List of substrates found:

FGFR-1  ALK  LCK  SYK  PDGF-R alpha  CD31  SH3 domain-binding protein 2  FGFR-3  Gab1  c-kit  LAT  ZAP70  CBL E3 ubiquitin protein ligase  EGFR  RET  CD136  PDGF-R beta  c-met  CD3 zeta  VEGFR-1  VEGFR-2  AT1AR  TRKA 


Substrate: FGFR-1 (Receptor tyrosine kinase)
Seq-ID: P11362 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 766 RIVALTSNQEYLDLSMPLDQY - 9880324
LTP
0.89
PLCG1 SH2 -
0.29
--
Y 766 RIVALTSNQEYLDLSMPLDQY FGFR1 8622701
LTP
0.89
PLCG1 SH2 -
0.29
--

Substrate: ALK (Receptor tyrosine kinase)
Seq-ID: Q9UM73 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1278 IGDFGMARDIYRASYYRKGGC - 15592455
HTP
1.00
PLCG1 SH2 TyrKc
0.07
- medium
Y 1278 IGDFGMARDIYRASYYRKGGC - 15938644
HTP
1.00
PLCG1 SH2 TyrKc
0.07
- medium
Y 1278 IGDFGMARDIYRASYYRKGGC - 18083107
HTP
1.00
PLCG1 SH2 TyrKc
0.07
- medium

Substrate: LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))
Seq-ID: P06239 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 192 KIRNLDNGGFYISPRITFPGL - 15659558
HTP
1.00
PLCG1 SH2 SH2
0.20
1LKK 20.09%
Y 192 KIRNLDNGGFYISPRITFPGL - 17192257
HTP
1.00
PLCG1 SH2 SH2
0.20
1LKK 20.09%
Y 192 KIRNLDNGGFYISPRITFPGL - 18083107
HTP
1.00
PLCG1 SH2 SH2
0.20
1LKK 20.09%

Substrate: SYK (Spleen tyrosine kinase )
Seq-ID: P43405 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 348 REALPMDTEVYESPYADPEEI SYK 8657103
LTP
0.93
FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2
-
0.59
--
Y 348 REALPMDTEVYESPYADPEEI - 12522270
HTP
0.93
FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2
-
0.59
--
Y 348 REALPMDTEVYESPYADPEEI - 18083107
HTP
0.93
FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2
-
0.59
--
Y 352 PMDTEVYESPYADPEEIRPKE SYK 8657103
LTP
1.00
FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2
-
0.53
--
Y 352 PMDTEVYESPYADPEEIRPKE - 12522270
HTP
1.00
FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2
-
0.53
--
Y 352 PMDTEVYESPYADPEEIRPKE - 18083107
HTP
1.00
FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2
-
0.53
--

Substrate: PDGF-R alpha (Receptor tyrosine kinase)
Seq-ID: P16234 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 988 ARMRVDSDNAYIGVTYKNEED PDGFR_alpha 7535778
LTP
0.12
PLCG1 SH2 -
0.41
- medium
Y 1018 DEQRLSADSGYIIPLPDIDPV PDGFR_alpha 7535778
LTP
1.00
PLCG1 SH2 -
0.49
- medium
Y 1018 DEQRLSADSGYIIPLPDIDPV - 18083107
HTP
1.00
PLCG1 SH2 -
0.49
- medium

Substrate: CD31 (Adhesion molecule)
Seq-ID: P16284 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 690 NKEPLNSDVQYTEVQVSSAES - 15201144
LTP
1.00
INPP5D SH2;
PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2
-
0.58
- medium
Y 713 DLGKKDTETVYSEVRKAVPDA - 15592455
HTP
1.00
PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2
-
0.63
- medium
Y 713 DLGKKDTETVYSEVRKAVPDA - 18088087
HTP
1.00
PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2
-
0.63
- medium
Y 713 DLGKKDTETVYSEVRKAVPDA - 18083107
HTP
1.00
PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2
-
0.63
- medium

Substrate: SH3 domain-binding protein 2 (Adaptor molecule)
Seq-ID: P78314 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
SH3/SH2 adaptor activity
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 183 DYEHDDEDDSYLEPDSPEPGR - 11390470
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV2 SH2;
VAV_group SH2
-
0.89
- medium

Substrate: FGFR-3 (Receptor tyrosine kinase)
Seq-ID: P22607 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 760 RVLTVTSTDEYLDLSAPFEQY FGFR3 11294897
LTP
0.95
PLCG1 SH2 -
0.33
- medium

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 307 ETQMRHVSISYDIPPTPGNTY Met 10734310
LTP
0.12
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2
-
0.70
- low
Y 307 ETQMRHVSISYDIPPTPGNTY EGFR 10734310
LTP
0.12
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2
-
0.70
- low
Y 317 YDIPPTPGNTYQIPRTFPEGT - 16497976
HTP
0.24
CRKL SH2;
CRK SH2;
PLCG1 SH2;
RASA_group SH2
-
0.74
- low
Y 373 PRTASDTDSSYCIPTAGMSPS INSR 10978177
LTP
0.08
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.66
- low
Y 373 PRTASDTDSSYCIPTAGMSPS EGFR 9890893
LTP
0.08
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.66
- low
Y 373 PRTASDTDSSYCIPTAGMSPS - 10753869
LTP
0.08
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.66
- low
Y 373 PRTASDTDSSYCIPTAGMSPS Met 10734310
LTP
0.08
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.66
- low
Y 406 LRKDASSQDCYDIPRAFPSDR EGFR 9890893
LTP
1.00
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2
-
0.61
- low
Y 406 LRKDASSQDCYDIPRAFPSDR - 10753869
LTP
1.00
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2
-
0.61
- low
Y 406 LRKDASSQDCYDIPRAFPSDR Met 10734310
LTP
1.00
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2
-
0.61
- low
Y 406 LRKDASSQDCYDIPRAFPSDR - 18083107
HTP
1.00
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2
-
0.61
- low

Substrate: c-kit (Receptor tyrosine kinase)
Seq-ID: P10721 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 936 KQISESTNHIYSNLANCSPNR Kit 10377264
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PLCG1 SH2
-
0.38
--
Y 936 KQISESTNHIYSNLANCSPNR - 18083107
HTP
1.00
GRB2 SH2;
GRB7 SH2;
PLCG1 SH2
-
0.38
--

Substrate: LAT (Adaptor molecule involved in the TCR signal pathway)
Seq-ID: O43561 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 220 AEASLDGSREYVNVSQELHPG - 15659558
HTP
1.00
GRAP2 SH2;
GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
VAV1 SH2
-
0.71
- medium

Substrate: ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID: P43403 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 11828374
LTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 7798261
LTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 12522270
HTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 15592455
HTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 16094384
HTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 10037717
LTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 319 PMDTSVYESPYSDPEELKDKK - 10202147
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 10318843
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 12522270
HTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15592455
HTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 16094384
HTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 10037717
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15268851
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15292262
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%

Substrate: CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID: P22681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 674 IKPSSSANAIYSLAARPLPVP - 12522270
HTP
0.25
CRKL SH2;
PLCG1 SH2
-
0.55
--
Y 674 IKPSSSANAIYSLAARPLPVP - 15144186
HTP
0.25
CRKL SH2;
PLCG1 SH2
-
0.55
--
Y 674 IKPSSSANAIYSLAARPLPVP - 15592455
HTP
0.25
CRKL SH2;
PLCG1 SH2
-
0.55
--
Y 674 IKPSSSANAIYSLAARPLPVP - 15922744
LTP
0.25
CRKL SH2;
PLCG1 SH2
-
0.55
--
Y 700 EQCEGEEDTEYMTPSSRPLRP Fyn 9525940
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP SYK 9525940
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP Yes 9525940
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP - 9102067
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP - 12522270
HTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP INSR 11997497
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP - 10829062
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP - 15922744
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA SYK 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA Yes 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 10934191
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9890970
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 12604776
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 15922744
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 774 PEESENEDDGYDVPKPPVPAV Fyn 9525940
LTP
0.28
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.89
--
Y 774 PEESENEDDGYDVPKPPVPAV SYK 9525940
LTP
0.28
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.89
--
Y 774 PEESENEDDGYDVPKPPVPAV Yes 9525940
LTP
0.28
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.89
--
Y 774 PEESENEDDGYDVPKPPVPAV - 12522270
HTP
0.28
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.89
--
Y 774 PEESENEDDGYDVPKPPVPAV - 12604776
LTP
0.28
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.89
--
Y 774 PEESENEDDGYDVPKPPVPAV - 10829062
LTP
0.28
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.89
--
Y 774 PEESENEDDGYDVPKPPVPAV - 15922744
LTP
0.28
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.89
--

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 915 WELMTFGSKPYDGIPASEISS SRC 11983694
LTP
1.00
PLCG1 SH2;
Src SH2
TyrKc
0.18
3BEL 8.30%
Y 998 HLPSPTDSNFYRALMDEEDMD - 15951569
HTP
0.31
PLCG1 SH2 -
0.49
3BEL 13.10%
Y 998 HLPSPTDSNFYRALMDEEDMD - 17081983
HTP
0.31
PLCG1 SH2 -
0.49
3BEL 13.10%
Y 998 HLPSPTDSNFYRALMDEEDMD - 18669648
HTP
0.31
PLCG1 SH2 -
0.49
3BEL 13.10%
Y 1016 DMDDVVDADEYLIPQQGFFSS SRC 8845374
LTP
1.00
CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.41
1XKK 41.92%
Y 1016 DMDDVVDADEYLIPQQGFFSS - 7680558
LTP
1.00
CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.41
1XKK 41.92%
Y 1016 DMDDVVDADEYLIPQQGFFSS - 15302935
HTP
1.00
CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.41
1XKK 41.92%
Y 1069 PIKEDSFLQRYSSDPTGALTE - 15302935
HTP
1.00
PLCG1 SH2;
RASA_group SH2
-
0.57
--
Y 1069 PIKEDSFLQRYSSDPTGALTE - 17081983
HTP
1.00
PLCG1 SH2;
RASA_group SH2
-
0.57
--
Y 1069 PIKEDSFLQRYSSDPTGALTE - 18669648
HTP
1.00
PLCG1 SH2;
RASA_group SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA EGFR 8845374
LTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 15302935
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 17081983
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 18083107
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1110 RPAGSVQNPVYHNQPLNPAPS EGFR 8845374
LTP
1.00
GRB2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 PTB;
Src SH2;
STAT3 SH2
-
0.80
--
Y 1110 RPAGSVQNPVYHNQPLNPAPS - 15302935
HTP
1.00
GRB2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 PTB;
Src SH2;
STAT3 SH2
-
0.80
--
Y 1125 LNPAPSRDPHYQDPHSTAVGN SRC 8845374
LTP
1.00
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.86
--
Y 1125 LNPAPSRDPHYQDPHSTAVGN SRC 11983694
LTP
1.00
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.86
--
Y 1125 LNPAPSRDPHYQDPHSTAVGN SRC 10075741
LTP
1.00
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.86
--
Y 1172 SHQISLDNPDYQQDFFPKEAK EGFR 8845374
LTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2
-
0.67
--
Y 1172 SHQISLDNPDYQQDFFPKEAK - 15302935
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2
-
0.67
--
Y 1172 SHQISLDNPDYQQDFFPKEAK - 17081983
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2
-
0.67
--
Y 1172 SHQISLDNPDYQQDFFPKEAK - 18083107
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2
-
0.67
--
Y 1197 FKGSTAENAEYLRVAPQSSEF EGFR 8845374
LTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--
Y 1197 FKGSTAENAEYLRVAPQSSEF - 15302935
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--
Y 1197 FKGSTAENAEYLRVAPQSSEF - 17081983
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--
Y 1197 FKGSTAENAEYLRVAPQSSEF - 18083107
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--

Substrate: RET (Probable receptor with tyrosine-protein kinase activity; important for development.)
Seq-ID: P07949 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1015 LEKMMVKRRDYLDLAASTPSD - 11470823
LTP
1.00
PLCG1 SH2;
SHC1 SH2;
Src SH2
-
0.33
--
Y 1015 LEKMMVKRRDYLDLAASTPSD RET 14981541
LTP
1.00
PLCG1 SH2;
SHC1 SH2;
Src SH2
-
0.33
--

Substrate: CD136 (Receptor tyrosine kinase)
Seq-ID: Q04912 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1353 QIVSALLGDHYVQLPATYMNL RON 10871856
LTP
1.00
GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
SHC1 SH2
-
0.21
- low
Y 1360 GDHYVQLPATYMNLGPSTSHE RON 10871856
LTP
1.00
GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
SHC1 SH2
-
0.40
- low

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 579 IESVSSDGHEYIYVDPMQLPY PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2
-
0.15
- medium
Y 581 SVSSDGHEYIYVDPMQLPYDS PDGFR_beta 8617789
LTP
1.00
Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2
-
0.16
- medium
Y 740 VSLTGESDGGYMDMSKDESVD PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2
TyrKc
0.45
- medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2
TyrKc
0.29
- medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_group 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2
TyrKc
0.29
- medium
Y 771 VKYADIESSNYMAPYDNYVPS PDGFR_beta 8195171
LTP
1.00
CRK SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2
TyrKc
0.25
- medium
Y 1009 RSPLDTSSVLYTAVQPNEGDN PDGFR_beta 8195171
LTP
0.02
NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2
-
0.61
- medium
Y 1021 AVQPNEGDNDYIIPLPDPKPE PDGFR_beta 12062403
LTP
1.00
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2
-
0.75
- medium

Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID: P08581 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1356 GEHYVHVNATYVNVKCVAPYP - 12475979
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9444958
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9252406
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 7513258
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7731718
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 8662889
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7961992
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7687741
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9826708
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%

Substrate: CD3 zeta (T-cell surface glycoprotein CD3 zeta chain precursor (from PhosphoBase))
Seq-ID: P20963 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 142 RRRGKGHDGLYQGLSTATKDT - 12522270
HTP
1.00
Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.65
- medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 15592455
HTP
1.00
Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.65
- medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 16094384
HTP
1.00
Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.65
- medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 15659558
HTP
1.00
Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.65
- medium

Substrate: VEGFR-1 (Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity.)
Seq-ID: P17948 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 794 KRSSSEIKTDYLSIIMDPDEV - 11741094
LTP
0.97
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low
Y 794 KRSSSEIKTDYLSIIMDPDEV - 9398617
LTP
0.97
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low
Y 1169 QANVQQDGKDYIPINAILTGN - 11513746
LTP
1.00
PIK3R1 SH2;
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low
Y 1169 QANVQQDGKDYIPINAILTGN - 9299537
LTP
1.00
PIK3R1 SH2;
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low

Substrate: VEGFR-2 (Receptor tyrosine kinase)
Seq-ID: P35968 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 801 RANGGELKTGYLSIVMDPDEL - 11741094
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.23
--
Y 1175 QANAQQDGKDYIVLPISETLS KDR 10579917
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2
-
0.41
--
Y 1175 QANAQQDGKDYIVLPISETLS KDR 11387210
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2
-
0.41
--
Y 1175 QANAQQDGKDYIVLPISETLS - 10749680
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2
-
0.41
--
Y 1175 QANAQQDGKDYIVLPISETLS - 14532277
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2
-
0.41
--

Substrate: AT1AR (G protein coupled receptor)
Seq-ID: P30556 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 319 FKRYFLQLLKYIPPKAKSHSN - 12522132
LTP
0.05
JAK2 SH2;
PLCG1 SH2;
PTPN11 SH2
-
0.03
- medium

Substrate: TRKA (Required for high affinity binding to nerve growth factor , neurotrophin-3 and neurotrophin-4/5r.)
Seq-ID: P04629 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 496 LQGHIIENPQYFSDACVHHIK TRKA 11159935
LTP
1.00
FRS2 PTB;
GRB2 SH2;
PLCG1 SH2;
SHC1 PTB;
SHC1 SH2
-
0.16
- medium
Y 496 LQGHIIENPQYFSDACVHHIK TRKA 8155326
LTP
1.00
FRS2 PTB;
GRB2 SH2;
PLCG1 SH2;
SHC1 PTB;
SHC1 SH2
-
0.16
- medium
Y 791 LQALAQAPPVYLDVLG      TRKA 11159935
LTP
1.00
MATK SH2;
PLCG1 SH2;
SHC1 SH2
-
0.11
- medium
Y 791 LQALAQAPPVYLDVLG      TRKA 8155326
LTP
1.00
MATK SH2;
PLCG1 SH2;
SHC1 SH2
-
0.11
- medium


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