Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

40S ribosomal protein S3
APBB1
Bcl-2-like protein 11
C-ets-2 protein
c-myc
C/EBP alpha
C/EBP beta
CAD
CAPN2
Caspase 9
CHOP
Connexin 43
Cryptochrome-1
Cryptochrome-2
Cyclin dependent kinase inhibitor 1B
Cytosolic phospholipase A2
DAP kinase 1
DNA topoisomerase II, alpha
DUSP16
DUSP6
EGFR
ERF
Estrogen receptor alpha
ETS domain protein Elk-1
Fos
Gab1
GATA4
Grb10
GSK-3 beta
Inositol 1,4,5-trisphosphate receptor type 1
Kinase suppressor of ras-1
LCK
LIF-R
MAP kinase-activated protein kinase 2
MAP2K1
MAPKAPK5
MBP
MCL1
MKP-1
NCoA-1
Neurabin II protein
Neural interleukin 16 protein
NeuroD1
NFATC4
Orphan nuclear receptor NR4A2
p21
p65
PITPNM1
PPARG
Progesterone receptor
Retinoic acid receptor RXR-alpha
RGS19
RPB1
RPS6KA5
Sam68
Separin
Serine/threonine-protein kinase PAK 1
SH2-B beta signaling protein
SMAD1
SMAD3
SMAD4
SOS1
Sp1
SREBF2
SREBP1
STAT 5
Steroidogenic factor 1
THRB
TNFRSF1A
TRAP220
Tuberin
UBF-1
Vinexin

Substrate:

40S ribosomal protein S3 (ribosomal protein)

Seq-ID:

P23396 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48153   NEMO_HUMAN
MINT-48709   NFKB2_HUMAN
MINT-48801   M3K14_HUMAN
MINT-49388   TNR1B_HUMAN
MINT-3297088   1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural constituent of ribosome, endonuclease activity, iron-sulfur cluster binding, protein kinase binding, mRNA binding, damaged DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity, NF-kappaB binding	ruffle membrane, nucleus, cytosolic small ribosomal subunit	negative regulation of NF-kappaB transcription factor activity, activation of caspase activity, negative regulation of DNA repair, translational initiation, response to DNA damage stimulus, translational elongation, induction of apoptosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	42	DGYSGVEVRVTPTRTEIIILA	MAPK1	15950189	LTP	-	MOD_ProDKin_1	-	KH	0.19	-	-

Substrate:

APBB1 (beta-amyloid binding, histone acetyltransferase binding)

Seq-ID:

O00213 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-74469   EGFR_HUMAN
MINT-74470   ERBB2_HUMAN
MINT-2856943   ATX1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
histone binding, beta-amyloid binding, transcription activator activity, chromatin binding, transcription factor binding, proline-rich region binding	plasma membrane, cytoplasm, lamellipodium, synapse, nucleus, growth cone	negative regulation of thymidylate synthase biosynthetic process, transcription, histone H4 acetylation, apoptosis, negative regulation of cell growth, cell cycle arrest, signal transduction, negative regulation of S phase of mitotic cell cycle, positive regulation of apoptosis, axonogenesis, response to DNA damage stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	175	DDEEEEEDLSSPPGLPEPLES	MAPK1	14697653	LTP	1.00	MOD_ProDKin_1	-	-	0.97	-	-
S	287	TTQWEPPGRASPSQGSSPQEE	MAPK1	14697653	LTP	0.01	MOD_ProDKin_1	-	-	0.95	-	-
S	347	GTLTFPAQSLSPEPLPQEEEK	MAPK1	14697653	LTP	0.04	MOD_ProDKin_1	-	-	0.82	-	-
T	709	SLKPKRLGAHTP	MAPK1	14697653	LTP	0.00		-	-	0.31	-	-

Substrate:

Bcl-2-like protein 11 (Unclassified)

Seq-ID:

O43521 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-68751   MCL1_HUMAN
MINT-6629252   BCL2_HUMAN
MINT-7034069   BAX_HUMAN
MINT-7034091   BAD_HUMAN
MINT-7965699   MCL1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	plasma membrane, mitochondrion, cytosol, endomembrane system	induction of apoptosis by extracellular signals, activation of pro-apoptotic gene products

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	69	SPQGPLAPPASPGPFATRSPL	MAPK1	15486195	LTP	0.93	MOD_ProDKin_1	-	-	0.76	-	low
S	69	SPQGPLAPPASPGPFATRSPL	MAPK1	15486195	LTP	0.93	MOD_ProDKin_1	-	-	0.76	-	low

Substrate:

C-ets-2 protein (Transcription factor)

Seq-ID:

P15037 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding	nucleus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	72	DSASCELPLLTPCSKAVMSQA	MAPK1	9710599	LTP	1.00	MOD_ProDKin_1	-	-	0.22	-	medium

Substrate:

c-myc (Myc proto-oncogene protein (c-myc))

Seq-ID:

P01106 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-25075   MAX_HUMAN
MINT-6628157   VE7_HPV16
MINT-7040788   AXN1_HUMAN
MINT-7306800   BIN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity, E-box binding, sequence-specific DNA binding transcription factor activity	nucleolus	branching involved in ureteric bud morphogenesis, cellular iron ion homeostasis, cell cycle arrest, response to drug, cell proliferation, positive regulation of metanephric cap mesenchymal cell proliferation, regulation of telomere maintenance

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	62	KFELLPTPPLSPSRRSGLCSP	MAPK1	1651323	LTP	1.00	MOD_ProDKin_1	-	Myc_N	0.37	-	low

Substrate:

C/EBP alpha (Transcription factor)

Seq-ID:

P49715 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-4791133 RUNX1_HUMAN
MINT-7720853 UBF1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
RNA polymerase II transcription factor activity, enhancer binding, transcription factor binding, promoter binding		transcription from RNA polymerase II promoter, generation of precursor metabolites and energy, cytokine-mediated signaling pathway, interspecies interaction between organisms, positive regulation of transcription from RNA polymerase III promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	21	PRPPMSSHLQSPPHAPSSAAF	MAPK1	14701740	LTP	0.41	MOD_ProDKin_1	-	-	0.85	-	low

Substrate:

C/EBP beta (Transcription factor)

Seq-ID:

P28033 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, protein homodimerization activity, transcription activator activity, RNA polymerase II transcription factor activity, enhancer binding	cytoplasm	mammary gland epithelial cell differentiation, regulation of interleukin-6 biosynthetic process, transcription, mammary gland epithelial cell proliferation, anti-apoptosis, embryonic placenta development, brown fat cell differentiation, response to lipopolysaccharide, induction of apoptosis, positive regulation of transcription from RNA polymerase II promoter, neuron differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	188	STSSSSSPPGTPSPADAKAAP	MAPK1	15367685	LTP	0.86	MOD_ProDKin_1	-	-	0.82	-	medium

Substrate:

CAD (carbamoyl-phosphate synthase (glutamine-hyd...)

Seq-ID:

P08955 [Mesocricetus auratus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
aspartate carbamoyltransferase activity, dihydroorotase activity, carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, metal ion binding, ATP binding, protein kinase activity, aspartate binding, UTP binding	mitochondrion, cytosol, nuclear matrix	`de novo` pyrimidine base biosynthetic process, protein amino acid autophosphorylation, pyrimidine nucleotide biosynthetic process, peptidyl-threonine phosphorylation, glutamine metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	456	LADKVYFLPITPHYVTQVIRN	MAPK1	11872754	LTP	1.00	MOD_ProDKin_1	-	CPSase_L_chain	0.17	-	medium
T	456	LADKVYFLPITPHYVTQVIRN	MAPK1	10659854	LTP	1.00	MOD_ProDKin_1	-	CPSase_L_chain	0.17	-	medium

Substrate:

CAD (carbamoyl-phosphate synthase (glutamine-hyd...)

Seq-ID:

P27708 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48168   NEMO_HUMAN
MINT-48300   M3K1_HUMAN
MINT-48426   M3K3_HUMAN
MINT-48660   NFKB1_HUMAN
MINT-48723   NFKB2_HUMAN
MINT-48821   M3K14_HUMAN
MINT-48995   RELB_HUMAN
MINT-49046   RIPK1_HUMAN
MINT-49196   TAB2_HUMAN
MINT-49403   TNR1B_HUMAN
MINT-3318321   1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
aspartate carbamoyltransferase activity, dihydroorotase activity, carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, metal ion binding, ATP binding, enzyme binding, protein kinase activity, aspartate binding	cytosol, nuclear matrix	`de novo` pyrimidine base biosynthetic process, protein amino acid autophosphorylation, pyrimidine nucleotide biosynthetic process, peptidyl-threonine phosphorylation, glutamine metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	456	LADKVYFLPITPHYVTQVIRN	MAPK1	15890648	LTP	1.00	MOD_ProDKin_1	-	CPSase_L_chain	0.20	-	medium

Substrate:

CAPN2 (cysteine-type peptidase activity)

Seq-ID:

P17655 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-1795337 NMT1_HUMAN
MINT-6793394 PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	plasma membrane, cytoplasm

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	50	LEAGTLFQDPSFPAIPSALGF	MAPK1	14993287	LTP	0.46		-	CysPc	0.16	1KFX	38.52%

Substrate:

Caspase 9 (Cysteine protease)

Seq-ID:

P55211 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15372   APAF_HUMAN
MINT-18815   CASP3_HUMAN
MINT-25026   XIAP_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
enzyme activator activity, cysteine-type endopeptidase activity, protein binding	cytosol	proteolysis, activation of caspase activity by cytochrome c

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	125	IRKPEVLRPETPRPVDIGSGG	MAPK1	12792650	LTP	0.08	MOD_ProDKin_1	-	-	0.56	-	-

Substrate:

CHOP (Transcription factor)

Seq-ID:

P35639 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity, protein binding	nucleus	cell cycle arrest, negative regulation of canonical Wnt receptor signaling pathway, ER overload response, regulation of transcription, DNA-dependent, endoplasmic reticulum unfolded protein response

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	78	GPTEVTRTSQSPRSPDSSQSS	MAPK1	8650547	LTP	1.00	MOD_ProDKin_1	-	-	0.93	-	medium

Substrate:

Connexin 43 (Intercellular channel)

Seq-ID:

P08050 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-1791070 ZO1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, gap junction channel activity, PDZ domain binding	connexon complex, Golgi-associated vesicle membrane, early endosome, integral to plasma membrane, lysosome, fascia adherens, mitochondrial outer membrane, endoplasmic reticulum membrane, multivesicular body, membrane raft	positive regulation of protein catabolic process, ATP transport, response to pH, negative regulation of cell proliferation, apoptosis, vascular transport, gap junction assembly, protein oligomerization, cell-cell signaling, neuron projection morphogenesis, regulation of calcium ion transport, response to peptide hormone stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	255	DPYHATTGPLSPSKDCGSPKY	MAPK1	9535909	LTP	0.22	MOD_ProDKin_1	-	-	0.40	-	-
S	279	NGCSSPTAPLSPMSPPGYKLV	MAPK1	9535909	LTP	0.15	MOD_ProDKin_1	-	-	0.45	-	-
S	279	NGCSSPTAPLSPMSPPGYKLV	MAPK1	15843167	LTP	0.15	MOD_ProDKin_1	-	-	0.45	-	-
S	282	SSPTAPLSPMSPPGYKLVTGD	MAPK1	9535909	LTP	0.98	MOD_ProDKin_1	-	-	0.57	-	-
S	282	SSPTAPLSPMSPPGYKLVTGD	MAPK1	15843167	LTP	0.98	MOD_ProDKin_1	-	-	0.57	-	-

Substrate:

Cryptochrome-1 (Transcription regulatory protein)

Seq-ID:

P97784 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleotide binding, photoreceptor activity, DNA photolyase activity, protein binding	mitochondrion, nucleus	transcription, DNA repair, regulation of transcription, protein-chromophore linkage, circadian rhythm

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	247	PRMNANSLLASPTGLSPYLRF	MAPK1	15298678	LTP	1.00	MOD_ProDKin_1	-	FAD_binding_7	0.24	-	low

Substrate:

Cryptochrome-2 (Transcription regulatory protein)

Seq-ID:

Q9R194 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleotide binding, photoreceptor activity, DNA photolyase activity, protein binding	cytoplasm, nucleus	transcription, DNA repair, protein import into nucleus, regulation of transcription, protein-chromophore linkage, circadian rhythm

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	265	PRMNANSLLASPTGLSPYLRF	MAPK1	15298678	LTP	1.00	MOD_ProDKin_1	-	FAD_binding_7	0.23	-	low

Substrate:

Cyclin dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1))

Seq-ID:

P46527 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17680   AKT1_HUMAN
MINT-17889   1433T_HUMAN
MINT-63858   GDIR1_HUMAN
MINT-1779946   MCM7_HUMAN
MINT-3379700   CDK2_HUMAN
MINT-3379718   CDK4_HUMAN
MINT-7219650   GRB2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cyclin-dependent protein kinase inhibitor activity, transforming growth factor beta receptor, cytoplasmic mediator activity, protein binding	cytosol, nucleus	negative regulation of kinase activity, regulation of cyclin-dependent protein kinase activity, negative regulation of cell proliferation, negative regulation of cell growth, cell cycle arrest, G1/S transition of mitotic cell cycle, autophagic cell death, cellular response to lithium ion, induction of apoptosis, negative regulation of gene-specific transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	178	NRTEENVSDGSPNAGSVEQTP	MAPK1	10831586	LTP	0.15	MOD_ProDKin_1	-	-	0.94	-	-

Substrate:

Cytosolic phospholipase A2 (Enzyme: Phospholipase)

Seq-ID:

P47712 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
lysophospholipase activity	cytosol, integral to membrane, endoplasmic reticulum membrane	platelet activating factor biosynthetic process, phospholipid catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	505	GLNLNTSYPLSPLSDFATQDS	MAPK1	9468497	LTP	0.14	MOD_ProDKin_1	-	PLAc	0.36	-	-

Substrate:

Cytosolic phospholipase A2 (Enzyme: Phospholipase)

Seq-ID:

P47713 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
lysophospholipase activity		phospholipid catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	505	GLNLNTSYPLSPLRDFSSQDS	MAPK1	8381049	LTP	0.17	MOD_ProDKin_1	-	PLAc	0.38	-	medium

Substrate:

DAP kinase 1 (Serine/threonine kinase)

Seq-ID:

P53355 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7014569 BECN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, calmodulin binding	cytoplasm, actin cytoskeleton	induction of apoptosis by extracellular signals, protein amino acid phosphorylation, apoptosis, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	736	SSTNSSRFPPSPLASKPTVSV	MAPK1	15616583	LTP	0.43	MOD_ProDKin_1	-	-	0.53	-	medium

Substrate:

DNA topoisomerase II, alpha (DNA topoisomerase II alpha)

Seq-ID:

P11388 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-15316 PIN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C binding, DNA topoisomerase (ATP-hydrolyzing) activity, protein heterodimerization activity, protein C-terminus binding, protein homodimerization activity, DNA-dependent ATPase activity, chromatin binding, histone deacetylase binding, ATP binding, ubiquitin binding, drug binding	DNA topoisomerase complex (ATP-hydrolyzing), cytoplasm, chromosome, nucleoplasm	DNA repair, chromosome segregation, phosphoinositide-mediated signaling, positive regulation of apoptosis, DNA ligation, apoptotic chromosome condensation, DNA topological change, DNA replication, positive regulation of retroviral genome replication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1213	KKTQMAEVLPSPRGQRVIPRI	MAPK1	7635160	LTP	0.91	MOD_ProDKin_1	-	-	0.70	-	-
S	1247	KKIKNENTEGSPQEDGVELEG	MAPK1	7635160	LTP	0.20	MOD_ProDKin_1	-	-	0.82	-	-
S	1354	DDEDFVPSDASPPKTKTSPKL	MAPK1	7635160	LTP	0.04	MOD_CDK_SPxK_1	-	-	0.87	-	-
S	1361	SDASPPKTKTSPKLSNKELKP	MAPK1	7635160	LTP	0.24	MOD_ProDKin_1	-	-	0.89	-	-
S	1393	DVKGSVPLSSSPPATHFPDET	MAPK1	7635160	LTP	0.19	MOD_ProDKin_1	-	-	0.86	-	-

Substrate:

DUSP16 (phosphoprotein phosphatase activity)

Seq-ID:

Q9BY84 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, MAP kinase tyrosine/serine/threonine phosphatase activity	cytoplasmic membrane-bounded vesicle, nucleus	MAPK phosphatase export from nucleus, leptomycin B sensitive, inactivation of MAPK activity, protein amino acid dephosphorylation, MAPK export from nucleus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	446	LDGTNKLCQFSPVQELSEQTP	MAPK1	12794087	LTP	1.00	MOD_ProDKin_1	-	-	0.60	-	medium

Substrate:

DUSP6 (protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity)

Seq-ID:

Q16828 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, MAP kinase tyrosine/serine/threonine phosphatase activity	cytoplasm, nucleoplasm	inactivation of MAPK activity, peptidyl-tyrosine dephosphorylation, positive regulation of apoptosis, response to nitrosative stress, negative regulation of ERK1 and ERK2 cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	159	TNLDGSCSSSSPPLPVLGLGG	MAPK1	15632084	LTP	1.00	MOD_ProDKin_1	-	-	0.37	-	-

Substrate:

EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)

Seq-ID:

P00533 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
epidermal growth factor receptor activity, protein heterodimerization activity, identical protein binding, receptor signaling protein tyrosine kinase activity, double-stranded DNA binding, ATP binding, protein phosphatase binding, actin filament binding, MAP/ERK kinase kinase activity	Shc-EGFR complex, endosome, basolateral plasma membrane, integral to membrane, extracellular space, nucleus	activation of phospholipase C activity, protein insertion into membrane, response to UV-A, positive regulation of nitric oxide biosynthetic process, positive regulation of cell migration, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, positive regulation of catenin protein nuclear translocation, regulation of nitric-oxide synthase activity, positive regulation of protein kinase B signaling cascade, ossification, positive regulation of epithelial cell proliferation, activation of phospholipase A2 activity by calcium-mediated signaling, cell-cell adhesion, regulation of peptidyl-tyrosine phosphorylation, positive regulation of phosphorylation, positive regulation of MAP kinase activity, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	693	LQERELVEPLTPSGEAPNQAL	MAPK1	1939237	LTP	1.00	MOD_ProDKin_1	-	-	0.41	-	-

Substrate:

ERF (ligand-regulated transcription factor activity, transcription corepressor activity)

Seq-ID:

P50548 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-17504 KC1A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, transcription corepressor activity, sequence-specific DNA binding transcription factor activity, ligand-regulated transcription factor activity	nucleus	transcription, regulation of transcription from RNA polymerase II promoter, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	161	EVLSPTEDPRSPPACSSSSSS	MAPK1	10330152	LTP	1.00	MOD_ProDKin_1	-	-	0.69	-	low
T	526	EGPGEAGGPLTPRRVSSDLQH	MAPK1	7588608	LTP	0.99	MOD_ProDKin_1	-	-	0.91	-	low

Substrate:

Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )

Seq-ID:

P03372 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13786   BRCA1_HUMAN
MINT-50646   STA5A_HUMAN
MINT-50709   M3K1_HUMAN
MINT-5222241   NCOA1_HUMAN
MINT-6169667   EGFR_HUMAN
MINT-6614126   SMCA4_HUMAN
MINT-6614301   CHD3_HUMAN
MINT-6614361   MTA1_HUMAN
MINT-6614421   MTA2_HUMAN
MINT-6761899   PTN1_HUMAN
MINT-6761906   PTN6_HUMAN
MINT-7013584   PA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
beta-catenin binding, nitric-oxide synthase regulator activity, estrogen response element binding, steroid binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, estrogen receptor activity	chromatin remodeling complex	response to estradiol stimulus, transcription, DNA-dependent, regulation of transcription, DNA-dependent, positive regulation of retinoic acid receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	118	LMLLHPPPQLSPFLQPHGQQV	MAPK1	15059947	LTP	1.00	MOD_ProDKin_1	-	Oest_recep	0.50	-	-

Substrate:

ETS domain protein Elk-1 (Transcription factor)

Seq-ID:

P41969 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity	nucleoplasm	transcription, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	384	PPSIHFWSTLSPIAPRSPAKL	MAPK1	7889942	LTP	1.00	MOD_ProDKin_1	-	-	0.40	-	medium
S	390	WSTLSPIAPRSPAKLSFQFPS	MAPK1	7889942	LTP	0.74	MOD_ProDKin_1	-	-	0.44	-	medium

Substrate:

Fos (Transcription factor)

Seq-ID:

P01100 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-68804   JUN_HUMAN
MINT-68820   VE7_HPV16
MINT-1788374   JUNB_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
R-SMAD binding, specific RNA polymerase II transcription factor activity, promoter binding, sequence-specific DNA binding transcription factor activity		DNA methylation, inflammatory response, SMAD protein signal transduction, transforming growth factor beta receptor signaling pathway, cellular response to reactive oxygen species

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	232	DLTGGLPEVATPESEEAFTLP	MAPK1	7816602	LTP	1.00	MOD_ProDKin_1	PIN1 WW	-	0.60	-	low

Substrate:

Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)

Seq-ID:

Q13480 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-58395   GRB2_HUMAN
MINT-58403   GRAP2_HUMAN
MINT-58404   MET_HUMAN
MINT-68564   BMX_HUMAN
MINT-1893011   P85A_HUMAN
MINT-6169406   PTN11_HUMAN
MINT-6169502   PAXI_HUMAN
MINT-7971128   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3/SH2 adaptor activity	cytosol	epidermal growth factor receptor signaling pathway, insulin receptor signaling pathway, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	476	PIQEANYVPMTPGTFDFSSFG	MAPK1	15379552	LTP	0.18	MOD_ProDKin_1	-	-	0.50	-	low

Substrate:

GATA4 (protein binding, RNA polymerase II transcription factor acti...)

Seq-ID:

Q08369 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-17787 EP300_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity, specific RNA polymerase II transcription factor activity, RNA polymerase II transcription factor activity, enhancer binding, zinc ion binding, protein binding	nucleus	embryonic heart tube anterior/posterior pattern formation, lung morphogenesis, ventricular septum development, transcription from RNA polymerase II promoter, cardiac muscle cell differentiation, cellular response to follicle-stimulating hormone stimulus, embryonic foregut morphogenesis, positive regulation of gene-specific transcription from RNA polymerase II promoter, positive regulation vascular endothelial growth factor production, gastrulation with mouth forming second, response to estrogen stimulus, cardiac right ventricle morphogenesis, in utero embryonic development, SMAD protein signal transduction, cell-cell signaling, diaphragm morphogenesis, heart looping, embryonic digestive tract morphogenesis, atrial septum primum morphogenesis, positive regulation of angiogenesis, response to retinoic acid, regulation of cardiac muscle cell proliferation, endocardial cushion development, positive regulation of cardioblast differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	105	EGAAYTPPPVSPRFSFPGTTG	MAPK1	11585926	LTP	0.21	MOD_ProDKin_1	-	GATA-N	0.59	-	medium

Substrate:

Grb10 (Adapter molecule)

Seq-ID:

Q13322 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15644   IGF1R_HUMAN
MINT-16516   INSR_HUMAN
MINT-16802   EGFR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
insulin receptor binding, SH3/SH2 adaptor activity	plasma membrane, cytoplasm	negative regulation of glycogen biosynthetic process, negative regulation of insulin receptor signaling pathway, negative regulation of glucose import, positive regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of Wnt receptor signaling pathway, insulin receptor signaling pathway, positive regulation of phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	150	NPFPELCGPGSPPVLTPGSLP	MAPK1	15952796	LTP	0.71	MOD_ProDKin_1	-	-	0.65	-	low
S	476	STRMNILGSQSPLHPSTLSTV	MAPK1	15952796	LTP	0.89	MOD_ProDKin_1	-	-	0.42	-	low

Substrate:

GSK-3 beta (Glycogen synthase kinase-3 beta)

Seq-ID:

P49841 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-65985   DBPA_HUMAN
MINT-65986   YBOX1_HUMAN
MINT-2837737   PSN1_HUMAN
MINT-3974216   TAU_HUMAN
MINT-4049759   PCM1_HUMAN
MINT-4049773   NIN_HUMAN
MINT-4508051   CTNB1_HUMAN
MINT-4508259   AXN1_HUMAN
MINT-4793253   P53_HUMAN
MINT-6761890   PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, tau-protein kinase activity, p53 binding, beta-catenin binding, ATP binding, protein kinase A catalytic subunit binding, NF-kappaB binding	Axin-APC-beta-catenin-GSK3B complex, beta-catenin destruction complex, cytosol, nucleus	positive regulation of protein catabolic process, hippocampus development, negative regulation of apoptosis, positive regulation of protein export from nucleus, positive regulation of Rac GTPase activity, positive regulation of protein complex assembly, peptidyl-serine phosphorylation, glycogen metabolic process, superior temporal gyrus development, canonical Wnt receptor signaling pathway, ER overload response, negative regulation of protein binding, positive regulation of cell-matrix adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	43	DGSKVTTVVATPGQGPDRPQE	MAPK1	16039586	LTP	0.83	MOD_ProDKin_1	-	-	0.66	1Q5K	12.33%

Substrate:

Inositol 1,4,5-trisphosphate receptor type 1 (inositol 1,4,5-trisphosphate-binding protein type 1 receptor (from PhosphoBase))

Seq-ID:

P11881 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity, phosphoinositide binding, protein binding	nuclear inner membrane, sarcoplasmic reticulum, microsome, integral to membrane, nucleolus, endoplasmic reticulum membrane, calcineurin complex, postsynaptic density	response to hypoxia, endoplasmic reticulum calcium ion homeostasis, post-embryonic development, voluntary musculoskeletal movement

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	436	DKEAFAIVPVSPAEVRDLDFA	MAPK1	16925983	LTP	0.84	MOD_ProDKin_1	-	-	0.30	1N4K	51.64%
S	1765	SLTSFGNGPLSPGGPSKPGGG	MAPK1	16925983	LTP	0.95	MOD_ProDKin_1	-	-	0.83	-	-

Substrate:

Kinase suppressor of ras-1 (ATP binding)

Seq-ID:

Q61097 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13707   1433B_HUMAN
MINT-13837   CDC37_HUMAN
MINT-14037   HS90B_HUMAN
MINT-16002   MP2K1_HUMAN
MINT-17370   HSP71_HUMAN
MINT-17529   MP2K2_HUMAN
MINT-17608   MK03_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, metal ion binding, ATP binding, protein binding	cytoplasm, membrane	protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	260	ALHSFITPPTTPQLRRHAKLK	MAPK1	9858547	LTP	1.00	MOD_ProDKin_1	-	-	0.67	-	medium
T	274	RRHAKLKPPRTPPPPSRKVFQ	MAPK1	9858547	LTP	1.00	MOD_ProDKin_1	-	-	0.77	-	medium
S	443	PSSTTSSTPSSPAPFLTSSNP	MAPK1	9858547	LTP	1.00	MOD_ProDKin_1	-	-	0.83	-	medium

Substrate:

LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))

Seq-ID:

P06239 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15516   CBL_HUMAN
MINT-56730   KSYK_HUMAN
MINT-59474   LCP2_HUMAN
MINT-59476   ZAP70_HUMAN
MINT-60779   MK01_HUMAN
MINT-60782   CD3Z_HUMAN
MINT-61276   G3BP1_HUMAN
MINT-66002   CD4_HUMAN
MINT-66003   P85A_HUMAN
MINT-68489   DLG1_HUMAN
MINT-3373863   HS90A_HUMAN
MINT-3373920   GCR_HUMAN
MINT-7135817   SH22A_HUMAN
MINT-7212471   KHDR1_HUMAN
MINT-7212499   WASP_HUMAN
MINT-7218109   ADA15_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide 3-kinase binding, protein C-terminus binding, protein kinase binding, protein serine/threonine phosphatase activity, glycoprotein binding, non-membrane spanning protein tyrosine kinase activity, ATP binding, CD8 receptor binding, ATPase binding, CD4 receptor binding, SH2 domain binding	plasma membrane, cytosol, Golgi apparatus, membrane raft, pericentriolar material	protein amino acid phosphorylation, T cell differentiation, response to drug, activation of caspase activity, positive regulation of T cell activation, positive regulation of T cell receptor signaling pathway, release of sequestered calcium ion into cytosol, interspecies interaction between organisms, cellular zinc ion homeostasis, induction of apoptosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	42	GKGTLLIRNGSEVRDPLVTYE	MAPK1	8226850	LTP	0.25		-	-	0.40	-	-
S	42	GKGTLLIRNGSEVRDPLVTYE	MAPK1	8506364	LTP	0.25		-	-	0.40	-	-

Substrate:

LIF-R (Cytokine receptor)

Seq-ID:

P42702 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
growth factor binding, leukemia inhibitory factor receptor activity, ciliary neurotrophic factor receptor binding	extracellular region, integral to plasma membrane	positive regulation of cell proliferation, leukemia inhibitory factor signaling pathway, response to cytokine stimulus, ciliary neurotrophic factor-mediated signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1044	VNTWNLVSPDSPRSIDSNSEI	MAPK1	7777512	LTP	1.00	MOD_ProDKin_1	-	-	0.61	-	medium

Substrate:

MAP kinase-activated protein kinase 2 (MAP kinase-activated protein kinase 2 (EC 2.7.1.-) (from PhosphoBase))

Seq-ID:

P49137 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-2833388 LIMK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, signal transducer activity, protein binding	cytosol, nucleus	protein amino acid phosphorylation, MAPKKK cascade, Ras protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	9	MLSNSQGQSPPVPFPAPAP	MAPK1	8846784	LTP	0.09	MOD_ProDKin_1	-	-	0.84	-	-

Substrate:

MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1))

Seq-ID:

Q02750 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16002   KSR1_MOUSE
MINT-3391583   M3K1_HUMAN
MINT-4300484   MK01_HUMAN
MINT-7014370   RAF1_HUMAN
MINT-7014390   MK03_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, MAP kinase kinase activity, ATP binding, protein tyrosine kinase activity	cytosol	senescence, negative regulation of cell proliferation, cell cycle arrest, chemotaxis, Ras protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	292	DAAETPPRPRTPGRPLSSYGM	MAPK1	10567369	LTP	0.12	MOD_ProDKin_1	-	S_TKc	0.78	-	-
T	386	CSTIGLNQPSTPTHAAGV	MAPK1	10567369	LTP	0.71	MOD_ProDKin_1	-	-	0.48	-	-

Substrate:

MAPKAPK5 (MAP kinase kinase activity, protein serine/threonine kinase activity)

Seq-ID:

Q8IW41 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, MAP kinase kinase activity, ATP binding, protein binding	cytoplasm, nucleus	protein amino acid phosphorylation, signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	182	FAKIDQGDLMTPQFTPYYVAP	MAPK1	9628874	LTP	0.02	MOD_ProDKin_1	-	S_TKc	0.18	-	medium

Substrate:

MBP (myelin basic protein (MBP) (from PhosphoBase))

Seq-ID:

P02686 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-1792581   TOPK_HUMAN
MINT-2860743   ATN1_HUMAN
MINT-2860762   ATX1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	plasma membrane	central nervous system development, immune response, synaptic transmission

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	232	HFFKNIVTPRTPPPSQGKGRG	MAPK1	1939237	LTP	1.00	MOD_ProDKin_1	-	Myelin_MBP	0.77	-	medium

Substrate:

MCL1 (protein binding, protein channel activity)

Seq-ID:

Q07820 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17381   B2L11_MOUSE
MINT-68750   HUWE1_HUMAN
MINT-68751   B2L11_HUMAN
MINT-4821036   BECN1_HUMAN
MINT-4980380   B2L11_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, protein channel activity	integral to membrane, mitochondrial outer membrane, nucleoplasm	apoptosis, anti-apoptosis, cellular homeostasis, response to cytokine stimulus, cell fate determination, multicellular organismal development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	163	NTSTDGSLPSTPPPAEEEEDE	MAPK1	15241487	LTP	1.00	MOD_ProDKin_1	-	-	0.94	-	low

Substrate:

MKP-1 (Dual specificity phosphatase)

Seq-ID:

P28562 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
MAP kinase tyrosine/serine/threonine phosphatase activity, non-membrane spanning protein tyrosine phosphatase activity, protein binding		cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	296	EFVKQRRSIISPNFSFMGQLL	MAPK1	16286470	LTP	1.00	MOD_ProDKin_1	-	DSPc	0.11	-	medium
S	323	LAPHCSAEAGSPAMAVLDRGT	MAPK1	16286470	LTP	1.00	MOD_ProDKin_1	-	-	0.35	-	medium

Substrate:

NCoA-1 (Nuclear receptor coactivator 1)

Seq-ID:

Q15788 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19932   CBP_HUMAN
MINT-4958560   NCOA3_HUMAN
MINT-4958729   KANK2_HUMAN
MINT-5209864   RARA_HUMAN
MINT-5222241   ESR1_HUMAN
MINT-5224970   RXRA_HUMAN
MINT-7013379   PA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	395	RVNPSVNPSISPAHGVARSST	MAPK1	10660621	LTP	1.00	MOD_ProDKin_1	-	-	0.71	-	-
T	1179	YPPNYGTNPGTPPASTSPFSQ	MAPK1	10660621	LTP	0.03	MOD_ProDKin_1	-	DUF1518	0.86	-	-
S	1185	TNPGTPPASTSPFSQLAANPE	MAPK1	10660621	LTP	1.00	MOD_ProDKin_1	-	DUF1518	0.88	-	-

Substrate:

Neurabin II protein (Cytoskeletal protein)

Seq-ID:

Q6R891 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-4953730 RGS2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
actin binding	filopodium, dendritic spine, cell junction, cortical actin cytoskeleton, synapse, nucleus	dendrite development, actin filament organization, regulation of protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	15	EPRGPGGPLRSASPHRSAYEA	MAPK1	15728359	LTP	1.00	MOD_ProDKin_1	-	-	0.87	-	low
S	205	ALDKLDADAVSPTVSQLSAVF	MAPK1	15728359	LTP	1.00	MOD_ProDKin_1	-	-	0.63	-	low

Substrate:

Neural interleukin 16 protein (Cytokine)

Seq-ID:

Q14005 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cytokine activity	cytoplasm, extracellular space, nucleus	transcription, regulation of transcription, immune response, interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	144	SSSSIRQRISSFETFGSSQLP	MAPK1	14768064	LTP	0.00		-	-	0.68	-	medium

Substrate:

NeuroD1 (Transcription factor)

Seq-ID:

Q60867 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, protein heterodimerization activity, transcription activator activity	cytoplasm, nucleus	camera-type eye development, negative regulation of apoptosis, transcription, glucose homeostasis, embryonic organ morphogenesis, pancreatic PP cell fate commitment, anterior/posterior pattern formation, pancreatic A cell fate commitment, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	162	ALSEILRSGKSPDLVSFVQTL	MAPK1	12810726	LTP	0.47	MOD_ProDKin_1	-	-	0.29	-	-
S	259	YSAALEPFFESPLTDCTSPSF	MAPK1	12810726	LTP	0.42	MOD_ProDKin_1	-	-	0.32	-	-
S	266	FFESPLTDCTSPSFDGPLSPP	MAPK1	12810726	LTP	0.62	MOD_ProDKin_1	-	-	0.44	-	-
S	274	CTSPSFDGPLSPPLSINGNFS	MAPK1	12810726	LTP	0.78	MOD_ProDKin_1	-	-	0.42	-	-

Substrate:

NFATC4 (transcription coactivator activity)

Seq-ID:

Q14934 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7972976 DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription coactivator activity, sequence-specific DNA binding transcription factor activity	cytoplasm, nucleus	transcription from RNA polymerase II promoter, inflammatory response, regulation of transcription, DNA-dependent, cell differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	676	FYVSNGRRKRSPTQSFRFLPV	MAPK1	15657420	LTP	1.00	MOD_ProDKin_1	-	IPT	0.32	-	-

Substrate:

Orphan nuclear receptor NR4A2 (ligand-dependent nuclear receptor activity)

Seq-ID:

P43354 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, protein binding, steroid hormone receptor activity	nucleus	cellular response to extracellular stimulus, transcription, response to protein stimulus, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	126	HSGSVYYKPSSPPTPTTPGFQ	MAPK1	17681692	LTP	0.29	MOD_ProDKin_1	-	-	0.64	-	-
T	132	YKPSSPPTPTTPGFQVQHSPM	MAPK1	17681692	LTP	0.91	MOD_ProDKin_1	-	-	0.71	-	-

Substrate:

p21 (Cyclin-dependent kinase inhibitor 1 (p21))

Seq-ID:

P38936 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50392   CC45L_HUMAN
MINT-50407   CDC6_HUMAN
MINT-50418   CDK4_HUMAN
MINT-50421   CDK6_HUMAN
MINT-50432   CCNB2_HUMAN
MINT-50437   CCND1_HUMAN
MINT-50441   CCND3_HUMAN
MINT-50445   GEMI_HUMAN
MINT-50660   CCNB1_HUMAN
MINT-73322   VE7_HPV16
MINT-73323   CDK2_HUMAN
MINT-1774121   SKP2_HUMAN
MINT-1780042   MCM7_HUMAN
MINT-1891378   P53_HUMAN
MINT-2635177   CCNE1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cyclin-dependent protein kinase inhibitor activity, metal ion binding	cytosol, cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, PCNA-p21 complex	cellular response to extracellular stimulus, positive regulation of fibroblast proliferation, senescence, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, negative regulation of cell proliferation, negative regulation of cell growth, cell cycle arrest, G1/S transition of mitotic cell cycle, induction of apoptosis by intracellular signals, Ras protein signal transduction, G2/M transition of mitotic cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	57	ERWNFDFVTETPLEGDFAWER	MAPK1	19364816	LTP	1.00	MOD_ProDKin_1	-	CDI	0.36	-	medium

Substrate:

p65 (Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit), RelA)

Seq-ID:

Q04206 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50016   IKBA_MOUSE
MINT-50017   IKBB_MOUSE
MINT-50025   KAPCA_HUMAN
MINT-50073   KS6A5_HUMAN
MINT-50084   KPCZ_HUMAN
MINT-50090   CSK21_HUMAN
MINT-50107   IKKA_HUMAN
MINT-50167   IKKB_HUMAN
MINT-50171   HDAC1_HUMAN
MINT-50175   KAT2B_HUMAN
MINT-50178   EP300_HUMAN
MINT-50179   HDAC3_HUMAN
MINT-58638   NCF1_HUMAN
MINT-62399   TF2B_HUMAN
MINT-2834593   NCOA3_HUMAN
MINT-6166971   OGT1_HUMAN
MINT-7235700   ASPP2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription repressor activity, transcription repressor binding, identical protein binding, protein kinase binding, ubiquitin protein ligase binding, transcription activator binding, transcription activator activity, RNA polymerase II transcription factor activity, enhancer binding, promoter binding, protein N-terminus binding, phosphate binding, NF-kappaB binding	cytosol, transcription factor complex	transcription, positive regulation of I-kappaB kinase/NF-kappaB cascade, cytokine-mediated signaling pathway, anti-apoptosis, defense response to virus, membrane protein intracellular domain proteolysis, cellular defense response, inflammatory response, nucleotide-binding oligomerization domain containing 2 signaling pathway, response to interleukin-1, interspecies interaction between organisms, positive regulation of NF-kappaB transcription factor activity, positive regulation of transcription from RNA polymerase II promoter, response to UV-B, negative regulation of gene-specific transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	435	APKPTQAGEGTLSEALLQLQF	MAPK1	15073167	LTP	0.33		-	-	0.75	-	-

Substrate:

PITPNM1 (Cell cycle control protein)

Seq-ID:

O00562 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphatidylinositol transporter activity, metal ion binding	lipid particle, membrane fraction, endoplasmic reticulum membrane, Golgi cisterna membrane	brain development, phototransduction, lipid metabolic process, protein transport

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	794	LEELEMLVPSTPTSTSGAFWK	MAPK1	15125835	LTP	0.16	MOD_ProDKin_1	-	DDHD	0.26	-	low
T	1223	PSQAEREGPGTPPTTLARGKA	MAPK1	15125835	LTP	0.00	MOD_ProDKin_1	-	-	0.88	-	low

Substrate:

PPARG (Transcription factor)

Seq-ID:

P37231 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
specific transcriptional repressor activity, transcription activator binding, transcription activator activity, arachidonic acid binding, zinc ion binding, promoter binding, sequence-specific DNA binding transcription factor activity, drug binding, retinoid X receptor binding, prostaglandin receptor activity, steroid hormone receptor activity	cytosol, nucleus	negative regulation of gene-specific transcription from RNA polymerase II promoter, positive regulation of gene-specific transcription from RNA polymerase II promoter, regulation of blood pressure, epithelial cell differentiation, white fat cell differentiation, lipoprotein transport, negative regulation of receptor biosynthetic process, negative regulation of sequestering of triglyceride, positive regulation of transcription factor activity, activation of caspase activity, placenta development, cell fate commitment, cell maturation, innate immune response, lipid homeostasis, negative regulation of macrophage derived foam cell differentiation, low-density lipoprotein receptor biosynthetic process, monocyte differentiation, regulation of cholesterol transporter activity, response to lipid, long-chain fatty acid transport, positive regulation of fat cell differentiation, response to low-density lipoprotein stimulus, cellular response to insulin stimulus, negative regulation of cholesterol storage, induction of apoptosis, transcription, glucose homeostasis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	112	YQSAIKVEPASPPYYSEKTQL	MAPK1	9030579	LTP	1.00	MOD_ProDKin_1	-	-	0.37	-	medium

Substrate:

Progesterone receptor (Progesterone receptor (PR))

Seq-ID:

P06401 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-4788079 JDP2_HUMAN
MINT-4788120 NCOR2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
steroid binding, zinc ion binding, receptor binding, sequence-specific DNA binding transcription factor activity, protein binding, steroid hormone receptor activity	cytoplasm, nucleus	transcription, cell-cell signaling

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	294	EQDAPMAPGRSPLATTVMDFI	MAPK1	10655479	LTP	0.90	MOD_ProDKin_1	-	Prog_receptor	0.58	-	medium
S	294	EQDAPMAPGRSPLATTVMDFI	MAPK1	12529413	LTP	0.90	MOD_ProDKin_1	-	Prog_receptor	0.58	-	medium

Substrate:

Progesterone receptor (Progesterone receptor (PR))

Seq-ID:

Q00175 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, steroid binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, protein binding, steroid hormone receptor activity	cytoplasm, nucleus	regulation of epithelial cell proliferation, transcription, epithelial cell maturation, ovulation from ovarian follicle, progesterone receptor signaling pathway, regulation of transcription, DNA-dependent, tertiary branching involved in mammary gland duct morphogenesis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	294	EQDSPIAPGRSPLATTVVDFI	MAPK1	12529413	LTP	0.77	MOD_ProDKin_1	-	Prog_receptor	0.57	-	medium

Substrate:

Retinoic acid receptor RXR-alpha (Retinoic acid receptor RXR-alpha)

Seq-ID:

P19793 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-24895   RARA_HUMAN
MINT-61590   SMAD2_HUMAN
MINT-61758   KPCD2_HUMAN
MINT-5224970   NCOA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, retinoid-X receptor activity, transcription coactivator activity, zinc ion binding, sequence-specific DNA binding transcription factor activity, ligand-regulated transcription factor activity, vitamin D receptor binding, steroid hormone receptor activity	nucleus	negative regulation of gene-specific transcription from RNA polymerase II promoter, transcription, vitamin metabolic process, interspecies interaction between organisms, response to retinoic acid, cholesterol metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	260	VEANMGLNPSSPNDPVTNICQ	MAPK1	12048211	LTP	0.67	MOD_ProDKin_1	-	-	0.53	1FM6	60.66%

Substrate:

RGS19 (Unclassified)

Seq-ID:

P49795 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
signal transducer activity, protein binding	membrane fraction, Golgi apparatus, membrane	autophagy, negative regulation of signal transduction, small GTPase mediated signal transduction, G-protein coupled receptor protein signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	151	LIYEDYVSILSPKEVSLDSRV	MAPK1	10993892	LTP	1.00	MOD_CK2_1	-	RGS	0.22	-	-

Substrate:

RPB1 (RNA polymerase)

Seq-ID:

P24928 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19371 CTDP1_HUMAN
MINT-72765 WWOX_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA-directed RNA polymerase activity, DNA binding, RNA-directed RNA polymerase activity, ubiquitin protein ligase binding, metal ion binding	DNA-directed RNA polymerase II, core complex	transcription initiation from RNA polymerase II promoter, regulation of transcription, DNA-dependent, RNA elongation from RNA polymerase II promoter, RNA splicing

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1619	TPQSPSYSPTSPSYSPTSPSY	MAPK1	12721286	LTP	0.98	MOD_ProDKin_1	PIN1 WW	RNA_pol_Rpb1_R	0.68	-	medium

Substrate:

RPS6KA5 (serine/threonine kinase)

Seq-ID:

O75582 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50073 TF65_HUMAN
MINT-6771456 GCR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding, protein binding	cytoplasm, nucleoplasm	response to chemical stimulus, response to stress, epidermal growth factor receptor signaling pathway, regulation of transcription, DNA-dependent, histone phosphorylation, response to external stimulus, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	360	EEFTEMDPTYSPAALPQSSEK	MAPK1	15568999	LTP	1.00	MOD_ProDKin_1	-	S_TK_X	0.47	-	-
T	581	LKPPDNQPLKTPCFTLHYAAP	MAPK1	15568999	LTP	1.00	MOD_ProDKin_1	-	S_TKc	0.33	-	-

Substrate:

Sam68 (Adapter molecule)

Seq-ID:

Q60749 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19628   NCK1_HUMAN
MINT-19779   FYN_MOUSE
MINT-7300569   VAV_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, transcription repressor activity, SH3/SH2 adaptor activity, RNA binding	nucleus, membrane	transcription, cell cycle, regulation of RNA export from nucleus, cell surface receptor linked signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	58	GGGPRGGARASPATQPPPLLP	MAPK1	12478298	LTP	0.10	MOD_ProDKin_1	-	-	0.96	-	medium
T	71	TQPPPLLPPSTPGPDATVVGS	MAPK1	12478298	LTP	0.18	MOD_ProDKin_1	-	-	0.92	-	medium
T	84	PDATVVGSAPTPLLPPSATAA	MAPK1	12478298	LTP	0.27	MOD_ProDKin_1	-	-	0.75	-	medium

Substrate:

Separin (Cysteine protease)

Seq-ID:

Q14674 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cysteine-type peptidase activity, protein binding	centrosome, nucleus	positive regulation of mitotic metaphase/anaphase transition, proteolysis, cytokinesis, apoptosis, mitotic sister chromatid segregation, negative regulation of sister chromatid cohesion, establishment of mitotic spindle localization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1126	PGPIAPSTNSSPVLKTKPQPI	MAPK1	11747808	LTP	0.15	MOD_ProDKin_1	-	-	0.64	-	medium

Substrate:

Serine/threonine-protein kinase PAK 1 (Ser/Thr protein kinase family)

Seq-ID:

Q13153 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14030   CDC42_HUMAN
MINT-61476   NCK1_HUMAN
MINT-1771821   CD11B_HUMAN
MINT-1953519   GIT1_HUMAN
MINT-1953555   GIT2_HUMAN
MINT-3389399   RAF1_HUMAN
MINT-6541935   SRC8_HUMAN
MINT-7211888   SH3K1_HUMAN
MINT-7212697   ARHG7_HUMAN
MINT-7217644   RAC1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, collagen binding, ATP binding	focal adhesion, cytosol, Golgi apparatus	ER-nucleus signaling pathway, apoptosis, positive regulation of JUN kinase activity, protein amino acid autophosphorylation, cytoskeleton organization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	212	TRSVIEPLPVTPTRDVATSPI	MAPK1	15542607	LTP	0.12	MOD_CDK_SPxK_1	-	-	0.68	-	-

Substrate:

SH2-B beta signaling protein (Unclassified)

Seq-ID:

ENSP00000352232 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-74717 EGFR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
signal transducer activity	cytoplasm, nucleus, membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	96	SLSPPILAPLSPGAEISPHDL	MAPK1	10473609	LTP	0.14	MOD_ProDKin_1	-	-	0.56	-	medium

Substrate:

SMAD1 (Transcription factor)

Seq-ID:

Q15797 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14742   MED15_HUMAN
MINT-16453   MED24_HUMAN
MINT-58496   RAB3B_MOUSE
MINT-58506   UBXN1_MOUSE
MINT-60839   Z512B_HUMAN
MINT-61985   PIAS1_HUMAN
MINT-61986   XPC_HUMAN
MINT-61989   NOTC2_HUMAN
MINT-61990   GMEB1_HUMAN
MINT-61992   ZEB2_HUMAN
MINT-61993   SMAD5_HUMAN
MINT-61994   TTF2_HUMAN
MINT-61996   MLL2_HUMAN
MINT-61997   SF3B1_HUMAN
MINT-61998   RFX1_HUMAN
MINT-61999   MAN1_HUMAN
MINT-62001   SMAD4_HUMAN
MINT-62004   SOX5_HUMAN
MINT-62006   MKL2_HUMAN
MINT-62007   TTF1_HUMAN
MINT-62009   CASL_HUMAN
MINT-62011   INP4A_HUMAN
MINT-62014   PUM1_HUMAN
MINT-62015   PSB4_HUMAN
MINT-62016   ANR27_HUMAN
MINT-62017   MGAP_HUMAN
MINT-62018   I2BP1_HUMAN
MINT-62019   ICK_HUMAN
MINT-62024   PSMD1_HUMAN
MINT-62025   ZN251_HUMAN
MINT-62027   HBP1_HUMAN
MINT-62028   RU17_HUMAN
MINT-4298089   TBA4A_HUMAN
MINT-4298190   ANDR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
I-SMAD binding, identical protein binding, protein kinase binding, co-SMAD binding, transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity, sequence-specific DNA binding transcription factor activity	nuclear inner membrane, cytosol, integral to membrane	embryonic pattern specification, primary microRNA processing, transcription, BMP signaling pathway, SMAD protein complex assembly, transforming growth factor beta receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	187	QQPNSHPFPHSPNSSYPNSPG	MAPK1	9335504	LTP	0.91	MOD_ProDKin_1	-	-	0.81	-	-
S	195	PHSPNSSYPNSPGSSSSTYPH	MAPK1	9335504	LTP	1.00	MOD_ProDKin_1	-	-	0.78	-	-
S	206	PGSSSSTYPHSPTSSDPGSPF	MAPK1	9335504	LTP	0.70	MOD_ProDKin_1	-	-	0.85	-	-
S	214	PHSPTSSDPGSPFQMPADTPP	MAPK1	9335504	LTP	0.87	MOD_ProDKin_1	-	-	0.87	-	-

Substrate:

SMAD3 (Transcription regulatory protein)

Seq-ID:

P84022 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14023   CEBPB_HUMAN
MINT-15105   MED15_HUMAN
MINT-19375   LAP2_MOUSE
MINT-51235   SRBP2_HUMAN
MINT-51239   41_HUMAN
MINT-51243   MYO5B_HUMAN
MINT-51244   TPM3_HUMAN
MINT-51245   CRK_HUMAN
MINT-51247   GT2D1_HUMAN
MINT-51248   LMNA_HUMAN
MINT-51249   VIME_HUMAN
MINT-51250   SF3A1_HUMAN
MINT-51251   ACTB_HUMAN
MINT-51253   PYGL_HUMAN
MINT-61695   MLL4_HUMAN
MINT-61696   KU70_HUMAN
MINT-61697   KDM2A_HUMAN
MINT-61703   GMEB1_HUMAN
MINT-61705   PCDH1_HUMAN
MINT-61707   ZEB2_HUMAN
MINT-61710   RANB9_HUMAN
MINT-61711   MCM3A_HUMAN
MINT-61716   MTF2_HUMAN
MINT-61717   CFDP1_HUMAN
MINT-61720   SP130_HUMAN
MINT-61721   NCOA6_HUMAN
MINT-61723   K1267_HUMAN
MINT-61726   ZEP1_HUMAN
MINT-61732   GI24_HUMAN
MINT-61733   FLNA_HUMAN
MINT-61734   RLA0_HUMAN
MINT-61735   RU17_HUMAN
MINT-61737   TGM2_HUMAN
MINT-61949   SMAD4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transforming growth factor beta receptor binding, protein homodimerization activity, R-SMAD binding, protein kinase binding, co-SMAD binding, ubiquitin protein ligase binding, transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity, beta-catenin binding, transcription factor binding, promoter binding, sequence-specific DNA binding transcription factor activity	nuclear inner membrane, receptor complex, cytosol	protein stabilization, negative regulation of cell growth, SMAD protein complex assembly, cell cycle arrest, positive regulation of canonical Wnt receptor signaling pathway, positive regulation of catenin protein nuclear translocation, activation of caspase activity, immune response, regulation of transforming growth factor beta receptor signaling pathway, transport, positive regulation of transcription factor import into nucleus, regulation of transforming growth factor-beta2 production, transforming growth factor beta receptor signaling pathway, negative regulation of mitotic cell cycle, wound healing, induction of apoptosis, positive regulation of epithelial to mesenchymal transition, cell-cell junction organization, negative regulation of protein amino acid phosphorylation, primary microRNA processing, transcription, evasion of host defenses by virus, negative regulation of protein catabolic process, response to hypoxia

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	179	GIEPQSNIPETPPPGYLSEDG	MAPK1	10197981	LTP	0.57	MOD_ProDKin_1	-	-	0.80	-	-
T	179	GIEPQSNIPETPPPGYLSEDG	MAPK1	16156666	LTP	0.57	MOD_ProDKin_1	-	-	0.80	-	-
S	204	HQMNHSMDAGSPNLSPNPMSP	MAPK1	15241418	LTP	0.77	MOD_ProDKin_1	-	-	0.81	-	-
S	204	HQMNHSMDAGSPNLSPNPMSP	MAPK1	10197981	LTP	0.77	MOD_ProDKin_1	-	-	0.81	-	-
S	204	HQMNHSMDAGSPNLSPNPMSP	MAPK1	16156666	LTP	0.77	MOD_ProDKin_1	-	-	0.81	-	-
S	208	HSMDAGSPNLSPNPMSPAHNN	MAPK1	15241418	LTP	0.47	MOD_ProDKin_1	-	-	0.77	-	-
S	208	HSMDAGSPNLSPNPMSPAHNN	MAPK1	10197981	LTP	0.47	MOD_ProDKin_1	-	-	0.77	-	-
S	208	HSMDAGSPNLSPNPMSPAHNN	MAPK1	16156666	LTP	0.47	MOD_ProDKin_1	-	-	0.77	-	-
S	213	GSPNLSPNPMSPAHNNLDLQP	MAPK1	10197981	LTP	0.82	MOD_ProDKin_1	-	-	0.68	-	-

Substrate:

SMAD4 (Transcription factor)

Seq-ID:

P97471 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-49782 LAP2_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity, collagen binding, chromatin binding, sequence-specific DNA binding transcription factor activity	cytoplasm	branching involved in ureteric bud morphogenesis, regulation of binding, positive regulation of pathway-restricted SMAD protein phosphorylation, transcription, gastrulation with mouth forming second, negative regulation of cell death, negative regulation of cell proliferation, neuron fate commitment, formation of anatomical boundary, mesoderm development, nephrogenic mesenchyme morphogenesis, in utero embryonic development, endoderm development, transforming growth factor beta receptor signaling pathway, developmental growth, palate development, positive regulation of transcription from RNA polymerase II promoter, positive regulation of SMAD protein nuclear translocation, cell proliferation, metanephric mesenchyme morphogenesis, positive regulation of epithelial to mesenchymal transition, somite rostral/caudal axis specification

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	276	TWTGSRTAPYTPNLPHHQNGH	MAPK1	12801888	LTP	0.91	MOD_ProDKin_1	-	-	0.77	-	medium

Substrate:

SOS1 (Guanine nucleotide exchange factor)

Seq-ID:

Q07889 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16551   ABI1_HUMAN
MINT-16777   ITSN1_HUMAN
MINT-1782423   SHC1_HUMAN
MINT-3389635   RASH_HUMAN
MINT-6170118   GRB2_HUMAN
MINT-7051548   HCK_HUMAN
MINT-7135462   EPS8_HUMAN
MINT-7230708   SPD2A_HUMAN
MINT-7245622   SRC_HUMAN
MINT-7247530   FYN_HUMAN
MINT-7250662   NCK1_HUMAN
MINT-7251526   P85A_HUMAN
MINT-7252678   PLCG1_HUMAN
MINT-7254274   CRK_HUMAN
MINT-7971296   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
Rho guanyl-nucleotide exchange factor activity, DNA binding, Rho GTPase activator activity, protein binding	cytosol	induction of apoptosis by extracellular signals, apoptosis, Ras protein signal transduction, regulation of Rho protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1132	IQVTLPHGPRSASVSSISLTK	MAPK1	8816480	LTP	0.26		-	-	0.71	-	-
S	1167	RRPESAPAESSPSKIMSKHLD	MAPK1	8816480	LTP	0.50	MOD_ProDKin_1	-	-	0.90	-	-
S	1178	PSKIMSKHLDSPPAIPPRQPT	MAPK1	8816480	LTP	0.21	MOD_ProDKin_1	-	-	0.88	-	-
S	1193	PPRQPTSKAYSPRYSISDRTS	MAPK1	8816480	LTP	0.28	MOD_ProDKin_1	-	-	0.79	-	-
S	1197	PTSKAYSPRYSISDRTSISDP	MAPK1	8816480	LTP	0.31		-	-	0.78	-	-

Substrate:

Sp1 (Transcription factor Sp1)

Seq-ID:

P08047 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14843   HD_HUMAN
MINT-49665   AATF_HUMAN
MINT-49667   HDAC1_HUMAN
MINT-49728   HMGA1_HUMAN
MINT-56524   P53_HUMAN
MINT-69591   LT_SV40
MINT-3378435   HIF1A_HUMAN
MINT-6803426   PO2F1_HUMAN
MINT-7244314   ABL1_HUMAN
MINT-7245562   SRC_HUMAN
MINT-7246450   FYN_HUMAN
MINT-7249690   NCK1_HUMAN
MINT-7254478   CRK_HUMAN
MINT-7384908   EGR1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein C-terminus binding, protein homodimerization activity, RNA polymerase II transcription factor activity, transcription activator activity, histone deacetylase binding, zinc ion binding, promoter binding, sequence-specific DNA binding transcription factor activity	cytoplasm, nucleus	transcription, positive regulation by host of viral transcription, positive regulation of transcription from RNA polymerase II promoter, global

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	453	VPNSGPIIIRTPTVGPNGQVS	MAPK1	14593115	LTP	0.58	MOD_ProDKin_1	-	-	0.58	-	-
T	739	GAGSEGSGTATPSALITTNMV	MAPK1	14593115	LTP	0.45	MOD_ProDKin_1	-	-	0.56	-	-

Substrate:

SREBF2 (protein binding, RNA polymerase II transcription factor acti...)

Seq-ID:

Q12772 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16696 HNF4A_HUMAN
MINT-51235 SMAD3_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein C-terminus binding	Golgi membrane, ER to Golgi transport vesicle membrane, SREBP-SCAP-Insig complex, nucleus	transcription, cholesterol metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	432	EDFNQNVLLMSPPASDSGSQA	MAPK1	14988395	LTP	0.05	MOD_ProDKin_1	-	-	0.46	-	medium
S	455	SPYSIDSEPGSPLLDDAKVKD	MAPK1	14988395	LTP	1.00	MOD_ProDKin_1	-	-	0.45	-	medium

Substrate:

SREBP1 (Transcription factor)

Seq-ID:

P36956 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-2863379 ATX1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sterol response element binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, protein binding	Golgi membrane, ER to Golgi transport vesicle membrane, integral to membrane, nuclear envelope, endoplasmic reticulum membrane, nucleus, endoplasmic reticulum	cellular response to starvation, transcription, regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, cholesterol metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	117	LKMYPSMPAFSPGPGIKEESV	MAPK1	10915800	LTP	0.13	MOD_ProDKin_1	-	-	0.66	-	medium

Substrate:

STAT 5 (Transcription factor)

Seq-ID:

P42229 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50646   ESR1_HUMAN
MINT-58264   STAP2_HUMAN
MINT-6793989   PTN1_HUMAN
MINT-7891339   EPOR_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, sequence-specific DNA binding transcription factor activity, protein binding	cytoplasm, nucleus	valine metabolic process, oxaloacetate metabolic process, transcription, creatinine metabolic process, isoleucine metabolic process, JAK-STAT cascade, taurine metabolic process, allantoin metabolic process, fatty acid metabolic process, citrate metabolic process, 2-oxoglutarate metabolic process, succinate metabolic process, creatine metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	780	RPMDSLDSRLSPPAGLFTSAR	MAPK1	10194762	LTP	0.43	MOD_ProDKin_1	-	-	0.55	-	medium

Substrate:

Steroidogenic factor 1 (Nuclear receptor)

Seq-ID:

P33242 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity, chromatin binding, zinc ion binding, steroid hormone receptor activity	nucleus	male gonad development, tissue development, adrenal gland development, maintenance of protein location in nucleus, cell differentiation, luteinization, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	203	IKSEYPEPYASPPQQPGPPYS	MAPK1	10230405	LTP	0.78	MOD_ProDKin_1	-	-	0.74	-	low

Substrate:

THRB (protein binding, thyroid hormone receptor activity)

Seq-ID:

P10828 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, thyroid hormone receptor activity, transcription corepressor activity, zinc ion binding, sequence-specific DNA binding transcription factor activity, steroid hormone receptor activity	nucleus	transcription, DNA-dependent, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	142	RRTIQKNLHPSYSCKYEGKCV	MAPK1	12809513	LTP	0.46		-	ZnF_C4	0.17	2NLL	75.41%

Substrate:

TNFRSF1A (Cell surface receptor)

Seq-ID:

P25118 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-2631403 RIPK1_MOUSE
MINT-2631419 CALX_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
tumor necrosis factor receptor activity	plasma membrane, integral to membrane, membrane raft	defense response to bacterium, apoptosis, inflammatory response, positive regulation of inflammatory response, positive regulation of transcription from RNA polymerase II promoter, prostaglandin metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	265	VKEEKAGKPLTPAPSPAFSPT	MAPK1	10702263	LTP	0.10	MOD_ProDKin_1	-	-	0.56	-	medium
S	269	KAGKPLTPAPSPAFSPTSGFN	MAPK1	10702263	LTP	0.14	MOD_ProDKin_1	-	-	0.53	-	medium
S	273	PLTPAPSPAFSPTSGFNPTLG	MAPK1	10702263	LTP	0.14	MOD_ProDKin_1	-	-	0.44	-	medium
S	299	FSSPVSSTPISPIFGPSNWHF	MAPK1	10702263	LTP	1.00	MOD_ProDKin_1	-	-	0.28	-	medium

Substrate:

TRAP220 (Transcription regulatory protein)

Seq-ID:

Q15648 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-58469   MDM2_HUMAN
MINT-58470   P53_HUMAN
MINT-5209905   RARA_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
peroxisome proliferator activated receptor binding, RNA polymerase II transcription mediator activity, receptor activity, DNA binding, estrogen receptor binding, ligand-dependent nuclear receptor transcription coactivator activity, retinoic acid receptor binding, ligand-dependent nuclear receptor binding, vitamin D receptor binding, thyroid hormone receptor binding	mediator complex	fat cell differentiation, androgen receptor signaling pathway, transcription initiation from RNA polymerase II promoter, androgen biosynthetic process, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	1457	SPSHSKSPAYTPQNLDSESES	MAPK1	12356758	LTP	0.13	MOD_ProDKin_1	-	Med1-Trap220	0.89	-	medium

Substrate:

Tuberin (GTPase activating protein)

Seq-ID:

P49815 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14051   1433T_HUMAN
MINT-16238   TSC1_HUMAN
MINT-16580   1433F_HUMAN
MINT-17162   1433B_HUMAN
MINT-17710   1433S_HUMAN
MINT-3317863   1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein homodimerization activity, GTPase activator activity	TSC1-TSC2 complex, Golgi apparatus, nucleus, perinuclear region of cytoplasm	neural tube closure, protein import into nucleus, regulation of insulin receptor signaling pathway, positive regulation of GTPase activity, insulin-like growth factor receptor signaling pathway, heart development, negative regulation of phosphoinositide 3-kinase cascade, superior temporal gyrus development, positive chemotaxis, protein kinase B signaling cascade, regulation of small GTPase mediated signal transduction, regulation of endocytosis, endocytosis, negative regulation of protein kinase B signaling cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	664	GSEKKTSGPLSPPTGPPGPAP	MAPK1	15851026	LTP	1.00	MOD_ProDKin_1	-	Tuberin	0.88	-	medium

Substrate:

UBF-1 (Transcription factor)

Seq-ID:

P17480 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-62331   ZMYM2_HUMAN
MINT-63514   SCG1_HUMAN
MINT-1894291   FBRL_HUMAN
MINT-4543985   SET_HUMAN
MINT-7720853   CEBPA_HUMAN
MINT-7971422   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, RNA polymerase I transcription factor activity, protein binding	nucleolus, nucleoplasm	transcription, positive regulation of transcription from RNA polymerase I promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	117	KHPDFPKKPLTPYFRFFMEKR	MAPK1	11741541	LTP	1.00	MOD_ProDKin_1	-	HMG	0.27	-	-
T	201	KKSDIPEKPKTPQQLWYTHEK	MAPK1	11741541	LTP	1.00	MOD_ProDKin_1	-	HMG	0.56	-	-

Substrate:

Vinexin (unclassified)

Seq-ID:

Q9R1Z8 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription factor binding	focal adhesion, cytoplasm, cytoskeleton, nucleus	positive regulation of MAPKKK cascade, negative regulation of transcription from RNA polymerase II promoter, cell-substrate adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	594	LCDDGPQLPASPNPTTTAHLS	MAPK1	15184391	LTP	1.00	MOD_ProDKin_1	-	-	0.78	-	medium