a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

FGFR-1  ALK  LCK  SYK  PDGF-R alpha  CD31  SH3 domain-binding protein 2  FGFR-3  Gab1  c-kit  LAT  ZAP70  CBL E3 ubiquitin protein ligase  EGFR  RET  CD136  PDGF-R beta  c-met  CD3 zeta  VEGFR-1  VEGFR-2  AT1AR  TRKA 

Substrate:	FGFR-1 (Receptor tyrosine kinase)
Seq-ID:	P11362 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-74539   ERBB3_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process heparin binding, fibroblast growth factor receptor activity, ATP binding extracellular region, membrane fraction, integral to plasma membrane protein amino acid phosphorylation, MAPKKK cascade, cell growth
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	766	RIVALTSNQEYLDLSMPLDQY	-	9880324	LTP	0.89		PLCG1 SH2	-	0.29	-	-
Y	766	RIVALTSNQEYLDLSMPLDQY	FGFR1	8622701	LTP	0.89		PLCG1 SH2	-	0.29	-	-

Substrate:	ALK (Receptor tyrosine kinase)
Seq-ID:	Q9UM73 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-48477   M3K3_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane receptor protein tyrosine kinase activity, ATP binding, protein binding integral to plasma membrane protein amino acid autophosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1278	IGDFGMARDIYRASYYRKGGC	-	15592455	HTP	1.00		PLCG1 SH2	TyrKc	0.07	-	medium
Y	1278	IGDFGMARDIYRASYYRKGGC	-	15938644	HTP	1.00		PLCG1 SH2	TyrKc	0.07	-	medium
Y	1278	IGDFGMARDIYRASYYRKGGC	-	18083107	HTP	1.00		PLCG1 SH2	TyrKc	0.07	-	medium

Substrate:	LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))
Seq-ID:	P06239 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-15516   CBL_HUMAN MINT-56730   KSYK_HUMAN MINT-59474   LCP2_HUMAN MINT-59476   ZAP70_HUMAN MINT-60779   MK01_HUMAN MINT-60782   CD3Z_HUMAN MINT-61276   G3BP1_HUMAN MINT-66002   CD4_HUMAN MINT-66003   P85A_HUMAN MINT-68489   DLG1_HUMAN MINT-3373863   HS90A_HUMAN MINT-3373920   GCR_HUMAN MINT-7135817   SH22A_HUMAN MINT-7212471   KHDR1_HUMAN MINT-7212499   WASP_HUMAN MINT-7218109   ADA15_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphoinositide 3-kinase binding, protein C-terminus binding, protein kinase binding, protein serine/threonine phosphatase activity, glycoprotein binding, non-membrane spanning protein tyrosine kinase activity, ATP binding, CD8 receptor binding, ATPase binding, CD4 receptor binding, SH2 domain binding plasma membrane, cytosol, Golgi apparatus, membrane raft, pericentriolar material protein amino acid phosphorylation, T cell differentiation, response to drug, activation of caspase activity, positive regulation of T cell activation, positive regulation of T cell receptor signaling pathway, release of sequestered calcium ion into cytosol, interspecies interaction between organisms, cellular zinc ion homeostasis, induction of apoptosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	192	KIRNLDNGGFYISPRITFPGL	-	15659558	HTP	1.00		PLCG1 SH2	SH2	0.20	1LKK	20.09%
Y	192	KIRNLDNGGFYISPRITFPGL	-	17192257	HTP	1.00		PLCG1 SH2	SH2	0.20	1LKK	20.09%
Y	192	KIRNLDNGGFYISPRITFPGL	-	18083107	HTP	1.00		PLCG1 SH2	SH2	0.20	1LKK	20.09%

Substrate:	SYK (Spleen tyrosine kinase )
Seq-ID:	P43405 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-56730   LCK_HUMAN MINT-56732   P85A_HUMAN MINT-56739   FGR_HUMAN MINT-56749   P85B_HUMAN MINT-74763   EGFR_HUMAN MINT-74769   ERBB2_HUMAN MINT-74775   ERBB3_HUMAN MINT-74776   ERBB4_HUMAN MINT-6538977   CBL_HUMAN MINT-6621148   BLNK_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine kinase activity, ATP binding, integrin binding cytoplasm, T cell receptor complex protein complex assembly, organ morphogenesis, integrin-mediated signaling pathway, neutrophil chemotaxis, interspecies interaction between organisms, cell proliferation, leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	348	REALPMDTEVYESPYADPEEI	SYK	8657103	LTP	0.93		FGR SH2; Lck SH2; PLCG1 SH2; VAV1 SH2	-	0.59	-	-
Y	348	REALPMDTEVYESPYADPEEI	-	12522270	HTP	0.93		FGR SH2; Lck SH2; PLCG1 SH2; VAV1 SH2	-	0.59	-	-
Y	348	REALPMDTEVYESPYADPEEI	-	18083107	HTP	0.93		FGR SH2; Lck SH2; PLCG1 SH2; VAV1 SH2	-	0.59	-	-
Y	352	PMDTEVYESPYADPEEIRPKE	SYK	8657103	LTP	1.00		FGR SH2; Lck SH2; PLCG1 SH2; VAV1 SH2	-	0.53	-	-
Y	352	PMDTEVYESPYADPEEIRPKE	-	12522270	HTP	1.00		FGR SH2; Lck SH2; PLCG1 SH2; VAV1 SH2	-	0.53	-	-
Y	352	PMDTEVYESPYADPEEIRPKE	-	18083107	HTP	1.00		FGR SH2; Lck SH2; PLCG1 SH2; VAV1 SH2	-	0.53	-	-

Substrate:	PDGF-R alpha (Receptor tyrosine kinase)
Seq-ID:	P16234 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process platelet-derived growth factor alpha-receptor activity, vascular endothelial growth factor receptor activity, platelet-derived growth factor binding, protein homodimerization activity, platelet-derived growth factor receptor binding, ATP binding integral to plasma membrane positive regulation of DNA replication, positive regulation of fibroblast proliferation, cell activation, positive regulation of cell migration, protein amino acid autophosphorylation, peptidyl-tyrosine phosphorylation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	988	ARMRVDSDNAYIGVTYKNEED	PDGFR_alpha	7535778	LTP	0.12		PLCG1 SH2	-	0.41	-	medium
Y	1018	DEQRLSADSGYIIPLPDIDPV	PDGFR_alpha	7535778	LTP	1.00		PLCG1 SH2	-	0.49	-	medium
Y	1018	DEQRLSADSGYIIPLPDIDPV	-	18083107	HTP	1.00		PLCG1 SH2	-	0.49	-	medium

Substrate:	CD31 (Adhesion molecule)
Seq-ID:	P16284 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	[show] MINT-61866   PR40A_HUMAN MINT-63486   KU70_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein binding cell junction, integral to membrane, extracellular space, platelet alpha granule membrane signal transduction, diapedesis, cell recognition, cell adhesion, phagocytosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	690	NKEPLNSDVQYTEVQVSSAES	-	15201144	LTP	1.00		INPP5D SH2; PLCG1 SH2; PTPN11 SH2; PTPN6 SH2; Src SH2	-	0.58	-	medium
Y	713	DLGKKDTETVYSEVRKAVPDA	-	15592455	HTP	1.00		PLCG1 SH2; PTPN11 SH2; PTPN6 SH2; Src SH2	-	0.63	-	medium
Y	713	DLGKKDTETVYSEVRKAVPDA	-	18088087	HTP	1.00		PLCG1 SH2; PTPN11 SH2; PTPN6 SH2; Src SH2	-	0.63	-	medium
Y	713	DLGKKDTETVYSEVRKAVPDA	-	18083107	HTP	1.00		PLCG1 SH2; PTPN11 SH2; PTPN6 SH2; Src SH2	-	0.63	-	medium

Substrate:	SH3 domain-binding protein 2 (Adaptor molecule)
Seq-ID:	P78314 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-17097   1433T_HUMAN MINT-74724   ERBB2_HUMAN MINT-4549720   VAV_HUMAN MINT-4563345   DBNL_HUMAN MINT-4563367   SH3K1_HUMAN MINT-7301276   VAV2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3 domain binding, SH3/SH2 adaptor activity
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	183	DYEHDDEDDSYLEPDSPEPGR	-	11390470	LTP	1.00		PLCG1 SH2; PLCG2 SH2; PLCG_group SH2; VAV1 SH2; VAV2 SH2; VAV_group SH2	-	0.89	-	medium

Substrate:	FGFR-3 (Receptor tyrosine kinase)
Seq-ID:	P22607 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process identical protein binding, fibroblast growth factor binding, fibroblast growth factor receptor activity, ATP binding integral to plasma membrane positive regulation of cell proliferation, protein amino acid phosphorylation, MAPKKK cascade, cell growth, JAK-STAT cascade, skeletal system development
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	760	RVLTVTSTDEYLDLSAPFEQY	FGFR3	11294897	LTP	0.95		PLCG1 SH2	-	0.33	-	medium

Substrate:	Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID:	Q13480 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-58395   GRB2_HUMAN MINT-58403   GRAP2_HUMAN MINT-58404   MET_HUMAN MINT-68564   BMX_HUMAN MINT-1893011   P85A_HUMAN MINT-6169406   PTN11_HUMAN MINT-6169502   PAXI_HUMAN MINT-7971128   DLG4_RAT
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3/SH2 adaptor activity cytosol epidermal growth factor receptor signaling pathway, insulin receptor signaling pathway, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	307	ETQMRHVSISYDIPPTPGNTY	Met	10734310	LTP	0.12		CRKL SH2; CRK SH2; NCK SH2; PLCG1 SH2	-	0.70	-	low
Y	307	ETQMRHVSISYDIPPTPGNTY	EGFR	10734310	LTP	0.12		CRKL SH2; CRK SH2; NCK SH2; PLCG1 SH2	-	0.70	-	low
Y	317	YDIPPTPGNTYQIPRTFPEGT	-	16497976	HTP	0.24		CRKL SH2; CRK SH2; PLCG1 SH2; RASA_group SH2	-	0.74	-	low
Y	373	PRTASDTDSSYCIPTAGMSPS	INSR	10978177	LTP	0.08		CRKL SH2; CRK SH2; PLCG1 SH2	-	0.66	-	low
Y	373	PRTASDTDSSYCIPTAGMSPS	EGFR	9890893	LTP	0.08		CRKL SH2; CRK SH2; PLCG1 SH2	-	0.66	-	low
Y	373	PRTASDTDSSYCIPTAGMSPS	-	10753869	LTP	0.08		CRKL SH2; CRK SH2; PLCG1 SH2	-	0.66	-	low
Y	373	PRTASDTDSSYCIPTAGMSPS	Met	10734310	LTP	0.08		CRKL SH2; CRK SH2; PLCG1 SH2	-	0.66	-	low
Y	406	LRKDASSQDCYDIPRAFPSDR	EGFR	9890893	LTP	1.00		CRKL SH2; CRK SH2; NCK SH2; PLCG1 SH2; SHC_group SH2	-	0.61	-	low
Y	406	LRKDASSQDCYDIPRAFPSDR	-	10753869	LTP	1.00		CRKL SH2; CRK SH2; NCK SH2; PLCG1 SH2; SHC_group SH2	-	0.61	-	low
Y	406	LRKDASSQDCYDIPRAFPSDR	Met	10734310	LTP	1.00		CRKL SH2; CRK SH2; NCK SH2; PLCG1 SH2; SHC_group SH2	-	0.61	-	low
Y	406	LRKDASSQDCYDIPRAFPSDR	-	18083107	HTP	1.00		CRKL SH2; CRK SH2; NCK SH2; PLCG1 SH2; SHC_group SH2	-	0.61	-	low

Substrate:	c-kit (Receptor tyrosine kinase)
Seq-ID:	P10721 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process receptor signaling protein tyrosine kinase activity, ATP binding, protein binding integral to membrane, extracellular space male gonad development, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	936	KQISESTNHIYSNLANCSPNR	Kit	10377264	LTP	1.00		GRB2 SH2; GRB7 SH2; PLCG1 SH2	-	0.38	-	-
Y	936	KQISESTNHIYSNLANCSPNR	-	18083107	HTP	1.00		GRB2 SH2; GRB7 SH2; PLCG1 SH2	-	0.38	-	-

Substrate:	LAT (Adaptor molecule involved in the TCR signal pathway)
Seq-ID:	O43561 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-3382436   GRB2_HUMAN MINT-3382457   SOS1_MOUSE MINT-3382488   ZAP70_HUMAN MINT-6794135   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3/SH2 adaptor activity immunological synapse, integral to membrane, membrane raft calcium-mediated signaling, integrin-mediated signaling pathway, mast cell degranulation, regulation of T cell activation, Ras protein signal transduction
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	220	AEASLDGSREYVNVSQELHPG	-	15659558	HTP	1.00		GRAP2 SH2; GRB2 SH2; PIK3R1 SH2; PLCG1 SH2; VAV1 SH2	-	0.71	-	medium

Substrate:	ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID:	P43403 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-59476   LCK_HUMAN MINT-60980   SHC1_HUMAN MINT-74806   ERBB3_HUMAN MINT-74807   EGFR_HUMAN MINT-3374106   HS90A_HUMAN MINT-3382488   LAT_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine kinase activity, ATP binding cytosol, T cell receptor complex positive thymic T cell selection, immune response, intracellular protein kinase cascade
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	315	PRPMPMDTSVYESPYSDPEEL	ZAP70	11828374	LTP	1.00		CRKL SH2; CRK SH2; PLCG1 SH2; PLCG_group SH2; VAV1 SH2; VAV_group SH2	-	0.69	2OZO	6.42%
Y	315	PRPMPMDTSVYESPYSDPEEL	ZAP70	7798261	LTP	1.00		CRKL SH2; CRK SH2; PLCG1 SH2; PLCG_group SH2; VAV1 SH2; VAV_group SH2	-	0.69	2OZO	6.42%
Y	315	PRPMPMDTSVYESPYSDPEEL	-	12522270	HTP	1.00		CRKL SH2; CRK SH2; PLCG1 SH2; PLCG_group SH2; VAV1 SH2; VAV_group SH2	-	0.69	2OZO	6.42%
Y	315	PRPMPMDTSVYESPYSDPEEL	-	15592455	HTP	1.00		CRKL SH2; CRK SH2; PLCG1 SH2; PLCG_group SH2; VAV1 SH2; VAV_group SH2	-	0.69	2OZO	6.42%
Y	315	PRPMPMDTSVYESPYSDPEEL	-	16094384	HTP	1.00		CRKL SH2; CRK SH2; PLCG1 SH2; PLCG_group SH2; VAV1 SH2; VAV_group SH2	-	0.69	2OZO	6.42%
Y	315	PRPMPMDTSVYESPYSDPEEL	ZAP70	10037717	LTP	1.00		CRKL SH2; CRK SH2; PLCG1 SH2; PLCG_group SH2; VAV1 SH2; VAV_group SH2	-	0.69	2OZO	6.42%
Y	319	PMDTSVYESPYSDPEELKDKK	-	10202147	LTP	1.00		CRKL SH2; CRK SH2; Lck SH2; PLCG1 SH2; PLCG_group SH2	-	0.52	2OZO	1.83%
Y	319	PMDTSVYESPYSDPEELKDKK	-	10318843	LTP	1.00		CRKL SH2; CRK SH2; Lck SH2; PLCG1 SH2; PLCG_group SH2	-	0.52	2OZO	1.83%
Y	319	PMDTSVYESPYSDPEELKDKK	-	12522270	HTP	1.00		CRKL SH2; CRK SH2; Lck SH2; PLCG1 SH2; PLCG_group SH2	-	0.52	2OZO	1.83%
Y	319	PMDTSVYESPYSDPEELKDKK	-	15592455	HTP	1.00		CRKL SH2; CRK SH2; Lck SH2; PLCG1 SH2; PLCG_group SH2	-	0.52	2OZO	1.83%
Y	319	PMDTSVYESPYSDPEELKDKK	-	16094384	HTP	1.00		CRKL SH2; CRK SH2; Lck SH2; PLCG1 SH2; PLCG_group SH2	-	0.52	2OZO	1.83%
Y	319	PMDTSVYESPYSDPEELKDKK	-	10037717	LTP	1.00		CRKL SH2; CRK SH2; Lck SH2; PLCG1 SH2; PLCG_group SH2	-	0.52	2OZO	1.83%
Y	319	PMDTSVYESPYSDPEELKDKK	-	15268851	LTP	1.00		CRKL SH2; CRK SH2; Lck SH2; PLCG1 SH2; PLCG_group SH2	-	0.52	2OZO	1.83%
Y	319	PMDTSVYESPYSDPEELKDKK	-	15292262	LTP	1.00		CRKL SH2; CRK SH2; Lck SH2; PLCG1 SH2; PLCG_group SH2	-	0.52	2OZO	1.83%

Substrate:	CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID:	P22681 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-15516   LCK_HUMAN MINT-15716   CRK_HUMAN MINT-16022   CD2AP_HUMAN MINT-16347   LYN_HUMAN MINT-16846   LCP2_HUMAN MINT-17062   FCGR1_HUMAN MINT-17932   NCK1_HUMAN MINT-50666   FYN_HUMAN MINT-50717   ABL1_HUMAN MINT-50722   CRKL_HUMAN MINT-58331   ITCH_HUMAN MINT-60970   RET_HUMAN MINT-60973   EGFR_HUMAN MINT-60978   SHC1_HUMAN MINT-68500   P85A_HUMAN MINT-2837344   PLCG1_BOVIN MINT-4299918   ASAP1_HUMAN MINT-6169713   SPY1_HUMAN MINT-6170244   SH3G2_HUMAN MINT-6538940   SPY4_HUMAN MINT-6538977   KSYK_HUMAN MINT-6539587   MET_HUMAN MINT-6539601   SPY2_HUMAN MINT-6539646   VGFR1_HUMAN MINT-6539679   RON_HUMAN MINT-6539730   SRC_HUMAN MINT-7040249   GRB2_HUMAN MINT-7046364   ITSN1_HUMAN MINT-7103623   MK08_HUMAN MINT-7211864   ARHG7_HUMAN MINT-7214822   FYN_MOUSE MINT-7218352   SH3K1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3 domain binding, calcium ion binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, signal transducer activity, ubiquitin-protein ligase activity cytosol, nucleus epidermal growth factor receptor signaling pathway, positive regulation of receptor-mediated endocytosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	674	IKPSSSANAIYSLAARPLPVP	-	12522270	HTP	0.25		CRKL SH2; PLCG1 SH2	-	0.55	-	-
Y	674	IKPSSSANAIYSLAARPLPVP	-	15144186	HTP	0.25		CRKL SH2; PLCG1 SH2	-	0.55	-	-
Y	674	IKPSSSANAIYSLAARPLPVP	-	15592455	HTP	0.25		CRKL SH2; PLCG1 SH2	-	0.55	-	-
Y	674	IKPSSSANAIYSLAARPLPVP	-	15922744	LTP	0.25		CRKL SH2; PLCG1 SH2	-	0.55	-	-
Y	700	EQCEGEEDTEYMTPSSRPLRP	Fyn	9525940	LTP	0.63		CRKL SH2; CRK SH2; PIK3R2 SH2; PLCG1 SH2; VAV_group SH2	-	0.85	-	-
Y	700	EQCEGEEDTEYMTPSSRPLRP	SYK	9525940	LTP	0.63		CRKL SH2; CRK SH2; PIK3R2 SH2; PLCG1 SH2; VAV_group SH2	-	0.85	-	-
Y	700	EQCEGEEDTEYMTPSSRPLRP	Yes	9525940	LTP	0.63		CRKL SH2; CRK SH2; PIK3R2 SH2; PLCG1 SH2; VAV_group SH2	-	0.85	-	-
Y	700	EQCEGEEDTEYMTPSSRPLRP	-	9102067	LTP	0.63		CRKL SH2; CRK SH2; PIK3R2 SH2; PLCG1 SH2; VAV_group SH2	-	0.85	-	-
Y	700	EQCEGEEDTEYMTPSSRPLRP	-	12522270	HTP	0.63		CRKL SH2; CRK SH2; PIK3R2 SH2; PLCG1 SH2; VAV_group SH2	-	0.85	-	-
Y	700	EQCEGEEDTEYMTPSSRPLRP	INSR	11997497	LTP	0.63		CRKL SH2; CRK SH2; PIK3R2 SH2; PLCG1 SH2; VAV_group SH2	-	0.85	-	-
Y	700	EQCEGEEDTEYMTPSSRPLRP	-	10829062	LTP	0.63		CRKL SH2; CRK SH2; PIK3R2 SH2; PLCG1 SH2; VAV_group SH2	-	0.85	-	-
Y	700	EQCEGEEDTEYMTPSSRPLRP	-	15922744	LTP	0.63		CRKL SH2; CRK SH2; PIK3R2 SH2; PLCG1 SH2; VAV_group SH2	-	0.85	-	-
Y	731	DCDQQIDSCTYEAMYNIQSQA	Fyn	9525940	LTP	0.29		CRKL SH2; CRK SH2; Lyn SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2	-	0.47	-	-
Y	731	DCDQQIDSCTYEAMYNIQSQA	SYK	9525940	LTP	0.29		CRKL SH2; CRK SH2; Lyn SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2	-	0.47	-	-
Y	731	DCDQQIDSCTYEAMYNIQSQA	Yes	9525940	LTP	0.29		CRKL SH2; CRK SH2; Lyn SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2	-	0.47	-	-
Y	731	DCDQQIDSCTYEAMYNIQSQA	-	10934191	LTP	0.29		CRKL SH2; CRK SH2; Lyn SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2	-	0.47	-	-
Y	731	DCDQQIDSCTYEAMYNIQSQA	Fyn	9890970	LTP	0.29		CRKL SH2; CRK SH2; Lyn SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2	-	0.47	-	-
Y	731	DCDQQIDSCTYEAMYNIQSQA	-	12604776	LTP	0.29		CRKL SH2; CRK SH2; Lyn SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2	-	0.47	-	-
Y	731	DCDQQIDSCTYEAMYNIQSQA	-	15922744	LTP	0.29		CRKL SH2; CRK SH2; Lyn SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2	-	0.47	-	-
Y	774	PEESENEDDGYDVPKPPVPAV	Fyn	9525940	LTP	0.28		CRKL SH2; CRK SH2; PLCG1 SH2	-	0.89	-	-
Y	774	PEESENEDDGYDVPKPPVPAV	SYK	9525940	LTP	0.28		CRKL SH2; CRK SH2; PLCG1 SH2	-	0.89	-	-
Y	774	PEESENEDDGYDVPKPPVPAV	Yes	9525940	LTP	0.28		CRKL SH2; CRK SH2; PLCG1 SH2	-	0.89	-	-
Y	774	PEESENEDDGYDVPKPPVPAV	-	12522270	HTP	0.28		CRKL SH2; CRK SH2; PLCG1 SH2	-	0.89	-	-
Y	774	PEESENEDDGYDVPKPPVPAV	-	12604776	LTP	0.28		CRKL SH2; CRK SH2; PLCG1 SH2	-	0.89	-	-
Y	774	PEESENEDDGYDVPKPPVPAV	-	10829062	LTP	0.28		CRKL SH2; CRK SH2; PLCG1 SH2	-	0.89	-	-
Y	774	PEESENEDDGYDVPKPPVPAV	-	15922744	LTP	0.28		CRKL SH2; CRK SH2; PLCG1 SH2	-	0.89	-	-

Substrate:	EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID:	P00533 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16802   GRB10_HUMAN MINT-50935   1433Z_HUMAN MINT-51101   ANXA1_HUMAN MINT-51490   ARBK1_HUMAN MINT-60973   CBL_HUMAN MINT-61486   CRKL_HUMAN MINT-61487   CSK_HUMAN MINT-61490   STA5B_HUMAN MINT-61540   GRB2_HUMAN MINT-68514   PDC6I_HUMAN MINT-74427   ABL1_HUMAN MINT-74438   ABL2_HUMAN MINT-74460   ANS1A_HUMAN MINT-74469   APBB1_HUMAN MINT-74479   DP13A_HUMAN MINT-74487   BMX_HUMAN MINT-74497   CRK_HUMAN MINT-74535   FES_HUMAN MINT-74551   IRS1_HUMAN MINT-74555   IRS4_HUMAN MINT-74562   JAK2_HUMAN MINT-74566   SH2B3_HUMAN MINT-74572   JIP1_HUMAN MINT-74587   NCK1_HUMAN MINT-74593   NUMB_HUMAN MINT-74594   NUMBL_HUMAN MINT-74606   P85A_HUMAN MINT-74630   P85B_HUMAN MINT-74659   P55G_HUMAN MINT-74678   PLCG1_HUMAN MINT-74685   PLCG2_HUMAN MINT-74687   PTK6_HUMAN MINT-74689   PTN11_HUMAN MINT-74711   RASA1_HUMAN MINT-74717   SH2B1_HUMAN MINT-74720   SH22A_HUMAN MINT-74732   SHC1_HUMAN MINT-74746   SLAP1_HUMAN MINT-74763   KSYK_HUMAN MINT-74790   TLN1_HUMAN MINT-74807   ZAP70_HUMAN MINT-1788719   ERBB2_HUMAN MINT-6169667   ESR1_HUMAN MINT-6170031   SOS1_MOUSE MINT-6170198   SH3G2_HUMAN MINT-6170268   SH3K1_HUMAN MINT-6793358   PTN1_HUMAN MINT-7980526   TM1L1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process epidermal growth factor receptor activity, protein heterodimerization activity, identical protein binding, receptor signaling protein tyrosine kinase activity, double-stranded DNA binding, ATP binding, protein phosphatase binding, actin filament binding, MAP/ERK kinase kinase activity Shc-EGFR complex, endosome, basolateral plasma membrane, integral to membrane, extracellular space, nucleus activation of phospholipase C activity, protein insertion into membrane, response to UV-A, positive regulation of nitric oxide biosynthetic process, positive regulation of cell migration, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, positive regulation of catenin protein nuclear translocation, regulation of nitric-oxide synthase activity, positive regulation of protein kinase B signaling cascade, ossification, positive regulation of epithelial cell proliferation, activation of phospholipase A2 activity by calcium-mediated signaling, cell-cell adhesion, regulation of peptidyl-tyrosine phosphorylation, positive regulation of phosphorylation, positive regulation of MAP kinase activity, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	915	WELMTFGSKPYDGIPASEISS	SRC	11983694	LTP	1.00		PLCG1 SH2; Src SH2	TyrKc	0.18	3BEL	8.30%
Y	998	HLPSPTDSNFYRALMDEEDMD	-	15951569	HTP	0.31		PLCG1 SH2	-	0.49	3BEL	13.10%
Y	998	HLPSPTDSNFYRALMDEEDMD	-	17081983	HTP	0.31		PLCG1 SH2	-	0.49	3BEL	13.10%
Y	998	HLPSPTDSNFYRALMDEEDMD	-	18669648	HTP	0.31		PLCG1 SH2	-	0.49	3BEL	13.10%
Y	1016	DMDDVVDADEYLIPQQGFFSS	SRC	8845374	LTP	1.00		CRK SH2; PLCG1 SH2; RASA_group SH2; Src SH2	-	0.41	1XKK	41.92%
Y	1016	DMDDVVDADEYLIPQQGFFSS	-	7680558	LTP	1.00		CRK SH2; PLCG1 SH2; RASA_group SH2; Src SH2	-	0.41	1XKK	41.92%
Y	1016	DMDDVVDADEYLIPQQGFFSS	-	15302935	HTP	1.00		CRK SH2; PLCG1 SH2; RASA_group SH2; Src SH2	-	0.41	1XKK	41.92%
Y	1069	PIKEDSFLQRYSSDPTGALTE	-	15302935	HTP	1.00		PLCG1 SH2; RASA_group SH2	-	0.57	-	-
Y	1069	PIKEDSFLQRYSSDPTGALTE	-	17081983	HTP	1.00		PLCG1 SH2; RASA_group SH2	-	0.57	-	-
Y	1069	PIKEDSFLQRYSSDPTGALTE	-	18669648	HTP	1.00		PLCG1 SH2; RASA_group SH2	-	0.57	-	-
Y	1092	IDDTFLPVPEYINQSVPKRPA	EGFR	8845374	LTP	0.05		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; STAT3 SH2	-	0.57	-	-
Y	1092	IDDTFLPVPEYINQSVPKRPA	-	15302935	HTP	0.05		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; STAT3 SH2	-	0.57	-	-
Y	1092	IDDTFLPVPEYINQSVPKRPA	-	17081983	HTP	0.05		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; STAT3 SH2	-	0.57	-	-
Y	1092	IDDTFLPVPEYINQSVPKRPA	-	18083107	HTP	0.05		GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; STAT3 SH2	-	0.57	-	-
Y	1110	RPAGSVQNPVYHNQPLNPAPS	EGFR	8845374	LTP	1.00		GRB2 SH2; PLCG1 SH2; RASA_group SH2; SHC1 PTB; Src SH2; STAT3 SH2	-	0.80	-	-
Y	1110	RPAGSVQNPVYHNQPLNPAPS	-	15302935	HTP	1.00		GRB2 SH2; PLCG1 SH2; RASA_group SH2; SHC1 PTB; Src SH2; STAT3 SH2	-	0.80	-	-
Y	1125	LNPAPSRDPHYQDPHSTAVGN	SRC	8845374	LTP	1.00		PLCG1 SH2; RASA_group SH2; Src SH2	-	0.86	-	-
Y	1125	LNPAPSRDPHYQDPHSTAVGN	SRC	11983694	LTP	1.00		PLCG1 SH2; RASA_group SH2; Src SH2	-	0.86	-	-
Y	1125	LNPAPSRDPHYQDPHSTAVGN	SRC	10075741	LTP	1.00		PLCG1 SH2; RASA_group SH2; Src SH2	-	0.86	-	-
Y	1172	SHQISLDNPDYQQDFFPKEAK	EGFR	8845374	LTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 PTB; SHC3 PTB; Src SH2; VAV2 SH2	-	0.67	-	-
Y	1172	SHQISLDNPDYQQDFFPKEAK	-	15302935	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 PTB; SHC3 PTB; Src SH2; VAV2 SH2	-	0.67	-	-
Y	1172	SHQISLDNPDYQQDFFPKEAK	-	17081983	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 PTB; SHC3 PTB; Src SH2; VAV2 SH2	-	0.67	-	-
Y	1172	SHQISLDNPDYQQDFFPKEAK	-	18083107	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 PTB; SHC3 PTB; Src SH2; VAV2 SH2	-	0.67	-	-
Y	1197	FKGSTAENAEYLRVAPQSSEF	EGFR	8845374	LTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 SH2; SHC3 SH2; Src SH2	-	0.54	-	-
Y	1197	FKGSTAENAEYLRVAPQSSEF	-	15302935	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 SH2; SHC3 SH2; Src SH2	-	0.54	-	-
Y	1197	FKGSTAENAEYLRVAPQSSEF	-	17081983	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 SH2; SHC3 SH2; Src SH2	-	0.54	-	-
Y	1197	FKGSTAENAEYLRVAPQSSEF	-	18083107	HTP	1.00		ABL1 SH2; GRB2 SH2; PLCG1 SH2; PTPN6 SH2; RASA_group SH2; SHC1 SH2; SHC3 SH2; Src SH2	-	0.54	-	-

Substrate:	RET (Probable receptor with tyrosine-protein kinase activity; important for development.)
Seq-ID:	P07949 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-60970   CBL_HUMAN MINT-60975   GRB2_HUMAN MINT-60981   SHC1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process calcium ion binding, transmembrane receptor protein tyrosine kinase activity, ATP binding integral to membrane protein amino acid phosphorylation, posterior midgut development, homophilic cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1015	LEKMMVKRRDYLDLAASTPSD	-	11470823	LTP	1.00		PLCG1 SH2; SHC1 SH2; Src SH2	-	0.33	-	-
Y	1015	LEKMMVKRRDYLDLAASTPSD	RET	14981541	LTP	1.00		PLCG1 SH2; SHC1 SH2; Src SH2	-	0.33	-	-

Substrate:	CD136 (Receptor tyrosine kinase)
Seq-ID:	Q04912 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-6539679   CBL_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process macrophage colony-stimulating factor receptor activity, ATP binding, protein binding integral to plasma membrane positive regulation of cell proliferation, protein amino acid phosphorylation, cellular component movement, single fertilization, transmembrane receptor protein tyrosine kinase signaling pathway, multicellular organismal development, defense response
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1353	QIVSALLGDHYVQLPATYMNL	RON	10871856	LTP	1.00		GRB2 SH2; PIK3R1 SH2; PLCG1 SH2; SHC1 SH2	-	0.21	-	low
Y	1360	GDHYVQLPATYMNLGPSTSHE	RON	10871856	LTP	1.00		GRB2 SH2; PIK3R1 SH2; PLCG1 SH2; SHC1 SH2	-	0.40	-	low

Substrate:	PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID:	P09619 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-2832596   NHRF2_HUMAN MINT-2832984   PTEN_HUMAN MINT-2833042   NHRF1_HUMAN MINT-6762380   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process vascular endothelial growth factor receptor activity, platelet-derived growth factor binding, platelet activating factor receptor activity, platelet-derived growth factor receptor binding, ATP binding, platelet-derived growth factor beta-receptor activity integral to plasma membrane positive regulation of cell proliferation, positive regulation of cell migration, protein amino acid autophosphorylation, peptidyl-tyrosine phosphorylation, cell chemotaxis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	579	IESVSSDGHEYIYVDPMQLPY	PDGFR_beta	8195171	LTP	1.00		Fyn SH2; PIK3R1 SH2; PLCG1 SH2; PTPN11 SH2; RASA_group SH2; SHC1 SH2; SHC_group SH2; SLA SH2; Src SH2; STAT5 SH2; YES1 SH2	-	0.15	-	medium
Y	581	SVSSDGHEYIYVDPMQLPYDS	PDGFR_beta	8617789	LTP	1.00		Fyn SH2; PIK3R1 SH2; PLCG1 SH2; PTPN11 SH2; RASA_group SH2; SLA SH2; Src SH2; STAT5 SH2; YES1 SH2	-	0.16	-	medium
Y	740	VSLTGESDGGYMDMSKDESVD	PDGFR_beta	8195171	LTP	1.00		Fyn SH2; NCK SH2; PIK3R1 SH2; PLCG1 SH2; RASA_group SH2; SHC1 SH2; SHC_group SH2	TyrKc	0.45	-	medium
Y	751	MDMSKDESVDYVPMLDMKGDV	PDGFR_beta	8195171	LTP	1.00		Fyn SH2; NCK SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2; RASA_group SH2; SHC1 SH2; SHC_group SH2; Src SH2	TyrKc	0.29	-	medium
Y	751	MDMSKDESVDYVPMLDMKGDV	PDGFR_group	8195171	LTP	1.00		Fyn SH2; NCK SH2; PIK3R1 SH2; PIK3R2 SH2; PLCG1 SH2; RASA_group SH2; SHC1 SH2; SHC_group SH2; Src SH2	TyrKc	0.29	-	medium
Y	771	VKYADIESSNYMAPYDNYVPS	PDGFR_beta	8195171	LTP	1.00		CRK SH2; PLCG1 SH2; RASA_group SH2; SHC1 SH2; SHC_group SH2	TyrKc	0.25	-	medium
Y	1009	RSPLDTSSVLYTAVQPNEGDN	PDGFR_beta	8195171	LTP	0.02		NCK SH2; PIK3R1 SH2; PLCG1 SH2; PTPN11 SH2	-	0.61	-	medium
Y	1021	AVQPNEGDNDYIIPLPDPKPE	PDGFR_beta	12062403	LTP	1.00		PIK3R1 SH2; PLCG1 SH2; PTPN11 SH2	-	0.75	-	medium

Substrate:	c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID:	P08581 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-18299   RANB9_HUMAN MINT-58374   GAB1_MOUSE MINT-58404   GAB1_HUMAN MINT-6539587   CBL_HUMAN MINT-6787689   PTN1_HUMAN MINT-6798640   PTN11_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process hepatocyte growth factor receptor activity, ATP binding, protein binding integral to plasma membrane, basal plasma membrane protein amino acid phosphorylation, multicellular organismal development, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	12475979	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	9444958	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	9252406	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	7513258	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7731718	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	8662889	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7961992	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7687741	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	-	9826708	LTP	1.00		GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%

Substrate:	CD3 zeta (T-cell surface glycoprotein CD3 zeta chain precursor (from PhosphoBase))
Seq-ID:	P20963 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-60782   LCK_HUMAN MINT-7301967   NCK1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein homodimerization activity, transmembrane receptor activity cytoplasm, integral to membrane interspecies interaction between organisms
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	142	RRRGKGHDGLYQGLSTATKDT	-	12522270	HTP	1.00		Fyn SH2; Lck SH2; PLCG1 SH2; SHC1 SH2; SYK SH2; ZAP70 SH2	ITAM	0.65	-	medium
Y	142	RRRGKGHDGLYQGLSTATKDT	-	15592455	HTP	1.00		Fyn SH2; Lck SH2; PLCG1 SH2; SHC1 SH2; SYK SH2; ZAP70 SH2	ITAM	0.65	-	medium
Y	142	RRRGKGHDGLYQGLSTATKDT	-	16094384	HTP	1.00		Fyn SH2; Lck SH2; PLCG1 SH2; SHC1 SH2; SYK SH2; ZAP70 SH2	ITAM	0.65	-	medium
Y	142	RRRGKGHDGLYQGLSTATKDT	-	15659558	HTP	1.00		Fyn SH2; Lck SH2; PLCG1 SH2; SHC1 SH2; SYK SH2; ZAP70 SH2	ITAM	0.65	-	medium

Substrate:	VEGFR-1 (Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity.)
Seq-ID:	P17948 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-6177086   LDLR_HUMAN MINT-6539646   CBL_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process vascular endothelial growth factor receptor activity, ATP binding, growth factor binding cytoplasm, integral to plasma membrane, extracellular space positive regulation of vascular endothelial growth factor receptor signaling pathway, female pregnancy, peptidyl-tyrosine phosphorylation, cell differentiation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	794	KRSSSEIKTDYLSIIMDPDEV	-	11741094	LTP	0.97		PLCG1 SH2; PLCG2 SH2; PLCG_group SH2	-	0.30	-	low
Y	794	KRSSSEIKTDYLSIIMDPDEV	-	9398617	LTP	0.97		PLCG1 SH2; PLCG2 SH2; PLCG_group SH2	-	0.30	-	low
Y	1169	QANVQQDGKDYIPINAILTGN	-	11513746	LTP	1.00		PIK3R1 SH2; PLCG1 SH2; PLCG2 SH2; PLCG_group SH2	-	0.30	-	low
Y	1169	QANVQQDGKDYIPINAILTGN	-	9299537	LTP	1.00		PIK3R1 SH2; PLCG1 SH2; PLCG2 SH2; PLCG_group SH2	-	0.30	-	low

Substrate:	VEGFR-2 (Receptor tyrosine kinase)
Seq-ID:	P35968 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-49634   CADH5_HUMAN MINT-49637   SHC1_HUMAN MINT-2834292   NRP1_HUMAN MINT-3381238   GRB2_HUMAN MINT-3381278   NCK1_HUMAN MINT-3381335   FYN_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process Hsp90 protein binding, vascular endothelial growth factor receptor activity, receptor signaling protein tyrosine kinase activity, ATP binding, growth factor binding, integrin binding integral to plasma membrane positive regulation of positive chemotaxis, protein amino acid phosphorylation, positive regulation of endothelial cell proliferation, angiogenesis, regulation of cell shape, interspecies interaction between organisms, positive regulation of endothelial cell migration, positive regulation of focal adhesion assembly
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	801	RANGGELKTGYLSIVMDPDEL	-	11741094	LTP	1.00		PLCG1 SH2; PLCG2 SH2; PLCG_group SH2	-	0.23	-	-
Y	1175	QANAQQDGKDYIVLPISETLS	KDR	10579917	LTP	1.00		PLCG1 SH2; PLCG2 SH2; PLCG_group SH2; SHB SH2; SHC2 SH2	-	0.41	-	-
Y	1175	QANAQQDGKDYIVLPISETLS	KDR	11387210	LTP	1.00		PLCG1 SH2; PLCG2 SH2; PLCG_group SH2; SHB SH2; SHC2 SH2	-	0.41	-	-
Y	1175	QANAQQDGKDYIVLPISETLS	-	10749680	LTP	1.00		PLCG1 SH2; PLCG2 SH2; PLCG_group SH2; SHB SH2; SHC2 SH2	-	0.41	-	-
Y	1175	QANAQQDGKDYIVLPISETLS	-	14532277	LTP	1.00		PLCG1 SH2; PLCG2 SH2; PLCG_group SH2; SHB SH2; SHC2 SH2	-	0.41	-	-

Substrate:	AT1AR (G protein coupled receptor)
Seq-ID:	P30556 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-4791905   ARRB1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process acetyltransferase activator activity, angiotensin type II receptor activity, protein heterodimerization activity, bradykinin receptor binding, angiotensin type I receptor activity integral to plasma membrane elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger, regulation of cell growth, calcium-mediated signaling, regulation of vasoconstriction, Rho protein signal transduction, kidney development, low-density lipoprotein particle remodeling, regulation of vasodilation, positive regulation of macrophage derived foam cell differentiation, regulation of natriuresis, positive regulation of NAD(P)H oxidase activity, positive regulation of phospholipase A2 activity, positive regulation of inflammatory response, regulation of blood vessel size by renin-angiotensin, oxygen and reactive oxygen species metabolic process, regulation of cell proliferation, renin-angiotensin regulation of aldosterone production, cell chemotaxis, positive regulation of cellular protein metabolic process, positive regulation of cholesterol esterification
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	319	FKRYFLQLLKYIPPKAKSHSN	-	12522132	LTP	0.05		JAK2 SH2; PLCG1 SH2; PTPN11 SH2	-	0.03	-	medium

Substrate:	TRKA (Required for high affinity binding to nerve growth factor , neurotrophin-3 and neurotrophin-4/5r.)
Seq-ID:	P04629 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-6793941   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane receptor protein tyrosine kinase activity, neurotrophin receptor activity, ATP binding endosome, integral to plasma membrane activation of adenylate cyclase activity, Ras protein signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	496	LQGHIIENPQYFSDACVHHIK	TRKA	11159935	LTP	1.00		FRS2 PTB; GRB2 SH2; PLCG1 SH2; SHC1 PTB; SHC1 SH2	-	0.16	-	medium
Y	496	LQGHIIENPQYFSDACVHHIK	TRKA	8155326	LTP	1.00		FRS2 PTB; GRB2 SH2; PLCG1 SH2; SHC1 PTB; SHC1 SH2	-	0.16	-	medium
Y	791	LQALAQAPPVYLDVLG	TRKA	11159935	LTP	1.00		MATK SH2; PLCG1 SH2; SHC1 SH2	-	0.11	-	medium
Y	791	LQALAQAPPVYLDVLG	TRKA	8155326	LTP	1.00		MATK SH2; PLCG1 SH2; SHC1 SH2	-	0.11	-	medium