_HUMAN
MINT-6170603   SH3K1_HUMAN
MINT-6539601   CBL_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	plasma membrane, cytosol, microtubule	signal transduction, cell-cell signaling

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	55	QIRAIRNTNEYTEGPTVVPRP	SRC	15564375	LTP	1.00		CBL SH2	-	0.81	-	medium

Substrate:

Src (Proto-oncogene tyrosine-protein kinase Src)

Seq-ID:

P00523 [Gallus gallus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15440   HNRPK_RAT
MINT-16809   KHDR1_HUMAN
MINT-17269   SHC1_HUMAN
MINT-7212640   HCN2_MOUSE
MINT-7306585   LCP2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
non-membrane spanning protein tyrosine kinase activity, ATP binding		signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	416	GLARLIEDNEYTARQGAKFPI	SRC	6273838	LTP	1.00		-	TyrKc	0.16	1Y57	26.20%

Substrate:

Src (Proto-oncogene tyrosine-protein kinase Src)

Seq-ID:

P12931 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14765   DDR2_HUMAN
MINT-15459   CAV1_HUMAN
MINT-46002   CTNB1_MOUSE
MINT-50376   RASH_HUMAN
MINT-62340   KPCD_HUMAN
MINT-62342   CDCP1_HUMAN
MINT-65953   DYN1_HUMAN
MINT-65954   DYN2_HUMAN
MINT-68512   PDC6I_HUMAN
MINT-74753   ERBB3_HUMAN
MINT-2792760   PAK2_HUMAN
MINT-2793013   ADA15_HUMAN
MINT-2840132   TLR3_HUMAN
MINT-3381308   FAK1_HUMAN
MINT-3381360   FYN_HUMAN
MINT-4051815   ADRB2_HUMAN
MINT-4961196   AFAD_HUMAN
MINT-4980122   SNIP_MOUSE
MINT-5210599   SNIP_HUMAN
MINT-6539730   CBL_HUMAN
MINT-6771405   FAK1_MOUSE
MINT-6794909   ACTS_HUMAN
MINT-6795322   ACTN1_HUMAN
MINT-6795447   PTN1_HUMAN
MINT-7035260   HNRPK_HUMAN
MINT-7040283   CBLB_HUMAN
MINT-7104422   BCAR1_HUMAN
MINT-7145938   RL10_HUMAN
MINT-7244986   ASAP1_HUMAN
MINT-7244998   FANCA_HUMAN
MINT-7245022   PHAR2_HUMAN
MINT-7245034   ABL1_HUMAN
MINT-7245058   DLGP4_HUMAN
MINT-7245070   SNX17_HUMAN
MINT-7245106   RTN4_HUMAN
MINT-7245118   ASAP2_HUMAN
MINT-7245142   E41L3_HUMAN
MINT-7245154   ICAL_HUMAN
MINT-7245214   FCG2B_HUMAN
MINT-7245226   FCG2C_HUMAN
MINT-7245334   SHAN2_HUMAN
MINT-7245346   SHRM2_HUMAN
MINT-7245358   DNLI3_HUMAN
MINT-7245370   EIF3D_HUMAN
MINT-7245406   HCN2_HUMAN
MINT-7245490   CKAP5_HUMAN
MINT-7245502   M4K1_HUMAN
MINT-7245538   RPP38_HUMAN
MINT-7245562   SP1_HUMAN
MINT-7245574   DOCK1_HUMAN
MINT-7245586   RLGPB_HUMAN
MINT-7245598   ABL2_HUMAN
MINT-7245610   CELR2_HUMAN
MINT-7245622   SOS1_HUMAN
MINT-7245634   AKAP6_HUMAN
MINT-7245670   DPOD1_HUMAN
MINT-7245682   DAG1_HUMAN
MINT-7245694   SNX3_HUMAN
MINT-7245730   KI67_HUMAN
MINT-7245742   CD97_HUMAN
MINT-7245754   RPGF1_HUMAN
MINT-7245778   ACAP1_HUMAN
MINT-7245790   PRIC3_HUMAN
MINT-7245814   AKAP2_HUMAN
MINT-7245826   RRAS_HUMAN
MINT-7296136   P85A_HUMAN
MINT-7296149   ACTB_HUMAN
MINT-7306598   LCP2_HUMAN
MINT-7552515   PTPRA_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3/SH2 adaptor activity, non-membrane spanning protein tyrosine kinase activity, ATP binding, integrin binding, SH2 domain binding	caveola, cytosol	protein amino acid phosphorylation, regulation of bone resorption, signal complex assembly, regulation of vascular permeability, response to interleukin-1, interspecies interaction between organisms, Ras protein signal transduction, positive regulation of integrin activation, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	216	KIRKLDSGGFYITSRTQFNSL	SRC	12753909	LTP	1.00	-	SH2	0.20	1FMK	20.09%
Y	338	LYAVVSEEPIYIVTEYMSKGS	SRC	7578094	LTP	1.00	-	TyrKc	0.07	1FMK	17.03%
Y	419	GLARLIEDNEYTARQGAKFPI	SRC	7578094	LTP	1.00	CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	SRC	11804588	LTP	1.00	CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	SRC	15489898	LTP	1.00	CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%

Substrate:

Src substrate cortactin (Involved in the organization of cell structure)

Seq-ID:

Q01406 [Gallus gallus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	plasma membrane, cytoskeleton, endoplasmic reticulum

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	430	AEPKTPSSPVYQDAVSYDAES	SRC	8578591	LTP	0.12	-	-	0.78	-	medium
Y	477	QEAVSQREAEYEPETVYEVAG	SRC	8578591	LTP	0.50	-	-	0.66	-	medium
Y	483	REAEYEPETVYEVAGAGDHYQ	SRC	8578591	LTP	0.21	-	-	0.68	-	medium
Y	499	GDHYQAEENTYDEYENELGIT	SRC	8578591	LTP	0.95	-	-	0.65	-	medium

Substrate:

Src substrate cortactin (Involved in the organization of cell structure)

Seq-ID:

Q14247 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-6541916   WASL_HUMAN
MINT-6541935   PAK1_HUMAN
MINT-6541954   PAK2_HUMAN
MINT-6795199   PTN1_HUMAN
MINT-7103135   KCMA1_MOUSE
MINT-7145534   ASAP1_HUMAN
MINT-7145612   DYN2_HUMAN
MINT-7306884   MTSS1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	lamellipodium, cytoskeleton, soluble fraction, cell cortex, ruffle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	470	QGLAYATEAVYESAEAPGHYP	SRC	9748248	LTP	0.15		-	-	0.56	-	-
Y	486	PGHYPAEDSTYDEYENDLGYT	SRC	9748248	LTP	0.77		-	-	0.61	-	-

Substrate:

Src substrate cortactin (Involved in the organization of cell structure)

Seq-ID:

Q60598 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-58249   WIPF1_MOUSE
MINT-58757   LYN_MOUSE
MINT-6765355   PTN1_HUMAN
MINT-7103326   KCMA1_MOUSE
MINT-7146457   DYN2_HUMAN
MINT-7306926   MTSS1_HUMAN
MINT-7739614   UBIQ_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	lamellipodium, cytoskeleton, cell cortex, ruffle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	421	IEDRPPSSPIYEDAAPFKAEP	SRC	15169891	LTP	0.15	-	-	0.80	-	medium
Y	466	QGLTYTSEPVYETTEAPGHYQ	SRC	15169891	LTP	0.15	-	-	0.75	-	medium
Y	482	PGHYQAEDDTYDGYESDLGIT	SRC	10921917	LTP	1.00	-	-	0.64	-	medium

Substrate:

SRC-interacting protein (Adapter protein. Member of the p130Cas and CasL family plays a role in cell mobility. Other name: embryonal-Fyn associated substrate)

Seq-ID:

Q64355 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-58760 LYN_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding		cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	253	GESRDADEGIYDVPLLGPEPP	SRC	8647432	LTP	1.00		-	-	0.87	-	low

Substrate:

STAT 1 (Transcription factor)

Seq-ID:

P42224 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-74755 ERBB2_HUMAN
MINT-7264037 CBP_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity, sequence-specific DNA binding transcription factor activity, protein binding	cytoplasm, nucleolus	transcription from RNA polymerase II promoter, activation of caspase activity, I-kappaB kinase/NF-kappaB cascade, interspecies interaction between organisms, regulation of transcription, DNA-dependent, response to virus, tyrosine phosphorylation of STAT protein

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	701	MELDGPKGTGYIKTELISVSE	SRC	14978237	LTP	1.00		STAT1 SH2; STAT2 SH2	-	0.47	1BF5	139.74%

Substrate:

STAT 5 (Transcription factor)

Seq-ID:

P42229 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50646   ESR1_HUMAN
MINT-58264   STAP2_HUMAN
MINT-6793989   PTN1_HUMAN
MINT-7891339   EPOR_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, sequence-specific DNA binding transcription factor activity, protein binding	cytoplasm, nucleus	valine metabolic process, oxaloacetate metabolic process, transcription, creatinine metabolic process, isoleucine metabolic process, JAK-STAT cascade, taurine metabolic process, allantoin metabolic process, fatty acid metabolic process, citrate metabolic process, 2-oxoglutarate metabolic process, succinate metabolic process, creatine metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	694	TPVLAKAVDGYVKPQIKQVVP	SRC	11641791	LTP	0.25		CRKL SH2; PTPN11 SH2; STAT5 SH2	SH2	0.20	-	medium

Substrate:

STAT 5B (Transcription factor)

Seq-ID:

P51692 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-58270   STAP2_HUMAN
MINT-61490   EGFR_HUMAN
MINT-61524   ERBB4_HUMAN
MINT-6794005   PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
glucocorticoid receptor binding, calcium ion binding, sequence-specific DNA binding transcription factor activity	nucleus	valine metabolic process, oxaloacetate metabolic process, creatinine metabolic process, isoleucine metabolic process, taurine metabolic process, response to estradiol stimulus, allantoin metabolic process, fatty acid metabolic process, citrate metabolic process, JAK-STAT cascade involved in growth hormone signaling pathway, 2-oxoglutarate metabolic process, succinate metabolic process, creatine metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	679	VFPDRPKDEVYSKYYTPVPCE	SRC	12621061	LTP	0.00		-	SH2	0.29	-	medium

Substrate:

Telomerase reverse transcriptase (Telomerase reverse transcriptase)

Seq-ID:

O14746 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-6742762 AKT1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
telomeric RNA binding, telomeric template RNA reverse transcriptase activity, protein homodimerization activity, telomeric DNA binding	nuclear telomere cap complex, cytoplasm, nucleolus, telomerase holoenzyme complex, nucleoplasm	DNA strand elongation, senescence, anti-apoptosis, telomere maintenance via telomerase, telomere formation via telomerase

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	707	VRAQDPPPELYFVKVDVTGAY	SRC	12808100	LTP	1.00		-	-	0.24	-	medium

Substrate:

TRIP6 (interleukin-1 receptor binding, kinase binding)

Seq-ID:

Q9Z1Y4 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-19713 MEF2C_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
interleukin-1 receptor binding, kinase binding, zinc ion binding	focal adhesion, cytoplasm, cytoskeleton, nucleus	transcription, positive regulation of cell migration, regulation of transcription, release of cytoplasmic sequestered NF-kappaB, cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	55	NFCPLPPEHCYQPPGVPEDRG	SRC	15988003	LTP	0.01		-	-	0.74	-	low

Substrate:

Tyrosine-protein phosphatase, non-receptor type 6 (Protein tyrosine phosphatase containing SH2 domains)

Seq-ID:

P29350 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-56658   TFG_HUMAN
MINT-73504   EPOR_HUMAN
MINT-74919   FCG2B_HUMAN
MINT-6761906   ESR1_HUMAN
MINT-6793815   CAV1_HUMAN
MINT-6799844   ROS_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, protein binding	cytosol, nucleus, membrane	apoptosis, protein amino acid dephosphorylation, signal transduction, G-protein coupled receptor protein signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	536	LQSQKGQESEYGNITYPPAMK	SRC	14699166	LTP	1.00		Lck SH2; Src SH2	-	0.56	-	low
Y	564	RTSSKHKEDVYENLHTKNKRE	SRC	14699166	LTP	0.31		PIK3R1 SH2; SH3BP2 SH2	-	0.72	-	low

Substrate:

WASF1 (n.a.)

Seq-ID:

Q92558 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14901 CYFP2_HUMAN
MINT-16419 ABL1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
actin binding	actin cytoskeleton	cellular component movement, actin filament polymerization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	125	KTLPIPLQETYDVCEQPPPLN	SRC	16317717	LTP	0.97		-	-	0.51	-	low